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Efficacy ofβ2-adrenergic receptor agonist combined with corticosteroid in the treatment of children with cough variant asthma 被引量:2
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作者 Jun-Yi Cao Ying-Chun Wang Xiao-Xia Deng 《World Journal of Clinical Cases》 SCIE 2023年第31期7610-7618,共9页
BACKGROUND Cough variant asthma(CVA)is one of the most common respiratory diseases in children,which has a serious impact on the quality of life and daily activities of children.For severe CVA,immunomodulatory drugs a... BACKGROUND Cough variant asthma(CVA)is one of the most common respiratory diseases in children,which has a serious impact on the quality of life and daily activities of children.For severe CVA,immunomodulatory drugs are needed.AIM To evaluate the efficacy of salmeterol combined with budesonide in the treatment of pediatric CVA.METHODS 130 children with CVA from January 2020 to December 2022 were prospectively selected and randomly divided into an observation group(salmeterol combined with budesonide)and a control group(budesonide combined with a placebo).Compare the clinical efficacy of two groups before and after intervention.The evaluation parameters include cough frequency score,nocturnal cough arousal,and lung function indicators.Serum inflammatory markers,immune function markers and airway anatomical indicators were also measured.RESULTS After the intervention,the total effective rate of the observation group was significantly higher than that of the control group,and the cough frequency score and the night cough wake rate of the observation group were lower than that of the control group,with a statistically significant difference.In addition,the changes of lung function indicators,serum markers and immune function markers in the observation group were better than those in the control group.CONCLUSION The clinical efficacy of salmeterol combined with Budesonide in the treatment of CVA is better than that of Budesonide alone. 展开更多
关键词 SALMETEROL BUDESONIDE cough variant asthma PEDIATRICS Efficacy analysis
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Clinical Analysis of Dispelling Wind,Eliminating Lung and Relieving Cough Combined with Western Medicine in the Treatment of Cough Variant Asthma in Children 被引量:3
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作者 He Huang 《Journal of Clinical and Nursing Research》 2021年第5期136-141,共6页
Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough v... Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough variant asthma accepted by our hospital from January 2018 to December 2020 were randomly selected for the study and divided into two groups.One group was the reference group(40 cases)treated with procaterol hydrochloride tablets and montelukast sodium,and the other group was the research group(40 cases)・The method of eliminating wind,eliminating lung and relieving cough was combined with procaterol hydrochloride tablets and montelukast sodium to observe and compare the curative effects of the two groups.Results:There was no significant difference in TCM symptom score and eosinophil(EOS)count between the two groups before treatment(P>0.05);After treatment,the TCM symptom scores of coughs,pharyngeal itching,expectoration,nasal congestion and nasal itching in the research group were lower than those in the reference group,and the EOS count was lower than that in the reference group(P<0.05);The effective rate of research group was higher than that of reference group(P<0.05).Conclusions:For children with cough variant asthma,Qufeng Sufei cough relieving method combined with procaterol hydrochloride and montelukast sodium can improve children's symptoms and reduce eosinophil count. 展开更多
关键词 Dispelling wind Eliminating lung and relieving cough Procaterol hydrochloride Montelukast sodium CHILDREN cough variant asthma Clinical effect
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Effects of Huaiqihuang Granule on immunoglobulin, T lymphocyte subsets and cytokines in children with cough variant asthma 被引量:2
