期刊文献+
共找到94篇文章
< 1 2 5 >
每页显示 20 50 100
A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury
1
作者 Qi Liu Jianye Xie +5 位作者 Runxue Zhou Jin Deng Weihong Nie Shuwei Sun Haiping Wang Chunying Shi 《Neural Regeneration Research》 SCIE CAS 2025年第2期503-517,共15页
Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug deliv... Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury. 展开更多
关键词 angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 NEUROPROTECTION self-assembling nanofiber hydrogel
下载PDF
Immobilization of antibodies on the self-assembled monolayer by antigen-binding site protection and immobilization kinetic control 被引量:1
2
作者 Myungok Yoon Hyun Jin Hwang Jeong Hee Kim 《Journal of Biomedical Science and Engineering》 2011年第4期242-247,共6页
The orientation of the biological molecule immobi-lized on a solid surface has been critical in devel-opment of various applications. In this study, ori-entation of antibody was retained by protecting the antigen-bind... The orientation of the biological molecule immobi-lized on a solid surface has been critical in devel-opment of various applications. In this study, ori-entation of antibody was retained by protecting the antigen-binding site of the antibody prior to immo-bilization to -functionalized mixed self-assembled monolayer (SAM) of 12-mercaptododecanoic acid and 1-heptanethiol. More importantly, the number of immobilization bonds formed between each an-tigen-binding site protected antibody molecule and the solid surface was controlled by optimizing the mole fraction of the activated carboxyl group of the linker molecules in the mixed SAM. The amount of antibody used in this study was approximately equivalent to the amount for one monolayer surface coverage. The resulting activity of protected immo-bilized antibody was about 10 fold higher than that of random immobilized 展开更多
关键词 Antibody Oriented IMMOBILIZATION Antigen-Binding Site PROTECTION self-assemblED MONOLAYER Kinetic control
下载PDF
Enzymatic self-assembly/disassembly turns “ON”/“OFF” the mimetic hydrolytic activity of histidine nanofibers
3
作者 Xianbao Sun Manli Wang +6 位作者 Xiaoyang Liu Wenjun Zhan Guangqiong Xu Qiaochu Jiang Hai-Dong Xu Fuqiang Wang Gaolin Liang 《Science China Chemistry》 SCIE EI CAS CSCD 2024年第2期517-522,共6页
Mimetic enzymes are devised as alternates or supplements of natural enzymes in broad fields but regulating their activities in a switchable manner remains challenging.Herein,we proposed an enzymatic self-assembly/disa... Mimetic enzymes are devised as alternates or supplements of natural enzymes in broad fields but regulating their activities in a switchable manner remains challenging.Herein,we proposed an enzymatic self-assembly/disassembly strategy to address this issue.A peptide molecule Nap FFEYIH(YH) was rationally designed which,after self-assembling into nanofibers,lined up the histidine moieties to form active hydrolysis centers for mimicking hydrolase activity.Enzymatic dephosphorylation of Nap FFEYp IH(Yp H) by alkaline phosphatase to yield YH also turned “ON” the hydrolase activity.In turn,phosphorylation of YH by phosphokinase epidermal growth factor receptor to yield Yp H disassembled the nanofibers and thus turned the activity “OFF”.As such,the “ON”/“OFF” of the mimetic hydrolase activities could be regulated under physiological conditions through ALP/EGFR-mediated self-assembly/disassembly of histidine nanofibers.This work provides a feasible strategy for the on-demand fabrication of artificial enzymes with controllable and superior activities. 展开更多
关键词 disassembly hydrolytic activity mimetic enzyme phosphorylation self-assembly
原文传递
Controlled Release of the Indomethacin Microencapsulation Based on Layer-by-layer Assembly by Polyelectrolyte Multilayers
4
作者 CHEN You-fang LIN Xian-fu 《Chinese Journal of Biomedical Engineering(English Edition)》 2007年第1期8-13,共6页
Indomethacin has been encapsulated with polyelectrolyte multilayers for controlled release. Gelatin and alginate were alternatively deposited on indomethacin microcrystals. The released amount of indomethacin from coa... Indomethacin has been encapsulated with polyelectrolyte multilayers for controlled release. Gelatin and alginate were alternatively deposited on indomethacin microcrystals. The released amount of indomethacin from coated microcrystals in pH6. 8 phosphate buffer solution (PBS) was measured with a UV spectrophometer. The polyelectrolyte multilayer capsule thickness was proved to control the release rate. The effects of osmotic pressure existed during the release process of indomethacin from microcapsules coated by (gelatin/alginate) 4. 展开更多
