Stable and transparent aminosilicone oil microemulsion of the average particle size below 0.05 micron was prepared. The interaction of the aminosilicone oil, water, complex surfactants and cosurfactant was studied by...Stable and transparent aminosilicone oil microemulsion of the average particle size below 0.05 micron was prepared. The interaction of the aminosilicone oil, water, complex surfactants and cosurfactant was studied by part pseudoternary phase diagram. The effect of cosurfactants (such as alcohol) and the mechanism of its effect on the phase behaviour of the pseudoternary system were investigated.展开更多
t Since large amounts of oils, surfactants and penetration enhancers used in microemulsion systems might lead to seriously skin irritation, the percutaneous absorption and penetration of indomethacin（IMC, model drug...t Since large amounts of oils, surfactants and penetration enhancers used in microemulsion systems might lead to seriously skin irritation, the percutaneous absorption and penetration of indomethacin（IMC, model drug） from O/W microemulsion were enhanced by simply changing the composition of cosurfactants. Pseudo-ternary phase dia- grams were constructed with mixed cosurfactants at different ratios. Hairless rat skin was used as a barrier for per- meation experiments. Four formulations were prepared with fixed oil, surfactant and different cosurfactant con- tent（4%, 20% and 20%, mass fraction）, and formulation F4 with menthol added was evaluated to compare the en- hancement effect of it with those of mixed cosurfactants. The O/W microemulsion region was the largest when the mass ratio of ethanol/transcutol was 1：1. However, the region changed slightly for the system with incorporated mixed cosurfactants propylene glycol/transcutol. The flux and skin retention of IMC from O/W microemulsion with mixed cosurfactants were much higher than that with single cosurfactant（P〈0.01）, while incorporation of menthol would only enhance the drug flux through the skin. To conclude, mixed cosufactants could affect the phase behavior and improve the percutaneous absorption and penetration of IMC. Based on this, it provided a promising solution to enhance drug release from microemulsions without raising potential skin damage.展开更多
Lens-like vaterite CaCO3 microrings composed of CaCO3 nanoparticles were synthesized via a microemulsion-mediated route at room temperature with ethanol and n-hexanol as co-surfactant. This process did not demand any ...Lens-like vaterite CaCO3 microrings composed of CaCO3 nanoparticles were synthesized via a microemulsion-mediated route at room temperature with ethanol and n-hexanol as co-surfactant. This process did not demand any additional energy such as heating or continuous agitation. It was the first time to use ethanol as co-surfactant in the synthesis of micro or nanomaterials. And the ethanol was believed to play an important role in the aggregation fashion of CaCO3 nanoparticles. Moreover, shuttle-shaped nanorods, hexagonal nanoplates, and rice-like nanoparticles were also fabricated by modulating the growth parameters. Additionally, the introduce of ethanol into microemulsions as co-surfactant may be generalized as a novel green route to control the structure of other functional materials.展开更多
文摘Stable and transparent aminosilicone oil microemulsion of the average particle size below 0.05 micron was prepared. The interaction of the aminosilicone oil, water, complex surfactants and cosurfactant was studied by part pseudoternary phase diagram. The effect of cosurfactants (such as alcohol) and the mechanism of its effect on the phase behaviour of the pseudoternary system were investigated.
文摘t Since large amounts of oils, surfactants and penetration enhancers used in microemulsion systems might lead to seriously skin irritation, the percutaneous absorption and penetration of indomethacin（IMC, model drug） from O/W microemulsion were enhanced by simply changing the composition of cosurfactants. Pseudo-ternary phase dia- grams were constructed with mixed cosurfactants at different ratios. Hairless rat skin was used as a barrier for per- meation experiments. Four formulations were prepared with fixed oil, surfactant and different cosurfactant con- tent（4%, 20% and 20%, mass fraction）, and formulation F4 with menthol added was evaluated to compare the en- hancement effect of it with those of mixed cosurfactants. The O/W microemulsion region was the largest when the mass ratio of ethanol/transcutol was 1：1. However, the region changed slightly for the system with incorporated mixed cosurfactants propylene glycol/transcutol. The flux and skin retention of IMC from O/W microemulsion with mixed cosurfactants were much higher than that with single cosurfactant（P〈0.01）, while incorporation of menthol would only enhance the drug flux through the skin. To conclude, mixed cosufactants could affect the phase behavior and improve the percutaneous absorption and penetration of IMC. Based on this, it provided a promising solution to enhance drug release from microemulsions without raising potential skin damage.
基金Supported by the National Natural Science Foundation of China(No.20573017)the Natural Science Young Foundation of Northeast Normal University, China(No.20080303)the Analysis and Testing Foundation of Northeast Normal University,China
文摘Lens-like vaterite CaCO3 microrings composed of CaCO3 nanoparticles were synthesized via a microemulsion-mediated route at room temperature with ethanol and n-hexanol as co-surfactant. This process did not demand any additional energy such as heating or continuous agitation. It was the first time to use ethanol as co-surfactant in the synthesis of micro or nanomaterials. And the ethanol was believed to play an important role in the aggregation fashion of CaCO3 nanoparticles. Moreover, shuttle-shaped nanorods, hexagonal nanoplates, and rice-like nanoparticles were also fabricated by modulating the growth parameters. Additionally, the introduce of ethanol into microemulsions as co-surfactant may be generalized as a novel green route to control the structure of other functional materials.
