Efficacy evaluation of True Lift■,a nonsurgical facial ligament retightening injection technique:Two case reports

BACKGROUND With aging,four major facial retaining ligaments become elongated,leading to facial sagging and wrinkling.Even though synthetic fillers are popular,however,it cannot address the problems of soft tissue descent alone,and injection of these fillers requires knowledge of the injection technique including the selection of injection sites,the amount of filler,and the dosage used per injection site.CASE SUMMARY This report aimed to assess the safety and efficacy of a nonsurgical retightening technique to lift and tighten the true ligaments of the face,to improve age-related skin sagging and wrinkling.We objectively quantified the aesthetic lifting effect of a nonsurgical facial retightening procedure that strategically injected high G’ fillers into the base of the true retaining ligaments of the face in two female patients.Facial images were recorded with a three-dimensional facial imaging system for comparison of the clinical outcome.The primary efficacy outcome was the change in facial anthropometric measurements obtained prior to and after injection.The patients were followed for 6 mo after the procedure.Skin retightening was observed,with an evident lift in the orbital,zygomatic,and mandibular regions,and the lifting effect was still observable at the 6-mo followup.Few mild adverse events,such as mild-to-moderate pain,tenderness,and itching,occurred during the 1 st week after the procedure.No adverse events were reported 1 mo post-procedure.CONCLUSION The results of this study demonstrated that our nonsurgical retightening procedure with strategically placed high G’ fillers achieved quantifiable aesthetic improvements in the orbital,zygomatic,and mandibular regions of two patients.Future research with a larger sample could provide a more in-depth evaluation and validation of the aesthetic improvements observed in this study.

Efficacy and safety of newly developed cross-linked dextran gel injection for glans penis augmentation with a novel technique

There is no safe and effective standard method for glans penis augmentation. Furthermore, there has been scant research on glans penis augmentation due to a poor understanding of glans anatomy, technical difficulty, and a lack of suitable substances for augmentation. Cross-linked dextran gel is a newly developed filler for soft-tissue augmentation. We evaluated the efficacy and safety of using a novel technique to inject cross-linked dextran gel for glans penis augmentation during a 24-week follow-up study. This prospective, single-arm, multicenter study enrolled twenty healthy adult men who underwent glans penis augmentation between June and August 2013. Cross-linked dextran gel was injected into the glans penis using a simple and easy technique. The sizes of the glans penis and individual satisfaction were assessed. Any adverse event was also reported. A total of 18 individuals were analyzed; two of them were lost to follow-up. The mean procedure time and injected volume were about 30 rain and 6.6 ＋- 0.9 ml, respectively. The mean surface areas of the glans at baseline and 24 weeks were 20.0 _＋ 3.5 cm2 and 33.6 -＋ 5.4 cm2, respectively, representing a mean increase of 68.7% _＋ 14.0% （P 〈 0.001）. Sixteen individuals （88.9%） were satisfied with the outcomes, and none were dissatisfied. There were no serious adverse events during the study. Cross-linked dextran gel injection for glans penis augmentation was easy and showed a significant augmentative effect on the glans penis, good durability, and was well tolerated without serious adverse events. Therefore, cross-linked dextran gel injection may be an effective, new technique for glans penis augmentation.