Real-time model correction using Kalman filter for Raman-controlled cell culture processes

Raman spectroscopy has found extensive use in monitoring and controlling cell culture processes.In this context,the prediction accuracy of Raman-based models is of paramount importance.However,models established with data from manually fed-batch cultures often exhibit poor performance in Raman-controlled cultures.Thus,there is a need for effective methods to rectify these models.The objective of this paper is to investigate the efficacy of Kalman filter(KF)algorithm in correcting Raman-based models during cell culture.Initially,partial least squares(PLS)models for different components were constructed using data from manually fed-batch cultures,and the predictive performance of these models was compared.Subsequently,various correction methods including the PLS-KF-KF method proposed in this study were employed to refine the PLS models.Finally,a case study involving the auto-control of glucose concentration demonstrated the application of optimal model correction method.The results indicated that the original PLS models exhibited differential performance between manually fed-batch cultures and Raman-controlled cultures.For glucose,the root mean square error of prediction(RMSEP)of manually fed-batch culture and Raman-controlled culture was 0.23 and 0.40 g·L^(-1).With the implementation of model correction methods,there was a significant improvement in model performance within Raman-controlled cultures.The RMSEP for glucose from updating-PLS,KF-PLS,and PLS-KF-KF was 0.38,0.36 and 0.17 g·L^(-1),respectively.Notably,the proposed PLS-KF-KF model correction method was found to be more effective and stable,playing a vital role in the automated nutrient feeding of cell cultures.

Balancing act:The dilemma of rapid hyperglycemia correction in diabetes management

The global diabetes surge poses a critical public health challenge,emphasizing the need for effective glycemic control.However,rapid correction of chronic hyperglycemia can unexpectedly trigger microvascular complications,necessitating a reevaluation of the speed and intensity of glycemic correction.Theories suggest swift blood sugar reductions may cause inflammation,oxidative stress,and neurovascular changes,resulting in complications.Healthcare providers should cautiously approach aggressive glycemic control,especially in long-standing,poorly controlled diabetes.Preventing and managing these complications requires a personalized,comprehensive approach with education,monitoring,and interdisciplinary care.Diabetes management must balance short and longterm goals,prioritizing overall well-being.This editorial underscores the need for a personalized,nuanced approach,focusing on equilibrium between glycemic control and avoiding overcorrection.

Dispersed Wind Power Planning Method Considering Network Loss Correction with Cold Weather

In order to play a positive role of decentralised wind power on-grid for voltage stability improvement and loss reduction of distribution network,a multi-objective two-stage decentralised wind power planning method is proposed in the paper,which takes into account the network loss correction for the extreme cold region.Firstly,an electro-thermal model is introduced to reflect the effect of temperature on conductor resistance and to correct the results of active network loss calculation;secondly,a two-stage multi-objective two-stage decentralised wind power siting and capacity allocation and reactive voltage optimisation control model is constructed to take account of the network loss correction,and the multi-objective multi-planning model is established in the first stage to consider the whole-life cycle investment cost of WTGs,the system operating cost and the voltage quality of power supply,and the multi-objective planning model is established in the second stage.planning model,and the second stage further develops the reactive voltage control strategy of WTGs on this basis,and obtains the distribution network loss reduction method based on WTG siting and capacity allocation and reactive power control strategy.Finally,the optimal configuration scheme is solved by the manta ray foraging optimisation(MRFO)algorithm,and the loss of each branch line and bus loss of the distribution network before and after the adoption of this loss reduction method is calculated by taking the IEEE33 distribution system as an example,which verifies the practicability and validity of the proposed method,and provides a reference introduction for decision-making for the distributed energy planning of the distribution network.

Feedback control and quantum error correction assisted quantum multi-parameter estimation

Quantum metrology provides a fundamental limit on the precision of multi-parameter estimation,called the Heisenberg limit,which has been achieved in noiseless quantum systems.However,for systems subject to noises,it is hard to achieve this limit since noises are inclined to destroy quantum coherence and entanglement.In this paper,a combined control scheme with feedback and quantum error correction(QEC)is proposed to achieve the Heisenberg limit in the presence of spontaneous emission,where the feedback control is used to protect a stabilizer code space containing an optimal probe state and an additional control is applied to eliminate the measurement incompatibility among three parameters.Although an ancilla system is necessary for the preparation of the optimal probe state,our scheme does not require the ancilla system to be noiseless.In addition,the control scheme in this paper has a low-dimensional code space.For the three components of a magnetic field,it can achieve the highest estimation precision with only a 2-dimensional code space,while at least a4-dimensional code space is required in the common optimal error correction protocols.

