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TOOTH CURVES AND ENTIRE CONTACT AREA IN PROCESS OF SPLINE COLD ROLLING 被引量:7
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作者 ZHANG Dawei LI Yongtang FU Jianhua 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2008年第6期94-97,共4页
In spline rolling process, the contact area between roller and workpiece plays an important role in calculating rolling-force and rolling-moment. For the purpose of studying the contact area, contact state between rol... In spline rolling process, the contact area between roller and workpiece plays an important role in calculating rolling-force and rolling-moment. For the purpose of studying the contact area, contact state between roller and workpiece in process of spline cold rolling based upon cross rolling is analyzed. According to the suitable hypothesis, the mathematic model of roller-tooth-curve in optional position of rolling process is established. Combing the theory of conjugate curves with the theory of envelope curve, the corresponding mathematic model of workpiece-tooth-curve is established. By utilizing establishing mathematic models, the algorithm of entire contact area in rolling process is created. On the basis of the algorithm, calculation-program is compiled under MATLAB program language environment. The calculation-program actualizes quantitative analysis and quantitative calculation of contact areas. Utilizing the calculation-program, the influence of parameters on contact area is analyzed, and the tendency is consistent with the manufacturing experience. In consideration of rolling-force optimization, the primary process parameters may be selected according to results of calculation. The result of the present study may provide basis for research on rolling-force and rolling-moment. 展开更多
关键词 SPLINE Cold rolling Contact area Mathematic model MATLAB
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Effect of shear-induced contact area and aperture variations on nonlinear flow behaviors in fractal rock fractures 被引量:5
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作者 Changsheng Wang Richeng Liu +2 位作者 Yujing Jiang Gang Wang Hengjie Luan 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第2期309-322,共14页
This study experimentally analyzes the nonlinear flow characteristics and channelization of fluid through rough-walled fractures during the shear process using a shear-flow-visualization apparatus.A series of fluid fl... This study experimentally analyzes the nonlinear flow characteristics and channelization of fluid through rough-walled fractures during the shear process using a shear-flow-visualization apparatus.A series of fluid flow and visualization tests is performed on four transparent fracture specimens with various shear displacements of 1 mm,3 mm,5 mm,7 mm and 10 mm under a normal stress of 0.5 MPa.Four granite fractures with different roughnesses are selected and quantified using variogram fractal dimensions.The obtained results show that the critical Reynolds number tends to increase with increasing shear displacement but decrease with increasing roughness of fracture surface.The flow paths are more tortuous at the beginning of shear because of the wide distribution of small contact spots.As the shear displacement continues to increase,preferential flow paths are more distinctly observed due to the decrease in the number of contact spots caused by shear dilation;yet the area of single contacts in-creases.Based on the experimental results,an empirical mathematical equation is proposed to quantify the critical Reynolds number using the contact area ratio and fractal dimension. 展开更多
关键词 FRACTURE Shear displacement Fractal dimension Nonlinear flow Contact area Flow visualization
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Double-row repair of rotator cuff tears: Comparing tendon contact area between techniques 被引量:9
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作者 Shao Hui Allan Ng Chung Hui James Tan 《World Journal of Orthopedics》 2020年第1期10-17,共8页
BACKGROUND In rotator cuff repair surgery,the double-row technique is widely performed.Studies have shown that with increased contact area and pressure between tendon and bone interface,better healing is promoted.AIM ... BACKGROUND In rotator cuff repair surgery,the double-row technique is widely performed.Studies have shown that with increased contact area and pressure between tendon and bone interface,better healing is promoted.AIM To assess the different suture configurations with the double-row technique and how this influences the contact area of the rotator cuff tendon to bone.METHODS This was a controlled laboratory study where identical tears were created in 24 fresh porcine shoulders over a 1.5 cm×2.5 cm infraspinatus insertion footprint.Double-row repair techniques,with 3 to 4-suture anchors in different configurations(2 medial,2 lateral vs 2 medial,1 lateral vs 1 medial,2 lateral),were employed for three control groups.Each group consisted of eight shoulders with identical repair configurations.Footprint contact areas of the repaired tendon against the tuberosity were determined using pressure sensitive Fujifilm placed between the tendon and tuberosity.RESULTS The mean contact area between tendon and insertion footprint from the imprinted Fujifilm was obtained using computer software.The contact area measured from a standard 4-suture anchor double row repair was 75.1±9.3 mm2,whereas areas obtained for the 2 lateral-1 medial and 2 medial-1 lateral anchor configurations were 72.9±5.2 mm2 and 75.0±4.9 mm2 respectively.No statistical significance was noted between the three groups.CONCLUSION In the technique of double-row repair,using a 3-suture anchor configuration may offer a non-inferior alternative to the standard 4-anchor construct in terms of efficacy.This may also result in overall cost reduction and shorter surgical time. 展开更多
