Correlations of the expression of Cx43,SCF^(FBXW7),p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ubiquitination.Conversely,reduced expression results in a loss of this capacity to facilitate cyclin E degradation.The ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical residues.AIM To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon cancer.METHODS Expression levels of Cx43,SCF^(FBXW7),p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their correlations.RESULTS Positive rate of Cx43,SCF^(FBXW7),p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%respectively.Positive expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node metastasis.Cx43 and SCF^(FBXW7)(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCF^(FBXW7) and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon cancer.CONCLUSION Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCF^(FBXW7),thereby influencing the ubiquitination and degradation of cyclin E1.

Multi-Scenario Probabilistic Load Flow Calculation Considering Wind Speed Correlation

As the proportion of newenergy increases,the traditional cumulant method(CM)produces significant errorswhen performing probabilistic load flow(PLF)calculations with large-scale wind power integrated.Considering the wind speed correlation,a multi-scenario PLF calculation method that combines random sampling and segmented discrete wind farm power was proposed.Firstly,based on constructing discrete scenes of wind farms,the Nataf transform is used to handle the correlation between wind speeds.Then,the random sampling method determines the output probability of discrete wind power scenarios when wind speed exhibits correlation.Finally,the PLF calculation results of each scenario areweighted and superimposed following the total probability formula to obtain the final power flow calculation result.Verified in the IEEE standard node system,the absolute percent error(APE)for the mean and standard deviation(SD)of the node voltages and branch active power are all within 1%,and the average root mean square(AMSR)values of the probability curves are all less than 1%.

Canopy structural heterogeneity drivesαandβspeciesegenetic diversity correlations in a Chinese subtropical forest

Patterns and drivers of species–genetic diversity correlations(SGDCs)have been broadly examined across taxa and ecosystems and greatly deepen our understanding of how biodiversity is maintained.However,few studies have examined the role of canopy structural heterogeneity,which is a defining feature of forests,in shaping SGDCs.Here,we determine what factors contribute toα-andβ-species–genetic diversity correlations(i.e.,α-andβ-SGDCs)in a Chinese subtropical forest.For this purpose,we used neutral molecular markers to assess genetic variation in almost all adult individuals of the dominant tree species,Lithocarpus xylocarpus,across plots in the Ailaoshan National Natural Reserve.We also quantified microhabitat variation by quantifying canopy structure heterogeneity with airborne laser scanning on 201-ha subtropical forest plots.We found that speciesα-diversity was negatively correlated with geneticα-diversity.Canopy structural heterogeneity was positively correlated with speciesα-diversity but negatively correlated with geneticα-diversity.These contrasting effects contributed to the formation of a negativeα-SGDC.Further,we found that canopy structural heterogeneity increases speciesα-diversity and decreases geneticα-diversity by reducing the population size of target species.Speciesβ-diversity,in contrast,was positively correlated with geneticβ-diversity.Differences in canopy structural heterogeneity between plots had non-linear parallel effects on the two levels ofβ-diversity,while geographic distance had a relatively weak effect onβ-SGDC.Our study indicates that canopy structural heterogeneity simultaneously affects plot-level community species diversity and population genetic diversity,and species and genetic turnover across plots,thus drivingα-andβ-SGDCs.

Cross-Project Software Defect Prediction Based on SMOTE and Deep Canonical Correlation Analysis

Cross-Project Defect Prediction(CPDP)is a method that utilizes historical data from other source projects to train predictive models for defect prediction in the target project.However,existing CPDP methods only consider linear correlations between features(indicators)of the source and target projects.These models are not capable of evaluating non-linear correlations between features when they exist,for example,when there are differences in data distributions between the source and target projects.As a result,the performance of such CPDP models is compromised.In this paper,this paper proposes a novel CPDP method based on Synthetic Minority Oversampling Technique(SMOTE)and Deep Canonical Correlation Analysis(DCCA),referred to as S-DCCA.Canonical Correlation Analysis(CCA)is employed to address the issue of non-linear correlations between features of the source and target projects.S-DCCA extends CCA by incorporating the MlpNet model for feature extraction from the dataset.The redundant features are then eliminated by maximizing the correlated feature subset using the CCA loss function.Finally,cross-project defect prediction is achieved through the application of the SMOTE data sampling technique.Area Under Curve(AUC)and F1 scores(F1)are used as evaluation metrics.This paper conducted experiments on 27 projects from four public datasets to validate the proposed method.The results demonstrate that,on average,our method outperforms all baseline approaches by at least 1.2%in AUC and 5.5%in F1 score.This indicates that the proposed method exhibits favorable performance characteristics.