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作者 Hong-Yan Zhang Shu-Jing Zhao Fei Tian 《Journal of Hainan Medical University》 2017年第3期132-135,共4页
Objective:To observe the effect of Huaiqihuang granule on immunoglobulin, T lymphocyte subsets and cytokines in children with cough variant asthma (CVA). Methods:80 cases of children with CVA were enrolled in our hosp... Objective:To observe the effect of Huaiqihuang granule on immunoglobulin, T lymphocyte subsets and cytokines in children with cough variant asthma (CVA). Methods:80 cases of children with CVA were enrolled in our hospital from June 2015 to June 2016, and were randomly divided into study group and control group. Two groups were both given salbutamol aerosol powder. On this basis, the control group was given Montelukast Sodium Chewable Tablets, while the study group was treated with Huaiqihuang granules. The interleukin 4 (IL-4), interferon-γ(IFN-γ), IgA, IgG and IgE levels and CD4+, CD8+T lymphocyte ratio analyze in children after 3 months of treatment. Results:There were no significant differences between the two groups before treatment (P>0.05). Both IgA and IgG were significantly higher in the two groups after treatment, while IgE was significantly lower (P<0.05). Compared with the control group, the IgA and IgG in the study group were significantly higher than those in the control group (P<0.05), while IgE was significantly lower (P<0.05). After treatment, compared with the control group, the proportion of CD4+ and CD4+/CD8+ in the study group were significantly lower than that of the control group, and the CD8+ratio increased more significantly (P<0.05). After treatment, IL-4 decreased significantly, while IFN-γand IFN-γ/IL-4 were significantly increased (P<0.05), IL-4 level of the study group decreased significantly compared with the control group, and IFN-γincreased significantly compared with the control group, and the level of IFN-γ/IL-4 after treatment was significantly higher than that of the control group (P<0.05). Conclusions: Huaiqihuang granule can improve humoral immunity and cellular immunity of children with CVA, and can adjust the immune cells balance of Th1/Th2, and improve the immune function and prognosis of children with CVA. 展开更多
关键词 Huaiqihuang GRANULE cough variant asthma IMMUNOGLOBULIN T LYMPHOCYTE SUBSETS CYTOKINES
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The influence of vitamin D3 on airway inflammation and osteopontin expression in cough variant asthma rats
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作者 Jian-Wei Gu Yun Li +2 位作者 Yun-Feng Yang Yao-Dan Zhang Ju-Hua Liu 《Journal of Hainan Medical University》 2020年第10期33-37,共5页
Objective:To observe the effect of vitaminD3 on airway inflammation and osteopontin(OPN)expression on cough variant asthma(CVA)models.Methods:SD rats were randomly divided into blank group,model group and treatment gr... Objective:To observe the effect of vitaminD3 on airway inflammation and osteopontin(OPN)expression on cough variant asthma(CVA)models.Methods:SD rats were randomly divided into blank group,model group and treatment group,each group with 10 rats.The CVA model was induced by intraperitoneal injection combined with aerosolized ovalbumin(OVA),the treatment group was given 100 mg/ml of vitaminD330 minutes before challenge by administered orally.Airway hyperreaction were measured by airway resistance after inhalation of acetylcholine(Ach).Wright-Gimsa staining was used to observe the inflammatory cells in bronchoalveolar lavage fluid(BALF).HE and PAS were used to observe the morphological changes of lung tissue.OPN expression was detected by immunohistochemistry.Results:1)Airway hyperreaction:airway resistance after inhalation Ach in model group and treatment group were significantly higher than that in blank group(P<0.01),airway resistance in treatment group were lower than that in model group(P<0.01);2)Classification of inflammatory cells:The percentage of macrophages,lymphocytes,neutrophils,and eosinophils in the BALF of the model group and the treatment group were increased