关键词 Basic science study Double-row Different suture anchor configurations Footprint contact area Porcine model Pressure sensitive film Tendon healing
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An New Area Function for Sharp Indenter Tips in Nanoindentation 被引量:3
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作者 刘东旭 张泰华 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2004年第3期159-164,共6页
A new area function is introduced and applied to a Berkovich tip in order tocharacterize the contact projected area between an indenter and indented material. The function canbe related directly to tip-rounding, there... A new area function is introduced and applied to a Berkovich tip in order tocharacterize the contact projected area between an indenter and indented material. The function canbe related directly to tip-rounding, thereby having obviously physical meaning. Nanoindentationexperiments are performed on a commercial Nano Indenter XP^R system. The other two area functionsintroduced by Oliver and Pharr and by Thurn and Cook respectively are involved in this paper forcomparison. By comparison from experimental results among different area functions, the indenter tipdescribed by the proposed area function here is very close to the experimental indenter. 展开更多
关键词 INDENTATION indenter contact area area function tip-rounding
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A measurement method for distinguishing the real contact area of rough surfaces of transparent solids using improved Otsu technique 被引量:4
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作者 宋保江 阎绍泽 向吴维凯 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第1期354-360,共7页
An experimental method of measuring the real contact area of transparent blocks based on the principle of total internal reflection is presented, intending to support the investigation of friction characteristics, hea... An experimental method of measuring the real contact area of transparent blocks based on the principle of total internal reflection is presented, intending to support the investigation of friction characteristics, heat conduction, and energy dissipation at the contact interface. A laser sheet illuminates the contact interface, and the transmitted laser sheet is projected onto a screen. Then the contact information is acquired from the screen by a camera. An improved Otsu method is proposed to process the data of experimental images. It can compute the threshold of the overall image and filter out all the pixels one by one. Through analyzing the experimental results, we describe the relationship between the real contact area and the positive pressure during a continuous loading process, at different loading rates, with the polymethyl methacrylate(PMMA)material. A hysteresis phenomenon in the relationship between the real contact area and the positive pressure is found and explained. 展开更多
关键词 real contact area total internal reflection improved Otsu method hysteresis phenomenon
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Relationship between the real contact area and contact force in pre-sliding regime 被引量:2
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作者 宋保江 阎绍泽 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第7期212-217,共6页
The pre-sliding regime is typically neglected in the dynamic modelling of mechanical systems. However, the change in contact state caused by static friction may decrease positional accuracy and control precision. To i... The pre-sliding regime is typically neglected in the dynamic modelling of mechanical systems. However, the change in contact state caused by static friction may decrease positional accuracy and control precision. To investigate the relationship between contact status and contact force in pre-sliding friction, an optical experimental method is presented in this paper.With this method, the real contact state at the interface of a transparent material can be observed based on the total reflection principle of light by using an image processing technique. A novel setup, which includes a pair of rectangular trapezoidal blocks, is proposed to solve the challenging issue of accurately applying different tangential and normal forces to the contact interface. The improved Otsu's method is used for measurement. Through an experimental study performed on polymethyl methacrylate(PMMA), the quantity of contact asperities is proven to be the dominant factor that affects the real contact area. The relationship between the real contact area and the contact force in the pre-sliding regime is studied, and the distribution of static friction at the contact interface is qualitatively discussed. New phenomena in which the real contact area expands along with increasing static friction are identified. The aforementioned relationship is approximately linear at the contact interface under a constant normal pressure, and the distribution of friction stress decreases from the leading edge to the trailing edge. 展开更多
