期刊文献+
共找到14,107篇文章
< 1 2 250 >
每页显示 20 50 100
Computer-assisted three-dimensional individualized extreme liver resection for hepatoblastoma in proximity to the major liver vasculature
1
作者 Wen-Li Xiu Jie Liu +7 位作者 Jing-Li Zhang Jing-Miao Wang Xue-Feng Wang Fei-Fei Wang Jie Mi Xi-Wei Hao NanXia Qian Dong 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第4期1066-1077,共12页
BACKGROUND The management of hepatoblastoma(HB)becomes challenging when the tumor remains in close proximity to the major liver vasculature(PMV)even after a full course of neoadjuvant chemotherapy(NAC).In such cases,e... BACKGROUND The management of hepatoblastoma(HB)becomes challenging when the tumor remains in close proximity to the major liver vasculature(PMV)even after a full course of neoadjuvant chemotherapy(NAC).In such cases,extreme liver resection can be considered a potential option.AIM To explore whether computer-assisted three-dimensional individualized extreme liver resection is safe and feasible for children with HB who still have PMV after a full course of NAC.METHODS We retrospectively collected data from children with HB who underwent surgical resection at our center from June 2013 to June 2023.We then analyzed the detailed clinical and three-dimensional characteristics of children with HB who still had PMV after a full course of NAC.RESULTS Sixty-seven children diagnosed with HB underwent surgical resection.The age at diagnosis was 21.4±18.8 months,and 40 boys and 27 girls were included.Fifty-nine(88.1%)patients had a single tumor,39(58.2%)of which was located in the right lobe of the liver.A total of 47 patients(70.1%)had PRE-TEXT III or IV.Thirty-nine patients(58.2%)underwent delayed resection.After a full course of NAC,16 patients still had close PMV(within 1 cm in two patients,touching in 11 patients,compressing in four patients,and showing tumor thrombus in three patients).There were 6 patients of tumors in the middle lobe of the liver,and four of those patients exhibited liver anatomy variations.These 16 children underwent extreme liver resection after comprehensive preoperative evaluation.Intraoperative procedures were performed according to the preoperative plan,and the operations were successfully performed.Currently,the 3-year event-free survival of 67 children with HB is 88%.Among the 16 children who underwent extreme liver resection,three experienced recurrence,and one died due to multiple metastases.CONCLUSION Extreme liver resection for HB that is still in close PMV after a full course of NAC is both safe and feasible.This approach not only reduces the necessity for liver transplantation but also results in a favorable prognosis.Individualized three-dimensional surgical planning is beneficial for accurate and complete resection of HB,particularly for assessing vascular involvement,remnant liver volume and anatomical variations. 展开更多
关键词 Children HEPATOBLASTOMA Surgery THREE-DIMENSIONAL computer-assisted
下载PDF
Diagnostic efficacy of virtual organ computer-assisted analysis in measuring the volume ratio of subchorionic hematoma with serum progesterone
2
作者 Lin-Ling Shen Jing Shi +2 位作者 Chang-Wei Ding Gao-Le Dai Qi Ma 《World Journal of Clinical Cases》 SCIE 2024年第17期3053-3060,共8页
BACKGROUND Subchorionic hematoma(SCH)is a common complication in early pregnancy characterized by the accumulation of blood between the uterine wall and the chorionic membrane.SCH can lead to adverse pregnancy outcome... BACKGROUND Subchorionic hematoma(SCH)is a common complication in early pregnancy characterized by the accumulation of blood between the uterine wall and the chorionic membrane.SCH can lead to adverse pregnancy outcomes such as miscarriage,preterm birth,and other complications.Early detection and accurate assessment of SCH are crucial for appropriate management and improved pregnancy outcomes.AIM To evaluate the diagnostic efficacy of virtual organ computer-assisted analysis(VOCAL)in measuring the volume ratio of SCH to gestational sac(GS)combined with serum progesterone on early pregnancy outcomes in patients with SCH.METHODS A total of 153 patients with SCH in their first-trimester pregnancies between 6 and 11 wk were enrolled.All patients were followed up until a gestational age of 20 wk.The parameters of transvaginal two-dimensional ultrasound,including the circumference of SCH(Cs),surface area of SCH(Ss),circumference of GS(Cg),and surface area of GS(Sg),and the parameters of VOCAL with transvaginal