This study aimed to investigate the effects of copper and manganese on hemocyte apoptosis and the antagonism of iron and zinc in Oreochromis niloticus The heavy metal contents in fish blood and feed were determined by...This study aimed to investigate the effects of copper and manganese on hemocyte apoptosis and the antagonism of iron and zinc in Oreochromis niloticus The heavy metal contents in fish blood and feed were determined by atomic absorption spectrophotometry, and the hemocyte apoptosis was determined by flow cytometry. A total of 360 tilapias were selected, and they were divided randomly and evenly into 12 groups. In the challenge groups, the tilapias were fed with con stant-level copper sulfate（0, 200 mg/kg） and manganese sulfate（0, 120 mg/kg）; in the antagonism groups, the tilapias were fed with constant-level zinc sulfate（20320 mg/kg） and iron sulfate（150, 350 mg/kg）. After 20-week aquaculture, the hemocyte apoptosis rates in the copper and manganese groups were significantly increased; with the increased addition levels of iron and zinc, the hemocyte apopto sis rates in the iron and zinc groups were significantly reduced, but they were stil higher than that in the control group. In conclusion, excessive copper and manganese can cause apoptosis in hemocytes of O. niloticus. However, the toxic effects of copper and manganese can be antagonized by iron and zinc.展开更多
Concentrations of copper （Cu）, zinc （Zn） and manganese （Mn） were measured in four tissues of Tree Sparrow （Passer montanus） from three sites in Heilongjiang province, China, during four seasons. Among the four...Concentrations of copper （Cu）, zinc （Zn） and manganese （Mn） were measured in four tissues of Tree Sparrow （Passer montanus） from three sites in Heilongjiang province, China, during four seasons. Among the four measured tissues （primary feathers, liver, heart, and pectoral muscle）, the highest concentrations were found in feathers （Zn） or liver （Cu and Mn）, and the lowest concentrations were in muscle, except Cu. For Mn, mean concentrations of the birds from the three study sites were, in decreasing order： Didao mining area （DMA） 〉 urban district of Jixi （UDJ） 〉 Phoenix Mountain national nature reserve （PMR, the reference site）, but not for Zn and Cu. There were significant differences between metal concentrations at the three sites, but differences were not significant for Mn （in muscle and feathers） and Cu （in feathers）. For most elements, the mean concentrations were greatest in summer.展开更多
This work reports the spectrophotometric simultaneous determination of zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ） in pharmaceutical preparation, using orthogonal signal correctionpartial least squares （OSC-PLS）. All...This work reports the spectrophotometric simultaneous determination of zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ） in pharmaceutical preparation, using orthogonal signal correctionpartial least squares （OSC-PLS）. All the factors affecting on the sensitivity were optimized and the linear dynamic range for determination of these metals was found. The PLS modeling was used for the multivariate calibration of the spectrophotometric data. The OSC was used for preprocessing of data matrices and the prediction results of model. The experimental calibration matrix was designed by measuring the absorbance over the range 450-570 nm for 21 samples of 0.05-1.05, 0.10-1.10 and 0.05-1.05μg·mL^-1 of zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ）, respectively. The RMSEP for zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ） using OSC-PLS were 0.0164, 0.0132, 0.0146, respectively. The proposed method was successfully applied the determination of zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ） in pharmaceutical preparations.展开更多
Metals such as iron,manganese,copper,and zinc are recognized as essential trace elements.These trace metals play critical roles in development,growth,and metabolism,participating in various metabolic processes by acti...Metals such as iron,manganese,copper,and zinc are recognized as essential trace elements.These trace metals play critical roles in development,growth,and metabolism,participating in various metabolic processes by acting as cofactors of enzymes or providing structural support to proteins.Deficiency or toxicity of these metals can impact human and animal health,giving rise to a number of metabolic and neurological disorders.Proper breakdown,absorption,and elimination of these trace metals is a tightly regulated process that requires crosstalk between the host and these micronutrients.The gut is a complex system that serves as the interface between these components,but other factors that contribute to this delicate interaction are not well understood.The gut is home to trillions of microorganisms and microbial genes(the gut microbiome)that can regulate the metabolism and transport of micronutrients and contribute to the bioavailability of trace metals through their assimilation from food sources or by competing with the host.Furthermore,deficiency or toxicity of these metals can modulate the gut microenvironment,including microbiota,nutrient availability,stress,and immunity.Thus,understanding the role of the gut microbiota in the metabolism of manganese,iron,copper,and zinc,as well as in heavy metal deficiencies and toxicities,and vice versa,may provide insight into developing improved or alternative therapeutic strategies to address emerging health concerns.This review describes the current understanding of how the gut microbiome and trace metals interact and affect host health,particularly in pigs.展开更多