关键词 real contact area contact interface pre-sliding regime contact force
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New Equations for Describing Contact Area between Tire and Ground
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作者 CUI Zhibo SU Zhaoqian +4 位作者 HOU Dandan ZHANG Chunsheng WANG Youshan LIU Yuyan WU Jian 《橡胶工业》 CAS 2020年第9期670-676,共7页
New equations are proposed to describe the shapes and sizes of the contact areas between tire and ground(the contact areas)under the conditions of static load,slip,camber,and rolling.The equations are super ellipse an... New equations are proposed to describe the shapes and sizes of the contact areas between tire and ground(the contact areas)under the conditions of static load,slip,camber,and rolling.The equations are super ellipse and trigonometric function with four parameters.Results indicate that the contact areas under the conditions of static load,slip,camber can be well described by super ellipse,in the most complicated case,fourteen parameters are used.The rolling contact area can be reconstructed by the trigonometric function completely.Symmetrical and asymmetrical shapes can both be described perfectly.The suggested curves will make calculate size of the areas easily.The described shapes and sizes are in good agreement with the measured,the maximum deviation is only 2.88%.This work will provide an instrument for understanding the contact area and be helpful for analyzing tire and road. 展开更多
关键词 contact areas contact shape tire and ground super ellipse EQUATION
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Concussion in contact sport:A challenging area to tackle
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作者 Samuel Stuart Aodhan Hickey +2 位作者 Rosie Morris Karol O'Donovan Alan Godfrey 《Journal of Sport and Health Science》 SCIE 2017年第3期299-301,共3页
1.The problem The term'concussion'refers to a common form of traumatic brain injury,which typically occurs after a blow or injury to the head.It has been described as a'complex pathophysiological process a... 1.The problem The term'concussion'refers to a common form of traumatic brain injury,which typically occurs after a blow or injury to the head.It has been described as a'complex pathophysiological process affecting the brain,induced by biomechanical factors',and shear forces induced by rotational acceleration are believed to be the primary mechanism of injury in concussion.~1The incidence of concussion in the UK has been shown to be 展开更多
关键词 Concussion in contact sport:A challenging area to tackle
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Experimental Study on the Effect of Fine-Grained Soil Content on the Freezing Strength of Aeolian Sand-Cement Interface
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作者 Junhui Hu Honghuan Cui Zhishu Xie 《Journal of World Architecture》 2024年第2期43-48,共6页
In cold regions,understanding the freezing strength of the interface between soil and structure is crucial for designing frost-resistant foundations.To investigate how the content of cement powder in aeolian sand affe... In cold regions,understanding the freezing strength of the interface between soil and structure is crucial for designing frost-resistant foundations.To investigate how the content of cement powder in aeolian sand affects this strength,we conducted direct shear tests under various conditions such as different fine-grained soil content,normal stress,and initial moisture content of the soil.By analyzing parameters like soil properties,and volume of ice content,and using the Mohr-Coulomb strength theory to define interface strength,we aimed to indirectly measure the cementation strength of the interface.Our findings revealed that as the particle content increased,the interface stress-strain curves became noticeably stiffer.We also observed a positive linear relationship between freezing strength and silt content,while the initial moisture content of the soil did not significantly impact the strengthening effect of fine-grained soil on freezing strength.Moreover,we discovered that as the powder content increased,the force binding the ice to the interface decreased,while the friction angle at the interface increased.However,the cohesion force at the interface remained relatively unchanged.Overall,our analysis suggests that the increase in freezing strength due to fine-grained soil content is primarily due to the heightened friction between aeolian sand and the interface. 展开更多
关键词 Fine-grained soil content Contact area Freezing strength Influencing factors
