EXPERIMENTAL STUDY ON ELASTIC－PLASTIC CONTROLLING DESIGN FOR BOX STEEL STRUCTURES

The principle of increasing structural loading abillity by the using of elastic-plastic con- trolling design, which can make steel reach a highcr yield slrength through controlling undue strains produced in loaded box steel structures and no damager to the static mechanical properties of the used materials, is dealt with under the guarantee of strength, rigidity, and stability. A new idea of elastic--plastic controlling design, which is mainly based on the elastic-plastic theory and experi- mental results and is different from the current design which is mainly based handbooks and design- er' s experience, is established. That is: the loading time and its effect on loaded structures are con- sidered, and the potential strength in used matcrials is fully utilized through the controlling of struc- tural strains in design. By the using of this design method, the weight and cost of box structures will be reduced in large amount.

A bionic controllable strain membrane for cell stretching at air–liquid interface inspired by papercutting

Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human health.However,an in vitro model capable of simulating different deformations of the alveoli and a suitable material for mimicking basement membrane are currently lacking.Here,we present an innovative biomimetic controllable strain membrane(BCSM)at an air–liquid interface(ALI)to reconstruct alveolar respiration.The BCSM consists of a high-precision three-dimensional printing melt-electrowritten polycaprolactone(PCL)mesh,coated with a hydrogel substrate—to simulate the important functions(such as stiffness,porosity,wettability,and ALI)of alveolar microenvironments,and seeded pulmonary epithelial cells and vascular endothelial cells on either side,respectively.Inspired by papercutting,the BCSM was fabricated in the plane while it operated in three dimensions.A series of the topological structure of the BCSM was designed to control various local-area strain,mimicking alveolar varied deformation.Lopinavir/ritonavir could reduce Lamin A expression under over-stretch condition,which might be effective in preventing ventilator-induced lung injury.The biomimetic lung-unit model with BCSM has broader application prospects in alveoli-related research in the future,such as in drug toxicology and metabolism.

New loop pairing criterion based on interaction and integrity considerations

Loop pairing is one of the major concerns when designing decentralized control systems for multivariable processes.Most existing pairing tools,such as the relative gain array(RGA) method,have shortcomings both in measuring interaction and in integrity issues.To evaluate the overall interaction among loops,we propose a statistics-based criterion via enumerating all possible combinations of loop statuses.Furthermore,we quantify the traditional concept of integrity to represent the extent of integrity of a decentralized control system.Thus,we propose that a pairing decision should be made by taking both factors into consideration.Two examples are provided to illustrate the effectiveness of the proposed criterion.