three-dimensional ultrasound,including the three-dimensional volume of SCH(3DVs)and GS(3DVg),were recorded.The size of the SCH and its ratio to the GS size(Cs/Cg,Ss/Sg,3DVs/3DVg)were recorded and compared.RESULTS Compared with those in the normal pregnancy group,the adverse pregnancy group had higher Cs/Cg,Ss/Sg,and 3DVs/3DVg ratios(P<0.05).When 3DVs/3DVg was 0.220,the highest predictive performance predicted adverse pregnancy outcomes,resulting in an AUC of 0.767,and the sensitivity,specificity were 70.2%,75%respectively.VOCAL measuring 3DVs/3DVg combined with serum progesterone gave a diagnostic AUC of 0.824 for early pregnancy outcome in SCH patients,with a high sensitivity of 82.1%and a specificity of 72.1%,which showed a significant difference between AUC.CONCLUSION VOCAL-measured 3DVs/3DVg effectively quantifies the severity of SCH,while combined serum progesterone better predicts adverse pregnancy outcomes. 展开更多
关键词 Subchorionic hematoma Virtual organ computer-assisted analysis Gestational sac Serum progesterone Ultrasound parameters Adverse pregnancy outcomes
下载PDF
Computer-assisted rescue of the inferior mesenteric artery in a child with a giant ganglioneuroblastoma: A case report
3
作者 Wen-Li Xiu Jie Liu +5 位作者 Jing-Li Zhang Nan Su Feng-Jiao Wang Xi-Wei Hao Fei-Fei Wang Qian Dong 《World Journal of Gastrointestinal Surgery》 2023年第5期984-991,共8页
BACKGROUND Ganglioneuroblastoma(GNB)is a peripheral neuroblastoma(NB)with malignant degree between highly malignant NB and benign ganglioma(GN).Pathology is the gold standard of diagnosis.Although GNB is not uncommon ... BACKGROUND Ganglioneuroblastoma(GNB)is a peripheral neuroblastoma(NB)with malignant degree between highly malignant NB and benign ganglioma(GN).Pathology is the gold standard of diagnosis.Although GNB is not uncommon in children,biopsy alone may lead to an inaccurate diagnosis,especially for giant tumors.However,surgical resection may be associated with significant complications.Here,we report a case of computer-assisted surgical resection of a giant GNB in a child and successful rescue of the inferior mesenteric artery.CASE SUMMARY A 4-year-old girl was admitted to our department for a giant retroperitoneal lesion,which was considered to be an NB by her local hospital.The symptoms of the girl disappeared spontaneously without treatment.On physical examination,a mass of about 10 cm×7 cm could be palpated in her abdomen.Ultrasonography and contrast-enhanced computed tomography performed in our hospital also showed an NB,and there was a very thick blood vessel inside the tumor.However,aspiration biopsy revealed GN.Surgical resection is the best treatment option for this giant benign tumor.For precise preoperative evaluation,threedimensional reconstruction was performed.It was clear that the tumor was close to the abdominal aorta.The superior mesenteric vein was pushed forward,and the inferior mesenteric artery passed through the tumor.Because GN generally does not invade blood vessels,we split the tumor with a CUSA knife during the operation and found that there was indeed a straight and intact vascular sheath.Arterial pulsation was observed in the completely exposed inferior mesenteric artery.The pathologists interpreting the tissue finally diagnosed it as a mixed GNB(GNBi),which is more malignant than GN.However,both GN and GNBi usually have a good prognosis.CONCLUSION This was a case of successful surgical resection of a giant GNB,and aspiration biopsy underestimated the pathological staging of the tumor.Preoperative three-dimensional reconstruction assisted with the radical resection of the tumor and rescue of the inferior mesenteric artery. 展开更多
关键词 Surgery Children GANGLIONEUROBLASTOMA computer-assisted Tumor Case report
下载PDF
Computer-assisted Surgery for Scaphoid Fracture 被引量:6
4
作者 Zi-run XIAO Ge XIONG 《Current Medical Science》 SCIE CAS 2018年第6期941-948,共8页
The computer-assisted surgery (CAS)has significantly improved the accuracy, reliability and outcomes of traumatic,spinal,nerve surgery and many other operations with a less invasive way.The application of CAS for scap... The computer-assisted surgery (CAS)has significantly improved the accuracy, reliability and outcomes of traumatic,spinal,nerve surgery and many other operations with a less invasive way.The application of CAS for scaphoid fractures remains experimental.The related studies are scanty and most of them are cadaver researches.Some intrinsic defects from the registration procedure,scan and immobilization of limbs may inevitably result in deviations. Some deviations become more obvious with operations of small bones (such as scaphoid)although they are acceptable for spine and other orthopedic surgeries.We reviewed the current literatures on the applications of CAS for scaphoid operation and summarized technical principles,scan and registration methods,immobilization of limbs and their outcomes.On the basis of the data,we analyzed the limitations of this technique and envisioned its future development. 展开更多