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Analysis and Numerical Simulation of Rolling Contact between Sphere and Cone 被引量:18
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作者 ZHAO Yanling XIA Chengtao +4 位作者 WANG Hongbo XUAN Jiaping XIANG Jingzhong LIU Xianli SU Xiangguo 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2015年第3期521-529,共9页
In non-conforming rolling contact, the contact stress is highly concentrated in the contact area. However, there are some limitations of the special contact model and stress model used for the theoretical study of the... In non-conforming rolling contact, the contact stress is highly concentrated in the contact area. However, there are some limitations of the special contact model and stress model used for the theoretical study of the phenomenon, and this has prevented in-depth analysis of the associated friction, wear, and failure. This paper is particularly aimed at investigating the area of rolling contact between a sphere and a cone, for which purpose the boundary is determined by the Hertz theory and the geometries of the non-conforming surfaces. The phenomenon of stick-slip contact is observed to occur in the contact area under the condition of no-full-slip(Q 〈 μ·P). Using the two-dimensional rolling contact theory developed by CARTER, the relative positions of the stick and slip regions and the distribution of the tangential force over the contact area are analyzed. Furthermore, each stress component is calculated based on the Mc Ewen theory and the idea of narrow band. The stress equations for the three-dimensional rolling contact between the sphere and the cone are obtained by the principle of superposition, and are used to perform some numerical simulations. The results show that the stress components have a large gradient along the boundary between the stick and slip regions, and that the maximum stress is inversely proportional to the contact coefficient and proportional to the friction coefficient. A new method for investigating the stress during non-classical three-dimensional rolling contact is proposed as a theoretical foundation for the analysis of the associated friction, wear, and failure. 展开更多
关键词 tractive rolling Hertz theory stick-slip contact contact area contact stress
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Integrity of grinding face-gear with worm wheel 被引量:5
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作者 唐进元 崔伟 +1 位作者 周恒 尹凤 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第1期77-85,共9页
Aiming at the issue of the grinding integrity of face-gear with worm wheel, the envelope mathematical model of shaper, worm wheel and face-gear is established based on theories of differential geometry and gear mesh. ... Aiming at the issue of the grinding integrity of face-gear with worm wheel, the envelope mathematical model of shaper, worm wheel and face-gear is established based on theories of differential geometry and gear mesh. The judgment of completely grinding the face-gear with the avoidance of singularities is established, and the mathematical expression to show the reason why singularities appear is derived, through the research on the surface contact area and singularity rules of the worm thread surface. The disadvantage of current face-gear grinding method that only part of the working surface of the face-gear can be covered is analyzed and the influence of coefficient of judgment is studied through changing the design parameters. 展开更多
关键词 face-gear surface contact area singularity of worm integrity of tooth surface
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Parametric analysis of mixed lubrication characteristics in work zone of strip rolling 被引量:3
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作者 吴建清 梁小平 潘复生 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第12期3153-3159,共7页
A theoretical model for mixed lubrication with more accurate contact length has been developed based on the average volume flow model and asperity flattening model,and the lubricant volume flow rate and outlet speed r... A theoretical model for mixed lubrication with more accurate contact length has been developed based on the average volume flow model and asperity flattening model,and the lubricant volume flow rate and outlet speed ratio are determined by integrating differential equations based on rolling parameters.The lubrication characteristics at the roll-strip interface with different surface roughness,rolling speed,reduction and lubricant viscosity are analyzed respectively.Additionally,the average volume flow rates of lubricant under different rolling conditions are calculated and used to explain the change rule of lubrication characteristics.The developed scheme is able to determine the total pressure,lubricant pressure,film thickness and real contact area at any point within the work zone.The prediction and analysis of mixed lubrication characteristics at the interface is meaningful to better control the surface quality and optimize the rolling process. 展开更多
关键词 mixed lubrication ROLLING film thickness real contact area
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Cutting performance of micro-textured PCBN tool 被引量:3
