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A Building Information Modeling-Life Cycle Cost Analysis Integrated Model to Enhance Decisions Related to the Selection of Construction Methods at the Conceptual Design Stage of Buildings
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作者 Nkechi McNeil-Ayuk Ahmad Jrade 《Open Journal of Civil Engineering》 2024年第3期277-304,共28页
Life Cycle Cost Analysis (LCCA) provides a systematic approach to assess the total cost associated with owning, operating, and maintaining assets throughout their entire life. BIM empowers architects and designers to ... Life Cycle Cost Analysis (LCCA) provides a systematic approach to assess the total cost associated with owning, operating, and maintaining assets throughout their entire life. BIM empowers architects and designers to perform real-time evaluations to explore various design options. However, when integrated with LCCA, BIM provides a comprehensive economic perspective that helps stakeholders understand the long-term financial implications of design decisions. This study presents a methodology for developing a model that seamlessly integrates BIM and LCCA during the conceptual design stage of buildings. This integration allows for a comprehensive evaluation and analysis of the design process, ensuring that the development aligns with the principles of low carbon emissions by employing modular construction, 3D concrete printing methods, and different building design alternatives. The model considers the initial construction costs in addition to all the long-term operational, maintenance, and salvage values. It combines various tools and data through different modules, including energy analysis, Life Cycle Assessment (LCA), and Life Cycle Cost Analysis (LCCA) to execute a comprehensive assessment of the financial implications of a specific design option throughout the lifecycle of building projects. The development of the said model and its implementation involves the creation of a new plug-in for the BIM tool (i.e., Autodesk Revit) to enhance its functionalities and capabilities in forecasting the life-cycle costs of buildings in addition to generating associated cash flows, creating scenarios, and sensitivity analyses in an automatic manner. This model empowers designers to evaluate and justify their initial investments while designing and selecting potential construction methods for buildings, and enabling stakeholders to make informed decisions by assessing different design alternatives based on long-term financial considerations during the early stages of design. 展开更多
关键词 Life Cycle cost analysis (LCCA) Building Information Modeling (BIM) cost Decision Modular Construction and 3D Concrete Printing
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Comparative analysis of perpetual pavement structures based on pavement performance and life cycle cost 被引量:3
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作者 朱玉琴 倪富健 顾兴宇 《Journal of Southeast University(English Edition)》 EI CAS 2014年第1期84-87,共4页
Pavement performance and economic efficiency are researched on the perpetual test pavement of Yijiang-Suzhou Express Highway in Jiangsu province, China. Test sections were continuously monitored. The conditions and de... Pavement performance and economic efficiency are researched on the perpetual test pavement of Yijiang-Suzhou Express Highway in Jiangsu province, China. Test sections were continuously monitored. The conditions and developing laws of deflection, rutting and cracking are compared among the perpetual pavement with the rich binder layer (RBL), the perpetual pavement without the RBL, and the conventional semi-rigid asphalt pavement in the past eight years after opening for traffic. Economical evaluation is conducted via life cycle cost analysis (LCCA). Based on the performance comparison and LCCA analysis, sections with the RBL have good crack resistance, but they are not very satisfactory in the aspect of permanent deformation; the conventional semi-rigid asphalt pavement is the least economic one due to requiring more frequent maintenance. Research results show that the perpetual pavement without RBL is a more appropriate structure for the test site. 展开更多
关键词 perpetual pavement rich binder layer pavementperformance life cycle cost analysis
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Advances in microfluidic-based DNA methylation analysis 被引量:1
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作者 Jiwen Li Tiechuan Li Xuexin Duan 《Nanotechnology and Precision Engineering》 EI CAS CSCD 2024年第1期116-134,共19页
DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation ... DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation studies to both clinical medicine and scientific research.Microflu-idic chips are excellent carriers for molecular analysis,and their use can provide improvements from multiple aspects.On-chip molecular analysis has received extensive attention owing to its advantages of portability,high throughput,low cost,and high efficiency.In recent years,the use of novel microfluidic chips for DNA methylation analysis has been widely reported and has shown obvious superiority to conventional methods.In this review,wefirst focus on DNA methylation and its applications.Then,we discuss advanced microfluidic-based methods for DNA methylation analysis and describe the great progress that has been made in recent years.Finally,we summarize the advantages that microfluidic technology brings to DNA methylation analysis and describe several challenges and perspectives for on-chip DNA methylation analysis.This review should help researchers improve their understanding and make progress in developing microfluidic-based methods for DNA methylation analysis. 展开更多
关键词 Microfluidic chip DNA methylation analysis Molecular analysis High throughput Low cost
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Cost-effectiveness analysis of treatments for metastatic castration resistant prostate cancer 被引量:6
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作者 Matthew E.Pollard Alan J.Moskowitz +1 位作者 Michael A.Diefenbach Simon J.Hall 《Asian Journal of Urology》 2017年第1期37-43,共7页
Objective:Treatment options for metastatic castration resistant prostate cancer(mCRPC)have expanded rapidly in recent years.Given the significant economic burden,we sought perform a cost-effectiveness analysis(CEA)of ... Objective:Treatment options for metastatic castration resistant prostate cancer(mCRPC)have expanded rapidly in recent years.Given the significant economic burden,we sought perform a cost-effectiveness analysis(CEA)of the contemporary treatment paradigm for mCRPC.Methods:We devised a treatment protocol consisting of sipuleucel-T,enzalutamide,abiraterone,docetaxel,radium-223,and cabazitaxel.We estimated number and length of treatments for each therapy using dosing schedules or progression free survival data from published clinical trials.We estimated treatment cost using billing data and Medicare reimbursement values and performed a CEA.Our analysis assumed US$100,000 per life year saved(LYS)as the threshold societal willingness to pay.Results:Incremental cost-effectiveness ratios(ICER)for strategies incorporating sipuleucel-T that were not eliminated by extended dominance exceeded the societal threshold willingnessto-pay of US$100,000 per LYS,the lowest of which was sipuleucel-T+enzalutamide+abiraterone+docetaxel at US$207,714 per LYS.Enzalutamide+abiraterone+docetaxel exhibited the most favorable ICER among strategies without sipuleucel-T at US$165,460 per LYS.Conclusion:Based on the available survival data and current costs of treatment,all treatment strategies greatly exceed a commonly assumed societal willingness-to-pay threshold of US$100,000 per LYS.Improvements in this regard can only comewith a reduction in pricing,better tailoring of treatment or significant enhancements in survival with clinical use of treatment combinations or sequences. 展开更多
关键词 Metastatic prostate cancer costs and cost analysis Health expenditures ECONOMICS PHARMACEUTICAL
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Capparis spinosa L waste activated carbon as an efficient adsorbent for crystal violet toxic dye removal: Modeling, optimization by experimental design, and ecological analysis
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作者 Mohammed Benjelloun Youssef Miyah +8 位作者 Salma Ssouni Soulaiman Iaich Mohamed El-habacha Salek Lagdali Khadija Saka El Mustafa Iboustaten Abdelaziz Ait Addi Sanae Lairini Rabia Bouslamti 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第7期283-302,共20页
Textile dyes are dramatic sources of pollution and non-aesthetic disturbance of aquatic life and therefore represent a potential risk of bioaccumulation that can affect living species.It is imperative to reduce or eli... Textile dyes are dramatic sources of pollution and non-aesthetic disturbance of aquatic life and therefore represent a potential risk of bioaccumulation that can affect living species.It is imperative to reduce or eliminate these dyes from liquid effluents with innovative biomaterials and methods.Therefore,this research aims to highlight the performance of Capparis spinosa L waste-activated carbon(CSLW-AC)adsorbent to remove crystal violet(CV)from an aqueous solution.The mechanism of CV adsorption on CSLW-AC was evaluated based on the coupling of experimental data and different characterization techniques.The efficiency of the CSLW-AC material reflected by the equilibrium adsorption capacity of CV could reach more than 195.671 mg·g^(–1) when 0.5 g·L^(–1) of CSLW-AC(Particle size≤250μm)is introduced into the CV of initial concentration of 100 mg·L^(–1) at pH 6 and temperature 65℃ and in the presence of potassium ions after 60 min of contact