关键词 INDOMETHACIN ENCAPSULATED controlled release self-assembly POLYELECTROLYTE
下载PDF
Intelligent responsive self-assembled micro-nanocapsules:Used to delay gel gelation time
5
作者 Chuan-Hong Kang Ji-Xiang Guo +1 位作者 Dong-Tao Fei Wyclif Kiyingi 《Petroleum Science》 SCIE EI CAS CSCD 2024年第4期2433-2443,共11页
In the application of polymer gels to profile control and water shutoff,the gelation time will directly determine whether the gel can"go further"in the formation,but the most of the methods for delaying gel ... In the application of polymer gels to profile control and water shutoff,the gelation time will directly determine whether the gel can"go further"in the formation,but the most of the methods for delaying gel gelation time are complicated or have low responsiveness.There is an urgent need for an effective method for delaying gel gelation time with intelligent response.Inspired by the slow-release effect of drug capsules,this paper uses the self-assembly effect of gas-phase hydrophobic SiO_(2) in aqueous solution as a capsule to prepare an intelligent responsive self-assembled micro-nanocapsules.The capsule slowly releases the cross-linking agent under the stimulation of external conditions such as temperature and pH value,thus delaying gel gelation time.When the pH value is 2 and the concentration of gas-phase hydrophobic SiO_(2) particles is 10%,the gelation time of the capsule gel system at 30,60,90,and 120℃is12.5,13.2,15.2,and 21.1 times longer than that of the gel system without containing capsule,respectively.Compared with other methods,the yield stress of the gel without containing capsules was 78 Pa,and the yield stress after the addition of capsules was 322 Pa.The intelligent responsive self-assembled micronanocapsules prepared by gas-phase hydrophobic silica nanoparticles can not only delay the gel gelation time,but also increase the gel strength.The slow release of cross-linking agent from capsule provides an effective method for prolongating the gelation time of polymer gels. 展开更多
关键词 Profile control and water shutoff Polymer gel Delayed gelation time Intelligent response self-assemblED Micro-nanocapsules
下载PDF
A nitric oxide-triggered hydrolysis reaction to construct controlled self-assemblies with complex topologies
6
作者 Wenzhuo Chen Yuping Tang +7 位作者 Shuai Chen Zipei Chen Jia He Hongbin Huo Juan Zhang Jiajia Li Fei Yan Wei Tian 《Science China Chemistry》 SCIE EI CAS CSCD 2024年第4期1289-1299,共11页
Hydrolysis reactions are capable of directing the non-equilibrium assembly of biomolecular scaffolds to realize sophisticated structures and functions in natural systems.However,utilizing the proper hydrolysis reactio... Hydrolysis reactions are capable of directing the non-equilibrium assembly of biomolecular scaffolds to realize sophisticated structures and functions in natural systems.However,utilizing the proper hydrolysis reactions to construct controlled assemblies with complex topologies is still an arduous challenge in artificial systems and needs to be addressed.Herein,we report a nitric oxide(NO)-triggered slow hydrolysis strategy for the controlled construction of biomimetic supramolecular toroids(STs),thus realizing their visualization of intermediate structures and regulation of geometry parameters.This presented protocol harnesses hydrolysis reactions to control of non-equilibrium self-assembly processes for the construction of self-assemblies with complex topologies successfully,which sheds light on how the hydrolysis reaction rate can modulate the kinetic pathway of assembly,thus realizing the artificial establishment of bio-inspired hierarchical structures. 展开更多
关键词 supramolecular toroids controlled self-assembly nitic oxide-triggered hydrolysis pathway regulation
原文传递
Biological Stimuli-responsive Polymer Systems:Design,Construction and Controlled Self-assembly 被引量:3
7
作者 Miao-Miao Xu Ren-Jie Liu Qiang Yan 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2018年第3期347-365,共19页