compared with the blank group(P<0.01),furthermore,the number of treatment group were lower than the model group(P<0.05);3)Morphological changes of lung tissue:a large amount of inflammatory cells and goblet cell proliferation were observed in the lung tissue of the model group,and these changes were slight in treatment group compared with model group;OPN expression in lung tissue:The expression of OPN in model and treatment group were increased compared with blank group(P<0.05),and the treatment group was lower than that of model group(P<0.05).The OPN content was positively correlated with the percentage of inflammatory cells in BALF(P<0.05).Conclusions:Vitamin D3 can reduce airway hyperreaction and airway inflammation in CVA rats.The mechanism may be related to the intervention of OPN expression in lung tissue. 展开更多
关键词 Vitamin D cough variant asthma OSTEOPONTIN Airway hyperreaction Airway inflammation
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Effect of glycyrrhetinic acid on Th1/Th2 balance in cough variant asthma mice
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作者 CHEN Qiu-ling ZHOU Bei +3 位作者 LI Yan-ling LIN Hui WU Yan-chun LIU Han 《Journal of Hainan Medical University》 CAS 2023年第16期1-6,共6页
Objective:To evaluate the therapeutic effect of Glycyrrhetinic Acid on cough variant asthma(CVA)mice and to investigate the possible mechanism in reducing lung inflammation.Methods:48 young female Balb/c mice were div... Objective:To evaluate the therapeutic effect of Glycyrrhetinic Acid on cough variant asthma(CVA)mice and to investigate the possible mechanism in reducing lung inflammation.Methods:48 young female Balb/c mice were divided into Control,CVA,Prednisone Acetate,Glycyrrhetinic Acid high-dose,Glycyrrhetinic Acid middle-dose and Glycyrrhetinic Acid lowdose groups randomly,with 8 mice in each group.The CVA mice model was established by ovalbumin(OVA)sensitization and OVA challenge,the animal asthma behavior was observed after drug administration,and the index of the lung of mice were recorded.The level of OVAsIgE in the bronchoalveolar lavage fluid(BALF)was tested by ELISA.The pathological changes of the lung tissue were observed by Hematoxylin and Eosin(H&E)staining.The protein expressions of T-bet,IFN-γ,Gata3,IL-4 and IL-13 in the lung tissue were determined by Western blot.Results:Compared with the CVA group,the index of lung of mice,the OVA-sIgE level in BALF and expression levels of Th2-related factor in the lung tissue of mice in Prednisone Acetate and Glycyrrhetinic Acid groups were significantly decreased(P<0.05 or P<0.01),the infiltration of inflammatory cells in the lung tissue was reduced,while expressions of Th1-related factor in the lung tissue was significantly increased(P<0.05 or P<0.01).Conclusion:Glycyrrhetinic acid has therapeutic effect on CVA mice,the underlying mechanism of Glycyrrhetinic acid alleviating lung impairment and airway inflammation may be associated with mediating the Th1/Th2 imbalance in the lung tissue. 展开更多
关键词 Glycyrrhetinic acid cough variant asthma(cva) Th1/Th2 Balance
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Experimental study on the regulation effect of Qiaoqin Qingfei agent on cough variant asthma based on airway neurogenic inflammation
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作者 HUANG Hui-si HAN Chao +4 位作者 SHI Yan-hong QI Chun-li XIONG Ai-hua ZHANG Qiuling LIANG Hui-ling 《Journal of Hainan Medical University》 CAS 2023年第9期25-32,共8页
Objective:To investigate the mechanism of regulation of airway neurogenic inflammation by Qiaoqin Qingfei agent in rats with cough variant asthma(CVA).Methods:48 SD rats were randomly divided into blank group,model gr... Objective:To investigate the mechanism of regulation of airway neurogenic inflammation by Qiaoqin Qingfei agent in rats with cough variant asthma(CVA).Methods:48 SD rats were randomly divided into blank group,model group,montelukast sodium group(1.05 mg/kg)and high,medium and low dose groups(26,13,6.5 g/kg),with 8 rats in each group.The rat CVA model was established by the method of