time according to the one parameter at a time studies.The adsorption behavior of CV on CSLW-AC was found to be consistent with the pseudo-second-order kinetic model and Frumkin's linear isothermal model.The thermodynamic aspects indicate that the process is physical,spontaneous,and endothermic.The optimization of the process by the Box Behnken design of experiments resulted in an adsorption capacity approaching 183.544 mg·g^(–1)([CV]=100 mg·L^(–1) and[CSLW-AC]=0.5 g·L^(–1) at 35 min).The results of the Lactuca sativa seeds germination in treated CV(70%),adsorbent solvent and thermal regeneration(more than 5 cycles),and process cost analysis(1.0484 USD·L^(–1))tests are encouraging and promising for future exploitations of the CSLW-AC material in different industrial fields. 展开更多
关键词 Box Behnken Capparis spinosa L waste-activated carbon cost analysis ISOTHERM KINETIC Regeneration
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Competitive analysis of price online inventory problem with cost function 被引量:1
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作者 HAN Shu-guang GUO Jiu-ling +1 位作者 ZHANG Lu-ping HU Jue-liang 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2017年第4期493-502,共10页
In this paper,a new price is given to the online decision maker at the beginning of each day.The trader must decide how many items to purchase according to the current price.We present three variants and an online alg... In this paper,a new price is given to the online decision maker at the beginning of each day.The trader must decide how many items to purchase according to the current price.We present three variants and an online algorithm based on cost function.The competitive ratio of the online algorithm is given for each variant,which is a performance measure of an online algorithm.More importantly,we show that the online algorithm is optimal. 展开更多
关键词 inventory problem price online cost function competitive analysis
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Cost analysis and outcomes of simple elbow dislocations 被引量:1
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作者 Michalis Panteli Ippokratis Pountos +2 位作者 Nikolaos K Kanakaris Theodoros H Tosounidis Peter V Giannoudis 《World Journal of Orthopedics》 2015年第7期513-520,共8页
AIM: To evaluate the management, clinical outcome and cost implications of three different treatment regimes for simple elbow dislocations.METHODS: Following institutional board approval, we performed a retrospective ... AIM: To evaluate the management, clinical outcome and cost implications of three different treatment regimes for simple elbow dislocations.METHODS: Following institutional board approval, we performed a retrospective review of all consecutive patients treated for simple elbow dislocations in a Level Ⅰ trauma centre between January 2008 and December 2010. Based on the length of elbow immobilisation(LOI), patients were divided in three groups(Group I, < 2 wk; Group Ⅱ, 2-3 wk; and Group Ⅲ, > 3 wk). Outcome was considered satisfactory when a patient could achieve a pain-free range of motion ≥ 100°(from 30° to 130°). The associated direct medical costs for the treatment of each patient were then calculated and analysed.RESULTS: We identified 80 patients who met the inclusion criteria. Due to loss to follow up, 13 patients were excluded from further analysis, leaving 67 patients for the final analysis. The mean LOI was 14 d(median 15 d; range 3-43 d) with a mean duration of hospital engagement of 67 d(median 57 d; range 10-351 d). Group Ⅲ(prolonged immobilisation) had a statistically significant worse outcome in comparison to Group Ⅰ?and Ⅱ(P = 0.04 and P = 0.01 respectively); however, there was no significant difference in the outcome between groups Ⅰ?and Ⅱ(P = 0.30). No statistically significantdifference in the direct medical costs between the groups was identified.CONCLUSION: The length of elbow immobilization doesn't influence the medical cost; however immobilisation longer than three weeks is associated with persistent stiffness and a less satisfactory clinical outcome. 展开更多
关键词 ELBOW dislocations SIMPLE MANAGEMENT OUTCOME cost analysis
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Comparison of School Building Construction Costs Estimation Methods Using Regression Analysis, Neural Network, and Support Vector Machine 被引量:2
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作者 Gwang-Hee Kim Jae-Min Shin +1 位作者 Sangyong Kim Yoonseok Shin 《Journal of Building Construction and Planning Research》 2013年第1期1-7,共7页