关键词 computer-assisted SURGERY WRIST SCAPHOID FRACTURE
下载PDF
Establishment and validation of a computer-assisted colonic polyp localization system based on deep learning 被引量:6
5
作者 Sheng-Bing Zhao Wei Yang +24 位作者 Shu-Ling Wang Peng Pan Run-Dong Wang Xin Chang Zhong-Qian Sun Xing-Hui Fu Hong Shang Jian-Rong Wu Li-Zhu Chen Jia Chang Pu Song Ying-Lei Miao Shui-Xiang He Lin Miao Hui-Qing Jiang Wen Wang Xia Yang Yuan-Hang Dong Han Lin Yan Chen Jie Gao Qian-Qian Meng Zhen-Dong Jin Zhao-Shen Li Yu Bai 《World Journal of Gastroenterology》 SCIE CAS 2021年第31期5232-5246,共15页
BACKGROUND Artificial intelligence in colonoscopy is an emerging field,and its application may help colonoscopists improve inspection quality and reduce the rate of missed polyps and adenomas.Several deep learning-bas... BACKGROUND Artificial intelligence in colonoscopy is an emerging field,and its application may help colonoscopists improve inspection quality and reduce the rate of missed polyps and adenomas.Several deep learning-based computer-assisted detection(CADe)techniques were established from small single-center datasets,and unrepresentative learning materials might confine their application and generalization in wide practice.Although CADes have been reported to identify polyps in colonoscopic images and videos in real time,their diagnostic performance deserves to be further validated in clinical practice.AIM To train and test a CADe based on multicenter high-quality images of polyps and preliminarily validate it in clinical colonoscopies.METHODS With high-quality screening and labeling from 55 qualified colonoscopists,a dataset consisting of over 71000 images from 20 centers was used to train and test a deep learning-based CADe.In addition,the real-time diagnostic performance of CADe was tested frame by frame in 47 unaltered full-ranged videos that contained 86 histologically confirmed polyps.Finally,we conducted a selfcontrolled observational study to validate the diagnostic performance of CADe in real-world colonoscopy with the main outcome measure of polyps per colonoscopy in Changhai Hospital.RESULTS The CADe was able to identify polyps in the test dataset with 95.0%sensitivity and 99.1%specificity.For colonoscopy videos,all 86 polyps were detected with 92.2%sensitivity and 93.6%specificity in frame-by-frame analysis.In the prospective validation,the sensitivity of CAD in identifying polyps was 98.4%(185/188).Folds,reflections of light and fecal fluid were the main causes of false positives in both the test dataset and clinical colonoscopies.Colonoscopists can detect more polyps(0.90 vs 0.82,P<0.001)and adenomas(0.32 vs 0.30,P=0.045)with the aid of CADe,particularly polyps<5 mm and flat polyps(0.65 vs 0.57,P<0.001;0.74 vs 0.67,P=0.001,respectively).However,high efficacy is not realized in colonoscopies with inadequate bowel preparation and withdrawal time(P=0.32;P=0.16,respectively).CONCLUSION CADe is feasible in the clinical setting and might help endoscopists detect more polyps and adenomas,and further confirmation is warranted. 展开更多
关键词 computer-assisted detection Artificial intelligence Deep learning COLONOSCOPY Clinical validation Colorectal polyp
下载PDF
Glutathione Peroxidase Revisited—Simulation of the Catalytic Cycle by Computer-Assisted Molecular Modelling 被引量:6
6
作者 K. -D. AUMANN N. BEDORF +3 位作者 R. BRIGELIUS-FLOHED D. SCHOMBURG AND L. FLOHE(Gesellschaft fur Biotechnologische Forschung mbH (GBF) Mascheroder Weg 1, D-38124 Braunschweig, Germany Deutsches Institut fur Ernahrungsforschung (DIfE) Arthur-Scheunert-Allee 114 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1997年第2期136-155,共20页
