INDEPENDENTLY-TUNED CONCURRENT DUAL-BAND BRANCH-LINE COUPLER USING VARACTOR

This paper presents a concurrent dual-band branch-line coupler with an independently tunable center frequency. In the proposed architecture, the quarter-wavelength lines, which work at two separated bands concurrently and can be tuned in one of them, are key components. Based on the analysis of ABCD-matrix, a novel hybrid structure and a pair of varactors topology are utilized to achieve concurrent dual-band operation and independent tunability, respectively. Using this configuration, it is convenient to tune the center frequency of the upper band, while the responses of the lower band remain unaltered. To verify the proposed idea, a demonstration is implemented and the simulated results are presented.

NONLINEAR CHARACTERIZATION OF CONCURRENT DUAL-BAND RF POWER AMPLIFIERS

In this paper, the synchronous concurrent dual-band RF signal is used to drive the RF Power Amplifier (PA). The nonlinear characterization of a concurrent dual-band RF PA is discussed while two band signals in the dual-band are modulated by CDMA2000 and WCDMA signals. When the two band signals in the dual-band of the PA are modulated with the same signals, it is found that the nonlinearity of the PA can be expressed by any of the two corresponding baseband data. On the other hand, when the two band signals in the dual-band of the PA are modulated with two different signals, the PA nonlinearity cannot be characterized by any of the two corresponding baseband data. In this case, its nonlinearity has to be denoted by a composite signals consisting of the two baseband signals. Consequently, the requirements for the speed of the A/D converter can be largely reduced. The experimental results with CDMA2000 and WCDMA signals demonstrate the speed of the A/D converter required is only 30 M Sample Per Second (SaPS), but it will be at least 70 M SaPS for the conventional method.

Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced cases.Concurrent chemoradiotherapy(CCRT)has an inhibitory effect on MT.CASE SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our hospital.Computed tomography revealed right hydronephrosis and a 6-cm pelvic mass.Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell carci-noma.The patient was diagnosed with MT of MCT.Due to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse effects.After CCRT,her performance status improved,and the tumor size was reduced;surgery was performed.Five months postoperatively,the patient developed dis-semination and lymph node metastases.Palliative chemotherapy was ineffective.She died 18 months after treatment initiation.CONCLUSION EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

Miniaturized single-channel concurrent dual-band mixing architecture with one frequency-divided local oscillator

Concurrent dual-band transceiver system is widely used in conditions where transceivers are required to work in different bands at the same time.In order to miniaturize the concurrent dual-band transceiver system and reduce the number of components in a transceiver,a novel receiver mixing structure with one frequency-divided local oscillator is proposed.Compared to traditional mixing architecture with two local oscillators,the proposed structure reduces a local oscillator and a bandpass filter.In addition,the output signal of proposed mixing architecture has a better error vector magnitude(EVM)performance.The proposed mixing architecture is described in detail;the method of local oscillator signal frequency selection and the applicable conditions of the proposed structure are derived through math formula;and the conclusions are demonstrated by experimental results.

Low-cost FPGA implementation of 2D digital pre-distorter for concurrent dual-band power amplifier

This paper proposes a low-cost hardware architecture based on concurrent dual-band digital pre-distorter （DPD）. The architecture is implemented on field programmable gate array （FPGA） to compensate for the nonlinearity of the concurrent dual-band power amplifier （PA）. This implementation introduces a novel model complexity reduction technique into system, namely, time-division multiplexing for out-of-band lookup tables （LUTs） sharing. Performances are evaluated with an experimental test setup using a wideband class-F PA. The dual-band signal center frequency separated by 80 MHz. Lower and upper center frequency are located at 2.61 GHz and 2.69 GHz, respectively. This novel DPD implementation maintains excellent performance, but uses hardware resources reduced by 29.17% compared with conventional approaches. The results show that the adjacent channel power ratio （ACPR） is less than -59 dBc and normalized mean square error （NMSE） is around - 62dB for lower sideband （LSB） and - 63dB for upper sideband （USB）.

Design and implementation of a high-efficiency concurrent dual-band power amplifier

This paper studies the behaviors of power amplifier（PA） driven by a single-carrier continuous wave（CW） signal and a two-carrier CW signal both in theory and simulation, and explains why the traditional dual-band PA failed to perform satisfactory results when a two-carrier CW signal is applied to, called concurrently. Besides that, an evaluation standard of concurrent dual-band PA was presented to value its performance. Solution was given with design and fabrication of a concurrent 1.85 GHz/2.65 GHz class F PA, employing a 10 W GaN HEMT device from Cree, CGH40010, whose measurement shows the saturated output power is 40.6 d Bm and 40.8dB m with drain efficiencies（DE） of 77.4% and 75.3% at 1.85 GHz and 2.65 GHz, respectively. On the other hand, we see that the peak DE achieves 59.7% with an output power of 39.9 dB m in concurrent mode, which follows up with the standard.