Accurate cost estimation at the early stage of a construction project is key factor in a project’s success. But it is difficult to quickly and accurately estimate construction costs at the planning stage, when drawin... Accurate cost estimation at the early stage of a construction project is key factor in a project’s success. But it is difficult to quickly and accurately estimate construction costs at the planning stage, when drawings, documentation and the like are still incomplete. As such, various techniques have been applied to accurately estimate construction costs at an early stage, when project information is limited. While the various techniques have their pros and cons, there has been little effort made to determine the best technique in terms of cost estimating performance. The objective of this research is to compare the accuracy of three estimating techniques (regression analysis (RA), neural network (NN), and support vector machine techniques (SVM)) by performing estimations of construction costs. By comparing the accuracy of these techniques using historical cost data, it was found that NN model showed more accurate estimation results than the RA and SVM models. Consequently, it is determined that NN model is most suitable for estimating the cost of school building projects. 展开更多
关键词 ESTIMATING Construction costS Regression analysis NEURAL Network Support VECTOR MACHINE
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Economic Viability of Smallholder Agroforestry and Beekeeping Projects in Uluguru Mountains, Tanzania: A Cost Benefit Analysis 被引量:2
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作者 Willickister R. Kadigi Yonika M. Ngaga Reuben M. J. Kadigi 《Open Journal of Forestry》 2021年第2期83-107,共25页
Agroforestry and beekeeping are widely promoted as prospective Nature-</span></span><span><span><span style="font-family:""> </span></span></span><span... Agroforestry and beekeeping are widely promoted as prospective Nature-</span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">Based Income Generating Activities (NIGAs) to improve livelihoods while at </span><span style="font-family:Verdana;">the same time enhancing biodiversity conservation in degrading</span><span style="font-family:Verdana;"> agro-ecologies. These activities can diversify and increase famers’ incomes and support in</span><span style="font-family:Verdana;">stinctive biota and fauna resilience. However, evidence to showcase and compare their long-term benefits is scant. We use the case of Uluguru</span><span style="font-family:Verdana;"> Mountains in Tanzania to evaluate and compare viability of agroforestry and beekeeping projects using the Cost</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Benefit Analysis (CBA) approach. The results of analysis yielded positive NPVs for both agroforestry and beekeeping projects at discount rates not higher than 8.2% and 8.5% respectively. Overall, the comparison of economic viability between agroforestry and beekeeping projects revealed that the former was relatively more profitable than the later in terms of both the NPV and Benefit</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Cost Ratio (BCR) criteria. However, the Internal Rate of Return (IRR) for beekeeping was slightly higher than that of agroforestry. Yet, we underscore the fact that these two projects can jointly be implemented to enhance livelihoods of farmers and support biodiversity conservation in the study </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">area </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">and other parts with similar agro-ecologies in developing countries. However, farmers in these agro-ecologies need to be supported by governments and non-government development partners in terms of training and inspiration to shift from orthodox farming to sustainable NIGAs. 展开更多
关键词 Uluguru Mountains Uluguru Forestry Reserve cost Benefit analysis Net Present Values Benefit cost Ratios Nature-Based Income Generating Activities
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Modeling Anthrax with Optimal Control and Cost Effectiveness Analysis 被引量:1
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作者 Shaibu Osman Dominic Otoo Oluwole Daniel Makinde 《Applied Mathematics》 2020年第3期255-275,共21页
Anthrax is an infection caused by bacteria and it affects both human and animal populations. The disease can be categorized under zoonotic diseases and humans can contract infections through contact with infected anim... Anthrax is an infection caused by bacteria and it affects both human and animal populations. The disease can be categorized under zoonotic diseases and humans can contract infections through contact with infected animals, ingest contaminated dairy and animal products. In this paper, we developed a mathematical model for anthrax transmission dynamics in both human and animal populations with optimal control. The qualitative solution of the model behaviour was analyzed by determining Rhv, equilibrium points and sensitivity analysis. A vaccination class was incorporated into the model with waning immunity. Local and global stability of the model’s equilibria was found to be locally asymptotically stable whenever Rhv Rhv. It was revealed that reducing animal and human interaction rate, would decrease Rhv. We extended the model to optimal control in order to find the best control strategy in reducing anthrax infections. It showed that the effective strategy in combating the anthrax epidemics is vaccination of animals and prevention of humans. 展开更多
