Study on the Textual Coherence Function of Conjunctions in Political Texts and Their Translation Reconstruction

The assessment of translation quality in political texts is primarily based on achieving effective communication.Throughout the translation process,it is essential to not only accurately convey the original content but also effectively transform the structural mechanisms of the source language.In the translation reconstruction of political texts,various textual cohesion methods are often employed,with conjunctions serving as a primary means for semantic coherence within text units.

Topical ketotifen treatment for allergic conjunctivitis:a systematic review and Meta-analysis

AIM:To assess the efficacy of ketotifen in treating allergic conjunctivitis.METHODS:A systematic search of systematic reviews and Meta-analyses was conducted on the Pub Med and Web Science of Science until October 2021 to address this knowledge gap.Mean difference with 95%CI and P values were used to assess the efficacy of ketotifen.The heterogeneity(I^(2))was used to evaluate the impact of heterogeneity.RESULTS:Eight randomized controlled trials(RCTs)involving 1589 patients were included in this Meta-analysis.The results revealed that after treating with ketotifen,itching(MD=-0.91,95%CI:-1.63 to-0.20,I^(2)=94%,P=0.01),tearing(MD=-0.40,95%CI:-0.61 to-0.18,I^(2)=75%,P=0.0003)and total signs and symptoms(MD=-0.85,95%CI:-1.12 to-0.58,I2=0,P<0.00001)showed better benefit effect compared to the placebo group.CONCLUSION:Topical ketotifen is an effective treatment for patients with allergic conjunctivitis.

Pseudomembranous conjunctivitis in a patient with DRESS syndrome

Dear Editor,Drug rash with eosinophilia and systemic symptoms(DRESS)syndrome is a drug reaction featuring high fever,eosinophilia,skin rashes,and multi-organ involvement that may be fatal.Ocular manifestations,including cicatrizing conjunctivitis,corneal infiltration,and anterior uveitis,are rarely reported[1-6]but may cause serious complications if untreated.Therefore,it is important to diagnose DRESS syndrome in patients with ocular features promptly with appropriate treatment.This article reports a case diagnosed with DRESS syndrome associated with pseudomembranous conjunctivitis secondary to carfilzomib.

A Case of Serratia marcescens Conjunctivitis in a Young Male after Exposure to Contaminated Shampoo in a Fitness Club

The contamination of shampoo with bacteria is not very common but can happen and can be a potential cause of conjunctivitis. This case report describes a 24-year-old male who developed conjunctivitis after using a Serratia marcescens contaminated shampoo in a fitness club. The patient had redness, swelling, and discharge in both eyes. Cultures of the shampoo and eye swabs were positive for S. marcescens with indistinguishable DNA fingerprints. The patient was treated with an eye drop antibiotic and his symptoms resolved within a week. This case highlights the possibility of exposure in places where shampoos containers are refilled or shared. The avoidance of refilling them and using replaceable cartridges, single-sealed refill bags, or bringing personal shampoo is highly recommended to prevent such incidents.

A Novel Approach for Optimum Conjunctive Use Management of Groundwater and Surface Water Resources under Uncertainty

Uncertainty in determining optimum conjunctive water use lies not only on variability of hydrological cycle and climate but also on lack of adequate data and perfect knowledge about groundwater-surface water system interactions, errors in historic data and inherent variability of system parameters both in space and time. Simulation-optimization models are used for conjunctive water use management under uncertain conditions. However, direct application of such approach whereby all realizations are considered at every-iteration of the optimization process leads to a highly computational time-consuming optimization problem as the number of realizations increases. Hence, this study proposes a novel approach—a Retrospective Optimization Approximation (ROA) approach. In this approach, a simulation model was used to determine aquifer system responses (draw-downs) which were assembled as response matrices and incorporated in the optimization model (procedure) as coefficients in the constraints. The sample optimization sub-problems generated, were solved and analyzed through ROA-Active-Set procedure implemented under MATLAB code. The ROA-Active Set procedure solves and evaluates a sequence of sample path optimization sub-problems in an increasing number of realizations. The methodology was applied to a real-world conjunctive water use management problem found in Great Letaba River basin, South Africa. In the River basin, surface water source contributes 87% of the existing un-optimized total conjunctive water use withdrawal rate (6512.04 m3/day) and the remaining 13% is contributed by groundwater source. Through ROA approach, results indicate that the optimum percentages contribution of the surface and subsurface sources to the total water demand are 58% and 42% respectively. This implies that the existing percentage contribution can be increased or reduced by ±29% that is groundwater source can be increased by 29% while the surface water source contribution can be reduced by 29%. This reveals that the existing conjunctive water use practice is unsustainable wherein surface water system is overstressed while groundwater system is under-utilized. Through k-means sampling technique ROA-Active Set procedure was able to attain a converged maximum expected total optimum conjunctive water use withdrawal rate of 4.35 × 104 m3/day within a relatively few numbers of iterations (6 to 8 iterations) in about 2.30 Hrs. In conclusion, results demonstrated that ROA approach is capable of managing real-world regional aquifers sustainable conjunctive water use practice under hydro-geological uncertainty conditions.