ovalbumin(OVA)combined with aluminum hydroxide(Al(OH)3)sensitization and repeated stimulation.From the second day of sensitization,the rat CVA model was given by gavage for 28 days.The pathological changes of lung tissue were observed under microscope by HE staining.The content changes of nerve growth factor(NGF)and substance P(SP)in alveolar lavage fluid(BALF)were determined by double-antibody sandwich ABC-ELISA,and the protein expression levels of NGF and SP in lung tissue were detected by immunohistochemistry.Results:Pathological findings showed significant inflammatory manifestations in the model group,and the inflammatory infiltration in the high-dose,medium-dose and low-dose groups of Qiaoqin Qingfei agent and montelukast sodium groups were alleviated to varying degrees.Compared with blank group,the protein expression levels of NGF and SP in lung tissue of model group were significantly increased(P<0.01).Compared with model group,the protein expression levels of NGF and SP in lung tissue and the contents of NGF and SP in alveolar lavage fluid in high-dose,medium-dose and low-dose groups and montelukast sodium group were significantly decreased(P<0.05).Conclusion:Qiaoqin Qingfei agent may reduce airway inflammation and relieve cough variant asthma by regulating the protein expression levels of NGF and SP in airway neurogenic inflammation. 展开更多
关键词 Qiaoqin Qingfei agent cough variant asthma Airway neurogenic inflammation Nerve growth factor Substance P
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Effect of inhalant combined with Dingchuan Zhike decoction therapy on the airway remodeling, inflammation and PARC/CCL-18 pathways in patients with cough variant asthma
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作者 Ben Han Zi-Yan Huang 《Journal of Hainan Medical University》 2017年第8期52-56,共5页
Objective:To study the effect of inhalant combined with Dingchuan Zhike decoction therapy on the airway remodeling, inflammation and PARC/CCL-18 pathways in patients with cough variant asthma.Methods: A total of 60 pa... Objective:To study the effect of inhalant combined with Dingchuan Zhike decoction therapy on the airway remodeling, inflammation and PARC/CCL-18 pathways in patients with cough variant asthma.Methods: A total of 60 patients with cough variant asthma who were treated in our hospital between January 2014 and May 2016 were collected and divided into the control group (n=30) who received conventional inhalant treatment and the observation group (n=30) who received inhalant combined with Dingchuan Zhike decoction treatment according to single-blind randomized controlled method, and the treatment lasted for 6 months. Before treatment and after 6 months of treatment, high-resolution CT was used to determine the airway remodeling index levels, RIA method was used to detect the peripheral blood airway remodeling index contents, and enzyme-linked immunosorbent assay (ELISA) was used to detect the contents of inflammatory mediators in induced sputum and the PARC/CCL-18 in serum.Results: Before treatment, the differences in the airway remodeling degree as well as the contents of inflammatory mediators and PARC/CCL-18 were not statistically significant between the two groups. After 6 months of treatment, CT airway remodeling indexes LA and TA levels of observation group were higher than those of control group while WA level was lower than that of control group, and peripheral blood airway remodeling indexes CTGF, YKL-39, MMP-9 and TIMP-1 contents were lower tha=n those of control group;inflammatory mediators IL-5, IL-6 and IL-8 contents in induced sputum of observation group were lower than those of control group, and serum PARC/CCL-18 content was lower than that of control group.Conclusion:Inhalant combined with Dingchuan Zhike decoction can inhibit the airway remodeling and reduce the airway inflammation in patients with cough variant asthma. 展开更多
关键词 cough variant asthma Dingchuan Zhike DECOCTION Airway remodeling INFLAMMATION PARC/CCL-18 PATHWAYS