Anthropogenic Influence on Decadal Changes in Concurrent Hot and Dry Events over China around the Mid-1990s

The frequency and duration of observed concurrent hot and dry events(HDEs) over China during the growing season(April–September) exhibit significant decadal changes across the mid-1990s. These changes are characterized by increases in HDE frequency and duration over most of China, with relatively large increases over southeastern China(SEC), northern China(NC), and northeastern China(NEC). The frequency of HDEs averaged over China in the present day(PD,1994–2011) is double that in the early period(EP, 1964–81);the duration of HDEs increases by 60%. Climate experiments with the Met Office Unified Model(MetUM-GOML2) are used to estimate the contributions of anthropogenic forcing to HDE decadal changes over China. Anthropogenic forcing changes can explain 60%–70% of the observed decadal changes,suggesting an important anthropogenic influence on HDE changes over China across the mid-1990s. Single-forcing experiments indicate that the increase in greenhouse gas(GHG) concentrations dominates the simulated decadal changes,increasing the frequency and duration of HDEs throughout China. The change in anthropogenic aerosol(AA) emissions significantly decreases the frequency and duration of HDEs over SEC and NC, but the magnitude of the decrease is much smaller than the increase induced by GHGs. The changes in HDEs in response to anthropogenic forcing are mainly due to the response of climatological mean surface air temperatures. The contributions from changes in variability and changes in climatological mean soil moisture and evapotranspiration are relatively small. The physical processes associated with the response of HDEs to GHG and AA changes are also revealed.

Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)cancer.AIM To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative resection.METHODS This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and 2018.The impact of CCRT on advanced AoV cancer was analyzed.RESULTS The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,respectively.Lymphovas-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate analysis.Compared to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte ratio.CONCLUSION Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV cancer.These findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

Programmed cell death 1 inhibitor sintilimab plus concurrent chemoradiotherapy for locally advanced pancreatic adenocarcinoma

BACKGROUND Pancreatic adenocarcinoma,a malignancy that arises in the cells of the pancreas,is a devastating disease with unclear etiology and often poor prognosis.Locally advanced pancreatic cancer,a stage where the tumor has grown significantly but has not yet spread to distant organs,presents unique challenges in treatment.This article aims to discuss the current strategies,challenges,and future directions in the management of locally advanced pancreatic adenocarcinoma(LAPC).AIM To investigate the feasibility and efficacy of programmed cell death 1(PD-1)inhibitor sintilimab plus concurrent chemoradiotherapy for LAPC.METHODS Eligible patients had LAPC,an Eastern cooperative oncology group performance status of 0 or 1,adequate organ and marrow functions,and no prior anticancer therapy.In the observation group,participants received intravenous sintilimab 200 mg once every 3 wk,and received concurrent chemoradiotherapy(concurrent conventional fractionated radiotherapy with doses planning target volume 50.4 Gy and gross tumor volume 60 Gy in 28 fractions and oral S-140 mg/m2 twice daily on days 1-14 of a 21-d cycle and intravenous gemcitabine 1000 mg/m2 on days 1 and 8 of a 21-d cycle for eight cycles until disease progression,death,or unacceptable toxicity).In the control group,participants only received concurrent chemoradiotherapy.From April 2020 to November 2021,64 participants were finally enrolled with 34 in the observation group and 30 in the control group.RESULTS Thirty-four patients completed the scheduled course of chemoradiotherapy,while 32(94.1%)received sintilimab plus concurrent chemoradiotherapy with 2 patients discontinuing sintilimab in the observation group.Thirty patients completed the scheduled course of chemoradiotherapy in the control group.Based on the Response Evaluation Criteria in Solid Tumors guidelines,the analysis of the observation group revealed that a partial response was observed in 11 patients(32.4%),stable disease was evident in 19 patients(55.9%),and 4 patients(11.8%)experienced progressive disease;a partial response was observed in 6(20.0%)patients,stable disease in 18(60%),and progressive disease in 6(20%)in the control group.The major toxic effects were leukopenia and nausea.The incidence of severe adverse events(AEs)(grade 3 or 4)was 26.5%(9/34)in the observation group and 23.3%(7/30)in the control group.There were no treatment-related deaths.The observation group demonstrated a significantly longer median overall survival(22.1 mo compared to 15.8 mo)(P<0.05)and progression-free survival(12.2 mo vs 10.1 mo)(P<0.05)in comparison to the control group.The occurrence of severe AEs did not exhibit a statistically significant difference between the observation group and the control group(P>0.05).CONCLUSION Sintilimab plus concurrent chemoradiotherapy was effective and safe for LAPC patients,and warrants further investigation.

