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Effects of Lycium barbarum polysaccharide on cytokines in adolescents with subthreshold depression:a randomized controlled study
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作者 Xiaoyue Li Tao Liu +6 位作者 Xuan Mo Runhua Wang Xueyan Kong Robin Shao Roger S.Mclntyre Kwok-Fai So Kangguang Lin 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期2036-2040,共5页
Strong evidence has accumulated to show a correlation between depression symptoms and inflammatory responses.Moreover,anti-inflammatory treatment has shown partial effectiveness in alleviating depression symptoms.Lyci... Strong evidence has accumulated to show a correlation between depression symptoms and inflammatory responses.Moreover,anti-inflammatory treatment has shown partial effectiveness in alleviating depression symptoms.Lycium barbarum polysaccharide(LBP),derived from Goji berries,exhibits notable antioxidative and anti-inflammatory properties.In our recent double-blinded randomized placebo-controlled trial,we found that LBP significantly reduced depressive symptoms in adolescents with subthreshold depression.It is presumed that the antidepressant effect of LBP may be associated with its influence on inflammatory cytokines.In the double-blinded randomized controlled trial,we enrolled 29 adolescents with subthreshold depression and randomly divided them into an LBP group and a placebo group.In the LBP group,adolescents were given 300 mg/d LBP.A 6-week follow up was completed by 24 adolescents,comprising 14 adolescents from the LBP group(15.36±2.06 years,3 men and 11 women)and 10 adolescents from the placebo group(14.9±1.6 years,2 men and 8 women).Our results showed that after 6 weeks of treatment,the interleukin-17A level in the LBP group was lower than that in the placebo group.Network analysis showed that LBP reduced the correlations and connectivity between inflammatory factors,which were associated with the improvement in depressive symptoms.These findings suggest that 6-week administration of LBP suppresses the immune response by reducing interleukin-17A level,thereby exerting an antidepressant effect. 展开更多
关键词 adolescents CYTOKINES EFFICACY Goji berry inflammatory responses INTERLEUKIN-17A Lycium barbarum polysaccharide randomized controlled study subthreshold depression
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Clinical value of oral contrast-enhanced ultrasonography in diagnosis of gastric tumors
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作者 Chuan-Yu Wang Xiao-Jing Fan +6 位作者 Fei-Liang Wang Yue-Yue Ge Zhao Cai Wei Wang Xin-Ping Zhou Jun Du De-Wei Dai 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第1期110-117,共8页
BACKGROUND The incidence of gastric cancer remains high,and it is the sixth most common cancer and the fourth leading cause of cancer deaths worldwide.Oral contrastenhanced ultrasonography is a simple,non-invasive,and... BACKGROUND The incidence of gastric cancer remains high,and it is the sixth most common cancer and the fourth leading cause of cancer deaths worldwide.Oral contrastenhanced ultrasonography is a simple,non-invasive,and painless method for the diagnosis of gastric tumors.AIM To explore the diagnostic value of oral contrast-enhanced ultrasonography for the detection of gastric tumors.METHODS The screening results based on oral contrast-enhanced ultrasonography and electronic gastroscopy were compared with those of the postoperative pathological examination.RESULTS Among 42 patients with gastric tumors enrolled in the study,the diagnostic accordance rate was 95.2%for oral contrast-enhanced ultrasonography(n=40)and 90.5%for electronic gastroscopy(n=38)compared with postoperative pathological examination.The Kappa value of consistency test with pathological findings was 0.812 for oral contrast-enhanced ultrasonography and 0.718 for electronic gastroscopy,and there was no significant difference between them(P=0.397).For the TNM staging of gastric tumors,the accuracy rate of oral contrast enhanced ultrasonography was 81.9%for the overall T staging and 50%,77.8%,100%,and 100%for T1,T2,T3,and T4 staging,respectively.The sensitivity and specificity were both 100%for stages T3 and T4.The diagnostic accuracy rate of oral contrast-enhanced ultrasonography was 93.8%,80%,100%,and 100%for stages N0,N1-N3,M0,and M1,respectively.CONCLUSION The accordance rate of qualitative diagnosis by oral contrast-enhanced ultrasonography is comparable to that of gastroscopy,and it could be used as the preferred method for the early screening of gastric tumors. 展开更多
关键词 Oral contrast-enhanced ultrasonography Gastric tumor Electronic gastroscopy controlled study Pathological examination DIAGNOSIS
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Associations of lifestyle and diet with the risk of nasopharyngeal carcinoma in Singapore:a case–control study 被引量:12
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作者 Sook Kwin Yong Tam Cam Ha +3 位作者 Ming Chert Richard Yeo Valerie Gaborieau James D.McKay Joseph Wee 《Chinese Journal of Cancer》 SCIE CAS CSCD 2017年第2期63-70,共8页