People Recognition by RGB and NIR Analysis from Digital Image Database Using Cross-Correlation and Wavelets

This document presents a framework for recognizing people by palm vein distribution analysis using cross-correlation based signatures to obtain descriptors. Haar wavelets are useful in reducing the number of features while maintaining high recognition rates. This experiment achieved 97.5% of individuals classified correctly with two levels of Haar wavelets. This study used twelve-version of RGB and NIR (near infrared) wavelength images per individual. One hundred people were studied;therefore 4,800 instances compose the complete database. A Multilayer Perceptron (MLP) was trained to improve the recognition rate in a k-fold cross-validation test with k = 10. Classification results using MLP neural network were obtained using Weka (open source machine learning software).

Cross-Correlation between Global Temperature and Atmospheric CO2 with a Temperature-Leading Time Lag

The temperature change and rate of CO2 change are correlated with a time lag, as reported in a previous paper. The correlation was investigated by calculating a correlation coefficient r of these changes for selected ENSO events in this study. Annual periodical increases and decreases in the CO2 concentration were considered, with a regular pattern of minimum values in August and maximum values in May each year. An increased deviation in CO2 and temperature was found in response to the occurrence of El Niño, but the increase in CO2 lagged behind the change in temperature by 5 months. This pattern was not observed for La Niña events. An increase in global CO2 emissions and a subsequent increase in global temperature proposed by IPCC were not observed, but an increase in global temperature, an increase in soil respiration, and a subsequent increase in global CO2 emissions were noticed. This natural process can be clearly detected during periods of increasing temperature specifically during El Niño events. The results cast strong doubts that anthropogenic CO2 is the cause of global warming.

Channel Correlation Based User Grouping Algorithm for Nonlinear Precoding Satellite Communication System

Low Earth Orbit(LEO)multibeam satellites will be widely used in the next generation of satellite communication systems,whose inter-beam interference will inevitably limit the performance of the whole system.Nonlinear precoding such as Tomlinson-Harashima precoding(THP)algorithm has been proved to be a promising technology to solve this problem,which has smaller noise amplification effect compared with linear precoding.However,the similarity of different user channels(defined as channel correlation)will degrade the performance of THP algorithm.In this paper,we qualitatively analyze the inter-beam interference in the whole process of LEO satellite over a specific coverage area,and the impact of channel correlation on Signal-to-Noise Ratio(SNR)of receivers when THP is applied.One user grouping algorithm is proposed based on the analysis of channel correlation,which could decrease the number of users with high channel correlation in each precoding group,thus improve the performance of THP.Furthermore,our algorithm is designed under the premise of co-frequency deployment and orthogonal frequency division multiplexing(OFDM),which leads to more users under severe inter-beam interference compared to the existing research on geostationary orbit satellites broadcasting systems.Simulation results show that the proposed user grouping algorithm possesses higher channel capacity and better bit error rate(BER)performance in high SNR conditions relative to existing works.

Repeatability,interocular correlation and agreement of optic nerve head vessel density in healthy eyes:a sweptsource optical coherence tomographic angiography study

AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy subjects.METHODS:Thir ty-three healthy subjects were enrolled.The ONH of both eyes were imaged four times by a swept-source-OCTA using a 3 mm×3 mm scanning protocol.Images of the radial peripapillary capillary were analyzed by a customized Matlab program,and the vessel density,fractal dimension,and vessel diameter index were measured.The repeatability of the four scans was determined by the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analysis using the Pearson correlation coefficient,ICC and Bland-Altman plots.RESULTS:All swept-source-OCTA ONH parameters exhibited certain repeatability,with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary vessel density(ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary vessel density exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.26%to 6.21%for circumpapillary vessel density.CONCLUSION:OCTA ONH parameters demonstrate good repeatability in healthy subjects.The interocular correlations of papillary vessel density,fractal dimension and vessel diameter index are high,but the correlation for circumpapillary vessel density is moderate.