Glutathione peroxidase, the first example of selenoproteins identified in mammals, was subjected to force field calculations and molecular dynamics in order to enable a clearer comprehension of enzymatic selenium cata... Glutathione peroxidase, the first example of selenoproteins identified in mammals, was subjected to force field calculations and molecular dynamics in order to enable a clearer comprehension of enzymatic selenium catalysis. Starting from the established X-ray structure of bovine GPX, all kinetically defined intermediates and enzyme substrate complexes were modelled. The models thus obtained support the hypothesis that the essential steps of the catalysis are three distinct redox changes of the active site selenium which, in the ground state, presents itself at the surface of selenoperoxidases as the center of a characteristic triad built by selenocysteine, glutarnine and tryptophan. In GPX, four arginine residues and a lysine residue provide an electrostatic architecture which, in each reductive step, directs the donor substrate GSH towards the catalytic center in such a way that 1ts sulfhydryl group must react with the selenium moiety. To this end, different equally efficient modes of substrate binding appear possible. The models are consistent with substrate specificity data, kinetic pattern and other functional characteristics of the enzyme. Comparison of molecular models of GPX with those of other members of the GPX superfamily reveals that the cosubstrate binding mechanisrns are unique for the classical type of cytosolic glutathione peroxidases but cannot operate e. g. in plasma GPX and phospholipid hydroperoxide GPX. The structural differences between the selenoperoxidases, shown to be relevant to their specificities, are discussed in terms of functional diversification within the GPX superfamily 展开更多
关键词 GPX Glutathione Peroxidase Revisited Simulation of the Catalytic Cycle by computer-assisted Molecular Modelling
下载PDF
Application of a novel computer-assisted surgery system in percutaneous nephrolithotomy:A controlled study 被引量:1
7
作者 Fei Qin Ye-Feng Sun +8 位作者 Xin-Ning Wang Bin Li Zhi-Lei Zhang Ming-Xin Zhang Fei Xie Shuai-Hong Liu Zi-Jie Wang Yuan-Chao Cao Wei Jiao 《World Journal of Clinical Cases》 SCIE 2022年第18期6039-6049,共11页
BACKGROUND Most complex renal stones are managed primarily with percutaneous nephrolithotomy(PCNL).However,PCNL is still a great challenge for surgeons because of poor comprehension on complex adjacent structures.Nove... BACKGROUND Most complex renal stones are managed primarily with percutaneous nephrolithotomy(PCNL).However,PCNL is still a great challenge for surgeons because of poor comprehension on complex adjacent structures.Novel techniques are required to assist in planning and navigation.AIM To apply and evaluate the Hisense computer-assisted surgery(CAS)system in PCNL.METHODS A total of 60 patients with complex renal stones were included.Thirty patients in the CAS group had three-dimensional(3 D)virtual models constructed with the CAS system.The model assisted in planning and navigating in the CAS system.Thirty patients in the control group planned and navigated as standard PCNL,without the application of the CAS system.Success rate of one attempt,operation time,initial stone-free rate,decrease in hemoglobin,and complications were collected and analyzed.RESULTS There were no statistically significant differences in the baseline characteristics or planning characteristics.The success rate of one puncturing attempt(90%vs 67%,P=0.028)and the initial stone-free rate(87%vs 63%,P=0.037)were significantly higher in the CAS group.However,there were no statistically significant differences in the operation time(89.20±29.60 min vs 92.33±33.08 min,P=0.859)or in the decrease in hemoglobin(11.07±8.32 g/L vs 9.03±11.72 g/L,P=0.300)between the CAS group and the control group.No statistically significant differences in the incidence of complications(Clavien-Dindo grade≥2)were found.CONCLUSION Compared with standard PCNL,CAS-assisted PCNL had advantages in terms of the puncturing success rate and stone-free rate.The Hisense CAS System was recommended to assist in preoperative planning and intraoperative navigation for an intuitive,precise and convenient PCNL. 展开更多
关键词 computer-assisted surgery system Percutaneous nephrolithotomy Three-dimensional reconstruction PLANNING NAVIGATION
下载PDF
Application of computer-assisted navigation in treating congenital maxillomandibular syngnathia:A case report
8
作者 Li-Qin Lin Shan-Shan Bai Min Wei 《World Journal of Clinical Cases》 SCIE 2019年第5期650-655,共6页
