Today the most important challenge facing the pediatrician is the increasing prevalence of chronic diseases. With this regard, pediatricians play a key role in the management of these conditions. The closeness with th...Today the most important challenge facing the pediatrician is the increasing prevalence of chronic diseases. With this regard, pediatricians play a key role in the management of these conditions. The closeness with the family, the knowledge of the clinical case and the care continuity allow the pediatrician to acquire a position of director of every case. When pathological events have a chronic feature, suddenly the quality of life of the whole family changes. For this reason the first communication of chronic disease is very important and the task of the pediatrician should be to provide a positive message to help the family in facing the difficulty of this new challenge. The bronchial asthma is the most common chronic disease worldwide. The incidence, the prevalence, and the mortality of the disease have increased in children over the past decades. These trends are particularly marked above all in preschool children. The success reached by Pediatricians is closely related to the compliance and the implementation of the therapy followed by the little patient and his family. With this regard authors, in this review, focus on the illustration of several strategies, based on the pediatrician’ skills and medicine documents, that can be used for the improvement of communication among pedia- trician-family and child, never forgetting the hu- man aspect of the same doctor, that should con- ciliate with the scientific knowledge in the taking care of a specific chronic disease.展开更多
The delay fault induced by cross-talk effect is one of the difficult problems in the fault diagnosis of digital circuit. An intelligent fault diagnosis based on IDDT testing and support vector machines （SVM） classif...The delay fault induced by cross-talk effect is one of the difficult problems in the fault diagnosis of digital circuit. An intelligent fault diagnosis based on IDDT testing and support vector machines （SVM） classifier was proposed in this paper. Firstly, the fault model induced by cross-talk effect and the IDDT testing method were analyzed, and then a delay fault localization method based on SVM was presented. The fault features of the sampled signals were extracted by wavelet packet decomposition and served as input parameters of SVM classifier to classify the different fault types. The simulation results illustrate that the method presented is accurate and effective, reaches a high diagnosis rate above 95%.展开更多
Objective： BCR/ABL oncoprotein-expression is associated with uncontrolled cell growth. Sphingosine kinase 1 （SPK1） regulates the production of sphingosine 1-phosphate （S1P）, a key lipid signal molecular in cell p...Objective： BCR/ABL oncoprotein-expression is associated with uncontrolled cell growth. Sphingosine kinase 1 （SPK1） regulates the production of sphingosine 1-phosphate （S1P）, a key lipid signal molecular in cell proliferation and survival. The objective of this study was to elucidate the roles of S1P and its receptors in bcr/abl positive chronic myeloid leukemia （CML） cells. Methods： The expressions of SIP receptors： S1P1, S1P2 and S1P3 in CML cells were detected by RT-PCR. SPK1 expression, activity and extracellular S1P were determined in ECV304 and HL-60 cells which were transfected with bcr/abl gene. To elucidate the relationship between the BCR/ABL, ERK/MAPK （extracellular signal-regulated kinase/mitogen-activated protein kinase）, SPK/S 1P and S 1P/S 1 P2 signal pathways, bcr/abl positive CML cell line K562 was treated with STI571, PD98059, N,N-dimethyl sphingosine （DMS） and JTE-013. Results： Retrovirus-mediated overexpression of bcr/abl gene in ECV304 and HL-60 cells resulted in upregulation of the expression, activity of SPK1 and increase of the secretion of SIP, whereas treatment of STI571 and PD98059 decreased the BCR/ABL-induced S1P secretion. Treatment of DMS reduced S1P secretion and P42/44MAPK phosphorylation. S1P2-selective antagonist JTE-013 could also decrease P42/44MAPK phosphorylation. Conclusion： These results suggest that BCR/ABL up-regulates extracellular sphingosine 1-phosphate through sphingosine kinase 1 and there is cross-talk between SPK1/S1P/S1P2 and P42/44MAPK in bcr/abl positive CML cells.展开更多
Packages in Chinese cross talk are the origin of cross talk humor.By using the literature investigation method,the paper find the effect of humor when create the packages and unpack the packages,which is the process t...Packages in Chinese cross talk are the origin of cross talk humor.By using the literature investigation method,the paper find the effect of humor when create the packages and unpack the packages,which is the process that audiences construct mental spaces and create mappings between mental spaces,but the detail process of mental spaces and the mappings of mental spaces is uncertain.Thus,the paper uses literature investigation and illustration as the main research methods.This paper means to make a better understanding of the humor of cross talk and can help to create more humor discourse.展开更多