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The effectiveness and safety of HuangQiXiXin decoction for cough variant asthma:protocol for a systematic review
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作者 Qing-Qing Xia Cong Wang +2 位作者 Yu-Feng Zhang Wei-Long Jiang Jia Qi 《Clinical Research Communications》 2022年第2期5-8,共4页
Objective:A comprehensive and updated systematic review is needed to evaluate the effectiveness and safety of HuangQiXiXin decoction(HQXXD)for cough variant asthma(CVA).The aim of this systematic review protocol is to... Objective:A comprehensive and updated systematic review is needed to evaluate the effectiveness and safety of HuangQiXiXin decoction(HQXXD)for cough variant asthma(CVA).The aim of this systematic review protocol is to comprehensively assess the effectiveness and safety of HQXXD for CVA.Methods:An overall search for studies in main English and Chinese electronic databases from their inception to January 2021 will be performed.Randomized controlled trials regarding HQXXD for CVA will be included.We will use RevMan 5.3 software to perform statistical analysis and meta-analysis.Results:The findings of this systematic review will be disseminated through peer-reviewed publications.Conclusion:The systematic review will provide more evidence regarding the effectiveness and safety of HQXXD for CVA. 展开更多
关键词 HuangQiXiXin decoction cough variant asthma PROTOCOL systematic review
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Meta-analysis of the efficacy and safety of Ding-Chuan Tang in the treatment of pediatric cough variant asthma
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作者 Wen Zhang Hai-Tao Zheng Shu-Xia Ma 《Clinical Research Communications》 2022年第1期5-19,共15页
Objective:To systematically evaluate the clinical efficacy and safety of Ding-Chuan Tang in the treatment of pediatric cough variant asthma(CVA).Methods:Randomized controlled trials on the treatment of pediatric CVA w... Objective:To systematically evaluate the clinical efficacy and safety of Ding-Chuan Tang in the treatment of pediatric cough variant asthma(CVA).Methods:Randomized controlled trials on the treatment of pediatric CVA with Ding-Chuan Tang were searched by computer through the China Journal Full Text Database(CNKI),WanFang Digital Journal Full Text Database(WanFang Data),Vipe Chinese Science and Technology Journal Database(VIP),Pubmed Database,Ovid Database,Embase Database,etc.The search time was from database establishment to April 1,2021.Based on the inclusion and exclusion criteria,the Executive editor:Nuo-Xi Pi.Received:10 September 2021;Accepted:13 January 2022;Available online:19 January 2022.©2022 By Author(s).Published by TMR Publishing Group Limited.This is an open access article under the CC-BY license.(http://creativecommons.Org/licenses/BY/4.0/)two researchers independently screened the literature,extracted information,and assessed the methodological quality evaluation of the literature,and Meta-analysis was performed by RevMan 5.4 software.Results:The final number of RCTs was included 17,including cases of affected 1308 children.According to the results of the Meta-analysis:the test group was significantly better than the control group in terms of clinical efficiency,percentage of first second force expiratory volume(FEV1%),percentage of peak expiratory flow rate(PEF%),time to treatment onset,time to the disappearance of symptoms,Chinese medicine symptom score,and recurrence rate;the difference in the incidence of adverse reactions between the two groups was not statistically significant.Conclusion:The clinical treatment of pediatric CVA with Ding-Chuan Tang is effective and does not increase the incidence of adverse reactions.However,the methodological and reporting quality of existing small-sample randomized controlled trials(RCTs)is low,so evidence of efficacy must be confirmed by rigorously designed large-sample clinical trials. 展开更多
关键词 Ding-Chuan Tang pediatric cough variant asthma META-ANALYSIS systematic evaluation randomized controlled trial
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A Brief Analysis on the Characteristics of Chinese Medicine and Treatment for Cough Variant