BACKGROUND Congenital maxillomandibular syngnathia is an extremely rare disorder characterized by craniofacial malformations and inability to open the mouth adequately, which leads to problems with feeding, swallowing... BACKGROUND Congenital maxillomandibular syngnathia is an extremely rare disorder characterized by craniofacial malformations and inability to open the mouth adequately, which leads to problems with feeding, swallowing, and breathing as well as temporomandibular joint ankylosis. The main goal of the surgery is to release the ankylosis, establish functioning mandible, and prevent re-fusion.However, surgical procedures for this disease are rarely reported.CASE SUMMARY Here, we report a 7-mo-old girl with bilateral maxillomandibular syngnathia. The patient presented with difficulty in feeding, breathing, sounding, and swallowing and had developmental dysplasia. For treatment, we performed bone isolation by computer-assisted navigation and used silicone to fix the wound surface to prevent refusion of bone. To our knowledge, this is the only syngnathia case in the literature treated using computer-assisted navigation. With the guidance of precise navigation, we were able to minimize operation time by at least one hour,the patient's blood vessels, nerves, and tooth germs were well protected, and excessive bleeding was avoided. After six weeks, the patient showed improvement in mouth opening and no major issues of feeding.CONCLUSION Application of computer-assisted navigation can significantly improve accuracy,effectiveness, and surgical safety in correcting congenital maxillomandibular syngnathia. 展开更多
关键词 CRANIOFACIAL ABNORMALITIES MANDIBULAR diseases MAXILLA computer-assisted NAVIGATION Case report
下载PDF
Novel computer-assisted method for revision arthroplasty of the knee
9
作者 Hanns-Edgar Hoffart Harald Dinges +2 位作者 Stefan Kolbeck Peter Ritschl Hagen Hommel 《World Journal of Orthopedics》 2015年第10期821-828,共8页
AIM: To introduce the navigation system of software and instruments designed specifically for revision total knee arthroplasty(TKA).METHODS: We present an imageless navigation system for revision TKA,with optical poin... AIM: To introduce the navigation system of software and instruments designed specifically for revision total knee arthroplasty(TKA).METHODS: We present an imageless navigation system for revision TKA,with optical point and tracker identification to assess kinematic and anatomical landmarks.The system automatically positions the cutting guides with a motorized cutting unit.The cutting unit is placed on the distal femur with a femoral clamp and acts as a rigid body and the base for all femoral cuts.The surgical technique for using the navigation system for revision TKA is based on the technique used in primary TKA.However,there are some important differences.The most notable are:(1) differences in estimation of the position of the primary implant relative to the bone and the mechanical axes;(2) the specific possibilities the revision navigation software offers in terms of optimal joint level positioning; and(3) the suggested "best fit" position,in which the clock position,stem position and offset,femoral component size,and mediolateral position of the femoral component are taken into account to find the optimal femoral component position.We assessed the surgical technique,and accompanying software procedural steps,of the system,identifying any advantages or disadvantages that they present.RESULTS: The system aims to visualize critical steps of the procedure and is intended as a tool to support the surgeon in surgical decision-making.Combining a computer-assisted cutting device with navigation makes it possible to carry out precise cuts without pinning.Furthermore,the femoral clamp provides a stable fixation mechanism for the motorized cutting unit.A stable clamp is paramount in the presence of periarticular bony defects.The system allows the position of the primary implant relative to the bone and mechanical axes to be estimated,at which point any malalignments can be corrected.It also offers an optimal joint level position for implantation,and suggests a "best fit" position,in which the clock position,stem position and offset,femoral component size,and mediolateral position of the femoral component are considered.The surgeon can therefore make decisions intraoperatively to maximise alignment and,hence,outcomes.Based on the intraoperative findings of joint stability,the surgeon can modify the preoperative plan and switch from a constrained condylar system to a hinged version,or vice versa.CONCLUSION: The system is flexible and easy to learn and allows improvements in workflow during TKA. 展开更多