Experimental data analysis and simulation calculations were performed in order to evaluate the cross-talk rejection performance of a typical neutron detection array. For very closely packed scintillation bars, the CT ...Experimental data analysis and simulation calculations were performed in order to evaluate the cross-talk rejection performance of a typical neutron detection array. For very closely packed scintillation bars, the CT rejection may rely on the position relation between the two signals. The criteria ｜△x｜≤ 15 cm and ｜△y｜≤12 cm are currently proposed for a rejection rate higher than 90%. For signals coming from distanced bars, the energy conservation relationship can be applied to reject the CT events with a similar performance. In both cases the results of simulation agree very well with the experimental data, assuring their applicability to other detection systems and physics problems.展开更多
In this paper, an optical waveguide junction is introduced to reduce crosstalk based on a hexagonal structure of photonic crystals for TE modes. The wavelength is 1330 nm which is an important wavelength for optical f...In this paper, an optical waveguide junction is introduced to reduce crosstalk based on a hexagonal structure of photonic crystals for TE modes. The wavelength is 1330 nm which is an important wavelength for optical fiber data transmission. Simulation results show that the proposed design exhibits a reduction of -50 dB in crosstalk. It translates to a considerable isolation improvement between two crossover waveguides. FDTD method is used to obtain the transmission coefficient.展开更多
Value-at-Risk （VaR） estimation via Monte Carlo （MC） simulation is studied here. The variance reduction technique is proposed in order to speed up MC algorithm. The algorithm for estimating the probability of high ...Value-at-Risk （VaR） estimation via Monte Carlo （MC） simulation is studied here. The variance reduction technique is proposed in order to speed up MC algorithm. The algorithm for estimating the probability of high portfolio losses （more general risk measure） based on the Cross - Entropy importance sampling is developed. This algorithm can easily be applied in any light- or heavy-tailed case without an extra adaptation. Besides, it does not loose in the performance in comparison to other known methods. A numerical study in both cases is performed and the variance reduction rate is compared with other known methods. The problem of VaR estimation using procedures for estimating the probability of high portfolio losses is also discussed.展开更多
肿瘤的发生发展涉及多个细胞信号传导通路,其中核因子-κB(Nuclear factor-kappaB,NF-κB)通路和哺乳动物雷帕霉素靶蛋白(Mammalian target of rapamycin,mTOR)通路尤为重要,已成为研究肿瘤药物治疗的新靶点。进一步探讨两信号通路间存...肿瘤的发生发展涉及多个细胞信号传导通路,其中核因子-κB(Nuclear factor-kappaB,NF-κB)通路和哺乳动物雷帕霉素靶蛋白(Mammalian target of rapamycin,mTOR)通路尤为重要,已成为研究肿瘤药物治疗的新靶点。进一步探讨两信号通路间存在的交联(Cross-talk)及其对肿瘤生物学特性的影响,有助于更好地调控肿瘤细胞的恶性行为。展开更多
文摘Today the most important challenge facing the pediatrician is the increasing prevalence of chronic diseases. With this regard, pediatricians play a key role in the management of these conditions. The closeness with the family, the knowledge of the clinical case and the care continuity allow the pediatrician to acquire a position of director of every case. When pathological events have a chronic feature, suddenly the quality of life of the whole family changes. For this reason the first communication of chronic disease is very important and the task of the pediatrician should be to provide a positive message to help the family in facing the difficulty of this new challenge. The bronchial asthma is the most common chronic disease worldwide. The incidence, the prevalence, and the mortality of the disease have increased in children over the past decades. These trends are particularly marked above all in preschool children. The success reached by Pediatricians is closely related to the compliance and the implementation of the therapy followed by the little patient and his family. With this regard authors, in this review, focus on the illustration of several strategies, based on the pediatrician’ skills and medicine documents, that can be used for the improvement of communication among pedia- trician-family and child, never forgetting the hu- man aspect of the same doctor, that should con- ciliate with the scientific knowledge in the taking care of a specific chronic disease.
基金Supported by the National Natural Science Foun-dation of China (60374008 ,60501022)
文摘The delay fault induced by cross-talk effect is one of the difficult problems in the fault diagnosis of digital circuit. An intelligent fault diagnosis based on IDDT testing and support vector machines （SVM） classifier was proposed in this paper. Firstly, the fault model induced by cross-talk effect and the IDDT testing method were analyzed, and then a delay fault localization method based on SVM was presented. The fault features of the sampled signals were extracted by wavelet packet decomposition and served as input parameters of SVM classifier to classify the different fault types. The simulation results illustrate that the method presented is accurate and effective, reaches a high diagnosis rate above 95%.
基金supported by the National Natural Science Foundation of China (No. 30570782).
