AIM: To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.
Primary liver cancer is amongst the commonest tumors worldwide,particularly in parts of the developing world,and is increasing in incidence. Over the past three decades,surgical hepatic resection has evolved from a hi...Primary liver cancer is amongst the commonest tumors worldwide,particularly in parts of the developing world,and is increasing in incidence. Over the past three decades,surgical hepatic resection has evolved from a high risk,resource intensive procedure with limited application,to a safe and commonly performed operation with a range of indications. This article reviews the approach to surgical resection for malignancies such as hepatocellular cancer,metastatic liver de-posits and neuroendocrine tumors. Survival data after resection is also reviewed,as well as indications for curative resection.展开更多
目的研究内镜黏膜下剥离术(ESD)治疗胃肠神经内分泌肿瘤(GI-NENs)及对血清血管内皮生长因子(VEGF)、嗜铬粒蛋白A(CgA)的影响。方法选择2012年1月至2018年5月收治的GI-NENs患者106例,依据随机数字表法分为ESD组和对照组,每组53例。ESD组...目的研究内镜黏膜下剥离术(ESD)治疗胃肠神经内分泌肿瘤(GI-NENs)及对血清血管内皮生长因子(VEGF)、嗜铬粒蛋白A(CgA)的影响。方法选择2012年1月至2018年5月收治的GI-NENs患者106例,依据随机数字表法分为ESD组和对照组,每组53例。ESD组行ESD治疗,对照组行内镜下黏膜切除术(EMR)治疗。观察2组病变切除、术中穿孔情况,术中出血量、手术时间及住院时间等手术相关指标。术前、术后7 d 2组血清VEGF、CgA水平,血清CD^+3CD^+4、CD^+3CD^+8、CD^+4/CD^+8等免疫指标水平。2组术后1年复发及3年生存情况。结果ESD组治愈性切除率、整块切除率均高于对照组(P<0.05);2组基底病灶残余率、术中穿孔率无差异(P>0.05)。ESD组术中出血量少于对照组,手术时间、住院时间均长于对照组(P<0.05)。术后7 d,ESD组VEGFA、VEGFB、VEGFC及CgA水平均低于对照组(P<0.05),ESD组CD^+3CD^+4、CD^+3CD^+8高于对照组,CD^+4/CD^+8低于对照组(P<0.05)。ESD组术后1年复发率低于对照组,3年生存率高于对照组(P<0.05)。结论ESD治疗GI-NENs,可有效切除病灶,降低VEGF、CgA水平,恢复机体免疫,且术后生存率高,复发率低,值得推荐于临床。展开更多
文摘AIM: To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.
基金Supported by NIHR Biomedical Research Centre funding scheme
文摘Primary liver cancer is amongst the commonest tumors worldwide,particularly in parts of the developing world,and is increasing in incidence. Over the past three decades,surgical hepatic resection has evolved from a high risk,resource intensive procedure with limited application,to a safe and commonly performed operation with a range of indications. This article reviews the approach to surgical resection for malignancies such as hepatocellular cancer,metastatic liver de-posits and neuroendocrine tumors. Survival data after resection is also reviewed,as well as indications for curative resection.
文摘目的研究内镜黏膜下剥离术(ESD)治疗胃肠神经内分泌肿瘤(GI-NENs)及对血清血管内皮生长因子(VEGF)、嗜铬粒蛋白A(CgA)的影响。方法选择2012年1月至2018年5月收治的GI-NENs患者106例,依据随机数字表法分为ESD组和对照组,每组53例。ESD组行ESD治疗,对照组行内镜下黏膜切除术(EMR)治疗。观察2组病变切除、术中穿孔情况,术中出血量、手术时间及住院时间等手术相关指标。术前、术后7 d 2组血清VEGF、CgA水平,血清CD^+3CD^+4、CD^+3CD^+8、CD^+4/CD^+8等免疫指标水平。2组术后1年复发及3年生存情况。结果ESD组治愈性切除率、整块切除率均高于对照组(P<0.05);2组基底病灶残余率、术中穿孔率无差异(P>0.05)。ESD组术中出血量少于对照组,手术时间、住院时间均长于对照组(P<0.05)。术后7 d,ESD组VEGFA、VEGFB、VEGFC及CgA水平均低于对照组(P<0.05),ESD组CD^+3CD^+4、CD^+3CD^+8高于对照组,CD^+4/CD^+8低于对照组(P<0.05)。ESD组术后1年复发率低于对照组,3年生存率高于对照组(P<0.05)。结论ESD治疗GI-NENs,可有效切除病灶,降低VEGF、CgA水平,恢复机体免疫,且术后生存率高,复发率低,值得推荐于临床。