Biological stimuli-responsive polymers have increasingly attracted attention in recent years because it can satisfy many requirements of applications related with human body while traditional systems do not meet.Due t... Biological stimuli-responsive polymers have increasingly attracted attention in recent years because it can satisfy many requirements of applications related with human body while traditional systems do not meet.Due to the importance of this burgeoning field,great efforts have been devoted and,up to now,polymer chemists have made a remarkable success in this prospective research topic.In this review,we systematically generalize the present state of biological stimuli-responsive polymer systems.We highlight several representative examples to specify the current problems and look ahead a clear sense of direction in this area. 展开更多
关键词 Biological stimuli Responsive polymer controlled self-assembly BIOMEDICINE
原文传递
Controllable preparation of hierarchical NiO hollow microspheres with high pseudo-capacitance 被引量:2
8
作者 Hong-zhi YANG Jian-peng ZOU 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2018年第9期1808-1818,共11页
Nickel oxide(NiO)hollow microspheres with hierarchical structure were fabricated through a process consisting of a self-assembling,hydrothermal reaction and calcination.The prepared NiO hollow microspheres composed of... Nickel oxide(NiO)hollow microspheres with hierarchical structure were fabricated through a process consisting of a self-assembling,hydrothermal reaction and calcination.The prepared NiO hollow microspheres composed of many nanoflakes,are about 2-3μm in diameter.The length of the NiO flakes,having clear edges,is about 500-700 nm,while the thickness is only about 40-50 nm.This indicates that the NiO microspheres possess a hierarchical structure that can provide porous channels to facilitate the transmission of both electrons and electrolyte ions.NiO microspheres exhibit a high specific capacitance of about 1340 F/g at a current density of 1 A/g and high capacitance retention about 96.5%after 1000 cycles.What’s more,the conductive mechanism of nickel oxide for electrochemical capacitor electrodes was also studied. 展开更多
关键词 nickel oxide hollow microsphere hierarchical structure controllable preparation self-assemblING PSEUDO-CAPACITANCE
下载PDF
Recent Advances in Activatable Probes for Molecular Imaging by Stimuli-Controlled Disassembly 被引量:1
9
作者 Weijing Huang Yanling Yang Deju Ye 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2023年第18期2382-2399,共18页
Comprehensive Summary,Stimuli-controlled disassembly process has shown promise to direct delivery of probes and/or spatial-temporally control imaging signals for molecular imaging in vivo.Via the disassembly process,w... Comprehensive Summary,Stimuli-controlled disassembly process has shown promise to direct delivery of probes and/or spatial-temporally control imaging signals for molecular imaging in vivo.Via the disassembly process,well defined nanoprobes with a stimulus-responsive moiety can be controllably converted into small-molecular imaging agents in response to a stimulus,leading to a switch in imaging signals.Moreover,the on-site released small-molecule probes could enhance penetration into the deep tissue for improved imaging of deep-seated molecular targets.Therefore,such a stimuli-controllable disassembly approach has been widely utilized to build activatable molecular imaging probes for the noninvasive detection of various molecular targets in living subjects.In this review article,we first briefly introduce the general principle of stimuli-controlled disassembly.We then summarize the activatable probes based on different internal or external stimulus that has been utilized to control disassembly process.Activatable probes by using multiple stimuli to control cascaded in situ self-assembly and disassembly processes are also discussed.Finally,we close with a conclusion of current challenges and perspective in this field. 展开更多
关键词 Stimuli-controlled disassembly Activatable probes Small-molecular imaging agents self-assembly Molecular imaging
原文传递
Amphiphilic poly(ethylene glycol)-b-poly(ethylene brassylate)copolymers: One-pot synthesis, self-assembly, and controlled drug release 被引量:2
10
作者 Jiu-Cun Chen Jun-Zhi Li +1 位作者 Jian-Hua Liu Li-Qun Xu 《Chinese Chemical Letters》 SCIE CAS CSCD 2015年第10期1319-1321,共3页