Background: Nasopharyngeal carcinoma(NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of t... Background: Nasopharyngeal carcinoma(NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of this study was to examine associations between modifiable lifestyle factors and the risk of NPC in the Singaporean population.Methods: We conducted a case–control study in Singapore with 300 patients and 310 controls who were recruited between 2008 and 2012. Each control was selected and individually matched to each patient based on sex, ethnicity, and age(±5 years). A total of 290 pairs of cases and controls were matched successfully. We examined lifestyle factors such as tobacco smoking, alcohol drinking, various salted and preserved food consumption, and weaning practices.Results: After adjusting for covariates, multivariate analysis showed that those participants who were current smokers and had ever smoked tobacco had a higher risk of NPC than participants who had never smoked, with odds ratios(ORs) of 4.50(95% confidence interval [CI] 2.58–7.86; P < 0.001) and 2.52(95% CI 1.54–4.12; P < 0.001), respectively. Those who consumed salted vegetables at least once a week also showed a significantly increased risk of NPC than those who never or rarely consumed salted vegetables, with an OR of 4.18(95% CI 1.69–10.38; P = 0.002).Conclusion: Smoking(currently and ever-smoked) and consuming salted vegetables once a week or more were lifestyle risk factors for NPC, and changes of these factors for the better may reduce the risk of NPC. 展开更多
关键词 Nasopharyngeal carcinoma DIET SMOKING Alcohol drinking Case–control study Preserved food
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Delayed improvements in visual memory task performance among chronic schizophrenia patients after high-frequency repetitive transcranial magnetic stimulation 被引量:3
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作者 Xiang-Dong Du Zhe Li +13 位作者 Nian Yuan Ming Yin Xue-Li Zhao Xiao-Li Lv Si-Yun Zou Jun Zhang Guang-Ya Zhang Chuan-Wei Li Hui Pan Li Yang Si-Qi Wu Yan Yue Yu-Xuan Wu Xiang-Yang Zhang 《World Journal of Psychiatry》 SCIE 2022年第9期1169-1182,共14页
BACKGROUND Cognitive impairments are core characteristics of schizophrenia,but are largely resistant to current treatments.Several recent studies have shown that highfrequency repetitive transcranial magnetic stimulat... BACKGROUND Cognitive impairments are core characteristics of schizophrenia,but are largely resistant to current treatments.Several recent studies have shown that highfrequency repetitive transcranial magnetic stimulation(rTMS)of the left dorsolateral prefrontal cortex(DLPFC)can reduce negative symptoms and improve certain cognitive deficits in schizophrenia patients.However,results are inconsistent across studies.AIM To examine if high-frequency rTMS of the DLPFC can improve visual memory deficits in patients with schizophrenia.METHODS Forty-seven chronic schizophrenia patients with severe negative symptoms on stable treatment regimens were randomly assigned to receive active rTMS to the DLPFC(n=25)or sham stimulation(n=22)on weekdays for four consecutive weeks.Patients performed the pattern recognition memory(PRM)task from the Cambridge Neuropsychological Test Automated Battery at baseline,at the end of rTMS treatment(week 4),and 4 wk after rTMS treatment(week 8).Clinical symptoms were also measured at these same time points using the Scale for the Assessment of Negative Symptoms(SANS)and the Positive and Negative Syndrome Scale(PANSS).RESULTS There were no significant differences in PRM performance metrics,SANS total score,SANS subscores,PANSS total score,and PANSS subscores between active and sham rTMS groups at the end of the 4-wk treatment period,but PRM performance metrics(percent correct and number correct)and changes in these metrics from baseline were significantly greater in the active rTMS group at week 8 compared to the sham group(all P<0.05).Active rTMS treatment also significantly reduced SANS score at week 8 compared to sham treatment.Moreover,the improvement in visual memory was correlated with the reduction in negative symptoms at week 8.In contrast,there were no between-group differences in PANSS total score and subscale scores at either week 4 or week 8(all P>0.05).CONCLUSION High-frequency transcranial magnetic stimulation improves visual memory and reduces negative symptoms in schizophrenia,but these effects are delayed,potentially due to the requirement for extensive neuroplastic changes within DLPFC networks. 展开更多
关键词 COGNITION High-frequency repetitive transcranial magnetic stimulation Non-invasive brain stimulation Randomized controlled study SCHIZOPHRENIA Visual memory deficits
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Therapeutic Effects of Integrated Traditional Chinese Medicine and Western Medicine in Treating Severe Acute Respiratory Syndrome 被引量:2
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作者 王融冰 刘军民 +5 位作者 江宇泳 吴云忠 王晓静 池频频 孙凤霞 高连印 《Chinese Journal of Integrated Traditional and Western Medicine》 2003年第4期259-262,共4页
