Sonoclot analyzer has been widely used in many countries. But the reference intervals provided by the manufacturer were derived from only 45 participants, and there was no cut-off value for transfusion for Sonoclot an...Sonoclot analyzer has been widely used in many countries. But the reference intervals provided by the manufacturer were derived from only 45 participants, and there was no cut-off value for transfusion for Sonoclot analysis. This study aimed to establish reference intervals and transfusion criterion for Sonoclot analysis. Volunteers were recruited from healthy Chinese adults and patients undergoing cardiac surgery. Blood samples were withdrawn from forearm vein and measured for activated clotting time（ACT）, clot rate（CR）, platelet function（PF）, activated partial thromboplastin time（APTT）, fibrinogen concentration（FIB）, and platelet count（PLT）. The reference intervals were determined by the nonparametric method. Cut-off values were determined by the receiver operating characteristics curve. A total of 135 healthy volunteers and 281 patients were enrolled. The 95% reference intervals were 96–195 s, 22–51 signal U/min, 〉1.6 for ACT, CR, PF respectively. In the 281 patients, the results of APTT, FIB, PLT, ACT, CR, and PF ranged from 20.5–300.0 s, 0.28–4.11 g/L,（19.0–387.3）×109/L, 80–514 s, 2.9–74 signal U/min, and 0.1–5.1 respectively. The cut-off values for transfusion were 〉208, ≤14, and ≤1.3 for ACT, CR, PF respectively. The cut-off values of Sonoclot analysis were within the manufacturer＇s reference intervals, while they were outside the reference intervals established in this study. The results suggested that the manufacturer＇s reference intervals were not suitable for Chinese. The reference intervals and cut-off values established in this study will be helpful to Chinese patients.展开更多
The intraclass correlation coefficient (ICC) plays an important role in various fields of study asa coefficient of reliability. In this paper, we consider objective Bayesian analysis for the ICCin the context of norma...The intraclass correlation coefficient (ICC) plays an important role in various fields of study asa coefficient of reliability. In this paper, we consider objective Bayesian analysis for the ICCin the context of normal linear regression model. We first derive two objective priors for theunknown parameters and show that both result in proper posterior distributions. Within aBayesian decision-theoretic framework, we then propose an objective Bayesian solution to theproblems of hypothesis testing and point estimation of the ICC based on a combined use of theintrinsic discrepancy loss function and objective priors. The proposed solution has an appealinginvariance property under one-to-one reparametrisation of the quantity of interest. Simulationstudies are conducted to investigate the performance the proposed solution. Finally, a real dataapplication is provided for illustrative purposes.展开更多
文摘Sonoclot analyzer has been widely used in many countries. But the reference intervals provided by the manufacturer were derived from only 45 participants, and there was no cut-off value for transfusion for Sonoclot analysis. This study aimed to establish reference intervals and transfusion criterion for Sonoclot analysis. Volunteers were recruited from healthy Chinese adults and patients undergoing cardiac surgery. Blood samples were withdrawn from forearm vein and measured for activated clotting time（ACT）, clot rate（CR）, platelet function（PF）, activated partial thromboplastin time（APTT）, fibrinogen concentration（FIB）, and platelet count（PLT）. The reference intervals were determined by the nonparametric method. Cut-off values were determined by the receiver operating characteristics curve. A total of 135 healthy volunteers and 281 patients were enrolled. The 95% reference intervals were 96–195 s, 22–51 signal U/min, 〉1.6 for ACT, CR, PF respectively. In the 281 patients, the results of APTT, FIB, PLT, ACT, CR, and PF ranged from 20.5–300.0 s, 0.28–4.11 g/L,（19.0–387.3）×109/L, 80–514 s, 2.9–74 signal U/min, and 0.1–5.1 respectively. The cut-off values for transfusion were 〉208, ≤14, and ≤1.3 for ACT, CR, PF respectively. The cut-off values of Sonoclot analysis were within the manufacturer＇s reference intervals, while they were outside the reference intervals established in this study. The results suggested that the manufacturer＇s reference intervals were not suitable for Chinese. The reference intervals and cut-off values established in this study will be helpful to Chinese patients.
文摘The intraclass correlation coefficient (ICC) plays an important role in various fields of study asa coefficient of reliability. In this paper, we consider objective Bayesian analysis for the ICCin the context of normal linear regression model. We first derive two objective priors for theunknown parameters and show that both result in proper posterior distributions. Within aBayesian decision-theoretic framework, we then propose an objective Bayesian solution to theproblems of hypothesis testing and point estimation of the ICC based on a combined use of theintrinsic discrepancy loss function and objective priors. The proposed solution has an appealinginvariance property under one-to-one reparametrisation of the quantity of interest. Simulationstudies are conducted to investigate the performance the proposed solution. Finally, a real dataapplication is provided for illustrative purposes.