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作者 Lin Fan Zilong Deng +1 位作者 Xingjun Gao Yan He 《Nanotechnology and Precision Engineering》 CAS CSCD 2021年第2期25-32,共8页
To study the efect of micro-texture on the cutting performance of polyrystalline cubic boron nitide(PCBN)tools,five types of micro-textures(circular pits,eliptical grooves,transverse grooves,composite grooves,and wavy... To study the efect of micro-texture on the cutting performance of polyrystalline cubic boron nitide(PCBN)tools,five types of micro-textures(circular pits,eliptical grooves,transverse grooves,composite grooves,and wavy grooves)were applied to the rake surface of PCBN tools by an optical fber laser marking machine.Through a combination of three dimensional cutting simulations and experiments,the influences of micro-texture on chip-tool contact area,cutting force,chip morphology,shear angle,and surface roughness during the cuting process were analyzed.The results indicated that the chip--tool contact area and cutting force of both non-textured and micro textured tools increased with increasing cutting speed,while the shear angle decreased with increasing cutting speed.The chip-tool contact area and cutting force of the five types of micro-textured tools were smaller than those of the non textured tool The chip-tool contact area and cutting force obtained by the wavy-groove micro textured tool were the smallest.The chip radius produced by the five types of micro-textured tools was smaller than that produced by the non-textured tool,and the chip morphology was more stable.The transverse-groove micro-textured tool had a better chip breaking efect.The chip rnadius generated by the lliptical groove micro textured tool was 0.96 cm,while that generated by the wavy-groove tool varied from 0.55 cm to 1.26 cm.The presence of a micro-texture reduced the surface roughness of the workpiece by 11.73%-56.7%.Under the same cutting conditions,the five types of micro-textured tools gave a smaller chip--tool contact area,cutting force,chip radius,and surface roughness and a larger shear angle than the non-textured tool.In addition,the elliptical groove and wavy-groove micro-textured tools had better cuting performance. 展开更多
关键词 Micro-textured tool Chip tool contact area Cutting force Chip radius
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Deformation characterization of conductive particles in anisotropically conductive adhesive simulated by FEM 被引量:3
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作者 YanliWang JunpinLin ZhiLin XinfaCui GuoliangChen 《Journal of University of Science and Technology Beijing》 CSCD 2005年第1期48-53,共6页
The deformation behavior and the contact area of conductive particles in anisotropically conductive adhesives (ACA) were investigated by finite element method (FEM). The solid conductive particles are made of pure Ni ... The deformation behavior and the contact area of conductive particles in anisotropically conductive adhesives (ACA) were investigated by finite element method (FEM). The solid conductive particles are made of pure Ni and Cu. The results indicate that the deformation of the conductive particles is inhomogeneous during fabrication. When the reduction in height is small the deformation concentrates in the area near the contact area. As the reduction in height increases, the strain in the area near the contact area increases, and the metal flows toward the circumference, resulting in the increase of the contact area between the conductive particles and pad. The higher the degree of deformation, the larger the contact area. The regression equations were offered to express the relations between the bounding force and the contact area or the reduction in height. An approach of how to obtain the maximum contact area in ACA was discussed. 展开更多
关键词 anisotropically conductive adhesive contact area of conductive particles in ACA finite element method
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Thermal contact conductance at continuous roll-casting interface 被引量:1
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作者 胡仕成 马维策 +2 位作者 杜磊 李晓谦 钟掘 《Journal of Central South University of Technology》 EI 2007年第3期374-379,共6页
The effects of surface roughness, strain rate, friction coefficient and pressure on real contact area were analyzed based on the research of Stupkiewicz. The real contact area model taking account of the effect of fri... The effects of surface roughness, strain rate, friction coefficient and pressure on real contact area were analyzed based on the research of Stupkiewicz. The real contact area model taking account of the effect of friction and deformation of material was obtained. The model of contact conductance at the rolling interface was obtained by integrating the specific feature of heat transfer through the interface of continuous roll-casting. The results indicate that the real contact area increases obviously when the material is under yield, and the real contact area varies inversely with surface roughness, whereas it varies exponentially with friction coefficient, strain rate and pressure, and the power factor depends on strain rate. 展开更多