A Data Driven Security Correction Method for Power Systems with UPFC

The access of unified power flow controllers(UPFC)has changed the structure and operation mode of power grids all across the world,and it has brought severe challenges to the traditional real-time calculation of security correction based on traditionalmodels.Considering the limitation of computational efficiency regarding complex,physical models,a data-driven power system security correction method with UPFC is,in this paper,proposed.Based on the complex mapping relationship between the operation state data and the security correction strategy,a two-stage deep neural network(DNN)learning framework is proposed,which divides the offline training task of security correction into two stages:in the first stage,the stacked auto-encoder(SAE)classification model is established,and the node correction state(0/1)output based on the fault information;in the second stage,the DNN learningmodel is established,and the correction amount of each action node is obtained based on the action nodes output in the previous stage.In this paper,the UPFC demonstration project of NanjingWest Ring Network is taken as a case study to validate the proposed method.The results show that the proposed method can fully meet the real-time security correction time requirements of power grids,and avoid the inherent defects of the traditional model method without an iterative solution and can also provide reasonable security correction strategies for N-1 and N-2 faults.

Width Compensation and Correction for the Plan View Pattern Control Function on Plate Mill

Research works on width compensation and correction were carried out in order to eliminate the effects of the PVPC （ plan view pattern control） on width accuracy of plate mill. The thickness correction calculation formula was derived for compensation the width deviation caused by PVPC function, and the formula is unified under the thinning and thickening conditions. In order to improve the width calculation accuracy, width spread calculation process was modified with dividing one large reduction pass to several small reduction calculation steps. The thickness wedge was simplified to rectangle based on the volume constant principle, and the width spread model for PVPC was constructed. The width compensation and correction for the PVPC functions are used for the online control process, and the Product dimension accuracy is improved. With the decrease of Crop losses, the Droduct yield was increased with 0. 2%.

Discussion on neighborhood optimal trajectory online correction algorithm and its application range

This paper presents a neighborhood optimal trajectory online correction algorithm considering terminal time variation,and investigates its application range.Firstly,the motion model of midcourse guidance is established,and the online trajectory correction-regenerating strategy is introduced.Secondly,based on the neighborhood optimal control theory,a neighborhood optimal trajectory online correction algorithm considering the terminal time variation is proposed by adding the consideration of terminal time variation to the traditional neighborhood optimal trajectory correction method.Thirdly,the Monte Carlo simulation method is used to analyze the application range of the algorithm,which provides a basis for the division of application domain of the online correction algorithm and the online regeneration algorithm of midcourse guidance trajectory.Finally,the simulation results show that the algorithm has high real-time performance,and the online correction trajectory can meet the requirements of terminal constraint change.The application range of the algorithm is obtained through Monte Carlo simulation.

Control System in Missiles for Whole-Trajectory-Controlled Trajectory Correction Projectile Based on DSP

A control system for correction mechanisms through the whole trajectory is proposed based on the principle of one-dimensional trajectory correction projectile. Digital signal processing( DSP) is utilized as the core controller and gobal positioning system( GPS) is used to measure trajectory parameters to meet the requirements of calculating ballistics and system functions. Firstly,the hardware,mainly including communication module,ballistic calculation module,boosting& detonating module and data storage module,is designed. Secondly,the supporting software is developed based on the communication protocols of GPS and the workflow of control system. Finally,the feasibility and the reliability of the control system are verified through dynamic tests in a car and live firing experiments. The system lays a foundation for the research on trajectory correction projectile for the whole trajectory.

Improved One-Cycle Control Algorithm in Five-Phase Six-Leg Switching Power Amplifiers for Magnetic Suspension Bearing

For the advantages of easy realization and rapidly intelligent response,the one-cycle control was applied in five-phase six-leg switching power amplifier for magnetic bearing.This paper improves the one-cycle control considering resistance voltage drop and derives its mathematical models.The improved algorithm is compared with the former one.The simulation and experimental results show that the improved algorithm can effectively reduce the output current ripple,achieve good tracking of the given current,improve the control accuracy,and verify the effectiveness and superiority of the method.

An Improved Non-isolated LED Converter with Power Factor Correction and Average Current Mode Control

A new type of high power LED drivers is proposed by adopting an improved two-stages non-isolated configuration. In order to improve power factor and achieve accurate average current control under universal input voltages ranging from 100 Vrms to 240 Vrms, the power factor correction and average current mode control methods operating in continuous current conduction mode are designed and implemented. With the LUMILEDS emitter type LEDs, a laboratory prototype is built and measured. And from the measured results, it could be concluded that the proposed driver has many better performances such as high power factor, low current harmonic, accurate average current control and switch protection.