This study assessed the iron, zinc and copper status of primary school-attending children in Lagos. A sample of 200 primary School-attending children was randomly selected using a stratified 2 – stage sampling techni...This study assessed the iron, zinc and copper status of primary school-attending children in Lagos. A sample of 200 primary School-attending children was randomly selected using a stratified 2 – stage sampling technique. Data was collected in the 2 major seasons in Nigeria;Dry and Rainy seasons using dietary intake (24 hr dietary recall protocol) venipuncture blood samples, and a self-administered questionnaire. The data were analyzed using descriptive and inferential statistics. Among ages 5 - 8 years, the main dietary intake for iron was 10.66 ± 12.44 mg/d (106% of DRI), for zinc, 7.30 ± 7.39 mg/d (92% of DRI) and for copper, 1.55 ± 1.31 mg/d (390% of DRI). For ages 9 - 13 yrs, the mean intake of micronutrients showed that iron was 11.03 ± 12.72 mg/d (138% of DRI), 3inc was 8.44 ± 7.7 mg/d (105% of DRI) and copper was 3.75 ± 15.17 mg/d (536% of DRI). Biochemical results indicated that 19.8% of the subjects had inadequate serum iron, 21% and 32.1% were zinc and copper deficient respectively prevalence of anemia was 38.1% while iron deficiency anemia was 13.06% and iron deficiency was 34.6%. Dietary intakes did not provide right amounts of micronutrients to meet body requirements. There is the need to formulate and implement nutrition education programs to correct micronutrient deficiency among primary school-attending children in Lagos, Nigeria.展开更多
The combinational use of alloying elements with positive and negative segregation has been shown to be very effective in strengthening the matrix of cast iron. Negative segregation alloying elements, Cu and Si, make t...The combinational use of alloying elements with positive and negative segregation has been shown to be very effective in strengthening the matrix of cast iron. Negative segregation alloying elements, Cu and Si, make the inner parts of dendritic austenites and eutectic cells get good hardenability. On the contrary, positive segregation alloying elements Cr and Mn make the outer parts of dendrites have higher microhardness. Appropriate combination of the above two types of alloying elements can produce a uniform microhardness and high strength in gray cast irons.展开更多
A wetland with attractive plants hosting birds and other wildlife is an esthetically pleasing prospect that is gaining popularity as a way of stabilizing or remediating metalcontaminated soils and sediment（Weber and ...A wetland with attractive plants hosting birds and other wildlife is an esthetically pleasing prospect that is gaining popularity as a way of stabilizing or remediating metalcontaminated soils and sediment（Weber and Gagnon,2014;展开更多
基金Supported by Scientific Operating Expenses of Hainan Province(11-201410-0009)~~
文摘This study aimed to investigate the effects of copper and manganese on hemocyte apoptosis and the antagonism of iron and zinc in Oreochromis niloticus The heavy metal contents in fish blood and feed were determined by atomic absorption spectrophotometry, and the hemocyte apoptosis was determined by flow cytometry. A total of 360 tilapias were selected, and they were divided randomly and evenly into 12 groups. In the challenge groups, the tilapias were fed with con stant-level copper sulfate（0, 200 mg/kg） and manganese sulfate（0, 120 mg/kg）; in the antagonism groups, the tilapias were fed with constant-level zinc sulfate（20320 mg/kg） and iron sulfate（150, 350 mg/kg）. After 20-week aquaculture, the hemocyte apoptosis rates in the copper and manganese groups were significantly increased; with the increased addition levels of iron and zinc, the hemocyte apopto sis rates in the iron and zinc groups were significantly reduced, but they were stil higher than that in the control group. In conclusion, excessive copper and manganese can cause apoptosis in hemocytes of O. niloticus. However, the toxic effects of copper and manganese can be antagonized by iron and zinc.
基金Supported by the National Natural Science Foundation of China（30270924） Natural Science Foundation of Anhui Province （070411004） +1 种基金 the National Science Foundation of Education Department of Anhui Province（2006KJ184B） the Foundation of Provincial Key Lab of Biotic Environment and Ecological Safety in Anhui Province
基金financially supported by Outstanding Youth Science Foundation of Heilongjiang Province (JC200709)
文摘Concentrations of copper （Cu）, zinc （Zn） and manganese （Mn） were measured in four tissues of Tree Sparrow （Passer montanus） from three sites in Heilongjiang province, China, during four seasons. Among the four measured tissues （primary feathers, liver, heart, and pectoral muscle）, the highest concentrations were found in feathers （Zn） or liver （Cu and Mn）, and the lowest concentrations were in muscle, except Cu. For Mn, mean concentrations of the birds from the three study sites were, in decreasing order： Didao mining area （DMA） 〉 urban district of Jixi （UDJ） 〉 Phoenix Mountain national nature reserve （PMR, the reference site）, but not for Zn and Cu. There were significant differences between metal concentrations at the three sites, but differences were not significant for Mn （in muscle and feathers） and Cu （in feathers）. For most elements, the mean concentrations were greatest in summer.