Objective: To improve the effects of treatment of severe acute re spiratory syndrome (SARS) and to explore the clinical significance of integrate d traditional Chinese medicine and western medicine (ICWM) in the treat... Objective: To improve the effects of treatment of severe acute re spiratory syndrome (SARS) and to explore the clinical significance of integrate d traditional Chinese medicine and western medicine (ICWM) in the treatment of S ARS and its influence on the chief indexes in the process of the disease. Methods: The clinical study involving observation of 135 patients of SARS was conducted in the randomized, synchronously controlled and open way. The patients were divided into two groups, 68 in the ICWM group and 67 in the c ontrol group, all of whom were treated with the same basic treatment of western medicine, but to the ICWM group, Chinese drugs for clearing Heat, detoxifying an d removing Dampness were given additionally. The comprehensive effect on relievi ng fever, cell mediated immunity, pulmonary inflammation and secondary infect ion was compared between the two groups. Results: The therapeutic effect in the ICWM group was better than that in the control group in such aspects as steadily lowering body temperature, alleviating general symptoms, accelerating the absorption of pulmonary infiltra tion and easing cellular immunity suppression. Conclusion: The therapeutic effect of ICWM is better in treating SARS than that of western medicine alone. 展开更多
关键词 integrated traditional Chinese and weste rn medicinal therapy severe acute respiratory syndrome synchronous controlled study
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Case Control Study of Impulsivity,Aggression,Pesticide Exposure and Suicide Attempts Using Pesticides among Farmers 被引量:2
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作者 LYU Chun Ping PEI Jian Ru +5 位作者 BESELER L. Cheryl LI Yu Ling LI Jian Hui REN Ming STALLONES Lorann REN Shu Ping 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2018年第3期242-246,共5页
A case-control study was conducted to investigate associations between organophosphate pesticide(OP)exposure,aggression,impulsivity,and attempted suicide.Questionnaires were used to collect information;impulsivity a... A case-control study was conducted to investigate associations between organophosphate pesticide(OP)exposure,aggression,impulsivity,and attempted suicide.Questionnaires were used to collect information;impulsivity and aggression were measured by the Barratt Impulsivity Scale(BIS)and the Aggression Inventory(AI). 展开更多
关键词 Case Control Study of Impulsivity Aggression Pesticide Exposure and Suicide Attempts Using Pesticides among Farmers OP
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Executive function during transient ischemic attacks 被引量:1
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作者 Jianhua Zhao Tong Li Yanxia Liu Ping Zhang Haiqing Yan 《Neural Regeneration Research》 SCIE CAS CSCD 2007年第3期142-145,共4页
BACKGROUND: Recent researches demonstrate that damage of executive function is an early manifestation of vascular cognitive disorder. OBJECTIVE: To investigate the executive functions of patients with transient isch... BACKGROUND: Recent researches demonstrate that damage of executive function is an early manifestation of vascular cognitive disorder. OBJECTIVE: To investigate the executive functions of patients with transient ischemic attack (TIA). DESIGN: Case control. SETTING: Department of Neurology, the First Affiliated Hospital of Xinxiang Medical College. PARTICIPANTS: A total of 83 TIA patients (46 males and 37 females, aged 32 - 74 years) were selected from Department of Neurology, the First Affiliated Hospital of Xinxiang Medical College from July 2005 to December 2006. The diagnosis of TIA was established by the criteria of cerebrovascular diseases made by the Fourth National Cerebrovascular Disease Meeting. In these cases, forty-five patients (54%) were involved in internal carotid artery, and thirty-eight patients (46%) were involved in vertebral basilar system. Fifty healthy adults (Control group: 28 males and 22 females, aged 32 - 74 years) were chosen from retiree in community and family of patients. All of them were right-handedness, without cerebrovascular disease, cerebral trauma, inborn oligophrenia, and heating and visual disorders; also they had no anxiety and depression nearly one week. In addition, all the subjects cooperated with examination. METHODS: After TIA diagnosis, all patients received neuropsychological examination, including attention and inhibition, working memory, flexibility, planning and diversion, based on Stroop tests (C and CW) and the Wisconsin card sorting tests (WCST). ① WCST test: The edition revised by Nelson was used. We would take the times of sorting, incorrect response, persistent incorrect response, and randomly incorrect response as the index of evaluation.