一种基于Concurrent Apla语言的共享内存并发分布式算法2层验证方法

形式化验证共享内存并发分布式算法已成为当前极具挑战性的问题之一,尤其是在云计算、多核、无线传感器网络、分布式数据库、区块链环境下.该文基于研究团队在形式化规约语言和方法、算法形式推导和验证方面的已有工作,以自定义泛型抽象顺序设计语言Apla为基础,进一步研究并提出简明、高抽象用于并发分布式计算的Concurrent Apla语言,使其既支持顺序算法的验证又能有效地验证并发分布式算法.在依赖-卫式推理的基础上,提出一种新颖的2层并发分布式算法形式化验证方法,其中系统层用于处理并发级验证,而组件层用于处理顺序级验证.最后,通过2个实例验证了该方法的有效性和可行性.

COOPERATIVE DESIGN UNDER CONCURRENT ENGINEERING ENVIRONMENT

This paper outlines a concurrent engineering environment that supports interaction between members of a geographically dispersed multidisciplinary team who is engaged in engineering design activities. Some ideas of engineering design, especially conceptual design are reviewed. A deeper scientific analysis of intelligent design is discussed. A new problem solving strategy and methodologies to implement cooperative design are proposed. Finally, a conceptual model of a blackboard system for accomplishing conceptual design automation is presented. Its fundamental principles, system organization and key implementation techniques are investigated in detail.

Integrated Assembly Structure Design Within Concurrent Engineering

Taking a microwave product as an example, a system of integrated assembly structure design is presented. Getting design constraints from the upstream design section through product data management(PDM), the system generates the assembly scheme using the case? based method, then assigns the design requirements into each component of the assembly. The detail design for each component can be performed under these design constraints. In order to practise concurrent design, the system sends the final design result to the upstream section and downstream section through PDM to achieve information sharing and integration.

MODELING METHOD FOR CROSSCUTTING CONCERNS IN CONCURRENT SOFTWARE SYSTEM

A method for modeling crosscutting concerns in the concurrent software system is presented based on the aspect-oriented（A-O） technique and the statechart of unified modeling language （UML）. Modeled with UML statechart diagrams, the primary system functions and corresponding traversal features are enveloped into various orthogonal regions of a composite state. The mutual relationships between orthogonal regions are implied by the orders of broadcast events. Using a modular transition system as a basic computational model, the formalization description of A-O statechart models is proposed. The precise semantics of model elements and modeling procedures is given. The example study indicates that the separation strategy of crosscutting concerns is implemented in the design phase of the concurrent software system with this method. Meanwhile, the software modeling method has advantages of loose coupling, adaptability and traceability.

Effect of concurrent precipitation on recrystallization textures in commercial Al-Mn alloys

The effect of concurrent precipitation on recrystallization textures in AA 3003 aluminum alloys was investigated using X-ray diffraction and electron backscattering diffraction（EBSD） analyses. A weak recrystallization texture was observed in the AA 3003 alloy annealed at 783 K due to the high annealing temperature. Under the same conditions, extremely high P {011 } （ 111 ） recrystallization textures were detected in the AA 3003 alloy added with 0. 39% Sc. Based on the EBSD results, no intensely preferential orientation nucleation of recrystallization grains was observed in the early stage of recrystallizafion for both alloys. However, concurrent precipitation strongly retarded the growth of recrystallization grains, except for P nucleation sites, thereby conferring an apparent initial growth advantage for P nucleation sites compared with other nucleation sites. Therefore, a sharp P {011 } 〈 111 〉 texture appeared in concurrently precipitated AA 3003 alloys.