关键词 ANTHRAX Model STABILITY analysis Sensitivity OPTIMAL Control cost EFFECTIVENESS
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Optimization of Evidence Analysis Cost Using Arbitrary Re-Sampling Techniques for Sample Influx into Forensic Science Laboratory 被引量:1
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作者 Samwel Victor Manyele 《Engineering(科研)》 2017年第5期457-481,共25页
This study analyzes the sample influx (samples per case file) into forensic science laboratory (FSL) and the corresponding analysis costs and uses arbitrary re-sampling plans to establish the minimum cost function. Th... This study analyzes the sample influx (samples per case file) into forensic science laboratory (FSL) and the corresponding analysis costs and uses arbitrary re-sampling plans to establish the minimum cost function. The demand for forensic analysis increased for all disciplines, especially biology/DNA between 2014 and 2015. While the average distribution of case files was about 42.5%, 40.6% and 17% for the three disciplines, the distribution of samples was rather different being 12%, 82.5% and 5.5% for samples requiring forensic biology, chemistry and toxicology analysis, respectively. Results show that most of the analysis workload was on forensic chemistry analysis. The cost of analysis for case files and the corresponding sample influx varied in the ratio of 35:6:1 and 28:12:1 for forensic chemistry, biology/DNA and toxicology for year 2014 for 2015, respectively. In the two consecutive years, the cost for forensic chemistry analysis was comparatively very high, necessitating re-sampling. The time series of sample influx in all disciplines are strongly stochastic, with higher magnitude for chemistry, biology/DNA and toxicology, in this order. The PDFs of sample influx data are highly skewed to the right, especially forensic toxicology and biology/DNA with peaks at 1 and 3 samples per case file. The arbitrary re-sampling plans were best suited to forensic chemistry case files (where re-sampling conditions apply). The locus of arbitrary number of samples to take from the submitted forensic samples was used to establish the minimum and scientifically acceptable samples by applying minimization function developed in this paper. The cost minimization function was also developed based on the average cost per sample and choice of re-sampling plans depending on the range of sample influx, from which the savings were determined and maximized. Thus, the study gives a forensic scientist a business model and scientific decision making tool on minimum number of samples to analyze focusing on savings on analysis cost. 展开更多
关键词 Forensic Science LABORATORY SAMPLE INFLUX ARBITRARY Sampling analysis cost Minimum Number of Samples Minimum analysis cost Toxicology Forensic Chemistry DNA analysis
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Cost analysis of childhood glaucoma surgeries using the US Medicaire allowable costs 被引量:1
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作者 Abdelrahman M.Elhusseiny Mohamed M.Khodeiry +3 位作者 Nicolas A.Yannuzzi Ta C.Chang Richard K.Lee William E.Smiddy 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第5期700-704,共5页
AIM: To analyze and calculate the relative cost of various childhood glaucoma surgical interventions per mm Hg intraocular pressure(IOP) reduction($/mm Hg).METHODS: Representative index studies were reviewed to quanti... AIM: To analyze and calculate the relative cost of various childhood glaucoma surgical interventions per mm Hg intraocular pressure(IOP) reduction($/mm Hg).METHODS: Representative index studies were reviewed to quantitate the reduction of mean IOP and glaucoma medications for each surgical intervention in childhood glaucoma. A US perspective was adopted, using Medicare allowable costs to calculate cost/mm Hg IOP reduction($/mm Hg) at 1y postoperatively.RESULTS: At 1y postoperatively, the cost/mm Hg IOP reduction was $226/mm Hg for microcatheter-assisted circumferential trabeculotomy, $284/mm Hg for cyclophotocoagulation, $288/mm Hg for conventional ab-externo trabeculotomy, $338/mm Hg for Ahmed glaucoma valve, $350/mm Hg for Baerveldt glaucoma implant, $351/mm Hg for goniotomy, and $400/mm Hg for trabeculectomy.CONCLUSION: Microcatheter-assisted circumferential trabeculotomy is the most cost-efficient surgical method to lower IOP in childhood glaucoma, while trabeculectomy is the least cost-efficient surgical method. 展开更多
关键词 GLAUCOMA cost analysis TRABECULOTOMY TRABECULECTOMY intraocular pressure childhood glaucoma