GENERATION OF DIFFERENTIAL GPS CORRECTIONS ALONG WITH PERFORMANCE OF QUALITY CONTROL

The DGPS technique can provide considerably better relative positioning accuracy than the stand_alone GPS positioning,but the improvement depends on the distance between the user and the reference station (spatial correlation),the latency of differential corrections (temporal correlation),and the quality of differential corrections.Therefore,how to correctly generate differential corrections as well as their pricision is very important to the DGPS positioning technique.This paper presents a new algorithm for generating differential GPS corrections.This algorithm directly uses code and carrier observations in the measurement model of a Kalman filter,so that it is possible to use a simple stochastic model and to use the standard algorithm of the Kalman filter.The algorithm accounts for biases like multipath errors and instrumental delays in code observations and it shows how differential corrections are differently affected by code biases when dual or single frequency data is used.In addition,the algorithm can be integrated with a real time quality control procedure.As a result,the quality of differential corrections can be guaranteed with a certain probability.

Improvement of one-cycle controller by use of proportional integral differential controller

The main advantage of one-cycle control is its ability to reject input disturbance in one-cycle. Despite this great ability, it can not provide good responses in following commands and rejecting load disturbance. This study explores the way to overcome these problems by using another controller. Although the idea of using output feedback has been used in previous works, by considering a simple model for one-cycle controller, the design of the controller has become simpler in this work. In the proposed method, difficult mathematical modeling is avoided. Based on decupling of effects of feedback and input voltage disturbance, a simple model for one-cycle controller has been given. Therefore, by employing a conventional averaging method and the model of one-cycle controller, design of proportional integral differential controller has become straightforward.

Dynamic inverse control of feedback linearization in ballistic correction based on nose cone swinging

It is a complicated nonlinear controlling problem to conduct a two-dimensional trajectory correction of rockets.By establishing the aerodynamic correction force mathematical model of rockets on nose cone swinging,the linear control is realized by the dynamic inverse nonlinear controlling theory and the three-time-scale separation method.The control ability and the simulation results are also tested and verified.The results show that the output responses of system track the expected curve well and the error is controlled in a given margin.The maximum correction is about±314 m in the lengthwise direction and±1 212 m in the crosswise direction from the moment of 5 s to the drop-point time when the angle of fire is 55°.Thus,based on the dynamic inverse control of feedback linearization,the trajectory correction capability of nose cone swinging can satisfy the requirements of two-dimensional ballistic correction,and the validity and effectiveness of the method are proved.

Construction Cost Control Strategy of Finished House Based on BIM-5D

Building Information Modeling(BIM)technology can not only achieve project refinement management of the construction process based on a 3D model but also form a BIM-5D model based on the fusion of progress data and cost data to achieve the dynamic control of the whole process of project cost.This paper discusses the application of BIM-5D in the cost control of finished house construction,aiming to provide technical reference for China’s finished house project units,so that they can master how to realize the construction of cost control system based on BIM,the monitoring of the key coefficients of the cost,corrective action,to ensure that the project cost deviation is within the controllable range,and to make an effective guarantee for the economic benefits of the project construction.

Trajectory and Correction Maneuver During the Transfer from Earth to Halo Orbit

This article addresses the design of the trajectory transferring from Earth to Halo orbit, and proposes a timing closed-loop strategy of correction maneuver during the transfer in the frame of circular restricted three body problem （CR3BP）. The relation between the Floquet multipliers and the magnitudes of Halo orbit is established, so that the suitable magnitude for the aerospace mission is chosen in terms of the stability of Halo orbit. The stable manifold is investigated from the Poincar6 mapping defined which is different from the previous researches, and six types of single-impulse transfer trajectories are attained from the geometry of the invariant manifolds. Based on one of the trajectories of indirect transfer which are ignored in the most of literatures, the stochastic control theory for imperfect information of the discrete linear stochastic system is applied to design the trajectory correction maneuver. The statistical dispersion analysis is performed by Monte-Carlo simulation,

Time-delay Correction Control Strategy for HVDC Frequency Regulation Services

With the advancements in voltage source converter(VSC)technology,VSC based high voltage direct current(VSCHVDC)systems provide system operators with a prospective approach to enhance system operating stability and resilience.In addition to long-distance transmission,the VSC-HVDC system can also provide multiple ancillary services,such as frequency regulation,due to its power controllability.However,if a time delay exists in the control signal,the VSC-HVDC system may bring destabilizing influences to the system,which will decrease the system resilience under the disturbance.In order to reduce control deviation caused by time delay,in this paper,a small signal model is first conducted to analyze the impact of time delay on system stability.Then a time-delay correction control strategy for HVDC frequency regulation control is developed to reduce the influence of the time delay.The control performance of the proposed time-delay correction control is verified both in the established small signal model and the runtime simulation in a modified IEEE 39 bus system.The results indicate that the proposed time-delay correction control strategy shows significant improvement in system stability.