QUANTITATIVE APPROACH TO REAL TIME STARTUP TIME DETERMINATION OF DOWNSTREAM PHASES IN CONCURRENT ENGINEERING

Implementation of simultaneous execution phases in the concurrent engineering (CE) needs careful planning when the downstream phase could be activated as the upstream phase developed to a certain point. The determination of startup time of overlapping jobs in CE has long been a disturbance in manufacturing industry implementing CE programs. A novel model based on both fuzzy logic and neural network is proposed to mathematically formulate the inter-connective information between the two coupled phases in CE projects, and to determine the startup time of downstream phases in real time. The information transferring between the two coupled phases is quantified by using the negative Shannon entropy. Based on this algorithm, a PDM-based framework is proposed to narrow the gap between pro-duct design and manufacture, in which five modules are built to monitor, reshuffle and implement the simultaneous executing processes. Finally, an example is given to illustrate applications of the algorithm in the real world.

Process Environment Oriented Concurrent Tolerance Analysis

Tolerance analysis is investigated under an environment of concurrent design in order to lead to optimized tolerance, as traditional tolerance analysis is often inefficient and liable to mistakes. Making full use of knowledge in manufacturing tolerance analysis combined with the beta distribution model is introduced and applied. The use of beta distribution reflects fully actual capabilities in manufacture. Concurrent tolerance design is a manufacturing environment oriented design process paying more attention to influences or restraints on product design caused by such factors as the manufacturing process, machine capabilities, economy in manufacturing, etc. Process environment oriented tolerance analysis is more flexible making the designed results more practical and effective.

Concurrent C及其运行时支撑系统在分布式环境中的实现

本文介绍我们在Ｓｕｎ工作站网络中实现的一种ＣｏｎｃｕｒｒｅｎｔＣ分布式版本。文章最后给出初步测试结果。

面向对象的并发程序设计语言ConcurrentC^（＋＋）

提出了一种面向对象的并发程序设计语言ＣｏｎｃｕｒｒｅｎｔＣ￣（＋＋）。在ＣｏｎｃｕｒｒｅｎｔＣ￣（＋＋）中，进程就是一种特殊的对象─—并发对象，因而具有抽象性（ａｂｓｔｒａｃｔｉｏｎ）、封装性（ｅｎｃａｐｓｕｌａｔｉｏｎ）、继承性（ｉｎｈｅｒｉｔａｎｃｅ）以及同式多型（ｐｏｌｙｍｏｒｐｈｉｓｍ）。并发对象可以动态地产生，动态地消亡。进程之间的通信与同步依据并发对象之间的消息传递。ＣｏｎｃｕｒｒｅｎｔＣ￣（＋＋）为实现复杂的并发问题提供了一种良好的手段，为仿真神经网络的实现奠定了基础。

Concurrent chemoradiotherapy combined with enteral nutrition support:a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant istulae

Background: Concurrent chemoradiotherapy(CCRT) significantly increases the survival rate of esophageal squa?mous cell carcinoma(ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long?term survival.Methods: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat?sen University Cancer Center between January 2010 and December 2012. Treatment outcome and toxicity were ret?rospectively evaluated in 40 ESCC patients with malignant fistulae. All the 40 patients were treated with CCRT and evaluated by clinical nutritionists using nutrition risk screening(NRS) before, during, and after treatment. Twenty?two patients received a nasogastric tube, and 18 underwent percutaneous endoscopic gastrostomy feeding. The median energy intake was 2166 kcal/day. Treatment response was evaluated at 3 months after the completion of CCRT.Results: With a median follow?up of 18 months(range, 3–39 months), patients' 1?year overall survival(OS) rate was 62.5%, and the estimated OS time was 25.5 months. Univariate analysis showed that the NRS score(P n NRS score(P se to treatment(P < 0.001) were sig= 0.003), increase i= 0.024), fistula closure(P = 0.011), and responnifi?cantly associated with OS. Multivariate analysis showed that tumor response(P = 0.044) and increase in NRS score(P = 0.044) were independent predictors of OS. Grade 3 vomiting was observed in 8 patients(20.0%), grade 3 neutro?penia was observed in 11 patients(27.5%), and grade 3 cough was observed in 13 patients(32.5%); 2 patients(5.0%) died of massive bleeding during treatment.Conclusions: CCRT combined with enteral nutrition support is effective for ESCC patients with malignant fistulae. Patients have an increased potential to be cured, especially those who experience complete response and have an increase in NRS score. Careful observation and nutrition support are required for patients with advanced T?category ESCC who undergo CCRT.

Concurrent malaria and dengue infection:a brief summary and comment

There are several tropical mosquito borne infections.Malaria and dengue are the two common mosquito infections that are very important and cause high morbidity and mortality for many patients around the world.Concurrent malaria and dengue infection is an important condition that is seldom reported.In this specific article,the author hereby summarizes on the topic of concurrent malaria and dengue infection.