A set of amphiphilic poly(ethylene glycol)-b-poly(ethylene brassylate)(PEG-b-PEB) copolymers based on the PEB hydrophobic block was first synthesized by ring-opening polymerization of ethylene brassylate with an... A set of amphiphilic poly(ethylene glycol)-b-poly(ethylene brassylate)(PEG-b-PEB) copolymers based on the PEB hydrophobic block was first synthesized by ring-opening polymerization of ethylene brassylate with an organic catalyst. The EB/PEG molar ratios and reaction times were adjusted to achieve different chain lengths of PEB. Block copolymers that were characterized by1 H NMR and GPC could selfassemble into multimorphological aggregates in aqueous solution, which were characterized by DLS and TEM. The hydrophobic doxorubicin(DOX) was chosen as a drug model and successfully encapsulated into the nanoparticles. The release kinetics of DOX were investigated. 展开更多
关键词 Poly(ethylene brassylate) self-assembly Nanoparticles controlled drug release
原文传递
Self-assembled Nanoparticles based on Folic Acid Modifi ed Carboxymethyl Chitosan Conjugated with Targeting Antibody 被引量:2
11
作者 虎征宇 ZHENG Hua +6 位作者 LI Dan XIONG Xiong TAN Mingyuan HUANG Dan GUO Xing 张雪琼 严晗 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2016年第2期446-453,共8页
Nanoparticles conjugated with antibody were designed as active drug delivery system to reduce the toxicity and side effects of drugs for acute myeloid leukemia(AML).Moreover,methotrexate(MTX)was chosen as modeldru... Nanoparticles conjugated with antibody were designed as active drug delivery system to reduce the toxicity and side effects of drugs for acute myeloid leukemia(AML).Moreover,methotrexate(MTX)was chosen as modeldrug and encapsulate within folic acid modified carboxymethylchitosan(FACMCS)nanoparticles through self-assembling.The chemicalstructure,morphology,release and targeting of nanoparticles were characterized by routine detection.It is demonstrated that the mean diameter is about 150 nm,the release rate increases with the decreasing of p H,the binding rate of CD33 antibody and FA-CMCS nanoparticles is about 5:2,and nanoparticles can effectively bind onto HL60 cells in vitro.The experimentalresults indicate that the FA-CMCS nanoparticles conjugated with antibody may be used as a potentialp Hsensitive drug delivery system with leukemic targeting properties. 展开更多
关键词 chitosan nanoparticles targeted drug delivery cancer controlled release self-assembly pH-sensitive
下载PDF
Controlled-release hydrogel loaded with magnesium-based nanoflowers synergize immunomodulation and cartilage regeneration in tendon-bone healing
12
作者 Jintao Li Haolin Ke +13 位作者 Xiangcheng Lei Jiexin Zhang Zhicheng Wen Zhisheng Xiao Huabin Chen Juncheng Yao Xuan Wang Zhengnong Wei Hongrui Zhang Weilun Pan Yan Shao Yitao Zhao Denghui Xie Chun Zeng 《Bioactive Materials》 SCIE 2024年第6期62-82,共21页
Tendon-bone interface injuries pose a significant challenge in tissue regeneration,necessitating innovative approaches.Hydrogels with integrated supportive features and controlled release of therapeutic agents have em... Tendon-bone interface injuries pose a significant challenge in tissue regeneration,necessitating innovative approaches.Hydrogels with integrated supportive features and controlled release of therapeutic agents have emerged as promising candidates for the treatment of such injuries.In this study,we aimed to develop a temperature-sensitive composite hydrogel capable of providing sustained release of magnesium ions(Mg^(2+)).We synthesized magnesium-Procyanidin coordinated metal polyphenol nanoparticles(Mg-PC)through a self-assembly process and integrated them into a two-component hydrogel.The hydrogel was composed of dopamine-modified hyaluronic acid(Dop-HA)and F127.To ensure controlled release and mitigate the“burst release”effect of Mg^(2+),we covalently crosslinked the Mg-PC nanoparticles through coordination bonds with the catechol moiety within the hydrogel.This crosslinking strategy extended the release window of Mg^(2+)concentrations for up to 56 days.The resulting hydrogel(Mg-PC@Dop-HA/F127)exhibited favorable properties,including injectability,thermosensitivity and shape adaptability,making it suitable for injection and adaptation to irregularly shaped supraspinatus implantation sites.Furthermore,the hydrogel sustained the release of Mg^(2+)and Procyanidins,which attracted mesenchymal stem and progenitor cells,alleviated inflammation,and promoted macrophage polarization towards the M2 phenotype.Additionally,it enhanced collagen synthesis and mineralization,facilitating the repair of the tendon-bone interface.By incorporating multilevel metal phenolic networks(MPN)to control ion release,these hybridized hydrogels can be customized for various biomedical applications. 展开更多