② Stroop tests: The edition revised by Trenarry was used and this test had two types: form color and form color-word. Their incorrect response and response time were recorded for data analysis in the end. MAIN OUTCOME MEASURES: Results of WCST test and Stroop tests. RESULTS: A total of 83 TIA patients and 50 healthy subjects were involved in the final analysis. Items of Stroop tests, including response time of Stroop-C test, incorrect response of Stroop-C test, response time of Stroop-CW test and incorrect response of Stroop-CW test, and items of WCST, including incorrect response, persistent incorrect response and random incorrect response, between internal carotid artery system and vertebral basilar artery system were (93.87±24.39) s, 3.16±3.97, (228.46±68.13) s, 12.91 ± 10.56, 55.42± 20.38, 26.58± 10.41, 28.62±11.22; (96.76±24.75) s, 3.89±4.77, (223.46±72.54) s, 18.71 ± 13.80, 52.47 ±22.25, 28.82± 16.20, 23.39±9.72, respectively; this was higher than those in the control group [(52.10± 12.18) s, 1.68± 1.97, (134.86±34.15) s, 4.22±4.21, 32.46± 17.97, 14.42±8.47, 18.24± 10.24, P 〈 0.05 - 0.01]. Times of sorting of WCST between internal carotid artery system and vertebral basilar artery system were obviously lower than those in the control group (8.27±2.73, 8.66±2.77, 11.22±2.41, P 〈 0.01). However, there were no significant differences between internal carotid artery system and vertebral basilar artery system (P 〉 0.05). CONCLUSION: Patients with TIA have executive dysfunctions, and the dysfunctions have no difference between internal carotid artery system and vertebral basilar artery system. 展开更多
关键词 ischemic attack transient neuropsychological tests case control studies
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Is endoscopic retrograde appendicitis therapy a better modality for acute uncomplicated appendicitis? A systematic review and metaanalysis 被引量:1
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作者 Ying Wang Chen-Yu Sun +11 位作者 Jie Liu Yue Chen Chandur Bhan John Pocholo Whitaker Tuason Sudha Misra Yu-Ting Huang Shao-Di Ma Xing-Yu Cheng Qin Zhou Wen-Chao Gu Dan-Dan Wu Xia Chen 《World Journal of Clinical Cases》 SCIE 2021年第33期10208-10221,共14页
BACKGROUND Previous studies had shown endoscopic retrograde appendicitis therapy(ERAT)is an effective treatment for acute appendicitis.However,different studies reported conflicting outcomes regarding the effectivenes... BACKGROUND Previous studies had shown endoscopic retrograde appendicitis therapy(ERAT)is an effective treatment for acute appendicitis.However,different studies reported conflicting outcomes regarding the effectiveness of ERAT in comparison with laparoscopic appendectomy(LA).AIM To compare the effectiveness of ERAT with LA.METHODS Randomized controlled trials(RCTs)and retrospective studies of ERAT for acute uncomplicated appendicitis were searched in PubMed,Cochrane Library,Web of Science,Embase database,China National Knowledge Infrastructure(CNKI),the WanFang Database,and Chinese Scientific Journals Database(VIP)from the establishment date to March 12021.Heterogeneity was assessed using the Isquared statistic.Pooled odds ratios(OR),weighted mean difference(WMD),and standard mean difference(SMD),with 95%confidence intervals(CI)were calculated through either fixed-effects or random-effects model.Sensitivity analysis was also performed.Publication bias was tested by Egger's test,and Begg’s test.The quality of included RCT were evaluated by the Jadad scale,while Newcastle-Ottawa scale is adopted for assessing the methodological quality of case-control studies.All statistical analysis was performed using Stata 15.1 statistical software.All statistical analysis was performed using Stata 15.1 statistical software.This study is registered with PROSPERO,CRD42021243955.RESULTS After screening,10 RCTs and 2 case-control studies were included in the current systematic review.Firstly,the length of hospitalizations[WMD=-1.15,95%CI:-1.99,-0.31;P=0.007]was shorter than LA group.Secondly,the level of postoperative CRP[WMD=-10.06,95%CI:(-17.39,-2.73);P=0.007],TNF-α[WMD=-7.70,95%CI:(-8.47,-6.93);P<0.001],and IL-6 Levels[WMD=-9.78,95%CI:(-10.69,-8.88);P<0.001;P<0.001]in ERAT group was significantly lower than LA group.Thirdly,ERAT group had a lower incidence of intestinal obstruction than LA group.[OR=0.19,95%CI:(0.05,0.79);P=0.020].Moreover,the quality of 10 RCTs were low with 0-3 Jadad scores,while the methodological quality of two case-control studies were fair with a score of 2(each).CONCLUSION Compared with LA,ERAT reduces operation time,the level of postoperative inflammation,and results in fewer complications and shorter recovery time,with preserving the appendix and its immune and biological functions. 展开更多
关键词 Endoscopic retrograde appendicitis therapy Acute appendicitis Meta analysis Laparoscopic appendectomy Randomized controlled study
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A Case-Control Study on Leisure Time Physical Activity (LTPA) during the Last Three Months of Pregnancy and Foetal Outcomes in Italy 被引量:1
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作者 Guglielmina Fantuzzi Elena Righi Gabriella Aggazzotti 《Health》 CAS 2016年第2期133-143,共11页