关键词 KNEE Navigation system REVISION TOTAL KNEE ARTHROPLASTY computer-assisted surgery SURGICAL technique
下载PDF
COMPUTER-ASSISTED TESTING OF METALINGUISTIC COMPETENCE
10
作者 Baisara Ludmila 《广州大学学报(社会科学版)》 1995年第2X期96-100,共5页
The paper is devoted to the description of possible approaches to designing materials for computer-assisted testing of metalinguistic competence of the intending foreign language teachers. By metalinguistic competence... The paper is devoted to the description of possible approaches to designing materials for computer-assisted testing of metalinguistic competence of the intending foreign language teachers. By metalinguistic competence we here mean the learners’ comprehension of such fundamental concepts of linguistic theory as: grammatical and lexical meanings and their types, the concepts of grammatical form and grammatical category, homonyms and synonyms, 展开更多
关键词 computer-assisted TESTING OF METALINGUISTIC COMPETENCE
下载PDF
Computer-Assisted Surgery for Mandibular Reconstruction Using a Patient-Specific Titanium Mesh Tray and Particulate Cancellous Bone and Marrow
11
作者 Seiji Kondo Hideyuki Katsuta +6 位作者 Ayako Akizuki Yuji Kurihara Takaaki Kamatani Atsushi Yaso Masahiro Nagasaki Toshikazu Shimane Tatsuo Shirota 《Case Reports in Clinical Medicine》 2015年第3期85-92,共8页
Craniomaxillofacial surgery is difficult due to the complexity of the regional anatomy. Computer-assisted surgery is a promising tool aiming to improve the safety and precision of such surgery. A computer-assisted sur... Craniomaxillofacial surgery is difficult due to the complexity of the regional anatomy. Computer-assisted surgery is a promising tool aiming to improve the safety and precision of such surgery. A computer-assisted surgical navigation approach for reconstruction of mandibular defects using a patient-specific titanium mesh tray and particulate cancellous bone and marrow (PCBM) harvested from bilateral anterior ilia is proposed. This case report involves a large multicystic ameloblastoma affecting the right mandible of a 31-year-old male patient. Following detailed clinical examination, radiological interpretation, and histopathological diagnosis, computer-assisted surgical simulation with a virtual 3-dimensional (3-D) model was designed using surgical planning software based on the pre-operative computed tomography data. Long-span segmental resection of the mandible was planned, and the defect was analyzed for reconstruction using a patient-specific reconstruction titanium mesh tray mediated with computer-aided design and manufacturing (CAD/CAM) techniques. During the actual surgery, the ultrasonic bone cutting instrument in the surgeon’s hand was connected to the navigation system to touch an anatomical position on the patient. Therefore, osteotomies were performed finely and smoothly according to the navigation images of the cutting bone line by sequentially moving the instrument. Finally, a CAD/CAM-mediated titanium mesh tray condensed by PCBM was adapted to the remaining mandibular fragments. Six months postoperatively, the patient had a good mandibular configuration and facial contour. Integration of different technologies, such as software planning and 3-D surgical simulation, combined with intraoperative navigation and CAD/CAM techniques, provides safe and precise mandibular reconstruction surgery. 展开更多
关键词 PATIENT-SPECIFIC Titanium Mesh TRAY computer-assisted Surgery MANDIBULAR Reconstruction PARTICULATE CANCELLOUS Bone and MARROW Surgical Navigation
下载PDF
A Leaking-Proof Theranostic Nanoplatform for Tumor-Targeted and Dual-Modality Imaging-Guided Photodynamic Therapy
12
作者 Duo Jin Yang Zhu +8 位作者 Manman Liu Wenxin Yu Jiaji Yu Xinwei Zheng Lulu Wang Yun Wu Kaiju Wei Junjie Cheng Yangzhong Liu 《Biomedical Engineering Frontiers》 CAS 2023年第1期187-196,共10页