关键词 Magnesium Metal-phenolic networks self-assembly process controlled release Immunomodulation Tendon-bone interface
原文传递
Capacitive Control of Spontaneously Induced Electrical Charge of Droplet by Electric Field-Assisted Pipetting
13
作者 Horim Lee Dongwhi Choi +1 位作者 Dong Sung Kim Geunbae Lim 《Nano-Micro Letters》 SCIE EI CAS 2015年第4期341-346,共6页
The spontaneously generated electrical charge of a droplet dispensed from conventional pipetting is undesirable and unpredictable for most experiments that use pipetting.Hence,a method for controlling and removing the... The spontaneously generated electrical charge of a droplet dispensed from conventional pipetting is undesirable and unpredictable for most experiments that use pipetting.Hence,a method for controlling and removing the electrical charge needs to be developed.In this study,by using the electrode-deposited pipet tip(E-pipet tip),the charge-controlling system is newly developed and the electrical charge of a droplet is precisely controlled.The effect of electrolyte concentration and volume of the transferred solution to the electrical charge of a dispensed droplet is theoretically and experimentally investigated by using the equivalent capacitor model.Furthermore,a proof-of-concept example of the self-alignment and self-assembly of sequentially dispensed multiple droplets is demonstrated as one of the potential applications.Given that the electrical charge of the various aqueous droplets can be precisely and simply controlled,the fabricated E-pipet tip can be broadly utilized not only as a general charge-controlling platform of aqueous droplets but also as a powerful tool to explore fundamental scientific research regarding electrical charge of a droplet,such as the surface oscillation and evaporation of charged droplets. 展开更多
关键词 Pipet tip Capacitive control Electrical charge self-assembly
下载PDF
反汇编工具中间接跳转表求解算法分析与测试
14
作者 庞成宾 徐雪兰 +1 位作者 张天泰 茅兵 《软件学报》 EI CSCD 北大核心 2024年第10期4623-4641,共19页
二进制反汇编是困难的,但是对于提高二进制软件的安全性至关重要.造成二进制反汇编比较困难的一大原因是编译器为了提高效率会在二进制代码中引入很多间接跳转表.为了求解间接跳转表,主流反汇编工具采用了各种策略.然而,这些策略的具体... 二进制反汇编是困难的,但是对于提高二进制软件的安全性至关重要.造成二进制反汇编比较困难的一大原因是编译器为了提高效率会在二进制代码中引入很多间接跳转表.为了求解间接跳转表,主流反汇编工具采用了各种策略.然而,这些策略的具体实现以及策略的效果不得而知.为了帮助研究人员理解反汇编工具的算法实现以及性能,首先系统总结反汇编工具求解间接跳转表的策略;然后构建自动化测试间接跳转表框架,基于该框架,可以大规模地生成关于间接跳转表的测试集(包含2410455个跳转表);最后,在该测试集上,对反汇编工具求解间接跳转表的性能进行评估,并人工分析反汇编工具的每个策略引入的错误.另外,得益于针对反汇编工具算法实现的系统性总结,发现6个反汇编工具实现上的bugs. 展开更多
关键词 二进制反汇编 控制流 间接跳转表 值集分析
下载PDF
Potential control of DNA self-assembly on gold electrode 被引量:2
15
作者 Cunwang Ge Yibin Tan +3 位作者 Jianhui Liao Yu Zhang Haiqian Zhang Ning Gu 《Chinese Science Bulletin》 SCIE EI CAS 2002年第5期370-375,共6页
The self-assembly monolayer (SAM) was prepared with 2-aminoethanethiol (AET) on the gold electrode. A new approach based on potential was first used to control DNA self-assembly covalently onto the SAM with the activa... The self-assembly monolayer (SAM) was prepared with 2-aminoethanethiol (AET) on the gold electrode. A new approach based on potential was first used to control DNA self-assembly covalently onto the SAM with the activation of l-ethyl-3(3-dimethylaminopropyl)-carbodiimide (EDC) and N-hydroxysulfosuccinimide (NHS). The influence of potential on DNA self-assembly was investigated by means of cyclic voltammetry (CV), AC impedance, Auger electron spectrometry (AES) and atomic force microscopy (AFM). The result proves that controlled potential can affect the course of DNA self-assembly. More negative potential can restrain the DNA self-assembly, while more positive potential can accelerate the DNA self-assembly, which is of great significance for the control of DNA self-assembly and will find wide application in the field of DNA-based devices. 展开更多
关键词 DNA self-assembly controlled POTENTIAL DNA-based device GOLD electrode.
