This paper proposes a multi-material topology optimization method based on the hybrid reliability of the probability-ellipsoid model with stress constraint for the stochastic uncertainty and epistemic uncertainty of m...This paper proposes a multi-material topology optimization method based on the hybrid reliability of the probability-ellipsoid model with stress constraint for the stochastic uncertainty and epistemic uncertainty of mechanical loads in optimization design.The probabilistic model is combined with the ellipsoidal model to describe the uncertainty of mechanical loads.The topology optimization formula is combined with the ordered solid isotropic material with penalization(ordered-SIMP)multi-material interpolation model.The stresses of all elements are integrated into a global stress measurement that approximates the maximum stress using the normalized p-norm function.Furthermore,the sequential optimization and reliability assessment(SORA)is applied to transform the original uncertainty optimization problem into an equivalent deterministic topology optimization(DTO)problem.Stochastic response surface and sparse grid technique are combined with SORA to get accurate information on the most probable failure point(MPP).In each cycle,the equivalent topology optimization formula is updated according to the MPP information obtained in the previous cycle.The adjoint variable method is used for deriving the sensitivity of the stress constraint and the moving asymptote method(MMA)is used to update design variables.Finally,the validity and feasibility of the method are verified by the numerical example of L-shape beam design,T-shape structure design,steering knuckle,and 3D T-shaped beam.展开更多
The hydraulic testing of pre-existing fractures(HTPF)is one of the most promising in situ stress measurement methods,particularly for three-dimensional stress tensor determination.However,the stress tensor determinati...The hydraulic testing of pre-existing fractures(HTPF)is one of the most promising in situ stress measurement methods,particularly for three-dimensional stress tensor determination.However,the stress tensor determination based on the HTPF method requires at least six tests or a minimum of 14-15 tests(under different conditions)for reliable results.In this study,we modified the HTPF method by considering the shear stress on each pre-existing fracture,which increased the number of equations for the stress tensor determination and decreased the number of tests required.Different shear stresses were attributed to different fractures by random sampling;therefore,the stress tensors were obtained by searching for the optimal solution using the least squares criterion based on the Monte Carlo method.Thereafter,we constrained the stress tensor based on the tensile strength criterion,compressive strength criterion,and vertical stress constraints.The inverted stress tensors were presented and analyzed based on the tensorial nature of the stress using the Euclidean mean stress tensor.Two stress-measurement campaigns in Weifang(Shandong Province,China)and Mercantour road tunnel(France)were implemented to highlight the validity and efficiency of the modified HTPF(M-HTPF)method.The results showed that the M-HTPF method can be applied for stress tensor inversion using only three to four tests on pre-existing fractures,neglecting the stress gradient.The inversion results were confined to relatively small distribution dispersions and were significantly reliable and stable due to the shear stresses on the fractures and the stress constraints employed.The M-HTPF method is highly feasible and efficient for complete stress tensor determination in a single borehole.展开更多
A mathematical model was developed for layout optimization of truss structures with discrete variables subjected to dynamic stress, dynamic displacement and dynamic stability constraints. By using the quasi-static met...A mathematical model was developed for layout optimization of truss structures with discrete variables subjected to dynamic stress, dynamic displacement and dynamic stability constraints. By using the quasi-static method, the mathematical model of structure optimization under dynamic stress, dynamic displacement and dynamic stability constraints were transformed into one subjected to static stress, displacement and stability constraints. The optimization procedures include two levels, i.e., the topology optimization and the shape optimization. In each level, the comprehensive algorithm was used and the relative difference quotients of two kinds of variables were used to search the optimum solution. A comparison between the optimum results of model with stability constraints and the optimum results of model without stability constraint was given. And that shows the stability constraints have a great effect on the optimum solutions.展开更多
A method for topological optimization of structures with discrete variables subjected to dynamic stress and displacement constraints is presented. By using the quasistatic method, the structure optimization problem un...A method for topological optimization of structures with discrete variables subjected to dynamic stress and displacement constraints is presented. By using the quasistatic method, the structure optimization problem under dynamic stress and displacement constraints is converted into one subjected to static stress and displacement constraints. The comprehensive algorithm for topological optimization of structures with discrete variables is used to find the optimum solution.展开更多