Impact Point Prediction and Lateral Correction Analysis of Two-dimensional Trajectory Correction Projectiles

Compared with the one-dimensional trajectory correction technology which adjusts longitudinal range, not only does the two-dimensional trajectory correction technology adjust the force in velocity direction, but also need to modulate the lateral force or trajectory (perpendicular to the vertical plane of fire direction). Therefore, the structure of control cabin of two-dimensional trajectory correction projectile (TDTCP) is more complicated than that of one-dimensional trajectory correction projectile (ODTCP). To simplify the structure of control cabin of TDTCP and reduce the cost, a scheme of adding a damping disk to the control cabin of ODTCP has been developed recently. The damping disk is unfolded at the right moment during its flight to change the ballistic drift of spin stabilized projectile. For this technical scheme of TDTCP, a fast and accurate impact point prediction method based on extended Kalman filter is presented. An approximate formula for predicting the ballistic drift and trajectory correction quantity is deduced. And the lateral correction capability for different fire angles and its influencing factors are analyzed. All the work is valuable for further research.

Key Techniques of Terminal Correction Mortar Projectiles

The operational principle, the impulse force and terminal guidance laws of terminal correction mortar projectiles（TCMP） are researched in this paper, by using the TCMP simulation program, key techniques such as the miss distance influenced by the acting point of impulse force, the impulse force value, the correction threshold, and the number of impulse rockets are researched in this paper. And the dual pulse control scheme is also studied. Simulation results indicate that the best acting point is near the center of gravity, sufficient correction resources are needed, the miss distance is insentive to the correction threshold, increasing the number of impulse rockets properly is beneficial to increase the hit precision, the velocity pursuit guidance law has less miss distance, the change of the attack angle is milder and the transient time becomes less in the dual impulse control scheme. These conclusions are important for choosing parameters and impulse correction schemes designed for TCMP.

Kinetic modeling of gamma-aminobutyric acid production by Lactobacillus brevis based on pH-dependent model and rolling correction

Gamma-aminobutyric acid(GABA)is a natural non-protein functio nal amino acid,which has potential for fermentation industrial production by Lactobacillus brevis.This work investigated the batch fermentation process and developed a kinetic model based on substrate restrictive model established by experimental data from L25(5~6)orthogonal experiments.In this study,the OD600 value of fermentation broth was fixed to constant after reaching its maximum because the microorganism death showed no effect on the enzyme activity of glutamate decarboxylase(GAD).As pH is one of the key parameters in fermentation process,a pH-dependent kinetic model based on radial basis function was developed to enhance the practicality of the model.Furthermore,as to decrease the deviations between the simulated curves and the experimental data,the rolling correction strategy with OD600 values that was measured in real-time was introduced into this work to modify the model.Finally,the accu racy of the rolling corrected and pH-dependent model was validated by good fitness between the simulated curves and data of the initial batch fermentation(pH 5.2).As a result,this pH-dependent kinetic model revealed that the optimal pH for biomass growth is 5.6-5.7 and for GABA production is about 5,respectively.Therefore,the developed model is practical and convenient for the instruction of GABA fermentation production,and it has instructive significance for the industrial scale.

Nuclear Fusion Research and Development Need New Relativistic Mass and Energy Corrections Given by the Information Relativity Theory

Hundred years after the conjecture of the British astronomer Eddington that the sun is powered by nuclear fusion of hydrogen, new physics theory may help make energy harvesting by nuclear fusion soon a reality. Researchers as well as investors funding fusion megaprojects are asked to deal with new relativistic corrections for mass and energy proposed by Suleiman in his Information Relativity Theory (IRT). These corrections were calculated in this contribution. It will help to decide whether a venture will be successful and to save big investments when in doubt. The assumed optimal kinetic energy for controlled nuclear fusion must be corrected to a somewhat higher level. At very high kinetic energy in the upper GeV range, it remains not enough baryonic mass to be transformed in energy. The fusion probability faded out to zero already at the golden limit of the recession speed of between target nucleon and projectile nucleon. Cold nuclear fusion, if ever possible, is recommended for protons rather than deuterons at highest experimental possible temperatures around 1000 (K) and needs fine-tuned kinetic nucleon energy. It would be also of interest whether a golden ratio based nuclear fuel confinement chamber could be beneficial. In this connection, also cold nuclear fusion setups should be discussed. Nature is governed by the golden ratio and criticality of physical systems influenced by it, and nuclear physics is not an exception. Computer simulations of the underlying controlled nuclear fusion processes should gain profit from IRT corrected starting information and may tackle anew possible low energy nuclear transmutations considering the wave-like dark components of matter and energy.