原文传递
Self-assembly control and experiments in swarm modular robots 被引量:2
16
作者 WEI HongXing LI HaiYuan +1 位作者 TAN JinDong WANG TianMiao 《Science China(Technological Sciences)》 SCIE EI CAS 2012年第4期1118-1131,共14页
This paper presents a self-assembly control strategy for the swarm modular robots. Simulated and physical experiments are conducted based on the Sambot platform, which is a novel self-assembly modular robot having the... This paper presents a self-assembly control strategy for the swarm modular robots. Simulated and physical experiments are conducted based on the Sambot platform, which is a novel self-assembly modular robot having the characteristics of both the chain-type and the mobile self-reconfigurable robots. Multiple Sambots can autonomously move and connect with one another through self-assembly to form robotic organisms. The configuration connection state table is used to describe the configuration of the robotic structure. A directional self-assembly control model is proposed to perform the self-assembly experiments. The self-assembly process begins with one Sambot as the seed, and then the Docking Sambots use a behavior-based controller to achieve connection with the seed Sambot. The controller is independent of the target configuration. The seed and connected Sambots execute a configuration comparison algorithm to control the growth of the robotic structure. Furthermore, the simul- taneous self-assembly of multiple Sambots is discussed. For multiple configurations, self-assembly experiments are conducted in simulation platform and physical platform of Sambot. The experimental results verify the effectiveness and scalability of the self-assembly algorithms. 展开更多
关键词 self-reconfigurable robot modular robot swarm robot self-assembly behavior-based control
原文传递
炉前多功能机械手遥控系统研究
17
作者 林瑶瑶 吴炫睿 +1 位作者 刘宁 徐伟 《有色设备》 2024年第2期19-23,共5页
针对传统工业冶炼炉耐火砖拆卸作业自动化水平低、危险性高等问题,为炉前多功能机械手研发了一套智能远程遥控系统。采用Lora无线通信技术作为遥控器与拆砖机通信的无线协议,研发了无线收发模块,实现了远距离遥控,抗干扰能力强。配置了1... 针对传统工业冶炼炉耐火砖拆卸作业自动化水平低、危险性高等问题,为炉前多功能机械手研发了一套智能远程遥控系统。采用Lora无线通信技术作为遥控器与拆砖机通信的无线协议,研发了无线收发模块,实现了远距离遥控,抗干扰能力强。配置了18650锂电池,并设计供电电路为遥控器硬件系统供电,供电电压3.6 V,可长期稳定输出。以ARM架构的STM32F103RCT芯片作为遥控器的主控制器,搭建了简洁高效的芯片外围电路,以及指令信号监测和滤波等辅助电路。使用分段算法,将直接摇杆指令转换为既符合低速精确定位,又符合快速响应要求的实际指令信号。该遥控系统已经应用到实际工程项目中,对提高工业冶炼炉耐火砖拆卸自动化水平具有重要意义。 展开更多
关键词 STM32F103RCT 机械手 遥控器 LoRa 耐火砖 冶炼炉 拆卸
下载PDF
拆装机器人灵巧手控制系统研究
18
作者 和金星 杨志成 +3 位作者 陆根财 唐宇欣 闫文舟 孙海洋 《仪表技术》 2024年第6期79-82,共4页
为了提高拆装机器人在控制工件时的控制能力与灵活性,综合设计制作了一种能够在狭窄空间内精准控制工件进行给进、退出及翻转动作的灵巧手。根据工件参数确定了灵巧手尺寸,采用SolidWorks软件构建了灵巧手的整体模型,设计了灵巧手的指... 为了提高拆装机器人在控制工件时的控制能力与灵活性,综合设计制作了一种能够在狭窄空间内精准控制工件进行给进、退出及翻转动作的灵巧手。根据工件参数确定了灵巧手尺寸,采用SolidWorks软件构建了灵巧手的整体模型,设计了灵巧手的指部结构。针对机器人的运动需求,设计了一套控制系统,并制作样机进行机器人控件实验。实验结果表明,所设计的机器人结构可以稳定执行给进、退出及反转等控制动作,且灵巧手系统表现出高度的安全性和可靠性。实验结果与仿真控制效果一致,验证了拆装机器人灵巧手设计方案的可行性与有效性。 展开更多