A new exist-null combined model is proposed for the structural topology optimization. The model is applied to the topology optimization of the truss with stress constraints. Satisfactory computational result can be ob...A new exist-null combined model is proposed for the structural topology optimization. The model is applied to the topology optimization of the truss with stress constraints. Satisfactory computational result can be obtained with more rapid and more stable convergence as compared with the cross-sectional optimization. This work also shows that the presence of independent and continuous topological variable motivates the research of structural topology optimization.展开更多
Objective: To investigate the dys-psychological stress effect on the growth of subcutaneous xenotransplanted tumor in nude mice bearing human epithelium ovarian carcinoma, and the influence on P53 and NFκBp65 expres...Objective: To investigate the dys-psychological stress effect on the growth of subcutaneous xenotransplanted tumor in nude mice bearing human epithelium ovarian carcinoma, and the influence on P53 and NFκBp65 expressions. Methods: The subcutaneous tumor xenografts were established by implanting human epithelium ovarian carcinoma tissues into nude mice and the dys-psychological stress model was established with restraint. The mice were randomized into the following four treatment groups with each group six mice respectively: tumor group (group A), normal saline intraperitoneal injection; tumor with stress group (group B), normal saline intraperitoneal injection; tumor therapy group (group C), cisplatin intraperitoneal injection; and tumor therapy with stress group (group D), cisplatin intraperitoneal injection. The expressions of P53 and NFκBp65 in tumor tissues were determined by Western blotting. Results: The expressions of P53 and NFκBp65 in each restraint group were enhanced compared with the control groups (P0.05). Conclusion: The dys-psychological stress may induce the high expressions of P53 and NFκBp65 proteins and further promote tumor growth.展开更多
Topology optimization (TO) has developed rapidly recently. However, topology optimization with stress constraints still faces many challenges due to its highly non-linear properties which will cause inefficient comput...Topology optimization (TO) has developed rapidly recently. However, topology optimization with stress constraints still faces many challenges due to its highly non-linear properties which will cause inefficient computation, iterative oscillation, and convergence guarantee problems. At the same time, isogeometric analysis (IGA) is accepted by more and more researchers, and it has become one important tool in the field of topology optimization because of its high fidelity. In this paper, we focus on topology optimization with stress constraints based on isogeometric analysis to improve computation efficiency and stability. A new hybrid solver combining the alternating direction method of multipliers and the method of moving asymptotes (ADMM-MMA) is proposed to solve this problem. We first generate an initial feasible point by alternating direction method of multipliers (ADMM) in virtue of the rapid initial descent property. After that, we adopt the method of moving asymptotes (MMA) to get the final results. Several benchmark examples are used to verify the proposed method, and the results show its feasibility and effectiveness.展开更多
基金supported by the National Natural Science Foundation of China(Grant 52175236).
文摘This paper proposes a multi-material topology optimization method based on the hybrid reliability of the probability-ellipsoid model with stress constraint for the stochastic uncertainty and epistemic uncertainty of mechanical loads in optimization design.The probabilistic model is combined with the ellipsoidal model to describe the uncertainty of mechanical loads.The topology optimization formula is combined with the ordered solid isotropic material with penalization(ordered-SIMP)multi-material interpolation model.The stresses of all elements are integrated into a global stress measurement that approximates the maximum stress using the normalized p-norm function.Furthermore,the sequential optimization and reliability assessment(SORA)is applied to transform the original uncertainty optimization problem into an equivalent deterministic topology optimization(DTO)problem.Stochastic response surface and sparse grid technique are combined with SORA to get accurate information on the most probable failure point(MPP).In each cycle,the equivalent topology optimization formula is updated according to the MPP information obtained in the previous cycle.The adjoint variable method is used for deriving the sensitivity of the stress constraint and the moving asymptote method(MMA)is used to update design variables.Finally,the validity and feasibility of the method are verified by the numerical example of L-shape beam design,T-shape structure design,steering knuckle,and 3D T-shaped beam.
基金supported by the National Natural Science Foundation of China(Grant No.42174118)a research grant(Grant No.ZDJ 2020-7)from the National Institute of Natural Hazards,Ministry of Emergency Management of China.
