Five major porcine coronaviruses （COVs） have been identifed which cause severe gastrointestinal （GI） and respiratory disease in pigs. They include transmissiblegastroenteritis （TGEV）, porcine epidemic diarrhea v...Five major porcine coronaviruses （COVs） have been identifed which cause severe gastrointestinal （GI） and respiratory disease in pigs. They include transmissiblegastroenteritis （TGEV）, porcine epidemic diarrhea virus （PEDV）, porcine deltacoronavirus, porcine respiratory coronavirus, and porcine hemagglutinating encephalo-myelitis. These diseases, especially TGEV and PEDV, have caused epidemics in Europe, Asia, and the Ameri-cas over the past 50 years, causing signifcant economic losses to swine producers. As pigs are a major protein source worldwide there is great interest in understanding, controlling, and preventing these diseases. These disea-ses have no cure, and current vaccines are not fully protective. On-farm prevention and biosecurity are difficult to enforce and have not stopped the spread of these diseases between herds. Recent advances in the immunology of porcine COVs has revealed that the immune response to porcine COVs shares many similarities with the response to human COVs, leading to increased interest in pigs as models for human disease. Highlights of these advances include the key role of local antigen presenting cells in the gastrointestinal tract in stimulating a protective immune response. This understanding has lead to new proposed vaccines. Advances in the understanding of the ways the viruses evade and degrade the host immune system have also lead to novel proposed therapies. Many of these therapies are in the early development stages, as resear-chers attempt to create effcacious, cost-effective, and practical therapies for these diseases.展开更多
Objective: To evaluate the role of prevention and control strategies for nosocomial infection in a tertiary teaching hospital during the sudden outbreak of Corona Virus Disease 2019 (COVID-19). Methods: The hospital i...Objective: To evaluate the role of prevention and control strategies for nosocomial infection in a tertiary teaching hospital during the sudden outbreak of Corona Virus Disease 2019 (COVID-19). Methods: The hospital initiated an emergency plan involving multi-departmental defense and control. It adopted a series of nosocomial infection prevention and control measures, including strengthening pre-examination and triage, optimizing the consultation process, improving the hospital’s architectural composition, implementing graded risk management, enhancing personal protection, and implementing staff training and supervision. Descriptive research was used to evaluate the short-term effects of these in-hospital prevention and control strategies. The analysis compared changes in related evaluation indicators between January 24, 2020 and February 12, 2020 (Chinese Lunar New Year’s Eve 2020 to lunar January 19) and the corresponding lunar period of the previous year. Results: Compared to the same period last year, the outpatient fever rate increased by 1.85-fold (P P Conclusion: The nosocomial infection prevention and control strategies implemented during this specific period improved the detection and control abilities for the COVID-19 source of infection and enhanced the compliance with measures. This likely contributed significantly to avoiding the occurrence of nosocomial infection.展开更多
A novel two-dimensional （2D） simulation method of positive corona current pulses is proposed. A control-volume- based finite element method （CV-FEM） is used to solve continuity equations, and the Galerkin finite e...A novel two-dimensional （2D） simulation method of positive corona current pulses is proposed. A control-volume- based finite element method （CV-FEM） is used to solve continuity equations, and the Galerkin finite element method （FEM） is used to solve Poisson＇s equation. In the proposed method, photoionization is considered by adopting an exact Helmholtz photoionization model. Furthermore, fully implicit discretization and variable time step are used to ensure the time-efficiency of the present method. Finally, the method is applied to a positive rod-plane corona problem. The numerical results are in agreement with the experimental results, and the validity of the proposed method is verified.展开更多
文摘Five major porcine coronaviruses （COVs） have been identifed which cause severe gastrointestinal （GI） and respiratory disease in pigs. They include transmissiblegastroenteritis （TGEV）, porcine epidemic diarrhea virus （PEDV）, porcine deltacoronavirus, porcine respiratory coronavirus, and porcine hemagglutinating encephalo-myelitis. These diseases, especially TGEV and PEDV, have caused epidemics in Europe, Asia, and the Ameri-cas over the past 50 years, causing signifcant economic losses to swine producers. As pigs are a major protein source worldwide there is great interest in understanding, controlling, and preventing these diseases. These disea-ses have no cure, and current vaccines are not fully protective. On-farm prevention and biosecurity are difficult to enforce and have not stopped the spread of these diseases between herds. Recent advances in the immunology of porcine COVs has revealed that the immune response to porcine COVs shares many similarities with the response to human COVs, leading to increased interest in pigs as models for human disease. Highlights of these advances include the key role of local antigen presenting cells in the gastrointestinal tract in stimulating a protective immune response. This understanding has lead to new proposed vaccines. Advances in the understanding of the ways the viruses evade and degrade the host immune system have also lead to novel proposed therapies. Many of these therapies are in the early development stages, as resear-chers attempt to create effcacious, cost-effective, and practical therapies for these diseases.
文摘Objective: To evaluate the role of prevention and control strategies for nosocomial infection in a tertiary teaching hospital during the sudden outbreak of Corona Virus Disease 2019 (COVID-19). Methods: The hospital initiated an emergency plan involving multi-departmental defense and control. It adopted a series of nosocomial infection prevention and control measures, including strengthening pre-examination and triage, optimizing the consultation process, improving the hospital’s architectural composition, implementing graded risk management, enhancing personal protection, and implementing staff training and supervision. Descriptive research was used to evaluate the short-term effects of these in-hospital prevention and control strategies. The analysis compared changes in related evaluation indicators between January 24, 2020 and February 12, 2020 (Chinese Lunar New Year’s Eve 2020 to lunar January 19) and the corresponding lunar period of the previous year. Results: Compared to the same period last year, the outpatient fever rate increased by 1.85-fold (P P Conclusion: The nosocomial infection prevention and control strategies implemented during this specific period improved the detection and control abilities for the COVID-19 source of infection and enhanced the compliance with measures. This likely contributed significantly to avoiding the occurrence of nosocomial infection.
基金Project supported by the National Basic Research Program of China(Grant No.2011CB209402)the National Natural Science Foundation of China(Grant No.51177041)the Fundamental Research Funds for the Central Universities,China(Grant No.12QX01)
文摘A novel two-dimensional （2D） simulation method of positive corona current pulses is proposed. A control-volume- based finite element method （CV-FEM） is used to solve continuity equations, and the Galerkin finite element method （FEM） is used to solve Poisson＇s equation. In the proposed method, photoionization is considered by adopting an exact Helmholtz photoionization model. Furthermore, fully implicit discretization and variable time step are used to ensure the time-efficiency of the present method. Finally, the method is applied to a positive rod-plane corona problem. The numerical results are in agreement with the experimental results, and the validity of the proposed method is verified.