The association between Leisure Time Physical Activity (LTPA) during pregnancy and foetal outcomes has been extensively investigated. However, epidemiological studies specifically referred to LPTA in the last months o... The association between Leisure Time Physical Activity (LTPA) during pregnancy and foetal outcomes has been extensively investigated. However, epidemiological studies specifically referred to LPTA in the last months of pregnancy are scarce. We evaluated the association between LPTA and the risk of both preterm delivery and small for gestational age (SGA) during the last three months of pregnancy in Italy. A nationwide case-control study was performed in nine Italian cities. A total of 299 preterm delivery, 364 SGA and 855 controls were enrolled in the study. A self-administered questionnaire was used to assess socio-demographic variables, medical and reproductive history, life-style habits and LTPA referred to the last three months of pregnancy. Univariate and multivariate regression analyses were performed in order to estimate Odds ratios and 95% CI. LTPA during the last three months of pregnancy decreases the risk of preterm delivery (adjusted OR = 0.56;95% CI 0.39 - 0.79). Among the different types of physical activity, walking, the most frequently referred activity, appears significantly protective against preterm delivery (adjusted OR = 0.53;95% CI 0.36 - 0.81). Moreover, a small protective effect of walking was evidenced against SGA (adjusted OR = 0.72;95% CI 0.51 - 1.00). In conclusion, a mild physical activity such as walking in the last three months of pregnancy seems to reduce the risk of preterm delivery and, at a lesser extent, of SGA, confirming the beneficial effects of physical activity along the whole pregnancy. 展开更多
关键词 Leisure Time Physical Activity (LTPA) Preterm Delivery Small for Gestational Age Last Three Months of Pregnancy Case Control Study
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Equity Study in Health Workforce on Tuberculosis Control in China: a Nationwide Evaluation 被引量:2
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作者 SHI Ying XU Biao +1 位作者 WANG Wei Bing ZHAO Qi 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第8期702-707,共6页
We aimed to describe the distribution of tuberculosis (TB) health workers in China and provide evidences of potential inequity for policy development. We used Lorenz curves and Gini index to characterize the distrib... We aimed to describe the distribution of tuberculosis (TB) health workers in China and provide evidences of potential inequity for policy development. We used Lorenz curves and Gini index to characterize the distribution of TB health workers by population size, geographical area and number of annual registered TB cases. An additional stratified analysis was done by three economic regions. The Gini index were 0.33 for population size, 0.62 for geographical area and 0.30 for number of registered tuberculosis cases that indicated an acceptable average, significant inequity and a relative average distribution nationwide respectively. 展开更多
关键词 TB a Nationwide Evaluation Equity Study in Health Workforce on Tuberculosis Control in China
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Fabrication of multiwalled carbon nanotube-surfactant modi fi ed sensor for the direct determination of toxic drug 4-aminoantipyrine 被引量:1
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作者 Jayant I.Gowda Arunkumar T.Buddanavar Sharanappa T.Nandibewoor 《Journal of Pharmaceutical Analysis》 SCIE CAS 2015年第4期231-238,共8页
A multi-walled carbon nanotube (MWCNT)-cetyltrimethylammonium bromide (CRAB) surfactant com- posite modified glassy carbon electrode (GCE) was developed as a novel system for the determination of 4-aminoantipyr... A multi-walled carbon nanotube (MWCNT)-cetyltrimethylammonium bromide (CRAB) surfactant com- posite modified glassy carbon electrode (GCE) was developed as a novel system for the determination of 4-aminoantipyrine(AAP). The oxidation process was irreversible over the pH range studied and exhibited a diffusion controlled behavior. All experimental parameters were optimized. The combination of MWCNT-CRAB endows the biosensor with large surface area, good biological compatibility, electricity and stability, high selectivity and sensitivity. MWCNT-CTAB/GCE electrode gave a linear response for AAP from 5.0 x 10-9 to 4.0 x 10-8 M with a detection limit of 1.63 x 10 lo M. The modified electrode showed good selectivity against interfering species and also exhibited good reproducibility. The present elec- trochemical sensor based on the MWCNT-CFAB/GCE electrode was applied to the determination of AAP in real samples. 展开更多
关键词 VoltammetryModified electrodeDiffusion controlled4-aminoantipyrinePharmacokinetic study
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Effect of Percutaneous Radiofrequency Ablation and Surgical Resection on Treating of Primary Small Liver Cancer: A Meta-Analysis 被引量:1
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作者 Qian He Xingwu Yang +1 位作者 Qi Wang Qian Wang 《Proceedings of Anticancer Research》 2021年第1期42-48,共7页