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AIDS Treatments Efficiency Analysis Based on Cost Efficiency Data Envelopment Analysis Model 被引量:1
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作者 边馥萍 许茵 《Transactions of Tianjin University》 EI CAS 2007年第1期1-7,共7页
Three data envelopment analysis (DEA) models were used to analyse the relative efficiencies of four AIDS treatments in AIDS Clinical Trial Group (ACTG) Study 193A(1 309 patients in total, classified into 4 age groups)... Three data envelopment analysis (DEA) models were used to analyse the relative efficiencies of four AIDS treatments in AIDS Clinical Trial Group (ACTG) Study 193A(1 309 patients in total, classified into 4 age groups). Results from the output-oriented BCC model show that Treatment 4 ( 600 mg of zidovudine plus 400 mg of didanosine plus 400 mg of nevirapine) is particularly efficient for age group 14—25, but not efficient for the older age groups; Treatment 1 (600 mg of zidovudine alternating monthly with 400 mg of didanosine)and Treatment 2 (600 mg of zidovudine plus 2.25 mg of zalcitabine) are efficient for the age groups 35—45 and 45— ; age group 25—35 does not have a particularly efficient treatment, but Treatments 1 and 2 are relatively good. The cost efficiency BCC model, which takes the treatment cost into account, gives similar results as the output-oriented model. Results from the indirect output-oriented BCC model, which allows the replacement among medicines, show that the efficiency of Treatment 2 has greatly decreased compared with that of the output-oriented model, and a set of optimal medicine amounts for different age groups is obtained. 展开更多
关键词 data envelopment analysis (DEA) decision making unit DMU) cost efficient AIDS treatment
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Life cycle cost analysis of new FRP based solar parabolic trough collector hot water generation system 被引量:1
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作者 A. VALAN ARASU T. SORNAKUMAR 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2008年第3期416-422,共7页
Parabolic trough collectors (PTCs) are employed for a variety of applications including steam generation and hot water generation. This paper deals with the experimental results and an economic analysis of a new fib... Parabolic trough collectors (PTCs) are employed for a variety of applications including steam generation and hot water generation. This paper deals with the experimental results and an economic analysis of a new fibre reinforced plastic (FRP) based solar PTC with an embedded electronic controlled tracking system designed and developed for hot water generation in a restaurant in Madurai, India. The new collector performance has been tested according to ASHRAE Standard 93 (1986). The performance of a new PTC hot water generation system with a well mixed hot water storage tank is investigated by a series of extensive tests over ten months period. The average maximum storage tank water temperature observed was 74.91℃, when no energy is withdrawn from the tank to the load during the collection period. The total cost of the new economic FRP based solar PTC for hot water generation with an embedded electronic controlled tracking system is Rs. 25000 (US$ 573) only. In the present work, life cycle savings (LCS) method is employed for a detailed economic analysis of the PTC system. A computer program is used as a tool for the economic analysis. The present worth of life cycle solar savings is evaluated for the new solar PTC hot water generation system that replaces an existing electric water heating system in the restaurant and attains a value of Rs. 23171.66 after 15 years, which is a significant saving. The LCS method and the MATLAB computer simulation program presented in this paper can be used to estimate the LCS of other renewable energy systems. 展开更多
关键词 Economic analysis Life cycle savings Life cycle cost (LCS) Parabolic trough collector (PTC) Solar water heating system (SWHS)
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Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study 被引量:3
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作者 Niall P McGoldrick Eabhann M O'Connor +2 位作者 Nikos Davarinos Rose Galvin John F Quinlan 《World Journal of Orthopedics》 2015年第11期977-982,共6页
AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb ... AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients(control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients(TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 ± 13 years. There were no significant differences between groups in terms of gender(P = 0.47), proportion of total hip replacement to total knee replacement(P = 0.25) or pre-operative haemoglobin(P = 0.43). In the control group, the transfusion rate was 22%. In the TXA group, the transfusion rate dropped to 2%(P < 0.001). The mean post-operative haemoglobin was 10.82 ± 1.55g/dL in the control group vs 11.33 ± 1.27 g/dL in the TXA group(P = 0.01). The total cost of transfused blood products was €11055 and €603 respectively. The mean length of stay in the control group was 6.53 ± 5.93 d vs 5.47 ± 4.26 d in the TXA group(P = 0.15) leading to an estimated financial saving of €114586. There was one pulmonary embolus in the control group and one deep venous thrombosis in the TXA group.CONCLUSION: Intravenous TXA reduces blood loss in lower limb arthroplasty. This leads to lower transfusion rates, shorter length of stay in hospital and significant financial savings. 展开更多