文摘This work reports the spectrophotometric simultaneous determination of zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ） in pharmaceutical preparation, using orthogonal signal correctionpartial least squares （OSC-PLS）. All the factors affecting on the sensitivity were optimized and the linear dynamic range for determination of these metals was found. The PLS modeling was used for the multivariate calibration of the spectrophotometric data. The OSC was used for preprocessing of data matrices and the prediction results of model. The experimental calibration matrix was designed by measuring the absorbance over the range 450-570 nm for 21 samples of 0.05-1.05, 0.10-1.10 and 0.05-1.05μg·mL^-1 of zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ）, respectively. The RMSEP for zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ） using OSC-PLS were 0.0164, 0.0132, 0.0146, respectively. The proposed method was successfully applied the determination of zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ） in pharmaceutical preparations.
基金supported by a grant from National Institute of Environmental Health Sciences(R01 ES024756)
文摘Metals such as iron,manganese,copper,and zinc are recognized as essential trace elements.These trace metals play critical roles in development,growth,and metabolism,participating in various metabolic processes by acting as cofactors of enzymes or providing structural support to proteins.Deficiency or toxicity of these metals can impact human and animal health,giving rise to a number of metabolic and neurological disorders.Proper breakdown,absorption,and elimination of these trace metals is a tightly regulated process that requires crosstalk between the host and these micronutrients.The gut is a complex system that serves as the interface between these components,but other factors that contribute to this delicate interaction are not well understood.The gut is home to trillions of microorganisms and microbial genes(the gut microbiome)that can regulate the metabolism and transport of micronutrients and contribute to the bioavailability of trace metals through their assimilation from food sources or by competing with the host.Furthermore,deficiency or toxicity of these metals can modulate the gut microenvironment,including microbiota,nutrient availability,stress,and immunity.Thus,understanding the role of the gut microbiota in the metabolism of manganese,iron,copper,and zinc,as well as in heavy metal deficiencies and toxicities,and vice versa,may provide insight into developing improved or alternative therapeutic strategies to address emerging health concerns.This review describes the current understanding of how the gut microbiome and trace metals interact and affect host health,particularly in pigs.
文摘This study assessed the iron, zinc and copper status of primary school-attending children in Lagos. A sample of 200 primary School-attending children was randomly selected using a stratified 2 – stage sampling technique. Data was collected in the 2 major seasons in Nigeria;Dry and Rainy seasons using dietary intake (24 hr dietary recall protocol) venipuncture blood samples, and a self-administered questionnaire. The data were analyzed using descriptive and inferential statistics. Among ages 5 - 8 years, the main dietary intake for iron was 10.66 ± 12.44 mg/d (106% of DRI), for zinc, 7.30 ± 7.39 mg/d (92% of DRI) and for copper, 1.55 ± 1.31 mg/d (390% of DRI). For ages 9 - 13 yrs, the mean intake of micronutrients showed that iron was 11.03 ± 12.72 mg/d (138% of DRI), 3inc was 8.44 ± 7.7 mg/d (105% of DRI) and copper was 3.75 ± 15.17 mg/d (536% of DRI). Biochemical results indicated that 19.8% of the subjects had inadequate serum iron, 21% and 32.1% were zinc and copper deficient respectively prevalence of anemia was 38.1% while iron deficiency anemia was 13.06% and iron deficiency was 34.6%. Dietary intakes did not provide right amounts of micronutrients to meet body requirements. There is the need to formulate and implement nutrition education programs to correct micronutrient deficiency among primary school-attending children in Lagos, Nigeria.
文摘The combinational use of alloying elements with positive and negative segregation has been shown to be very effective in strengthening the matrix of cast iron. Negative segregation alloying elements, Cu and Si, make the inner parts of dendritic austenites and eutectic cells get good hardenability. On the contrary, positive segregation alloying elements Cr and Mn make the outer parts of dendrites have higher microhardness. Appropriate combination of the above two types of alloying elements can produce a uniform microhardness and high strength in gray cast irons.
文摘A wetland with attractive plants hosting birds and other wildlife is an esthetically pleasing prospect that is gaining popularity as a way of stabilizing or remediating metalcontaminated soils and sediment（Weber and Gagnon,2014;