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作者 Yuntao Duan Junming Hou +1 位作者 Yang Hui Dezhen Yang 《Journal of Clinical and Nursing Research》 2021年第4期70-72,共3页
Cough variant is a common disease of the respiratory system and can lead to a unique type of asthma.The disease has no obvious symptoms such as wheezing nor shortness of breath.Coughing is the main clinical symptom,as... Cough variant is a common disease of the respiratory system and can lead to a unique type of asthma.The disease has no obvious symptoms such as wheezing nor shortness of breath.Coughing is the main clinical symptom,as it causes airway hyper-responsiveness.Traditional Chinese medicine(TCM)has a unique understanding of this disease,and the effect is obvious after treatment,as it's based on symptom differentiation.This article takes the concept of“mild fluid retention”from“The Synopsis of the Golden Chamber”as an entry point,briefly describes the relationship between cough variant and mild fluid retention,as well as the diagnosis and treatment of Chinese medicine. 展开更多
关键词 cough variant asthma cough Mild fluid retention Resolving fluid retention with warm medicine
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小儿肺咳颗粒辅助治疗小儿支原体感染伴CVA的疗效及对炎症因子的影响
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作者 侯红丽 张汶娟 +1 位作者 周汴生 余燕娟 《临床心身疾病杂志》 CAS 2024年第5期96-100,共5页
目的探讨小儿肺咳颗粒辅助治疗小儿支原体感染伴咳嗽变异性哮喘(CVA)的疗效及对患儿白细胞介素-4(IL-4)、干扰素-γ(IFN-γ)、C反应蛋白(CRP)水平的影响。方法将92例小儿支原体感染伴CVA患儿按简单随机分组法分为观察组(46例)与对照组(4... 目的探讨小儿肺咳颗粒辅助治疗小儿支原体感染伴咳嗽变异性哮喘(CVA)的疗效及对患儿白细胞介素-4(IL-4)、干扰素-γ(IFN-γ)、C反应蛋白(CRP)水平的影响。方法将92例小儿支原体感染伴CVA患儿按简单随机分组法分为观察组(46例)与对照组(46例)。对照组患儿予以常规西药(阿奇霉素+特布他林)治疗,观察组患儿在对照组基础上联合小儿肺咳颗粒治疗,持续治疗14 d。比较两组患儿临床疗效、不良反应发生率,治疗前后中医证候积分、哮喘控制测试(ACT)、莱斯特咳嗽问卷(LCQ)、心理弹性量表(CD-RISC)评分及炎症因子(IL-4、IFN-γ、CRP)水平。结果观察组患儿治疗总有效率较对照组明显升高(P<0.05)。与对照组相比,观察组患儿治疗后中医证候积分更低(P<0.01),ACT、LCQ及CD-RISC评分更高(P<0.01)。与对照组相比,治疗后观察组患儿IL-4、CRP水平更低(P<0.01),IFN-γ水平更高(P<0.01)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论小儿肺咳颗粒辅助治疗小儿肺炎支原体感染伴CVA疗效较好,可缓解临床症状,控制哮喘进展,减轻炎症反应,提高患儿心理韧性和生活质量。 展开更多
关键词 小儿肺咳颗粒 小儿支原体感染 咳嗽变异性哮喘 疗效 白细胞介素-4 干扰素-Γ C反应蛋白
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Inflammatorymemory of lung tissue inmicewith coughvariant asthma and intervention effect of Wuhudecoction
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作者 DING Yi DENG Yijue +4 位作者 HU Yan LUO Jing LI Fanpeng SHAO Lipeng ZENG Jie 《World Journal of Integrated Traditional and Western Medicine》 2024年第1期1-8,共8页
Objective:To explore the presence of inflammatory memory in the lung tissue of mice with cough variant asthma(CVA)and the mechanism of Wuhu decoction in preventing and treating CVA.Methods:Among the 90 SPF-grade femal... Objective:To explore the presence of inflammatory memory in the lung tissue of mice with cough variant asthma(CVA)and the mechanism of Wuhu decoction in preventing and treating CVA.Methods:Among the 90 SPF-grade female BALB/c mice,20 were randomly selected as the blank group,while the remaining 70 were sensitized by intraperitoneal injection of ovalbumin(OVA)combined with aluminum hydroxide and then exposed to OVA by nebulization to establish the CVA mouse model.From the conctrol group and the model group,10 mice were randomly selected to detect airway responsiveness using an animal ventilator.Successfully modeled mice were then randomly divided into 7 groups:a CVA model group,a CVA re-challenge group,low-,medium-,and high-dose Wuhu decoction groups,and a positive control(dexamethasone)group,with 10 mice in each group.After 30 days of rest,except for the conctrol group and the model group,mice in the other groups underwent a second OVA nebulization challenge and received corresponding drug interventions once a day for 10 consecutive days before further analysis.Pathological changes in lung tissue were observed using periodic acid-schiff(PAS)and Masson staining methods.Serum levels of tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),interferon-γ(IFN-γ),and interleukin-10(IL-10)were detected using enzyme-linked immunosorbent assay(ELISA).The