Kepler’s Conjunction for Two Strong Earthquakes in Türkiye in February 2023

This work is devoted to the study of the relationship between strong earthquakes and planetary configurations using the example of two consecutive strong earthquakes that occurred in Türkiye (Turkey), on February 6, 2023. It is shown that at the time of the earthquakes, linear alignment of the planets along the Jupiter-Venus-Sun line was observed, that is, the astronomical trigger belonged to the generalized Kepler conjunction scheme (gKc), when the Earth does not participate in the linearization scheme. It is shown that for the first earthquake that occurred at 01:17 UTC, the ratio of the distances between Jupiter-Earth and Jupiter-Mars was close to an integer value equal to 5.993. For the second earthquake that occurred on the same day at 10:25 UTC, no integer resonance ratios were detected, however, it was found that the terrestrial e UTC line at the time of the earthquake passed through the position of Mercury. Recall that the 12-hour line of the eUTC chart is always oriented towards the Sun. The conclusions of the work once again confirm the correctness of the theories of Archimedes and Kepler and convince us of the existence of a gravitational phenomenon that does not depend on the distances and masses of planets, has a pronounced inertial and wave character and does not fit into the general theory of relativity, developed in the last century by Albert Einstein.

Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis

AIM: To assess the efficacy of topical Semaphorin 3A(SEMA3A) in the treatment of allergic conjunctivitis.METHODS: Experimental allergic conjunctivitis(EAC)mice model induced by short ragweed pollen(SRW) in 4-week-old of BALB/c mice, mice were evaluated using haematoxylin and eosin(H&E) staining, immunofluor-escence and light microscope photographs. Early phase took the samples in 24 h after instillation and late phase took the samples between 4 to 14 d after the start of treatment. The study use of topical SEMA3A(10 U, 100 U,1000 U) eye drops and subconjunctival injection of SEMA3 A with same concentration. For comparison, five types of allergy eyedrops were quantified using clinical characteristics.· RESULTS: Clinical score of composite ocular symptoms of the mice treated with SEMA3 A were significantly decreased both in the immediate phase and the late phase compared to those treated with commercial ophthalmic formulations and non-treatment mice. SEMA3 A treatment attenuates infiltration of eosinophils entering into conjunctiva in EAC mice. The score of eosinophil infiltration in the conjunctiva of SEMA3 A 1000 U-treated group were significantly lower than low-concentration of SEMA3 A treated groups and non-treated group. SEMA3 A treatment also suppressed T-cell proliferation in vitro and decreased serum total Ig E levels in EAC mice. Moreover, treatment of SEMA3 A suppressed Th2-related cytokines(IL-5, IL-13 and IL-4)and pro-inflammatory cytokines(IFN-γ, IL-17 and TNF-α)release, but increased regulatory cytokine IL-10 concentration in the conjunctiva of EAC mice.CONCLUSION: SEMA3 A as a biological agent, showed the beneficial activity in ocular allergic processes with the less damage to the intraocular tissue. It is expected that SEMA3 A may be contributed in patients with a more severe spectrum of refractory ocular allergic diseases including allergic conjunctivitis in the near future.