文摘The hydraulic testing of pre-existing fractures(HTPF)is one of the most promising in situ stress measurement methods,particularly for three-dimensional stress tensor determination.However,the stress tensor determination based on the HTPF method requires at least six tests or a minimum of 14-15 tests(under different conditions)for reliable results.In this study,we modified the HTPF method by considering the shear stress on each pre-existing fracture,which increased the number of equations for the stress tensor determination and decreased the number of tests required.Different shear stresses were attributed to different fractures by random sampling;therefore,the stress tensors were obtained by searching for the optimal solution using the least squares criterion based on the Monte Carlo method.Thereafter,we constrained the stress tensor based on the tensile strength criterion,compressive strength criterion,and vertical stress constraints.The inverted stress tensors were presented and analyzed based on the tensorial nature of the stress using the Euclidean mean stress tensor.Two stress-measurement campaigns in Weifang(Shandong Province,China)and Mercantour road tunnel(France)were implemented to highlight the validity and efficiency of the modified HTPF(M-HTPF)method.The results showed that the M-HTPF method can be applied for stress tensor inversion using only three to four tests on pre-existing fractures,neglecting the stress gradient.The inversion results were confined to relatively small distribution dispersions and were significantly reliable and stable due to the shear stresses on the fractures and the stress constraints employed.The M-HTPF method is highly feasible and efficient for complete stress tensor determination in a single borehole.
基金Project supported by the National Natural Science Foundation of China (Nos. 10002005 and 10421002)the Natural Science Foundation of Tianjin (No.02360081)the Education Committee Foundation of Tianjin (No.20022104)the Program for Changjiang Scholars and Innovative Research Team in University of China and the 211 Foundation of Dalian University of Technology
文摘A mathematical model was developed for layout optimization of truss structures with discrete variables subjected to dynamic stress, dynamic displacement and dynamic stability constraints. By using the quasi-static method, the mathematical model of structure optimization under dynamic stress, dynamic displacement and dynamic stability constraints were transformed into one subjected to static stress, displacement and stability constraints. The optimization procedures include two levels, i.e., the topology optimization and the shape optimization. In each level, the comprehensive algorithm was used and the relative difference quotients of two kinds of variables were used to search the optimum solution. A comparison between the optimum results of model with stability constraints and the optimum results of model without stability constraint was given. And that shows the stability constraints have a great effect on the optimum solutions.
文摘A method for topological optimization of structures with discrete variables subjected to dynamic stress and displacement constraints is presented. By using the quasistatic method, the structure optimization problem under dynamic stress and displacement constraints is converted into one subjected to static stress and displacement constraints. The comprehensive algorithm for topological optimization of structures with discrete variables is used to find the optimum solution.
基金The project supported by the State Key Laboratory for Structural Analysis of Industrial Equipment,Dalian University of Technology.
文摘A new exist-null combined model is proposed for the structural topology optimization. The model is applied to the topology optimization of the truss with stress constraints. Satisfactory computational result can be obtained with more rapid and more stable convergence as compared with the cross-sectional optimization. This work also shows that the presence of independent and continuous topological variable motivates the research of structural topology optimization.
基金supported by the National Natural Science Foundation of China (No.30860301)
文摘Objective: To investigate the dys-psychological stress effect on the growth of subcutaneous xenotransplanted tumor in nude mice bearing human epithelium ovarian carcinoma, and the influence on P53 and NFκBp65 expressions. Methods: The subcutaneous tumor xenografts were established by implanting human epithelium ovarian carcinoma tissues into nude mice and the dys-psychological stress model was established with restraint. The mice were randomized into the following four treatment groups with each group six mice respectively: tumor group (group A), normal saline intraperitoneal injection; tumor with stress group (group B), normal saline intraperitoneal injection; tumor therapy group (group C), cisplatin intraperitoneal injection; and tumor therapy with stress group (group D), cisplatin intraperitoneal injection. The expressions of P53 and NFκBp65 in tumor tissues were determined by Western blotting. Results: The expressions of P53 and NFκBp65 in each restraint group were enhanced compared with the control groups (P0.05). Conclusion: The dys-psychological stress may induce the high expressions of P53 and NFκBp65 proteins and further promote tumor growth.
文摘Topology optimization (TO) has developed rapidly recently. However, topology optimization with stress constraints still faces many challenges due to its highly non-linear properties which will cause inefficient computation, iterative oscillation, and convergence guarantee problems. At the same time, isogeometric analysis (IGA) is accepted by more and more researchers, and it has become one important tool in the field of topology optimization because of its high fidelity. In this paper, we focus on topology optimization with stress constraints based on isogeometric analysis to improve computation efficiency and stability. A new hybrid solver combining the alternating direction method of multipliers and the method of moving asymptotes (ADMM-MMA) is proposed to solve this problem. We first generate an initial feasible point by alternating direction method of multipliers (ADMM) in virtue of the rapid initial descent property. After that, we adopt the method of moving asymptotes (MMA) to get the final results. Several benchmark examples are used to verify the proposed method, and the results show its feasibility and effectiveness.