Tumor-associated carbohydrate antigens(TACAs)provide a special class of tumor-specific antigens that show promising applications in cancer immunotherapy.However,the weak immunogenicity and structural complexity of TAC...Tumor-associated carbohydrate antigens(TACAs)provide a special class of tumor-specific antigens that show promising applications in cancer immunotherapy.However,the weak immunogenicity and structural complexity of TACAs are obstacles to their clinical application.Here,based on a fast and low-cost purification strategy for oligosaccharide synthesis,the synthesis of tumour-associated carbohydrate antigens Globo H and mannobiose which resembles repeat unit of mannan was achieved.To enhance the immunogenicity and multivalent effect,Globo H and mannobiose were covalently attached to degradable polymer backbones.2D spindle-like lamellar micelle and globular micelle were obtained from glycopolymer through a solvent-exchange method of self-assembly.The glyconanoparticle showed good biocompatibility and degradability.Immunological functions of these glyconanoparticles such as stimulation of BMDC to cause upregulation of inflammatory factors were preliminarily explored.展开更多
A series of novel ester-capped carbosilane dendrimers（G0-COOCH3–G2-COOCH3） were designed and successfully synthesized via a hybrid divergent–convergent method through a facile hydrosilylation reaction. The structu...A series of novel ester-capped carbosilane dendrimers（G0-COOCH3–G2-COOCH3） were designed and successfully synthesized via a hybrid divergent–convergent method through a facile hydrosilylation reaction. The structures of these dendrimers were confirmed by FTIR,1H NMR, and HRMS analyses.展开更多
Unsymmetrical dendrons 1,2 and 3 were easily prepared according to a novel convergent strategy from 3,4-methylenedioxybenzaldehyde as starting material.
Long chain branched dendrimers 1, 2 and 3 were easily prepared according to the convergent strategy based on the A2B type monomer from 5-hydroxyisophthalic acid. These dendrimers have a nucleophilic phenol focal group...Long chain branched dendrimers 1, 2 and 3 were easily prepared according to the convergent strategy based on the A2B type monomer from 5-hydroxyisophthalic acid. These dendrimers have a nucleophilic phenol focal group, which is useful to further chemistry.展开更多
基金supported by the National Key Research and Development Program of China(No.2023YFA0915300)the National Natural Science Foundation of China(Nos.52125303 and 92356305)Innovation Program of Shanghai Municipal Education Commission(No.2023ZKZD02)。
文摘Tumor-associated carbohydrate antigens(TACAs)provide a special class of tumor-specific antigens that show promising applications in cancer immunotherapy.However,the weak immunogenicity and structural complexity of TACAs are obstacles to their clinical application.Here,based on a fast and low-cost purification strategy for oligosaccharide synthesis,the synthesis of tumour-associated carbohydrate antigens Globo H and mannobiose which resembles repeat unit of mannan was achieved.To enhance the immunogenicity and multivalent effect,Globo H and mannobiose were covalently attached to degradable polymer backbones.2D spindle-like lamellar micelle and globular micelle were obtained from glycopolymer through a solvent-exchange method of self-assembly.The glyconanoparticle showed good biocompatibility and degradability.Immunological functions of these glyconanoparticles such as stimulation of BMDC to cause upregulation of inflammatory factors were preliminarily explored.
基金support by the National Natural Science Foundation of China(No.21307053)China Postdoctoral Science Foundation Funded Project(No.2013M541911)+1 种基金Promotive Research Fund for Excellent Young and Middle-Aged Scientists of Shandong Province(No.BS2013CL044)Natural Science Foundation of Ludong University(No.LY2011004)
文摘A series of novel ester-capped carbosilane dendrimers（G0-COOCH3–G2-COOCH3） were designed and successfully synthesized via a hybrid divergent–convergent method through a facile hydrosilylation reaction. The structures of these dendrimers were confirmed by FTIR,1H NMR, and HRMS analyses.
文摘Unsymmetrical dendrons 1,2 and 3 were easily prepared according to a novel convergent strategy from 3,4-methylenedioxybenzaldehyde as starting material.
基金Project supported by the National Natural Science Foundation of China （No. 20472025 and QT No. 20021001）.
文摘Long chain branched dendrimers 1, 2 and 3 were easily prepared according to the convergent strategy based on the A2B type monomer from 5-hydroxyisophthalic acid. These dendrimers have a nucleophilic phenol focal group, which is useful to further chemistry.