Effects of vernal and allergic conjunctivitis on severity of keratoconus

AIM: To demonstrate the effects of two different types of allergic conjunctivitis on severity of keratoconus (KC). ·METHODS: We retrospectively reviewed the medical records of 171 KC patients referred between June 2010 and June 2011. The KC patients were divided into 3 groups as KC (group A), KC with vernal keratoconjunctivitis (VKC) (group B) and KC with allergic conjunctivitis (AC) (group C). Main outcome measures were demographic and ocular clinical features including age at presentation, gender, spherical equivalent (SE), best spectacle corrected visual acuity (BCVA), mean keratometric measurement (Km), central corneal thickness (CCT), and intraocular pressure (IOP). Groups were compared in term of study variables. · RESULTS: The median age at presentation was significantly lower in group B (P 【0.001). According to the median SE (P =0.003), BCVA(P =0.022), Km(P 【0.001), CCT (P =0.015) and Amsler-Krumeich classification (P 【 0.001), KC was more severe in group B. There was no significant difference in terms of IOP and corrected IOP among the groups (P =0.44), however there were 4 patients who had increased corrected IOP developed after topical corticosteroid use in group B. The differences among the groups persisted even after controlling for age and gender. · CONCLUSION: Our findings demonstrated a more severe KC in VKC patients despite their younger age which suggests evaluation of VKC patients as a separate group in keratoconus disease.

Effect of diluted povidone iodine in adenoviral keratoconjunctivitis on the rate of subepithelial corneal infiltrates

AIM: To evaluate the clinical characteristics of adenoviral keratoconjunctivitis, the management modalities, as well as the incidence of subepithelial corneal infiltrates(SEI).METHODS: Patients with characteristic clinical symptoms and signs, who presented to our clinic within the first week of symptoms and received the diagnosis of adenoviral keratoconjunctivitis between January 2013 and April 2016, were included in the study. A total of 211 patients were included in the study. Patients were evaluated for the incidence of clinical signs, late complications, management preferences, and the effect of diluted povidone-iodine(d-PVP-I) 2%. RESULTS: Patients’ mean age was 33.03±14.76 y. We observed an increase in the number of cases according to the years. At presentation and/or early follow-up, the clinical signs were conjunctival hyperemia(100%), conjunctival follicules(79.1%), edema of the eyelids(39.3%), chemosis(16.1%), pseudomembrane formation(16.6%), and corneal epitheliopathy(29.9%). During late follow-up 13.3% patients developed conjunctival subepithelial fibrosis, and 39.8% developed SEI. A significant decrease in the incidence of SEI development was observed in patients who used d-PVP-I 2%(P=0.032;33.3% vs 45.9%, respectively in patients who received d-PVP-I 2% and who did not).CONCLUSION: Adenoviral keratoconjunctivitis has a tremendous effect on patient’s comfort and abilities in short-term. Additionally, almost half of the patients develop visual problems related to SEI. According to our clinical experience, using d-PVP-I 2% in the first days of adenoviral keratoconjunctivitis might be helpful in reducing the risk of SEI as a complication.

Investigation of possible risk factors in the development of seasonal allergic conjunctivitis

AIM： To analyze the possible risk factors in the development of seasonal allergic conjunctivitis（SAC） through an evaluation of skin allergy tests and data obtained from questionnaires.METHODS： The study included a total of 75 SAC patients and 71 control subjects without SAC diagnosis who were admitted to the Abant Izzet Baysal University Medical Faculty Ophthalmology Clinic between March 2016 and December 2016. Skin prick tests were performed for all participants. Serum levels of total IgE and 25-OH vitamin D were also measured. In the tear, total IgE levels were measured. Moreover, possible risk factors for the onset of SAC（smoking, paracetamol exposure, vitamin D supplementation and environmental factors etc.） were examined for all patients by both prenatal and postnatal aspects.RESULTS： The patients with SAC were found to have a history of maternal paracetamol exposure during the prenatal period. Likewise, in the same patient group, the duration of postnatal vitamin D supplementation was shorter（P〈0.001）. However, no significant correlation was found between SAC and maternal antibiotic exposure, maternal smoking, the mode of delivery and birth weight, as well as presence of pets. Moreover, patients with SAC were more likely to have asthma, allergic rhinitis and oral allergy syndrome. We have also found that SAC patients＇ mothers and siblings were more likely to have allergic conjunctivitis. Likewise, their fathers were more likely to have allergic rhinitis. CONCLUSION： Prenatal maternal paracetamol exposure and shorter duration of vitamin D supplementation in the postnatal period may play a role in development of SAC. Therefore prevention of unnecessary gestational paracetamol intake and vitamin D supplementation during infancy could potentially reduce the onset and development of SAC.