Objective:A protein-based leaking-proof theranostic nanoplatform for dual-modality imaging-guided tumor photodynamic therapy(PDT)has been designed.Impact Statement:A site-specific conjugation of chlorin e6(Ce6)to ferr... Objective:A protein-based leaking-proof theranostic nanoplatform for dual-modality imaging-guided tumor photodynamic therapy(PDT)has been designed.Impact Statement:A site-specific conjugation of chlorin e6(Ce6)to ferrimagnetic ferritin(MFtn-Ce6)has been constructed to address the challenge of unexpected leakage that often occurs during small-molecule drug delivery.Introduction:PDT is one of the most promising approaches for tumor treatment,while a delivery system is typically required for hydrophobic photosensitizers.However,the nonspecific distribution and leakage of photosensitizers could lead to insufficient drug accumulation in tumor sites.Methods:An engineered ferritin was generated for site-specific conjugation of Ce6 to obtain a leaking-proof delivery system,and a ferrimagnetic core was biomineralized in the cavity of ferritin,resulting in a fluorescent ferrimagnetic ferritin nanoplatform(MFtn-Ce6).The distribution and tumor targeting of MFtn-Ce6 can be detected by magnetic resonance imaging(MRI)and fluorescence imaging(FLI).Results:MFtn-Ce6 showed effective dual-modality MRI and FLI.A prolonged in vivo circulation and increased tumor accumulation and retention of photosensitizer was observed.The time-dependent distribution of MFtn-Ce6 can be precisely tracked in real time to find the optimal time window for PDT treatment.The colocalization of ferritin and the iron oxide core confirms the high stability of the nanoplatform in vivo.The results showed that mice treated with MFtn-Ce6 exhibited marked tumor-suppressive activity after laser irradiation.Conclusion:The ferritin-based leaking-proof nanoplatform can be used for the efficient delivery of the photosensitizer to achieve an enhanced therapeutic effect.This method established a general approach for the dual-modality imagingguided tumor delivery of PDT agents. 展开更多
关键词 proof distribution RETENTION
下载PDF
Block Verification Mechanism Based on Zero-Knowledge Proof in Blockchain
13
作者 Jin Wang Wei Ou +3 位作者 Osama Alfarraj Amr Tolba Gwang-Jun Kim Yongjun Ren 《Computer Systems Science & Engineering》 SCIE EI 2023年第5期1805-1819,共15页
Since transactions in blockchain are based on public ledger verification,this raises security concerns about privacy protection.And it will cause the accumulation of data on the chain and resulting in the low efficien... Since transactions in blockchain are based on public ledger verification,this raises security concerns about privacy protection.And it will cause the accumulation of data on the chain and resulting in the low efficiency of block verification,when the whole transaction on the chain is verified.In order to improve the efficiency and privacy protection of block data verification,this paper proposes an efficient block verification mechanism with privacy protection based on zeroknowledge proof(ZKP),which not only protects the privacy of users but also improves the speed of data block verification.There is no need to put the whole transaction on the chain when verifying block data.It just needs to generate the ZKP and root hash with the transaction information,then save them to the smart contract for verification.Moreover,the ZKP verification in smart contract is carried out to realize the privacy protection of the transaction and efficient verification of the block.When the data is validated,the buffer accepts the complete transaction,updates the transaction status in the cloud database,and packages up the chain.So,the ZKP strengthens the privacy protection ability of blockchain,and the smart contracts save the time cost of block verification. 展开更多
关键词 Blockchain privacy protection zero-knowledge proof smart contract
下载PDF
A Comparative Analysis of the New -3(-n) - 1 Remer Conjecture and a Proof of the 3n + 1 Collatz Conjecture
14
作者 Mike Remer 《Journal of Applied Mathematics and Physics》 2023年第8期2216-2220,共5页
This scientific paper is a comparative analysis of two mathematical conjectures. The newly proposed -3(-n) - 1 Remer conjecture and how it is related to and a proof of the more well known 3n + 1 Collatz conjecture. An... This scientific paper is a comparative analysis of two mathematical conjectures. The newly proposed -3(-n) - 1 Remer conjecture and how it is related to and a proof of the more well known 3n + 1 Collatz conjecture. An overview of both conjectures and their respective iterative processes will be presented. Showcasing their unique properties and behavior to each other. Through a detailed comparison, we highlight the similarities and differences between these two conjectures and discuss their significance in the field of mathematics. And how they prove each other to be true. 展开更多