文摘Objective： BCR/ABL oncoprotein-expression is associated with uncontrolled cell growth. Sphingosine kinase 1 （SPK1） regulates the production of sphingosine 1-phosphate （S1P）, a key lipid signal molecular in cell proliferation and survival. The objective of this study was to elucidate the roles of S1P and its receptors in bcr/abl positive chronic myeloid leukemia （CML） cells. Methods： The expressions of SIP receptors： S1P1, S1P2 and S1P3 in CML cells were detected by RT-PCR. SPK1 expression, activity and extracellular S1P were determined in ECV304 and HL-60 cells which were transfected with bcr/abl gene. To elucidate the relationship between the BCR/ABL, ERK/MAPK （extracellular signal-regulated kinase/mitogen-activated protein kinase）, SPK/S 1P and S 1P/S 1 P2 signal pathways, bcr/abl positive CML cell line K562 was treated with STI571, PD98059, N,N-dimethyl sphingosine （DMS） and JTE-013. Results： Retrovirus-mediated overexpression of bcr/abl gene in ECV304 and HL-60 cells resulted in upregulation of the expression, activity of SPK1 and increase of the secretion of SIP, whereas treatment of STI571 and PD98059 decreased the BCR/ABL-induced S1P secretion. Treatment of DMS reduced S1P secretion and P42/44MAPK phosphorylation. S1P2-selective antagonist JTE-013 could also decrease P42/44MAPK phosphorylation. Conclusion： These results suggest that BCR/ABL up-regulates extracellular sphingosine 1-phosphate through sphingosine kinase 1 and there is cross-talk between SPK1/S1P/S1P2 and P42/44MAPK in bcr/abl positive CML cells.
文摘Packages in Chinese cross talk are the origin of cross talk humor.By using the literature investigation method,the paper find the effect of humor when create the packages and unpack the packages,which is the process that audiences construct mental spaces and create mappings between mental spaces,but the detail process of mental spaces and the mappings of mental spaces is uncertain.Thus,the paper uses literature investigation and illustration as the main research methods.This paper means to make a better understanding of the humor of cross talk and can help to create more humor discourse.
基金supported by the National Basic Research Program of China (No. 2007CB815002)the Fundamental Research Funds for the Central Universities of China (HEUCF101501)Harbin Engineering University of China (002150260713)
文摘Experimental data analysis and simulation calculations were performed in order to evaluate the cross-talk rejection performance of a typical neutron detection array. For very closely packed scintillation bars, the CT rejection may rely on the position relation between the two signals. The criteria ｜△x｜≤ 15 cm and ｜△y｜≤12 cm are currently proposed for a rejection rate higher than 90%. For signals coming from distanced bars, the energy conservation relationship can be applied to reject the CT events with a similar performance. In both cases the results of simulation agree very well with the experimental data, assuring their applicability to other detection systems and physics problems.
文摘In this paper, an optical waveguide junction is introduced to reduce crosstalk based on a hexagonal structure of photonic crystals for TE modes. The wavelength is 1330 nm which is an important wavelength for optical fiber data transmission. Simulation results show that the proposed design exhibits a reduction of -50 dB in crosstalk. It translates to a considerable isolation improvement between two crossover waveguides. FDTD method is used to obtain the transmission coefficient.
文摘Value-at-Risk （VaR） estimation via Monte Carlo （MC） simulation is studied here. The variance reduction technique is proposed in order to speed up MC algorithm. The algorithm for estimating the probability of high portfolio losses （more general risk measure） based on the Cross - Entropy importance sampling is developed. This algorithm can easily be applied in any light- or heavy-tailed case without an extra adaptation. Besides, it does not loose in the performance in comparison to other known methods. A numerical study in both cases is performed and the variance reduction rate is compared with other known methods. The problem of VaR estimation using procedures for estimating the probability of high portfolio losses is also discussed.
基金This work was supported by the National Science Fundation of China for Outstanding Young Investigators (No. 30625033)the National Natural Science Foundation of China (No. 30471923, 30500577)the National Basic Research Development Program ofChina (No. 2007CB512106).
文摘肿瘤的发生发展涉及多个细胞信号传导通路,其中核因子-κB(Nuclear factor-kappaB,NF-κB)通路和哺乳动物雷帕霉素靶蛋白(Mammalian target of rapamycin,mTOR)通路尤为重要,已成为研究肿瘤药物治疗的新靶点。进一步探讨两信号通路间存在的交联(Cross-talk)及其对肿瘤生物学特性的影响,有助于更好地调控肿瘤细胞的恶性行为。