The Effect of BCG-PSN on T-cell Subsets and Cytokines in Vernal Conjunctivitis

The effects of BCG PSN on T cell subsets and cytokines in vernal conjunctivitis were observed. The level of total IgE was quantitatively determined before and after treatment with BCG PSN by allergen diagnostic instrument in vitro . The content of T cell subsets of peripheral blood and cytokine were determined by using indirect immune fluorescence method, and IL 4 and INF γ were quantified by ELISA. The results showed that the level of total IgE was substantially reduced ( P <0.01) after treatment in the BCG PSN group. Meanwhile, CD + 8 was decreased, CD + 4 and CD + 4/CD + 8 ratio elevated with significant differences ( P <0.05) as compared with pre treatment results. The changes in total IgE, CD + 8 ,CD + 4 and CD + 4/CD + 8 ratio after treatment also presented significant differences ( P <0.05) between BCG PSN group and routine treatment group. The level of IL 4 in serum declined ( P <0.05) after treatment in the BCG PSN group, and INF γ went up ( P <0 05). IL 4 and INF γ in serum showed significant differences ( P <0.05) between two groups after treatment. It is concluded that BCG PSN has a bi directional immunoregulating effect. It can bring CD + 4 and CD + 8 into homeostasis, thereby preventing the occurrence of anaphylaxis. At the same time, BCG PSN can restrain Th 2, decrease the synthesis of IL 4, switch the balance of Th l/Th 2 to Th 1 side, boost up the predominance of Th 1 relatively, which is propitious to perennial stabilization and recovery of vernal conjunctivitis.

The efficacy and safety of besifloxacin for acute bacterial conjunctivitis: a Meta-analysis

AIM: To evaluate the relative efficacy and safety of besifloxacin for treatment of acute bacterial conjunctivitis.METHODS: A comprehensive search in PubMed, EMBASE Web of Science, Cochrane Central Database and CNKI was undertaken for randomized controlled trials(RCTs) comparing besifloxacin with other treatments or placebo. The primary outcome measures were clinical resolution, rates of bacterial eradication, individual clinical outcomes, cure rates, and bacterial eradication rates of different kinds of pathogens. Safety outcomes were the number of adverse effects(AEs). The final search was performed on August 2018.RESULTS: Eight RCTs were included. Five studies compared the efficacy and safety of besifloxacin with placebo, 2 studies compared besifloxacin with moxifloxacin, and 1 study compared besifloxacin with gatifloxacin. A total of 3105 patients met the inclusion criteria. Besifloxacin presented higher efficacy and safety than did placebo in clinical resolution, rates of bacterial eradication, individual clinical outcomes, cure rates, bacterial eradication rates of different kinds of pathogens and the number of AEs. There was no significant difference between besifloxacin and moxifloxacin or gatifloxacin in the comparison items mentioned above.CONCLUSION: Besifloxacin is highly effective and safe for treatment of acute bacterial conjunctivitis. Further comparative trials regarding the effect of besifloxacin for treatment of acute bacterial conjunctivitis will aid in treatment decisions.

PHASE STRUCTURE FACTOR AND INTERFACE CONJUNCTION FACTOR OF CAST IRON AND ITS COMPOSITION DESIGN

Theempiricalelectrontheory of solidsand molecules( EET) and theimproved TFDtheory wereapplied tocalculatethe phasestructurefactorsand interfaceconjunction factorsofcom mon alloying elementsincastiron. Akind of Si- Mo- Cu ductileiron with rareearth Mg asnodularizer was designed accordingtothese valenceelectron structure parameters. Actual applicationtestsshow thatthelongevity of thisiron is 1.5 timesof thatof high manganesesteel. This accordance of theoretical results and actual effectsshows the composition design methodcan beused in othercastiron research.