关键词 real contact area strain rate PRESSURE thermal contact conductance
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A consecutive joint shear strength model considering the 3D roughness of real contact joint surface
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作者 Liren Ban Zhigang Tao +1 位作者 Weisheng Du Yuhang Hou 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2023年第5期617-624,共8页
A consecutive joint shear strength model for soft rock joints is proposed in this paper,which takes into account the degradation law of the actual contact three-dimensional(3D)roughness.The essence of the degradation ... A consecutive joint shear strength model for soft rock joints is proposed in this paper,which takes into account the degradation law of the actual contact three-dimensional(3D)roughness.The essence of the degradation of the maximum possible dilation angle is the degradation of the 3D average equivalent dip angle of the actual contact joint asperities.Firstly,models for calculating the maximum possible dilation angle at the initial and residual shear stress stages are proposed by analyzing the 3D joint morphology characteristics of the corresponding shear stages.Secondly,the variation law of the maximum possible dilation angle is quantified by studying the degradation law of the joint micro convex body.Based on the variation law of the maximum possible dilation angle,the maximum possible shear strength model is proposed.Furthermore,a method to calculate the shear stiffness degradation in the plastic stage is proposed.According to the maximum possible shear strength of rock joints,the shear stress-shear displacement prediction model of rock joints is obtained.The new model reveals that there is a close relationship between joint shear strength and actual contact joint roughness,and the degradation of shear strength after the peak is due to the degradation of actual contact joint roughness. 展开更多
关键词 Shear strength Actual contact area 3D roughness Shear test
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Influence of Friction Interface Contact on Ultrasonic Motor Efficiency Under Static Conditions
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作者 张毅锋 张武 +3 位作者 肖爱武 朱萌 潘云华 张小亚 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2015年第2期163-173,共11页
The friction interface matching plays a deterministic role in the motor efficiency,and the microcosmic contact status of friction interface should be investigated to improve the ultrasonic motor performance.The main p... The friction interface matching plays a deterministic role in the motor efficiency,and the microcosmic contact status of friction interface should be investigated to improve the ultrasonic motor performance.The main purpose is to improve the effective output power of ultrasonic motor.Hence,one studies the contact condition of the friction interface of the ultrasonic motor,analyzes the micro condition of contact interface through finite element analysis,optimizes unreasonable structures,and compares the two different-structure ultrasonic motors through experiments.The results reflect the necessity of optimization.After optimization,the stator and rotor deform after pre-pressure and the contact interface of them full contact theoretically.When reaching heat balance the effective output of the motor is 37%,and the average effective output efficiency is 2.384 times higher than that of the unoptimized.It can be seen that the total consumption of the ultrasonic motor system decreases significantly.Therefore,when using in certain system the consumption taken from the system will decreases largely,especially in the system with a strict consumption control. 展开更多
关键词 ultrasonic motor friction interface contact area EFFICIENCY
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Experimental analysis of interface contact behavior using a novel image processing method
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作者 Jingyu Han Zhijun Luo +1 位作者 Yuling Zhang Shaoze Yan 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第5期412-423,共12页
The spatial and temporal evolution of real contact area of contact interface with loads is a challenge.It is generally believed that there is a positive linear correlation between real contact area and normal load.How... The spatial and temporal evolution of real contact area of contact interface with loads is a challenge.It is generally believed that there is a positive linear correlation between real contact area and normal load.However,with the development of measuring instruments and methods,some scholars have found that the growth rate of real contact area will slow down with the increase of normal load under certain conditions,such as large-scale interface contact with small roughness surface,which is called the nonlinear phenomenon of real contact area.At present,there is no unified conclusion on the explanation of this phenomenon.We set up an experimental apparatus based on the total reflection principle to verify this phenomenon and analyze its mechanism.An image processing method is proposed,which can be used to quantitative analysis micro contact behaviors on macro contact phenomenon.The weighted superposition method is used to identify micro contact spots,to calculate the real contact area,and the color superimposed image is used to identify micro contact behaviors.Based on this method,the spatiotemporal evolution mechanism of real contact area nonlinear phenomena is quantitatively analyzed.Furthermore,the influence of nonlinear phenomenon of real contact area on the whole loading and unloading process is analyzed experimentally.It is found that the effects of fluid between contact interface,normal load amplitude and initial contact state on contact behavior cannot be ignored in large-scale interface contact with small roughness surface. 展开更多