关键词 ARTHROPLASTY HIP KNEE Tranexamic ACID cost-BENEFIT analysis
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High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis 被引量:9
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作者 Chin Hur Sung Eun Choi +8 位作者 Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy 《World Journal of Gastroenterology》 SCIE CAS 2015年第18期5513-5523,共11页
AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separa... AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. 展开更多
关键词 cost-EFFECTIVENESS analysis Diagnostic imaging ENDOSCOPY ESOPHAGEAL SQUAMOUS cell cancer Simulation disease model
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Desalination and Alternative Water-Shortage Mitigation Options in Israel: A Comparative Cost Analysis 被引量:2
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作者 Nir Becker Doron Lavee David Katz 《Journal of Water Resource and Protection》 2010年第12期1042-1056,共15页
Costs for seawater desalination have dropped significantly over the past decade due to technological advances. This has increased the attractiveness of desalination to policy-makers as a means to address water supply ... Costs for seawater desalination have dropped significantly over the past decade due to technological advances. This has increased the attractiveness of desalination to policy-makers as a means to address water supply shortages. Israel, a country that faces chronic water scarcity, is in the process of developing wide-scale desalination capacity that is projected to supply all of the nation's domestic water use within a few years. Two issues are often neglected, however, by policy-makers pursuing desalination. The first is that seawater desalination is associated with a number of external costs, consideration of which may influence the optimal scale and timing of desalination implementation. The second is that alternative measures for managing water scarcity, including conservation techniques, are often more cost-efficient. This study estimates the full cost of desalination in Israel, including externalities, and then compares this to the costs of several alternative options for addressing water scarcity, including both demand management and supply augmentation measures. We find that desalination, despite being the primary policy option pursued by Israel, is among the least cost-efficient of all the alternatives considered, even without taking into account the externalities involved. 展开更多
关键词 cost-EFFECTIVENESS analysis DESALINATION Israel WATER Policy
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Costs resulting from nonprofessional soccer injuries in Switzerland:A detailed analysis
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作者 Angela Gebert Markus Gerber +3 位作者 Uwe Pühse Philippe Gassmann Hanspeter Stamm Markus Lamprecht 《Journal of Sport and Health Science》 SCIE 2020年第3期240-247,共8页
Background:Soccer injuries constitute an important public health problem and cause a high economic burden.Nevertheless,comprehensive data regarding injury costs in nonprofessional soccer are missing.The aim of this st... Background:Soccer injuries constitute an important public health problem and cause a high economic burden.Nevertheless,comprehensive data regarding injury costs in nonprofessional soccer are missing.The aim of this study was to determine which groups of nonprofessional soccer athletes,injury types,and injury situations caused high injury costs.Methods:A cross-sectional,retrospective telephone survey was carried out with a random sample of persons who had sustained a soccer injury between July 2013 and June 2014 and who had reported this accident to the Swiss National Accident Insurance Fund(Suva).One year after the corresponding accident,every injury was linked to its costs and to the answers obtained in the interview about injury setting,injury characteristics,and injury causes.Finally,the costs of 702 injuries were analyzed.Results:The average cost of an injury in nonprofessional soccer amounted to€4030(bias-corrected and accelerated 95%confidence interval(BCa 95%CI):3427-4719).Persons aged 30 years and older experienced 35%of soccer injuries but accounted for 49%of all costs.A total of58%of all costs were the result of injuries that occurred during amateur