Comparative Study of Coumarin-120 (C-120) and Stilbine-3 (STB-3) Laser Dyes Doped in Sol-Gel Glasses

In 1967 the first work in solid state dye laser was performed by doping rhodamine dyes in Polymethylmethacrylate (PMMA) materials. Since then some materials like various types of polymers, co-polymers, poly composite glasses have been used as host matrices for doping different laser dyes. Polymers suffer from limited mechanical and thermal stability. Hence glasses can be the alternative hosts. However, because of high processing temperature leading to permanent destruction of dye molecules, the conventional glass preparation technique is not suitable for the introduction of organic laser dyes. This difficulty can be overcome by introducing the laser dye molecules in sol-gel glass which is prepared at low temperature. Recent work with sol-gel glasses shows that these glasses may prove to be better materials compared to polymeric materials because glasses being hard, best optically transparency in Near UV-UV and Visible region and show better photostability. In this research work we reported, comparative study of the photophysical properties of Coumarin-120 (C-120) belonging to 7-aminocoumarin family having two hydrogen atoms attached to the N atom at the 7-position, with Stilbene-3 (STB-3) in three types of HCl catalyzed SiO2 sol-gel matrices prepared by Method I, Method II and Method III respectively.

超声波辅助下合成香豆素-3-羧酸及其对有色金属的离子识别

以水杨醛为起始原料,在超声波辅助下,简便地合成了香豆素-3-羧酸(4)。利用紫外可见光光谱法和荧光光谱法研究了化合物(4)对一些有色金属离子的识别作用。结果表明,随着有色金属离子的加入,化合物(4)的紫外可见光光谱发生了红移和增色效应,荧光光谱发生猝灭现象;化合物(4)对Yb2+的识别作用最优,络合常数为7.5×106M-1。

新型含香豆素基哌嗪衍生物的超声辅助合成与表征

以水杨醛和丙二酸二乙酯为起始原料,经Knoevenagel缩合反应合成香豆素-3-羧酸乙酯,再经水解、酸化得到香豆素-3-羧酸,然后与新蒸的亚硫酰氯反应生成香豆素-3-甲酰氯,超声辅助KI催化,再与单取代哌嗪反应,合成了含有香豆素基和哌嗪两种生物活性基团的新化合物,并对中间体和目标产物的结构进行了表征。结果表明,设计的技术路线合理,反应条件温和,目标产物收率高,成本低,有较好的开发应用前景。

3-香豆素甲酸衍生物的合成与抗真菌活性

[目的]寻找有较高抗菌活性的3-香豆素甲酸衍生物。[方法]在哌啶催化下,取代水杨醛与丙二酸二乙酯发生Knoevenagel反应,生成3-香豆素甲酸乙酯类化合物,经碱性水解后得到目标化合物。采用~1H NMR、^(13)C NMR和ESI-MS对其结构进行表征。[结果]18个目标化合物在50 mg/L时对12种植物病原真菌均有不同程度的抑制活性,其中B3、B4、B6、B7、B16、B18对苹果腐烂、玉米弯孢、苹果轮纹、马铃薯干腐病菌抑制活性较高;B16对苹果腐烂、苹果轮纹病原菌的活性最高,EC_(50)值分别为8.7、19.4 mg/L。[结论]为香豆素类抗菌剂的研发提供了理论依据和技术支撑,B3、B6、B16和B18有进一步研究与开发价值。