Assessment of Dependent Performance Shaping Factors in SPAR-H Based on Pearson Correlation Coefficient

With the improvement of equipment reliability,human factors have become the most uncertain part in the system.The standardized Plant Analysis of Risk-Human Reliability Analysis(SPAR-H)method is a reliable method in the field of human reliability analysis(HRA)to evaluate human reliability and assess risk in large complex systems.However,the classical SPAR-H method does not consider the dependencies among performance shaping factors(PSFs),whichmay cause overestimation or underestimation of the risk of the actual situation.To address this issue,this paper proposes a new method to deal with the dependencies among PSFs in SPAR-H based on the Pearson correlation coefficient.First,the dependence between every two PSFs is measured by the Pearson correlation coefficient.Second,the weights of the PSFs are obtained by considering the total dependence degree.Finally,PSFs’multipliers are modified based on the weights of corresponding PSFs,and then used in the calculating of human error probability(HEP).A case study is used to illustrate the procedure and effectiveness of the proposed method.

Composition of high frequency ambient noise from cross-correlation:A case study using a small aperture array

Long-time cross correlation of ambient noise has been proved as a powerful tool to extract Green＇s function between two receivers. The study of composition of ambient noise is important for a better understanding of this method. Previous studies confirm that ambient noise in the long period （3 s and longer） mostly consists of surface wave, and 0.25-2.5 s noise consists more of body waves. In this paper, we perform cross correlation processing at much higher frequency （30-70 Hz） using ambient noise recorded by a small aperture array. No surface waves emerge from noise correlation function （NCF）, but weak P waves emerge. The absence of surface wave in NCF is not due to high attenuation since surface waves are strong from active source, therefore probably the high ambient noise mostly consists of body wave and lacks surface wave. Origin of such high frequency body waves in ambient noise remains to be studied.

Structural identification and antioxidative activity evaluation of flaxseed lignan macromolecules: structure-activity correlation

Flaxseed lignan macromolecules(FLM)are a class of important secondary metabolites in fl axseed,which have been widely concerned due to their biological and pharmacological properties,especially for their antioxidative activity.For the composition and structure of FLM,our results confirmed that ferulic acid glycoside(FerAG)was directly ester-linked with herbacetin diglucoside(HDG)or pinoresinol diglucoside(PDG),which might determine the beginning of FLM biosynthesis.Additionally,p-coumaric acid glycoside(CouAG)might determine the end of chain extension during FLM synthesis in fl axseed.FLM exhibited higher antioxidative activity in polar systems,as shown by its superior 1,1-diphenyl-2-picrylhydrazyl(DPPH)free radical scavenging capacity compared to the 2,2’-azinobis(3-ehtylbenzothiazolin-6-sulfnic acid)(ABTS)cation free radical scavenging capacity in non-polar systems.Moreover,the antioxidative activity of FLM was found to be highly dependent on its composition and structure.In particular,it was positively correlated with the number of phenolic hydroxyl groups(longer FLM chains)and inversely related to the steric hindrance at the ends(lower levels of FerAG and CouAG).These fi ndings verifi ed the potential application of FLM in nonpolar systems,particularly in functional food emulsions。

First results of turbulence investigation on Globus-M2 using radial correlation Doppler reflectometry

The first results of investigation of the turbulence structure using Doppler backscattering(DBS)on the Globus-M2 tokamak are presented.A one-channel DBS system with a variable probing frequency within the 18–26 GHz range was installed to investigate the edge plasma at normalized minor radiiρ=0.9–1.1.Radial correlation Doppler reflectometry was used to study the changes in turbulence eddies after the LH transition.Correlation analysis was applied to the phase derivative of complex in-phase and quadrature(IQ)signals of the DBS diagnostic as it contains information about the poloidal plasma rotation velocity.In L-mode,the radial correlation length L_(r)is estimated to be 3 cm and after transition to H-mode reduces to approximately 2 cm.Gyrokinetic modelling in a linear local approximation using code GENE indicates that the instability with positive growth rate at the normalized minor radiusρ=0.75 in L-mode and H-mode on Globus-M2 was the ion temperature gradient(ITG)mode.