games.In particular,game injuries sustained by players in separate leagues for players aged 30+/40+years led to high average costs of€8190(BCa 95%CI:5036-11,645).Knee injuries accounted for 25%of all injuries and were responsible for 53%of all costs.Although contact and foul play did not lead to above-average costs,twisting or turning situations were highly cost relevant,leading to an average sum of€7710(BCa 95%CI:5376-10,466)per injury.Conclusion:Nonprofessional soccer players aged 30 years and older and particularly players in 30+/40+leagues had above-average injury costs.Furthermore,the prevention of knee injuries,noncontact and nonfoul play injuries,and injuries caused by twisting and turning should be of highest priority in decreasing health care costs. 展开更多
关键词 AMATEUR SOCCER cost analysis INJURY causes INJURY characteristics INJURY costS
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Cost-analysis of inpatient and outpatient parenteral antimicrobial therapy in orthopaedics: A systematic literature review
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作者 Christoph Kolja Boese Philipp Lechler +3 位作者 Michael Frink Michael Hackl Peer Eysel Christian Ries 《World Journal of Clinical Cases》 SCIE 2019年第14期1825-1836,共12页
BACKGROUND Increasing numbers of total joint arthroplasties and consecutive revision surgery are associated with the risk of periprosthetic joint infections (PPJI). Treatment of PPJI is complex and associated with imm... BACKGROUND Increasing numbers of total joint arthroplasties and consecutive revision surgery are associated with the risk of periprosthetic joint infections (PPJI). Treatment of PPJI is complex and associated with immense socio-economic burden. One treatment aspect is parenteral antiinfective therapy, which usually requires an inpatient setting [Inpatient parenteral antibiotic therapy (IPAT)]. An alternative is outpatient parenteral treatment [Outpatient parenteral antibiotic therapy (OPAT)]. To conduct a health economic cost-benefit analysis of OPAT, a detailed cost analysis of IPAT and OPAT is required. So far, there is a lack of knowledge on the health economic effects of IPAT and OPAT for PPJI. AIM To review an economic comparison of IPAT and OPAT. METHODS A systematic literature review was performed through Medline following the PRISMA guidelines. RESULTS Of 619 identified studies, 174 included information of interest and 21 studies were included for quantitative analysis of OPAT and IPAT costs. Except for one study, all showed relevant cost savings for OPAT compared to IPAT. Costs for IPAT were between 1.10 to 17.34 times higher than those for OPAT. CONCLUSION There are only few reports on OPAT for PPJI. Detailed analyses to support economic or clinical guidelines are therefore limited. There is good clinical evidence supporting economic benefits of OPAT, but more high quality studies are needed for PPJI. 展开更多
关键词 Antibiotic THERAPY OUTPATIENT PARENTERAL antibiotic THERAPY INPATIENT PARENTERAL antibiotic THERAPY cost analysis PERIPROSTHETIC joint infection PARENTERAL
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Cost and Calorie Analysis of Fast Food Consumption in College Students
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作者 Kimberly B. Heidal Sarah E. Colby +3 位作者 Ginger T. Mirabella Khalid S. Al-Numair Brenda Bertrand Kevin H. Gross 《Food and Nutrition Sciences》 2012年第7期942-946,共5页
The purpose of this research was to assess money spent and calories consumed by college students from fast food restaurants located on and around a southern college campus. A convenience sample (n = 152) of undergradu... The purpose of this research was to assess money spent and calories consumed by college students from fast food restaurants located on and around a southern college campus. A convenience sample (n = 152) of undergraduate college students (aged 18 - 24) at a southern university participated in a survey that measured dietary intake from seven local fast food chains using a researcher developed food frequency questionnaire and a lifestyle behavior survey that collected data on health practices. A strong positive correlation was found between total monthly fast food expense and total monthly fast food caloric consumption (r(150) = 0.94, p t test comparing the mean monthly fast food restaurant expense males to females found a significant difference between the two groups (t(150) = 4.19, p < 0.05).The more money spent by college students contributed to a higher amount of calories consumed from fast food in a typical month. Future research needs to determine if college students are contributing to the high obesity rate and if limiting fast food restaurants on and around college campuses would help decrease fast food consumption in college students. 展开更多
关键词 cost analysis Students Health Food Energy INTAKE
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