We identified that oncological treatments in general (chemotherapies, immunotherapies and radiotherapies) frequently cause peripheral neuropathy, including cramps, characterized by excess protons due to metabolic and ...We identified that oncological treatments in general (chemotherapies, immunotherapies and radiotherapies) frequently cause peripheral neuropathy, including cramps, characterized by excess protons due to metabolic and neuronal factors, such as sudden changes in pH, uremia and aspects that affect neuromotor functions. Such situations and others like them are often neglected in treatment, which naturally concerns itself with the main problem: Cancer. Sometimes toxic solutions are implemented that have comorbid side effects, such as duloxetine (standard treatment). Based on monitoring of cancer patients who used the non-toxic product, called “Magicramp® Electrostatic Charge Reduction Cushion” (MECRC), approved in Europe more than 10 years ago, we carried out a controlled test in Brazil. In this clinical trial, we hypothesized that reducing excessive ionic charges (electrostatic charge), which is one of the side effects often described in the literature as “Chemotherapy-Induced Peripheral Neuropathy” (CIPN), would decrease or eliminate cramping, under the hypothesis that such elimination would prevent or attenuate muscular vulnerability to action impulses, and increase the power of relaxation through the same mechanism. In this double-blind and randomized clinical trial, 40 (forty) adult patients with muscle cramps caused by oncological treatments were tested, evaluating the degree of efficiency of the product that aims to reduce muscle cramps, by eliminating and/or reducing excess loads electrostatic ionic. Data from the clinical research conducted in this study are available online at https://doi.org/10.7910/DVN/QUS94U.展开更多
Background Writer＇s cramp is a type of task specific idiopathic focal dystonia and has an incompletely understood pathophysiology. The present study utilized functional magnetic resonance imaging （fMRI） to investig...Background Writer＇s cramp is a type of task specific idiopathic focal dystonia and has an incompletely understood pathophysiology. The present study utilized functional magnetic resonance imaging （fMRI） to investigate what type of brain activity correlates with writer＇s cramp and its physiological mechanism.Methods Ten patients with writer＇s cramp were age and gender matched with ten nealthy control suojects in a block design. Subjectswere scanned by fMRI while performing three consecutive, visually instructive, tasks with MR Vision 2000： （1） suppositional writing, （2） writing with finger and （3） writing with a pencil. Data was analysed using AFNI software for groups of patients and controls.Results The patients with writer＇s cramp showed significant activations of contralateral basal ganglion （especially the putamen）, motor cortex （primary sensorimotor cortex, supplementary motor cortex, premotor cortex） and ipsilateral cerebellar hemisphere in writing with a pencil compared with controls; whereas there was no obvious difference between patients and controls during writing with finger. Furthermore, these differences exist in the stibtractive activated maps for ＂writing with a pencil＂ minus ＂writing with finger＂ of patients, when the activation of subcortical area and insula in controls disappeared.Conclusions Abnormal activations of contralateral basal ganglion, motor cortex and ipsilateral cerebellar hemisphere of the patients with writer＇s cramp suggest dysfunction of basal ganglion and subcortical-cortical loop might play a pathophysiological role in writer＇s cramp.展开更多
Amyotrophic lateral sclerosis(ALS)is the most common form of motor neuron disease and is a progressive and devastating neurodegenerative disease that affects both lower and upper motor neurons.Muscle cramps,which are ...Amyotrophic lateral sclerosis(ALS)is the most common form of motor neuron disease and is a progressive and devastating neurodegenerative disease that affects both lower and upper motor neurons.Muscle cramps,which are characterized by a sudden,painful,involuntary contraction of muscles,are not rare in ALS patients.However,muscle cramps do not normally present early in ALS and therefore not used for the initial diagnosis of ALS.In this paper the authors present a case of ALS with initial manifestation of progressive painful muscle cramps in the absence of muscle weakness.This case might help people to recognize atypical foremost presentations of ALS and therefore formulate effective therapies.展开更多
文摘We identified that oncological treatments in general (chemotherapies, immunotherapies and radiotherapies) frequently cause peripheral neuropathy, including cramps, characterized by excess protons due to metabolic and neuronal factors, such as sudden changes in pH, uremia and aspects that affect neuromotor functions. Such situations and others like them are often neglected in treatment, which naturally concerns itself with the main problem: Cancer. Sometimes toxic solutions are implemented that have comorbid side effects, such as duloxetine (standard treatment). Based on monitoring of cancer patients who used the non-toxic product, called “Magicramp® Electrostatic Charge Reduction Cushion” (MECRC), approved in Europe more than 10 years ago, we carried out a controlled test in Brazil. In this clinical trial, we hypothesized that reducing excessive ionic charges (electrostatic charge), which is one of the side effects often described in the literature as “Chemotherapy-Induced Peripheral Neuropathy” (CIPN), would decrease or eliminate cramping, under the hypothesis that such elimination would prevent or attenuate muscular vulnerability to action impulses, and increase the power of relaxation through the same mechanism. In this double-blind and randomized clinical trial, 40 (forty) adult patients with muscle cramps caused by oncological treatments were tested, evaluating the degree of efficiency of the product that aims to reduce muscle cramps, by eliminating and/or reducing excess loads electrostatic ionic. Data from the clinical research conducted in this study are available online at https://doi.org/10.7910/DVN/QUS94U.
文摘Background Writer＇s cramp is a type of task specific idiopathic focal dystonia and has an incompletely understood pathophysiology. The present study utilized functional magnetic resonance imaging （fMRI） to investigate what type of brain activity correlates with writer＇s cramp and its physiological mechanism.Methods Ten patients with writer＇s cramp were age and gender matched with ten nealthy control suojects in a block design. Subjectswere scanned by fMRI while performing three consecutive, visually instructive, tasks with MR Vision 2000： （1） suppositional writing, （2） writing with finger and （3） writing with a pencil. Data was analysed using AFNI software for groups of patients and controls.Results The patients with writer＇s cramp showed significant activations of contralateral basal ganglion （especially the putamen）, motor cortex （primary sensorimotor cortex, supplementary motor cortex, premotor cortex） and ipsilateral cerebellar hemisphere in writing with a pencil compared with controls; whereas there was no obvious difference between patients and controls during writing with finger. Furthermore, these differences exist in the stibtractive activated maps for ＂writing with a pencil＂ minus ＂writing with finger＂ of patients, when the activation of subcortical area and insula in controls disappeared.Conclusions Abnormal activations of contralateral basal ganglion, motor cortex and ipsilateral cerebellar hemisphere of the patients with writer＇s cramp suggest dysfunction of basal ganglion and subcortical-cortical loop might play a pathophysiological role in writer＇s cramp.
文摘Amyotrophic lateral sclerosis(ALS)is the most common form of motor neuron disease and is a progressive and devastating neurodegenerative disease that affects both lower and upper motor neurons.Muscle cramps,which are characterized by a sudden,painful,involuntary contraction of muscles,are not rare in ALS patients.However,muscle cramps do not normally present early in ALS and therefore not used for the initial diagnosis of ALS.In this paper the authors present a case of ALS with initial manifestation of progressive painful muscle cramps in the absence of muscle weakness.This case might help people to recognize atypical foremost presentations of ALS and therefore formulate effective therapies.