关键词 灵巧手 拆装机器人 控制系统
下载PDF
公路隧道衬砌全断面拆换施工病害处治研究 被引量:1
19
作者 孙迪 《北方交通》 2024年第2期56-59,共4页
随着隧道运营年限的增加以及不良地质和气候条件等因素影响,隧道衬砌结构性病害逐年增多。以辽宁西部地区某运营公路隧道为背景,在专项检查的基础上分析病害成因,提出全断面衬砌拆换的处治方案。采取以超前支护注浆和分段拆除恢复为核... 随着隧道运营年限的增加以及不良地质和气候条件等因素影响,隧道衬砌结构性病害逐年增多。以辽宁西部地区某运营公路隧道为背景,在专项检查的基础上分析病害成因,提出全断面衬砌拆换的处治方案。采取以超前支护注浆和分段拆除恢复为核心的变形控制措施,和以锚杆注浆稳定膨胀性围岩、轻质混凝土回填背后空腔、加强初期支护和二衬为重点的恢复措施,辅以围岩压力监测、锚杆轴力监测和钢架内力监测为手段的长期监测,并论述了施工过程中的风险点和技术要点。方案可为类似工程提供经验借鉴。 展开更多
关键词 公路隧道 衬砌脱空 全断面拆换 变形控制 病害处治
下载PDF
Water-responsive 4D printing based on self-assembly of hydrophobic protein “Zein” for the control of degradation rate and drug release
20
作者 Yubei Zhang Ali Raza +6 位作者 Ya-Qi Xue Ganggang Yang Uzma Hayat Jingwen Yu Chang Liu Hua-Jie Wang Jin-Ye Wang 《Bioactive Materials》 SCIE CSCD 2023年第5期343-352,共10页
Four-dimensional(4D)printing is a promising technology that provides solutions for compelling needs in various fields.Most of the reported 4D printed systems are based on the temporal shape transformation of printed s... Four-dimensional(4D)printing is a promising technology that provides solutions for compelling needs in various fields.Most of the reported 4D printed systems are based on the temporal shape transformation of printed subjects.Induction of temporal heterogenicity in functions in addition to shape may extend the scope of 4D printing.Herein,we report a 4D printing approach using plant protein(zein)gel inspired by the amyloid fibrils formation mechanism.The printing of zein gel in a specialized layered-Carbopol supporting bath with different water concentrations in an ethanol-water mixture modulates hydrophobic and hydrogen bonding that causes temporal changes in functions.The part of the construct printed in a supporting bath with higher water content exhibits higher drug loading,faster drug release and degradation than those printed in the supporting bath with lower water content.Tri-segment conduit and butterfly-shaped construct with two asymmetrical wings are printed using this system to evaluate biomedical function as nerve conduit and drug delivery system.4D printed conduits are also effective as a drug-eluting urethral stent in the porcine model.Overall,this study extends the concept of 4D printing beyond shape transformation and presents an approach of fabricating specialized baths for 4D printing that can also be extended to other materials to obtain 4D printed medical devices with translational potential. 展开更多
关键词 Zein gels Water-driven 4D printing Protein self-assembly Tunable degradation controlled drug release
原文传递
上一页 1 2 5 下一页 到第
使用帮助 返回顶部