关键词 -3(-n) - 1 Remer Conjecture 3n + 1 Collatz Conjecture Comparative Analysis proof Natural Numbers Integer Sequences Factorial Processes Par-tial Differential Equations Bounded Values Collatz Conjecture Collatz Algo-rithm Collatz Operator Collatz Compliance And Mathematical Conjectures
下载PDF
Clinical application of improved 2D computer-assisted fluoroscopic navigation through simulating a 3D vertebrae image to guide pedicle screw internal fixation
15
作者 刘恩志 《外科研究与新技术》 2011年第2期94-94,共1页
Objective To study the effect of using improved 2D computer-assisted fluoroscopic navigation through simulating 3D vertebrae image to guide pedicle screw internal fixation.Methods Posterior pedicle screw internal fixa... Objective To study the effect of using improved 2D computer-assisted fluoroscopic navigation through simulating 3D vertebrae image to guide pedicle screw internal fixation.Methods Posterior pedicle screw internal fixation,distraction 展开更多
关键词 Clinical application of improved 2D computer-assisted fluoroscopic navigation through simulating a 3D vertebrae image to guide pedicle screw internal fixation
下载PDF
A Proof of Brouwer’s Fixed Point Theorem Using Sperner’s Lemma
16
作者 Cassie Lu 《数学计算(中英文版)》 2023年第2期1-6,共6页
This article offers a simple but rigorous proof of Brouwer’s fixed point theorem using Sperner’s Lemma.The general method I have used so far in the proof is mainly to convert the n-dimensional shapes to the correspo... This article offers a simple but rigorous proof of Brouwer’s fixed point theorem using Sperner’s Lemma.The general method I have used so far in the proof is mainly to convert the n-dimensional shapes to the corresponding case under the Sperner’s Labeling and apply the Sperner’s Lemma to solve the question. 展开更多
关键词 Brouwer’s Fixed Point Theorem Sperner’s Lemma proof
下载PDF
新时期刑事印证证明的误解与澄清 被引量:1
17
作者 张庆立 《辽宁警察学院学报》 2024年第1期40-46,共7页
印证是从属于自由心证的证明过程,既无法涵盖所有的犯罪类型,也无法适用于所有的待证事实,故无法成为与法定证明、自由证明相并列的一类新模式。但作为方法,印证证明仍然具有重要地位,实践中被广泛诟病的虚假印证、误解印证等不符合印... 印证是从属于自由心证的证明过程,既无法涵盖所有的犯罪类型,也无法适用于所有的待证事实,故无法成为与法定证明、自由证明相并列的一类新模式。但作为方法,印证证明仍然具有重要地位,实践中被广泛诟病的虚假印证、误解印证等不符合印证要求,故冤假错案也不能归咎于印证本身。实践中,印证证明与证明标准混同的问题突出,事实上二者之间既有联系又有区别,呈现方法和目的的关系,方法自然不同于目的,但方法是达成目的的手段,目的是方法努力的终点。因此,尽管印证具有提升裁判者心证的积极意义,但不能人为拔高至证明模式的程度,在实践中既要反对意图抛弃印证的“冤假错案成因论”,也要反对过度崇尚印证的“证明标准等同论”。 展开更多
关键词 刑事印证 证明模式 冤假错案 证明标准
下载PDF
矿井无线电波防爆安全发射功率研究 被引量:1
18
作者 孙继平 彭铭 《工矿自动化》 CSCD 北大核心 2024年第3期1-5,共5页
5G,5.5G,WiFi6,WiFi7,UWB,ZigBee等矿井移动通信系统及人员和车辆定位系统等发射的大功率无线电波有点燃瓦斯和煤尘的风险。因此,需要合理设置防爆无线电设备发射的无线电波防爆安全功率阈值,限制防爆无线电设备发射的无线电波功率。欧... 5G,5.5G,WiFi6,WiFi7,UWB,ZigBee等矿井移动通信系统及人员和车辆定位系统等发射的大功率无线电波有点燃瓦斯和煤尘的风险。因此,需要合理设置防爆无线电设备发射的无线电波防爆安全功率阈值,限制防爆无线电设备发射的无线电波功率。欧洲标准CLC/TR 50427:2004《Assessment of inadvertent ignition of flammable atmospheres by radio-frequency radiation-Guide》规定了爆炸性气体环境中无线电波防爆安全接收点火功率阈值,但缺少无线电波防爆安全发射功率阈值的内容。国家标准GB/T 3836.1—2021《爆炸性环境第1部分:设备通用要求》和国际标准IEC 60079-0:2017《Explosive atmospheres-Part 0:Equipment-General requirements》虽然有无线电波防爆安全发射功率阈值的相关规定,但错误地将欧洲标准CLC/TR 50427:2004中的无线电波防爆安全接收点火功率阈值修改为无线电波防爆安全发射功率阈值,大大降低了爆炸性环境中无线电设备所能允许的最大发射功率。由于煤矿井下没有能作为接收天线的起重机这类细长结构物体,且现有矿井无线通信及定位系统工作频率均远大于30 MHz,所以,无线电波防爆安全接收点火功率阈值应为8 W,而不是国家标准GB/T 3836.1—2021和国际标准IEC 60079-0:2017规定的无线电波防爆安全发射功率阈值6 W。在发射天线发射的无线电波能量全部被等效天线吸收的最不利于无线电防爆的传输和耦合情况下,无线电设备工作频率为等效天线谐振频率时,接收点火功率达到最大,为等效天线接收的总功率的一半,即发射功率的一半。在实际工程中,无线传输效率和耦合效率均不会为1,因此,无线电波防爆安全发射功率阈值应是无线电波防爆安全接收点火功率阈值2倍以上。煤矿井下无线电波防爆安全接收点火功率阈值为8 W,因此,煤矿井下无线电波防爆安全发射功率阈值应大于16 W。 展开更多
关键词 矿井无线电波 防爆安全 接收点火功率 发射功率
下载PDF
隔爆型电磁铁力-行程特性的优化分析及验证
19
作者 曹文斌 房瑞清 +2 位作者 杨国来 赵天昊 于忠元 《液压与气动》 北大核心 2024年第7期12-21,共10页
防爆阀是石油勘探等井下液压设备常用的核心控制元件。现有防爆阀常采用的隔爆型电磁铁体积相对较大,难以充分发挥液压元件及系统功重比大的优势。基于防爆阀可靠性的要求,在不增大矿用防爆阀外形尺寸的前提下,分别研究了衔铁高径比、... 防爆阀是石油勘探等井下液压设备常用的核心控制元件。现有防爆阀常采用的隔爆型电磁铁体积相对较大,难以充分发挥液压元件及系统功重比大的优势。基于防爆阀可靠性的要求,在不增大矿用防爆阀外形尺寸的前提下,分别研究了衔铁高径比、隔磁环位置、上端隔磁角对隔爆型电磁铁力-行程特性的影响。基于L_(9)(3^(4))正交试验,采用极差分析法获得了试验因素影响程度大小以及选择范围内最佳的结构参数组合。结果表明:当隔爆型电磁铁结构参数衔铁高径比为2.03,隔磁环位置距参考点位置下移0.5 mm,上端隔磁角30°时电磁力-行程特性曲线最佳,为隔爆型电磁铁的结构参数优化提供了指导,并通过对比试验验证了隔爆型电磁铁结构设计的合理性和可行性。 展开更多
关键词 防爆阀 隔爆型电磁铁 正交试验 力-行程特性
下载PDF
MATLAB在“张量分析”课程教学中的应用 被引量:1
20
作者 汪建军 许才军 《科教导刊》 2024年第1期130-132,共3页
张量分析是一种重要的数学工具,它在相对论、电磁场论和连续介质力学等诸多学科都有着广泛的应用。掌握这种数学工具,已成为从事相关科学研究的必备基础。然而,张量分析中非欧几里得空间局部切标架的存在,增加了张量计算和分析的复杂性... 张量分析是一种重要的数学工具,它在相对论、电磁场论和连续介质力学等诸多学科都有着广泛的应用。掌握这种数学工具,已成为从事相关科学研究的必备基础。然而,张量分析中非欧几里得空间局部切标架的存在,增加了张量计算和分析的复杂性。学生在学习“张量分析”课程时面临着抽象概念和复杂公式的理解上的困难。本文提出利用MATLAB工具在绘图、脚本编程和符号推导等方面的强大功能,从旋度分析、坐标变换和定理辅助证明这三个方面,并结合MATLAB脚本代码,展示MATLAB工具辅助于该课程教学的重要作用。教师借助该工具开展课程教学,将帮助学生有效提高对张量分析知识的理解。学生掌握了该课程的基础知识后,便能进一步使用MATLAB的张量工具箱或Pytorch深度学习库进行张量运算操作。 展开更多
关键词 张量分析 坐标变换 定理辅助证明 MATLAB
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部