A Hand Features Based Fusion Recognition Network with Enhancing Multi-Modal Correlation

Fusing hand-based features in multi-modal biometric recognition enhances anti-spoofing capabilities.Additionally,it leverages inter-modal correlation to enhance recognition performance.Concurrently,the robustness and recognition performance of the system can be enhanced through judiciously leveraging the correlation among multimodal features.Nevertheless,two issues persist in multi-modal feature fusion recognition:Firstly,the enhancement of recognition performance in fusion recognition has not comprehensively considered the inter-modality correlations among distinct modalities.Secondly,during modal fusion,improper weight selection diminishes the salience of crucial modal features,thereby diminishing the overall recognition performance.To address these two issues,we introduce an enhanced DenseNet multimodal recognition network founded on feature-level fusion.The information from the three modalities is fused akin to RGB,and the input network augments the correlation between modes through channel correlation.Within the enhanced DenseNet network,the Efficient Channel Attention Network(ECA-Net)dynamically adjusts the weight of each channel to amplify the salience of crucial information in each modal feature.Depthwise separable convolution markedly reduces the training parameters and further enhances the feature correlation.Experimental evaluations were conducted on four multimodal databases,comprising six unimodal databases,including multispectral palmprint and palm vein databases from the Chinese Academy of Sciences.The Equal Error Rates(EER)values were 0.0149%,0.0150%,0.0099%,and 0.0050%,correspondingly.In comparison to other network methods for palmprint,palm vein,and finger vein fusion recognition,this approach substantially enhances recognition performance,rendering it suitable for high-security environments with practical applicability.The experiments in this article utilized amodest sample database comprising 200 individuals.The subsequent phase involves preparing for the extension of the method to larger databases.

Correlation between Hysterosonography and Hysteroscopy in the Diagnosis of Submucosal Fibroids in Women Attending the Gynaecological Endoscopic Surgery and Human Reproductive Teaching Hospital (CHRACERH)

Background: Submucosal myomas can be responsible for abnormal bleeding, spontaneous abortions or even infertility. Objectives: This study aimed to study the correlation between the diagnosis and classification of submucosal fibroids at hysterosonography and at hysteroscopy at Gynaecological Endoscopic Surgery and Human Reproductive Teaching Hospital (CHRACERH), Yaoundé, Cameroon. Methodology: We conducted a hospital-based cross-sectional study with retrospective data collection. Included were the files of patients in whom a hysteroscopy for uterine cavity evaluation was done from the 1st of January 2020 to the 31st of July 2022. The data collected were analysed using SPSS version 25 and Microsoft Excel 2013. Hysterosonographic findings were compared to those of hysteroscopy using Cohen’s kappa inter-observer agreement test. Results: A total of 104 women had available hysterosonography results prior to diagnostic hysteroscopy. The ages of the participants ranged from 26 to 65 years with a mean age of 39.92 ± 7.02 years. A total of 69 submucosal fibroids were identified at hysterosonography and 47 (68.1%) were found at hysteroscopy. There was agreement between the two methods in 13/17 (76.5%) cases of FIGO 0 fibroids, 21/30 (70.0%) of FIGO 1 fibroids and 13/22 (59.1%) of FIGO 2 fibroids. The overall agreement was moderate with a kappa coefficient of 0.478 (p Conclusion: The results present hysteroscopy as the gold standard for the diagnosis of submucosal myomas, but clinicians need to recognize utility of hysterosonography in certain situations.

Study of baryon number transport dynamics and strangeness conservation effects using Ω-hadron correlations

In nuclear collisions at RHIC energies, an excess of Ω hyperons over ■ is observed, indicating that Ω has a net baryon number despite s and s quarks being produced in pairs. The baryon number in Ω may have been transported from the incident nuclei and/or produced in the baryon-pair production of Ω with other types of anti-hyperons such as Ξ. To investigate these two scenarios, we propose to measure the correlations between Ω and K and between Ω and anti-hyperons. We use two versions, the default and string-melting, of a multiphase transport(AMPT) model to illustrate the method for measuring the correlation and to demonstrate the general shape of the correlation. We present the Ω-hadron correlations from simulated Au+Au collisions at ■ =7.7 and 14.6 Ge V and discuss the dependence on the collision energy and on the hadronization scheme in these two AMPT versions. These correlations can be used to explore the mechanism of baryon number transport and the effects of baryon number and strangeness conservation on nuclear collisions.