expression of T-bet mRNA and GATA-3 mRNA in lung tissue was determined by real-time quantitative polymerase chain reaction(Real-time PCR).Results:The results of airway responsiveness indicated successful establishment of the model.Compared with the control group,the model group exhibited severalkey pathological changes including inflammatory cellinfiltration around the lung tissue,epithelialmetaplasia,airway collagen deposition,increased airway mucus accumulation index and airway collagen deposition index(P<0.05),elevated serum TNF-αand IL-4 expression(P<0.05),decreased IFN-γand IL-10 levels(P<0.05),decreased T-bet mRNA levels(P<0.05),increased GATA-3 mRNA levels(P<0.05),and a reduced T-bet mRNA/GATA-3 mRNA ratio(P<0.05)in lung tissue.When compared to the CVA re-challenge group,the Wuhu decoction groups and the dexamethasone group effectively alleviated pathological changes in lung tissue,reduced the airway mucus accumulation index and airway collagen deposition index(P<0.05),decreased serum TNF-αand IL-4 expression(P<0.05),increased serum IFN-γand IL-10 levels(P<0.05),upregulated T-bet mRNA levels(P<0.05),downregulated GATA-3 mRNA levels(P<0.05),and increased the T-bet mRNA/GATA-3 mRNA ratio(P<0.05)in lung tissue.Conclusion:The lung tissue of mice with cough variant asthma exhibits inflammatory memory,and Wuhu decoction may intervene in this inflammatory memory by restoring the balance between T-bet and GATA-3,thereby correcting the imbalance in Th1/Th2 immunity and exerting a preventive and therapeutic effect on cough variant asthma. 展开更多
关键词 Wuhu decoction cough variant asthma(cva) Inflammatory memory
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吸入性糖皮质激素(ICS)对咳嗽变异性哮喘(CVA)的气道高反应性和诱导痰中炎性介质的影响 被引量:54
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作者 刘美璇 朱柠 陈小东 《复旦学报(医学版)》 CAS CSCD 北大核心 2013年第1期76-79,87,共5页
目的探讨吸入糖皮质激素(inhaled corticosteroid,ICS)对咳嗽变异性哮喘(cough variant asthma,CVA)患者的气道高反应性和诱导痰中炎性介质的影响。方法本实验纳入28例CVA患者作为实验CVA组及22例健康体检者作为对照组。所有研究对象治... 目的探讨吸入糖皮质激素(inhaled corticosteroid,ICS)对咳嗽变异性哮喘(cough variant asthma,CVA)患者的气道高反应性和诱导痰中炎性介质的影响。方法本实验纳入28例CVA患者作为实验CVA组及22例健康体检者作为对照组。所有研究对象治疗前均进行基础肺功能、支气管激发试验(bronchial provocating test,BPT)和诱导痰检查,入组后所有CVA患者接受正规糖皮质激素,治疗方案为布地奈德粉吸入剂400μg/d,随访观察12个月。评估治疗前后0、3、6、9、12月PD20-FEV1值,通过酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)法检测CVA组治疗前和治疗后3、6、9、12个月诱导痰IL-5、IL-10的含量,用瑞氏吉姆萨染色法计数诱导痰中的嗜酸性粒细胞(eosinophils,EOS)百分比(%)。结果治疗前CVA患者的诱导痰中IL-5含量和EOS(%)明显高于健康对照组,IL-10含量低于健康组(P<0.05)。短期(3个月)ICS即可有效提高CVA患者PD20-FEV1,ICS干预12个月后,CVA组气道高反应性达极轻度水平。CVA组诱导痰IL-5、IL-10及EOS水平分别在ICS干预3个月、6个月后较基线水平出现明显变化(P<0.05),干预12个月后CVA组各炎症观察指标皆有不同程度的恢复,但与健康对照组比较差异仍有统计学意义(P<0.05)。结论 ICS治疗可以显著降低CVA患者的AHR和气道炎症,但CVA治疗12个月也仅有50%(14例)的AHR转阴率,且气道炎症未完全消退,因此CVA的ICS疗程大多数需要12个月以上,提示ICS对CVA的疗程也需要坚持长期的原则。 展开更多
关键词 咳嗽变异性哮喘(cva) 气道炎症 气道高反应性 吸入性糖皮质激素(ICS)
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266例咳嗽变异性哮喘(CVA)的治疗分析 被引量:22
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作者 何剑 朱柠 陈小东 《复旦学报(医学版)》 CAS CSCD 北大核心 2012年第2期176-179,共4页
目的调查和分析咳嗽变异性哮喘(cough variant asthma,CVA)患者的治疗情况。方法对2007年1月至2008年12月间我院诊断为CVA的266例患者的治疗情况进行回顾性调查和分析总结。将患者分为3组,分别给予吸入性糖皮质激素(inhaled corticoster... 目的调查和分析咳嗽变异性哮喘(cough variant asthma,CVA)患者的治疗情况。方法对2007年1月至2008年12月间我院诊断为CVA的266例患者的治疗情况进行回顾性调查和分析总结。将患者分为3组,分别给予吸入性糖皮质激素(inhaled corticosteroid,ICS)联合支气管扩张剂(A组,98例)、支气管扩张剂(B组,131例)、其他药物(C组,37例)。A组为标准治疗组,B、C组为非标准治疗组。评价指标包括:治疗前后的咳嗽评分、患者对疾病认知是否正确、停药后2年内的复发率、患者对疗效是否满意、ICS治疗的使用情况。结果 266例CVA患者中,能正确认知疾病者占50.4%(134/266)。36.8%的患者接受了标准治疗,其咳嗽评分较治疗前明显改善,且优于非标准治疗组,疗效满意度较高,2年随访复发率较低;63.2%的患者接受了非标准治疗,其疗效满意度较低,2年随访复发率较高。未使用ICS联合支气管扩张剂治疗的主要原因有:担心ICS不良反应(32.7%)、不认可CVA的诊断而拒绝使用(48.2%)、认为ICS装置使用不便(8.9%)。结论目前CVA患者对疾病的认知率和规范化治疗率均较低,应加强宣教,提高患者依从性。 展开更多
关键词 咳嗽变异性哮喘(cva) 吸入性糖皮质激素(ICS) 咳嗽症状评分 依从性
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氨茶碱对CVA患者Th1/Th2及FeNO的影响 被引量:8
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作者 王学亮 周传麟 +3 位作者 刘爱文 王丽娜 谢淑奇 卞明菊 《临床肺科杂志》 2015年第5期871-873,共3页