Objective:To analyze the clinical effect of primary small liver cancer under radiofrequency ablation(RFA)and surgical resection(SR)treatment,and to explore the best application timing of the two treatment methods.Meth... Objective:To analyze the clinical effect of primary small liver cancer under radiofrequency ablation(RFA)and surgical resection(SR)treatment,and to explore the best application timing of the two treatment methods.Methods:Randomly controlled clinical trials(RCT)of percutaneous radiofrequency ablation and surgical resection for the treatment of small liver cancer in various databases were searched according to the established search strategy,and Meta data was analyzed based on RevMan5.3 software provided by Cochrane collaborative organization.Results:A total of 10 articles were included in this study,including 1396 patients,699 in the RFA group and 697 in the SR group.Meta-analysis results showed that the two groups had no statistical difference in overall survival rate at 1 and 3 years,1-year disease-free survival rate,and 1-year recurrence rate(P>0.05).The 3-year disease-free survival rate of the RFA group was lower than that of the SR group,and the 3-year recurrence rate was higher than that of the SR group.The higher postoperative complication rate tended to the SR group,and the differences were statistically significant.(P<0.05).Conclusion:For short-term efficacy,radiofrequency ablation and surgical resection show consistency;for long-term efficacy,surgical resection is more effective. 展开更多
关键词 Primary liver cancer Radiofrequency ablation Surgical resection Randomized controlled study Meta analysis
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Nasopharyngeal colonization of otopathogens in South Indian children with acuteotitis media -- A case control pilot study
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作者 M.Napolean V.Rosemol +4 位作者 M.John A.M.Varghese J.Periyasamy V.Balaji P.Naina 《Journal of Otology》 CSCD 2021年第4期220-224,共5页
Background: Acute otitis media (AOM) is an inflammatory disease of the middle ear causing significantmorbidity in early childhood. A pilot study was undertaken to identify the role of various risk factorsSouth Indian ... Background: Acute otitis media (AOM) is an inflammatory disease of the middle ear causing significantmorbidity in early childhood. A pilot study was undertaken to identify the role of various risk factorsSouth Indian children with AOM, especially the role of nasopharyngeal otopathogens.Methodology: A prospective case control pilot study was conducted in children aged below six years,presenting to a single tertiary care from 2018 to 2019. Fifty cases with AOM and 45 age and gendermatched controls were recruited. Two nasopharyngeal swabs were collected, one was processed forbacterial culture. The other swab was processed according to the CDC recommended broth enrichmentmethod to identify carriage of S. pneumoniae. Subsequent serotyping was done by Quellung method andconventional sequential multiplex PCR.Result: Otalgia was the major presentation seen in 92% of the children with AOM. None of the clinical anddemographic characteristics were found to be statistically significant between the cases and controls. Themost common otopathogen was S. pneumoniae (55%) followed by H. influenza (29%). The commonS. pneumoniae serotypes encountered were 11A and 19F.Nasopharyngeal colonization with S. pneumoniae[OR 6.57, p < 0.003] and H. influenzae [OR14.18, p < 0.003] were significant risk factors for AOM inchildren. The risk increased with co-colonization (OR 13.89,p < 0.003).Conclusion: This study strengthens the significant association between nasopharyngeal colonization ofotopathogens and AOM as a risk factor that is enhanced by co-colonization.S. pneumoniae was the mainotopathogen in this population, serotypes 11A and 19F being the most common. 展开更多
关键词 Acute otitis media NASOPHARYNGEAL Otopathogens Case control study Streptococcus pneumoniae Haemophilus influenzae Moraxella catarrhalis Staphylococcus aureus
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A Case-control Study on High-risk Factors for Newborn Hearing Loss in Seven Cities of Shandong Province
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作者 聂文英 吴汉荣 +4 位作者 戚以胜 林倩 相丽丽 李惠 李应会 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2007年第2期217-220,共4页
To investigate the high-risk factors for newborn hearing loss and to provide information for preventing the development of hearing loss and delaying its progression, from May 2003 to June 2006, neonates who failed to ... To investigate the high-risk factors for newborn hearing loss and to provide information for preventing the development of hearing loss and delaying its progression, from May 2003 to June 2006, neonates who failed to pass the universal newborn hearing screening (UNHS) were referred to Jinan Newborn Hearing Screening and Rehabilitation Center from 7 newborn hearing screening centers in seven cities of Shandong province. One-to-one pair-matched case-control method was employed for statistical analysis of the basic features of definitely identified cases. High-risk factors relating to the bilateral hearing loss were evaluated by univariate and multivariate Logistic regression analysis. Our results revealed that 721 transferred newborns who didn't pass the heating screening received audiological and medical evaluation and 367 were confirmed to have hearing loss. Of them, 177 neonates with hearing loss who met the matching requirements were included in the study as subjects. Univariate analysis showed that high-risk factors related to hearing loss incuded age of father, education backgrounds of parents, parity, birth weight, gestational weeks, craniofacial deformity, history of receiving treatment in neonatal intensive care unit (NICU), neonatal disease, family history of otopathy and family history of congenital hearing loss. Multivariate Logistic regression analysis revealed that 4 independent risk factors were related to bilateral hearing loss, including parity (OR=16.285, 95% CI 3.379--78,481), neonatal disease (OR=34;968, 95% CI 2.720 449.534), family history of congenital hearing loss (OR=69.488, 95% CI 4.417--1093.300) and birth weight (OR=0.241, 95% CI 0.090--0.648). It is concluded that parity, neonatal disease and family history of heating loss are the promoting factors of bilateral hearing loss in neonates and appropriate intervention measures should be taken to deal with the risk factors. 展开更多