Track correlation algorithm based on CNN-LSTM for swarm targets

The rapid development of unmanned aerial vehicle(UAV) swarm, a new type of aerial threat target, has brought great pressure to the air defense early warning system. At present, most of the track correlation algorithms only use part of the target location, speed, and other information for correlation.In this paper, the artificial neural network method is used to establish the corresponding intelligent track correlation model and method according to the characteristics of swarm targets.Precisely, a route correlation method based on convolutional neural networks (CNN) and long short-term memory (LSTM)Neural network is designed. In this model, the CNN is used to extract the formation characteristics of UAV swarm and the spatial position characteristics of single UAV track in the formation,while the LSTM is used to extract the time characteristics of UAV swarm. Experimental results show that compared with the traditional algorithms, the algorithm based on CNN-LSTM neural network can make full use of multiple feature information of the target, and has better robustness and accuracy for swarm targets.

A News Media Bias and Factuality Profiling Framework Assisted by Modeling Correlation

News media profiling is helpful in preventing the spread of fake news at the source and maintaining a good media and news ecosystem.Most previous works only extract features and evaluate media from one dimension independently,ignoring the interconnections between different aspects.This paper proposes a novel news media bias and factuality profiling framework assisted by correlated features.This framework models the relationship and interaction between media bias and factuality,utilizing this relationship to assist in the prediction of profiling results.Our approach extracts features independently while aligning and fusing them through recursive convolu-tion and attention mechanisms,thus harnessing multi-scale interactive information across different dimensions and levels.This method improves the effectiveness of news media evaluation.Experimental results indicate that our proposed framework significantly outperforms existing methods,achieving the best performance in Accuracy and F1 score,improving by at least 1%compared to other methods.This paper further analyzes and discusses based on the experimental results.

Dynamics of Non-Markovianity, Quantum Correlations and Information Scrambling of Three Qubits Systems Interacting via Rashba Interaction

The behavior of the quantum correlations, information scrambling and the non-Markovianity of three entangling qubits systems via Rashba is discussed. The results showed that, the three physical quantities oscillate between their upper and lower bounds, where the number of oscillations increases as the Rashba interaction strength increases. The exchanging rate of these three quantities depends on the Rashba strength, and whether the entangled state is generated via direct/indirect interaction. Moreover, the coherence parameter can be used as a control parameter to maximize or minimize the three physical quantities.

Anomalous Hall effect and electronic correlation in a spin-reoriented kagome antiferromagnet LuFe_(6)Sn_(6)

The kagome lattice system has been identified as a fertile ground for the emergence of a number of new quantumstates,including superconductivity,quantum spin liquids,and topological electronic states.This has attracted significantinterest within the field of condensed matter physics.Here,we present the observation of an anomalous Hall effect in aniron-based kagome antiferromagnet LuFe_(6)Sn_(6),which implies a non-zero Berry curvature in this compound.By means ofextensive magnetic measurements,a high Neel temperature,T_(N)=552 K,and a spin reorientation behavior were identifiedand a simple temperature-field phase diagram was constructed.Furthermore,this compound was found to exhibit a largeSommerfeld coefficient ofγ=87 mJ·mol^(-1)·K^(-2),suggesting the presence of a strong electronic correlation effect.Ourresearch indicates that LuFe_(6)Sn_(6)is an intriguing compound that may exhibit magnetism,strong correlation,and topologicalstates.

Evaluation of frictional pressure drop correlations for air-water and air-oil two-phase flow in pipeline-riser system

Accurate prediction of the frictional pressure drop is important for the design and operation of subsea oil and gas transporting system considering the length of the pipeline. The applicability of the correlations to pipeline-riser flow needs evaluation since the flow condition in pipeline-riser is quite different from the original data where they were derived from. In the present study, a comprehensive evaluation of 24prevailing correlation in predicting frictional pressure drop is carried out based on experimentally measured data of air-water and air-oil two-phase flows in pipeline-riser. Experiments are performed in a system having different configuration of pipeline-riser with the inclination of the downcomer varied from-2°to-5°to investigated the effect of the elbow on the frictional pressure drop in the riser. The inlet gas velocity ranges from 0.03 to 6.2 m/s, and liquid velocity varies from 0.02 to 1.3 m/s. A total of885 experimental data points including 782 on air-water flows and 103 on air-oil flows are obtained and used to access the prediction ability of the correlations. Comparison of the predicted results with the measured data indicate that a majority of the investigated correlations under-predict the pressure drop on severe slugging. The result of this study highlights the requirement of new method considering the effect of pipe layout on the frictional pressure drop.