Ragweed pollen induces allergic conjunctivitis immune tolerance in mice via regulation of the NF-κB signal pathway

AIM:To investigate the feasibility and mechanism of immune tolerance in allergic conjunctivitis.METHODS:The allergic conjunctivitis immune tolerance mice model was established by ragweed pollen(RW)and the related cytokines were detected.The mice were divided into 9 groups and the maslinic acid(MA)or PBS were given for different group after modeling.The expression levels of chemokine ligand 5(CCL5)and P-65 in the conjunctival tissue were analyzed by immunohistochemistry,quantitative reverse transcription polymerase chain reaction(q RT-PCR)and Western blot.The percentage of interleukin-17(IL-17)and CD4+CD25+in the splenocyte supernatant was analyzed by flow cytometry.Fur thermore,the serum and splenocyte supernatant concentration of total-IgE,interleukin-10(IL-10),and IL-17 was analyzed by enzyme linked immune response(ELISA).RESULTS:After the model was established,symptoms of conjunctivitis were alleviated,the level of P-65,CCL5,IL-17,and total-IgE was raised,while the expression of IL-10,CD4+CD25+was decreased.This result fully demonstrated that a typical IL-17/regulatory-T-cells(Treg cells)imbalance and NF-κB activation.When the NF-κB signal pathway was suppressed,it showed that there was a further relief of conjunctivitis in mice.At the same time,the expression of total-IgE,IL-17,and CCL5 was decreased and the expression of anti-inflammatory factor(IL-10,CD4+CD25+)was increased.CONCLUSION:In the state of immune tolerance,symptoms of conjunctivitis in mice are alleviated,the Th-17 cells of allergic conjunctivitis mice are inhibited,and Treg cells activity is enhanced.

Expression levels of pro-inflammatory interleukin-8 and certain antimicrobial peptides in concurrent with bacterial conjunctivitis

AIM:To detect the quantitative expression levels of the pro-inflammatory interleukin-8(IL8),antimicrobial peptides human beta defense-2(HBD2),and human beta defense-3(HBD3)genes in bacterial conjunctivitis.METHODS:The human conjunctival epithelial cells were obtained using the impression cytology technique from healthy controls and patients.The genes expression levels were determined utilizing a reverse transcription quantitative polymerase chain reaction(RT-q PCR).The contribution of causative agent type,the number of isolates and severity of clinical features,in the increase of genes expression was also determined.RESULTS:The RT-q PCR showed that IL8,HBD2,and HBD3 expression increased in bacterial conjunctivitis as compared to healthy control(P<0.001).In gram-negative bacterial conjunctivitis,HBD2 was highly up-regulated(P<0.001)compared to other types of bacterial conjunctivitis.In mixed bacterial conjunctivitis,a direct correlation between HBD2 up-regulation and HBD3 up-regulation was observed(P<0.05).The severity of clinical features was related to the up-regulation of IL8 and HBD2(P<0.05).CONCLUSION:IL8,HBD2,and HBD3 are immuneeffectors in infectious conjunctivitis.HBD2 is active during different bacterial conjunctivitis but is more released with gram-negative bacteria compared to gram-positive bacteria.HBD3 is an obvious defender in different bacterial conjunctivitis.

Pediatric allergic conjunctivitis and allergic rhinitis

Objective： To assess the relationship between allergic conjunctivitis（AC） and allergic rhinitis（AR） in pediatric ophthalmology and E.N.T outpatient clinic. Methods：Eight hundred and ninety two patients were enrolled in survey during Mar. 2005-Jan. 2007, 407 allergic conjunctivitis cases were placed in the ophthalmology clinic group and 485 allergic rhinitis cases were from the E.N.T clinic. The comorbid disorders, histories, symptoms, signs of patients were recorded. Type 1 allergy was tested in 479 cases by a specific IgE antibody blood test. Eosinophils were detected in superficial conjunctival scrapings of the superior tarsal conjunctiva and mucosa surface scrapings of middle nasal meatus in 88 cases with both diseases. Results：302（74%）, 374（92%）, 116（29%） in 407 cases with allergic conjunctivitis had concomitant eczema, rhinitis and asthma, respectively; 334（69%）, 430（89%）, 145（30%） in 485 cases with allergic rhinitis had concomitant eczema, allergic conjunctivitis and asthma, respectively. The prevalence of allergic conjunctivitis concomitant allergic rhinitis and allergic rhinitis concomitant allergic conjunctivitis had no significant difference（x2=2,6, P 〉 0.05）. The prevalence of allergic conjunctivitis and allergic rhinitis concomitant eczema and asthma also had no significant difference （x2=3.08; x2=0.21, P 〉 0.05）. The degree of severity of two kinds of disease symptoms is not parallel, in the patients with seasonal allergic conjuctivitis（SAC） and perennial allergic conjunctivitis（PAC）, the clinical signs of AR were always severer（x2=258.2, P 〈 0.05） than those of AC. However, the results coincided with the cases with vernal keratoconjuctivitis（VKC）（x2=66.5, P 〈 0.05）; Eosinophils were revealed in 50（57%） conjunctival scrapings and nasal mucosa scrapings（x2=1.5, P〉 0.05）, 47（53%） cases had positive results in both scrapings. The main aeroallergens were house dust mites, house dust and fungi, and the main food-allergens were fish, crab and shrimp. Conclusion：The two disorders were shown to share more similarities than differences, as suggested that allergic conjunctivitis should be considered in future guidelines on preventing the development of rhinitis and asthma in children.