关键词 NEONATE hearing screening high-risk factors bilateral ears case control study
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Clinical value of needleless sling in treatment of female stress urinary incontinence
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作者 Yu-Guo Chen Yao-Guang Zhang +2 位作者 Wei Zhang Xin Li Xia Wang 《World Journal of Clinical Cases》 SCIE 2020年第18期4043-4050,共8页
BACKGROUND Stress urinary incontinence(SUI)is a common disease in women.The emergence of the needle-free sling has led to a new clinical treatment for SUI in women.AIM To explore the clinical value of the needleless s... BACKGROUND Stress urinary incontinence(SUI)is a common disease in women.The emergence of the needle-free sling has led to a new clinical treatment for SUI in women.AIM To explore the clinical value of the needleless sling without acupuncture in the treatment of SUI in women.METHODS From February 2017 to November 2018,according to the order of admission,44 patients(mid-suspension group)were treated by tension-free transobturator urethral suspension,and 44 patients(non-acupuncture group)were treated with a needleless non-acupuncture band.The clinical effects of the two treatments were evaluated.RESULTS There was no significant difference between the two groups in the total clinical effectiveness rate(P=0.374),but intraoperative blood loss and visual analogue scale score at postoperative day 1 were significantly lower in the non-acupuncture suspension group than in the middle urethral suspension group(P=0.396).The incidence of complications in the needle-free sling group was significantly lower than that in the middle urethral suspension group(P=0.025).CONCLUSION The clinical effectiveness of acupuncture-free suspension in treating SUI in female patients is better than that of traditional tension-free transobturator mid-urethral suspension. 展开更多
关键词 No needle sling Female stress urinary incontinence Mid-urethral suspension controlled study COMPLICATIONS Application value
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Serum Levels of Antioxidant Vitamins in Relation to Coronary Artery Disease: A Case Control Study of Koreans
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作者 KIM S. Y. LEE-KIM Y. C. +7 位作者 KIM M. K. SUH J. Y. CHUNG E. J. CHO. S. Y. CHO. B. K. AND SUHI(Department of Food and Nutrition Cardiovascular Center Department of Preventive Medicine Yonsei University, Seoul, Korea) 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1996年第2期229-235,共7页
With the changes in trends of disease pattern from infectious to chronic degenerative disease, cardiovascular disease has been considered as the major cause of death in Korea.Numerous studies have been done on the ant... With the changes in trends of disease pattern from infectious to chronic degenerative disease, cardiovascular disease has been considered as the major cause of death in Korea.Numerous studies have been done on the antioxidant effects of some vitamins in the prevention of chronic illness, but not many in relation to the cardiovascular disease.Therefore, the relation between antioxidant vitamins, mainly α-tocopherol (α-T) and B-carotene (B-C), and coronary artery disease (CAD) such as angina pectoris and myocardial infarction has been investigated in this study.The blood samples were obtained from the CAD patients who were angiographically diagnosed within a month (100 case group). Patients who had an experience of PTCA or CABG were excluded from the study. Control subjects were healthy adults who had normal EKG values, no chest pain and no past history of cardiac disease (100 control group). All subjects were free of serum lipid lowering drugs. Serum α-T and B-C were analysed using HPLC. In addition to antioxidant vitamins, serum lipids (total cholesterol, HDL, TG) were also measured. Each case and control was matched in terms of age and sex. And all the CAD risk factors such as blood pressure, smoking, alcohol, serum lipid profile and BMI were adjusted to determine pure effect(s) of α-T and B-C on the CAD.The concentrations of both α-T and B-C were significantly lower in the CAD group than those in control group (P<0.05); in CAD group, mean values of α-T and B-C were 11.9±7.2 (μg/ml), 35.8±3.1 (μg/dl) respectively. As for the levels of B-C, it shows inverse relation with age, but not for the α-T Ievels. Serum levels of both vitamins did not show any significant differences in terms of sex, but men have a tendency o higher levels of B-C,but lower levels of α-T 展开更多
关键词 CASE Serum Levels of Antioxidant Vitamins in Relation to Coronary Artery Disease A Case Control Study of Koreans GSH
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Risk Factors for Birth Defects: A Conditional LogisticRegression Analysis of a Case-Control Study in Guang-dong Province of China