关键词 real contact area total reflection method micro-contact spots interface contact experimental analysis
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A novel method for geometric quality assurance of rock joint replicas in direct shear testing-Part 2:Validation and mechanical replicability
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作者 J.Larsson F.Johansson +3 位作者 D.Mas Ivars E.Johnson M.Flansbjer N.W.Portal 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第9期2209-2223,共15页
Each rock joint is unique by nature which means that utilization of replicas in direct shear tests is required in experimental parameter studies.However,a method to acquire knowledge about the ability of the replicas ... Each rock joint is unique by nature which means that utilization of replicas in direct shear tests is required in experimental parameter studies.However,a method to acquire knowledge about the ability of the replicas to imitate the shear mechanical behavior of the rock joint and their dispersion in direct shear testing is lacking.In this study,a novel method is presented for geometric quality assurance of replicas.The aim is to facilitate generation of high-quality direct shear testing data as a prerequisite for reliable subsequent analyses of the results.In Part 1 of this study,two quality assurance parameters,smf and V_(Hp100),are derived and their usefulness for evaluation of geometric deviations,i.e.geometric reproducibility,is shown.In Part 2,the parameters are validated by showing a correlation between the parameters and the shear mechanical behavior,which qualifies the parameters for usage in the quality assurance method.Unique results from direct shear tests presenting comparisons between replicas and the rock joint show that replicas fulfilling proposed threshold values of σ_(mf)<0.06 mm and|V_(Hp100)|<0.2 mm have a narrow dispersion and imitate the shear mechanical behavior of the rock joint in all aspects apart from having a slightly lower peak shear strength.The wear in these replicas,which have similar morphology as the rock joint,is in the same areas as in the rock joint.The wear is slightly larger in the rock joint and therefore the discrepancy in peak shear strength derives from differences in material properties,possibly from differences in toughness.It is shown by application of the suggested method that the quality assured replicas manufactured following the process employed in this study phenomenologically capture the shear strength characteristics,which makes them useful in parameter studies. 展开更多
关键词 Three-dimensional(3D)scanning Contact area measurements Direct shear testing Geometric quality assurance Mechanical replicability Replicas Rock joint
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Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
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作者 江龙光 赵更香 +3 位作者 卞传兵 袁彩 黄子祥 黄明东 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2009年第2期253-259,共7页
Urokinase-type plasminogen activator (uPA) is a trypsin-like serine protease and plays a key role in several biological processes, including tissue remodeling, cell migration, and matrix degradation. The inhibitors ... Urokinase-type plasminogen activator (uPA) is a trypsin-like serine protease and plays a key role in several biological processes, including tissue remodeling, cell migration, and matrix degradation. The inhibitors of uPA have been shown to prevent the spread of metastasis and tumor growth, and accordingly uPA is widely recognized as a target for the treatment of cancer. In this work, we report the crystal structures of the complexes of uPA with its inhibitors: 4- (aminomethyl)-benzoic acid (AMBA) and 4-(aminomethyl-phenyl)-methanol (AMPM), both at a resolution of 2.35 А. The inhibitory constants of these two inhibitors were measured by a chromogenic competitive assay, and it was found that AMBA is a better inhibitor for uPA (Ki = 2.68 mM) than AMPM (Ki = 13.99 mM). The structural study shows that the binding mode of inhibitor AMBA on uPA is similar to that of AMPM on uPA, both docked into the active site S1 pocket of uPA. Structural details of these complexes are provided to explain the difference of inhibitory constants. 展开更多
关键词 urokinase-type plasminogen activator 4-(aminomethyl)benzoic acid (4-aminomethyl-phenyl)-methanol enzyme inhibition assays contact area
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