Treating with besifloxacin for acute bacterial conjunctivitis: a Meta-analysis

AIM: To evaluate the relative efficacy and safety of besifloxacin for treatment of acute bacterial conjunctivitis. METHODS: A comprehensive search in PubM ed, EMBASE Web of Science, Cochrane Central Database and CNKI was undertaken for randomized controlled trials(RCTs) comparing besifloxacin with other treatments or placebo. The primary outcome measures were clinical resolution, rates of bacterial eradication, individual clinical outcomes, cure rates, and bacterial eradication rates of different kinds of pathogens. Safety outcomes were the number of adverse effects(AEs). The final search was performed on August 2018. RESULTS: Six RCTs were included. Four studies compared the efficacy and safety of besifloxacin with placebo, 1 study compared besifloxacin with moxifloxacin, and 1 study compared besifloxacin with gatifloxacin. A total of 2780 patients met the inclusion criteria. Besifloxacin presented higher efficacy and safety than did placebo in clinical resolution, rates of bacterial eradication, individual clinical outcomes, cure rates, bacterial eradication rates of different kinds of pathogens and the number of AEs. There was no significant difference between besifloxacin and moxifloxacin or gatifloxacin in the comparison items mentioned above. CONCLUSION: Besifloxacin is highly effective and safe for treatment of acute bacterial conjunctivitis. Further comparative trials regarding the effect of besifloxacin for treatment of acute bacterial conjunctivitis will aid in treatment decisions.

Conjunctive Utilization of Water Resources at the Yulin Coal-Mine Base in China

Shortages in water resources and the fragile ecosystem by coal-mine water affect the Yulin coal-mine base in northwest China, so taking coal-mine water into account is an important issue for the sustainable management of water resources. This paper aims to explore how the Yulin coal-mine base can improve its conjunctive utilization of water resources. Integrated utilization is proposed by establishing a multi-objective, multi-water-source, optimal-allocation model;setting up an integrated information platform;and giving very useful measures and policy suggestions to the local government. Finally, this research can also serve as an example of integrated water utilization for other energy bases.

The Path of Grammaticalization for Coordinate Conjunctions and its Universality

From the study of polysemy of coordinate conjunctions, it can be found that there are grammaticalization processes from coordination to transition and from coordination to succession. It is a general evolutionary process in connective structures to go from non-specific semantic relationship to specific semantic relationship. This was caused by the cognitive tendency of approximately substituting typical functions for atypical functions.

IoT Services:Realizing Private Real-Time Detection via Authenticated Conjunctive Searchable Encryption

With the rapid development of wireless communication technology,the Internet of Things is playing an increasingly important role in our everyday.The amount of data generated by sensor devices is increasing as a large number of connectable devices are deployed in many fields,including the medical,agricultural,and industrial areas.Uploading data to the cloud solves the problem of data overhead but results in privacy issues.Therefore,the question of how to manage the privacy of uploading data and make it available to be interconnected between devices is a crucial issue.In this paper,we propose a scheme that supports real-time authentication with conjunctive keyword detection(RA-CKD),this scheme can realize the interconnection of encrypted data between devices while ensuring some measure of privacy for both encrypted data and detection tokens.Through authentication technology,connected devices can both authenticate each other’s identity and prevent malicious adversaries from interfering with device interconnection.Finally,we prove that our scheme can resist inside keyword guessing attack through rigorous security reduction.The experiment shows that the efficiency of RA-CKD is good enough to be practical.