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作者 王志瑾 穆荔 《Journal of Reproduction and Contraception》 CAS 1999年第3期170-175,共6页
Information was obtained from the same questionnaire (23 risk factors listed) of cases and controls. We used a multivariate logistic model, which described variables significantly increased risk of birth defects.... Information was obtained from the same questionnaire (23 risk factors listed) of cases and controls. We used a multivariate logistic model, which described variables significantly increased risk of birth defects. The risk factors included maternal educational levels, medicine taken during pregnancy and antenatal care. It was suggested to strengthen antenatal care was the main preventive measure against birth defects. 展开更多
关键词 Birth defects Risk factors Case control study Conditional logistic regression Antenatal care
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Simulation Study on the Controllable Dielectrophoresis Parameters of Graphene
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作者 冀健龙 刘亚丽 +7 位作者 葛阳 解胜东 张希 桑胜波 菅傲群 段倩倩 张强 张文栋 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第4期71-74,共4页
The method of using dielectrophoresis (DEP) to assemble graphene between micro-electrodes has been proven to be simple and efficient. We present an optimization method for the kinetic formula of graphene DEP, and di... The method of using dielectrophoresis (DEP) to assemble graphene between micro-electrodes has been proven to be simple and efficient. We present an optimization method for the kinetic formula of graphene DEP, and discuss the simulation of the graphene assembly process based on the finite element method. The simulated results illustrate that the accelerated motion of graphene is in agreement with the distribution of the electric field squared gradient. We also conduct research on the controllable parameters of the DEP assembly such as the alternating current (AC) frequency, the shape of micro-electrodes, and the ratio of the gap between electrodes to the characteristic/geometric length of graphene (λ). The simulations based on the Clausius-Mossotti factor reveal that both graphene velocity and direction are influenced by the AC frequency. When graphene is close to the electrodes, the shape of micro-electrodes will exert great influence on the velocity of graphene. Also, λ has a great influence on the velocity of graphene. Generally, the velocity of graphene would be greater when λ is in the range of 0.4 0.6. The study is of a theoretical guiding significance in improving the precision and efficiency of the graphene DEP assembly. 展开更多
关键词 DEP Simulation Study on the Controllable Dielectrophoresis Parameters of Graphene
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Experimental Study of Monitoring and Controlling of Composite Cure Process in Autoclave Featured with Fiber Optic Sensor
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作者 Boming ZHANG, Zhanjun WU , Dianfu WANG and Shanyi DU Center for composite, Harbin Institute of Technology Harbin 150001, China 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2001年第4期449-452,共4页
With the aid of the latest fiber optic sensing technology parameters in the cure process of ther- mosetting resin-matrix composite, such as temperature, viscosity,void and residual stress, can be monitored entirely an... With the aid of the latest fiber optic sensing technology parameters in the cure process of ther- mosetting resin-matrix composite, such as temperature, viscosity,void and residual stress, can be monitored entirely and efficiently.In this paper, experiment results of viscosity measurement in composite cure process in autoclave using fiber optic sensors are presented. Based on the sensed information, a computer program is utilized to control the cure process. With this technology, the cure process becomes more apparent and controllable, which will greatly improve the cured products and reduce the cost. 展开更多
关键词 Experimental Study of Monitoring and Controlling of Composite Cure Process in Autoclave Featured with Fiber Optic Sensor
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Control study of short-term curative effect of minimally invasive total hip arthroplasty using metal-on-metal large-diameter femoral head for the elderly patients with femoral neck fractures
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作者 何锐 《外科研究与新技术》 2011年第2期116-117,共2页
Objective To discuss the postoperative curative effects of two surgical techniques of minimally invasive total hip arthroplasty (THA) using metal-on-metal largediameter and conventional diameter femoral head for the e... Objective To discuss the postoperative curative effects of two surgical techniques of minimally invasive total hip arthroplasty (THA) using metal-on-metal largediameter and conventional diameter femoral head for the elderly patients 展开更多
关键词 THA head Control study of short-term curative effect of minimally invasive total hip arthroplasty using metal-on-metal large-diameter femoral head for the elderly patients with femoral neck fractures
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