目的探讨氨茶碱对咳嗽变异性哮喘(CVA)患者Thl/Th2平衡的调节及气道炎症的影响。方法将78例咳嗽变异性哮喘患者随机分为对照组和治疗组各39例。对照组予以布地耐德雾化吸入治疗;治疗组在对照组基础上加用氨茶碱缓释片0.1 g每日2次口服... 目的探讨氨茶碱对咳嗽变异性哮喘(CVA)患者Thl/Th2平衡的调节及气道炎症的影响。方法将78例咳嗽变异性哮喘患者随机分为对照组和治疗组各39例。对照组予以布地耐德雾化吸入治疗;治疗组在对照组基础上加用氨茶碱缓释片0.1 g每日2次口服。两组治疗前均行IFN-γ、IL-4检测,计算IFN-γ/IL-4比值,呼出气一氧化氮(Fe NO)检测评估气道炎症,2周为一疗程。结果治疗前两组IFN-γ和IL-4水平、IFN-γ/IL-4比值及Fe NO基本一致(P>0.05);治疗后IFN-γ/IL-4比值,治疗组明显高于对照组(P<0.05),治疗组Fe NO下降高于对照组(P<0.05)。结论氨茶碱对CVA患者的Thl/Th2平衡有一定的调节作用,可改善CVA患者的气道炎症,有一定的临床推广价值。 展开更多
关键词 咳嗽变异性哮喘 氨茶碱 Γ-干扰素 白介素-4 气道炎症 呼出气NO
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信必可治疗CVA的疗效及对细胞因子和小气道功能的影响 被引量:11
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作者 徐栋辉 邱忠民 徐镶怀 《临床肺科杂志》 2017年第1期85-88,共4页
目的探讨信必可辅助治疗咳嗽变异性哮喘(CVA)患者的临床效果及对患者细胞因子、小气道功能的影响作用。方法选取本院呼吸内科2015年4月-2015年12月收治的98例CVA患者进行回顾性分析,其中50例患者采用常规治疗措施(常规组),48例患者加用... 目的探讨信必可辅助治疗咳嗽变异性哮喘(CVA)患者的临床效果及对患者细胞因子、小气道功能的影响作用。方法选取本院呼吸内科2015年4月-2015年12月收治的98例CVA患者进行回顾性分析,其中50例患者采用常规治疗措施(常规组),48例患者加用信必可进行辅助治疗(信必可组),观察治疗效果差异。结果治疗前,信必可组和常规组的日间、夜间咳嗽症状积分、细胞因子、EOS计数、小气道功能指标差异无统计学意义(P>0.05);治疗后,信必可组患者的日间、夜间咳嗽症状积分、血清hs-CRP、IL-4、TNF-α及EOS计数显著的低于同期常规组患者(P<0.05);信必可组FEF25%、FEF50%、FEF75%测定值显著的高于同期常规组患者(P<0.05)。结论信必可辅助治疗CVA患者能够更加显著的改善患者的咳嗽情况,降低炎症反应水平,改善气道功能。 展开更多
关键词 信必可 咳嗽变异性哮喘 细胞因子 小气道功能
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苏黄止咳胶囊联合信必可都保治疗CVA的体会 被引量:15
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作者 曹磊 江莲 赵洪达 《临床肺科杂志》 2014年第12期2261-2262,共2页
目的观察苏黄止咳胶囊联合信必可都保(布地奈德福莫特罗粉吸入剂)治疗咳嗽变异性哮喘(CVA)的治疗效果。方法将80例诊断为咳嗽变异型哮喘的患者随机分成甲乙两组。甲组:布地奈德福莫特罗粉吸入剂(1吸/次,2次/d);乙组:予以苏黄止咳胶囊(3... 目的观察苏黄止咳胶囊联合信必可都保(布地奈德福莫特罗粉吸入剂)治疗咳嗽变异性哮喘(CVA)的治疗效果。方法将80例诊断为咳嗽变异型哮喘的患者随机分成甲乙两组。甲组:布地奈德福莫特罗粉吸入剂(1吸/次,2次/d);乙组:予以苏黄止咳胶囊(3粒/次,3次/d)联合布地奈德福莫特罗粉吸入剂(1吸/次,2次/d)。观察治疗1周后患者咳嗽症状及治疗1个月后肺功能改善状况。结果与甲组相比,乙组治疗1周后咳嗽症状及治疗1个月后肺功能明显好转(P<0.05)。结论采用苏黄止咳胶囊联合布地奈德福莫特罗粉吸入剂治疗咳嗽变异性哮喘的治疗效果更好,值得临床推广。 展开更多
关键词 苏黄止咳胶囊 布地奈德福莫特罗粉吸入剂 咳嗽变异性哮喘
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咳嗽变异性哮喘(CVA)患者支气管肺泡灌洗液中炎症因子IL-5、IL-13水平的研究 被引量:6
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作者 张雷 《中国现代医生》 2020年第20期18-22,共5页
目的研究咳嗽变异性哮喘(CVA)患者支气管肺泡灌洗液中炎症因子的水平。方法选取2018年4月~2019年10月在我院诊治的CVA患者75例为观察组,选取同期在我院诊治的非CVA慢性咳嗽患者75例为对照组,收集两组患者的支气管肺泡灌洗液,检测灌洗液... 目的研究咳嗽变异性哮喘(CVA)患者支气管肺泡灌洗液中炎症因子的水平。方法选取2018年4月~2019年10月在我院诊治的CVA患者75例为观察组,选取同期在我院诊治的非CVA慢性咳嗽患者75例为对照组,收集两组患者的支气管肺泡灌洗液,检测灌洗液中炎症因子IL-5、IL-13水平。结果CVA组患者灌洗液中的炎症因子IL-5、IL-13水平[(189.30±100.60)pg/L、(160.52±83.70)pg/L]明显高于非CVA组[(65.80±25.60)pg/L、(40.63±23.50)pg/L],差异有统计学意义(P<0.05)。结论诊断不明的慢性咳嗽患者可以行支气管肺泡灌洗液中炎症因子IL-5、IL-13水平检测以协助诊断。 展开更多
关键词 咳嗽变异性哮喘(cva) 支气管肺泡灌洗液 IL-5 IL-13
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诱导痰ECP在CVA咳嗽敏感性中的作用 被引量:2
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作者 邱志宏 余莉 +3 位作者 梁四维 徐镶怀 吕寒静 邱忠民 《中国实用医药》 2011年第33期1-4,共4页
目的探讨诱导痰嗜酸性粒细胞阳离子蛋白(eosinophil cation protein,ECP)对咳嗽变异性哮喘(cough variant asthma,CVA)患者咳嗽敏感性的影响。方法将84例CVA患者分为咳嗽敏感性增高(n=29)和正常(n=55)两个组,并以26例典型哮喘和26个健... 目的探讨诱导痰嗜酸性粒细胞阳离子蛋白(eosinophil cation protein,ECP)对咳嗽变异性哮喘(cough variant asthma,CVA)患者咳嗽敏感性的影响。方法将84例CVA患者分为咳嗽敏感性增高(n=29)和正常(n=55)两个组,并以26例典型哮喘和26个健康志愿者为对照组。受试者接受肺功能、辣椒素咳嗽敏感试验和诱导痰等检查,并用酶联免疫吸附法(ELISA)检测诱导痰上清液中ECP、组胺、PGD2、MCT、SP和NE等炎性介质的浓度。结果发现咳嗽敏感性增高CVA组诱导痰E%和ECP高于咳嗽敏感性正常组,两个CVA组诱导痰中组胺、PGD2、MCT和SP也都显著高于健康对照组。CVA患者咳嗽阈值LogC5与诱导痰ECP浓度呈显著负相关。结论诱导ECP的差异可能是导致CVA咳嗽敏感性不同的主要炎性介质基础。 展开更多
关键词 嗜酸性粒细胞阳离子蛋白 咳嗽变异性哮喘 咳嗽敏感性
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降气止咳免煎颗粒对CVA疗效及TNF-γ、IL-4和气道反应性的影响 被引量:2
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作者 苏成程 唐艳芬 +1 位作者 章匀 尤菊松 《西部中医药》 2017年第12期48-50,共3页
目的:观察降气止咳免煎颗粒治疗咳嗽变异性哮喘(cough variant asthma,CVA)的疗效及对肿瘤坏死因子γ(TNF-γ)和白介素4(IL-4)及气道反应性的影响。方法:将60例患者随机分为观察组与对照组,每组各30例,分别给予降气止咳免煎颗粒与苏黄... 目的:观察降气止咳免煎颗粒治疗咳嗽变异性哮喘(cough variant asthma,CVA)的疗效及对肿瘤坏死因子γ(TNF-γ)和白介素4(IL-4)及气道反应性的影响。方法:将60例患者随机分为观察组与对照组,每组各30例,分别给予降气止咳免煎颗粒与苏黄止咳胶囊口服,疗程4周。观察2组治疗前后证候积分及血清TNF-γ、IL-4及气道反应性的变化并进行对比分析。结果:证候总积分治疗后组间比较差异有统计学意义(P<0.05)。总有效率观察组为96.67%,对照组为93.33%,2组比较差异无统计学意义(P>0.05)。TNF-γ和IL-4治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后组间比较,差异有统计学意义(P<0.05)。气道反应性指标(PD20FEV1)治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后组间比较,差异有统计学意义(P<0.05)。2组在治疗过程中均未发现明显毒副作用(P<0.05)。结论:降气止咳免煎颗粒对CVA证候疗效与苏黄止咳胶囊相当,且安全性较好,能降低血清IL-4水平,提高血清TNF-γ水平,纠正Thl/Th2细胞因子平衡失调,有效降低气道反应性。 展开更多
关键词 咳嗽变异性哮喘 降气止咳免煎颗粒 TNF-γ IL-4 气道反应性
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