In order to study the universality of the interactions among different markets, we analyze the cross-correlation matrix of the price of the Chinese and American bank stocks. We then find that the stock prices of the e...In order to study the universality of the interactions among different markets, we analyze the cross-correlation matrix of the price of the Chinese and American bank stocks. We then find that the stock prices of the emerging market are more correlated than that of the developed market. Considering that the values of the components for the eigenvector may be positive or negative, we analyze the differences between two markets in combination with the endogenous and exogenous events which influence the financial markets. We find that the sparse pattern of components of eigenvectors out of the threshold value has no change in American bank stocks before and after the subprime crisis. However, it changes from sparse to dense for Chinese bank stocks. By using the threshold value to exclude the external factors, we simulate the interactions in financial markets.展开更多
The elastic thickness parameter was estimated using the mobile correlation technique between the observed isostatic disturbance and the gravity disturbance calculated through direct gravimetric modeling. We computed t...The elastic thickness parameter was estimated using the mobile correlation technique between the observed isostatic disturbance and the gravity disturbance calculated through direct gravimetric modeling. We computed the vertical flexure value of the crust for a specific elastic thickness using a given topographic dataset. The gravity disturbance due to the topography was determined after the calculation. A grid of values for the elastic thickness parameter was generated. Then, a moving correlation was performed between the observed gravity data(representing actual surface data) and the calculated data from the forward modeling. The optimum elastic thickness of the particular point corresponded to the highest correlation coefficient. The methodology was tested on synthetic data and showed that the synthetic depth closely matched the original depth, including the elastic thickness value. To validate the results, the described procedure was applied to a real dataset from the Barreirinhas Basin, situated in the northeastern region of Brazil. The results show that the obtained crustal depth is highly correlated with the depth from known models. Additionally, we noted that the elastic thickness behaves as expected, decreasing from the continent towards the ocean. Based on the results, this method has the potential to be employed as a direct estimate of crustal depth and elastic thickness for any region.展开更多
Rainbow particle image velocimetry(PIV)can restore the three-dimensional velocity field of particles with a single camera;however,it requires a relatively long time to complete the reconstruction.This paper proposes a...Rainbow particle image velocimetry(PIV)can restore the three-dimensional velocity field of particles with a single camera;however,it requires a relatively long time to complete the reconstruction.This paper proposes a hybrid algorithm that combines the fast Fourier transform(FFT)based co-correlation algorithm and the Horn–Schunck(HS)optical flow pyramid iterative algorithm to increase the reconstruction speed.The Rankine vortex simulation experiment was performed,in which the particle velocity field was reconstructed using the proposed algorithm and the rainbow PIV method.The average endpoint error and average angular error of the proposed algorithm were roughly the same as those of the rainbow PIV algorithm;nevertheless,the reconstruction time was 20%shorter.Furthermore,the effect of velocity magnitude and particle density on the reconstruction results was analyzed.In the end,the performance of the proposed algorithm was verified using real experimental single-vortex and double-vortex datasets,from which a similar particle velocity field was obtained compared with the rainbow PIV algorithm.The results show that the reconstruction speed of the proposed hybrid algorithm is approximately 25%faster than that of the rainbow PIV algorithm.展开更多
This research introduces a challenge in integrating and cleaning the data,which is a crucial task in object matching.While the object is detected and then measured,the vibration at different light intensities may influ...This research introduces a challenge in integrating and cleaning the data,which is a crucial task in object matching.While the object is detected and then measured,the vibration at different light intensities may influence the durability and reliability of mechanical systems or structures and cause problems such as damage,abnormal stopping,and disaster.Recent research failed to improve the accuracy rate and the computation time in tracking an object and in the vibration measurement.To solve all these problems,this proposed research simplifies the scaling factor determination by assigning a known real-world dimension to a predetermined portion of the image.A novel white color sticker of the known dimensions marked with a color dot is pasted on the surface of an object for the best result in the template matching using the Improved Up-Sampled Cross-Correlation(UCC)algorithm.The vibration measurement is calculated using the Finite-Difference Algorithm(FDA),a machine vision systemfitted with a macro lens sensor that is capable of capturing the image at a closer range,which does not affect the quality of displacement measurement from the video frames.Thefield test was conducted on the TAFE(Tractors and Farm Equipment Limited)tractor parts,and the percentage of error was recorded between 30%and 50%at very low vibration values close to zero,whereas it was recorded between 5%and 10%error in most high-accelerations,the essential range for vibration analysis.Finally,the suggested system is more suitable for measuring the vibration of stationary machinery having low frequency ranges.The use of a macro lens enables to capture of image frames at very close-ups.A 30%to 50%error percentage has been reported when the vibration amplitude is very small.Therefore,this study is not suitable for Nano vibration analysis.展开更多
BACKGROUND Cartilage defects are some of the most common causes of arthritis.Cartilage lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral defects.Previous studies have shown...BACKGROUND Cartilage defects are some of the most common causes of arthritis.Cartilage lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral defects.Previous studies have shown that decellularized extracellular matrix(ECM)derived from autologous,allogenic,or xenogeneic mesenchymal stromal cells(MSCs)can effectively restore osteochondral integrity.AIM To determine whether the decellularized ECM of antler reserve mesenchymal cells(RMCs),a xenogeneic material from antler stem cells,is superior to the currently available treatments for osteochondral defects.METHODS We isolated the RMCs from a 60-d-old sika deer antler and cultured them in vitro to 70%confluence;50 mg/mL L-ascorbic acid was then added to the medium to stimulate ECM deposition.Decellularized sheets of adipocyte-derived MSCs(aMSCs)and antlerogenic periosteal cells(another type of antler stem cells)were used as the controls.Three weeks after ascorbic acid stimulation,the ECM sheets were harvested and applied to the osteochondral defects in rat knee joints.RESULTS The defects were successfully repaired by applying the ECM-sheets.The highest quality of repair was achieved in the RMC-ECM group both in vitro(including cell attachment and proliferation),and in vivo(including the simultaneous regeneration of well-vascularized subchondral bone and avascular articular hyaline cartilage integrated with surrounding native tissues).Notably,the antler-stem-cell-derived ECM(xenogeneic)performed better than the aMSC-ECM(allogenic),while the ECM of the active antler stem cells was superior to that of the quiescent antler stem cells.CONCLUSION Decellularized xenogeneic ECM derived from the antler stem cell,particularly the active form(RMC-ECM),can achieve high quality repair/reconstruction of osteochondral defects,suggesting that selection of decellularized ECM for such repair should be focused more on bioactivity rather than kinship.展开更多
The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functio...The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.展开更多
In this paper, the matrix Riccati equation is considered. There is no general way for solving the matrix Riccati equation despite the many fields to which it applies. While scalar Riccati equation has been studied tho...In this paper, the matrix Riccati equation is considered. There is no general way for solving the matrix Riccati equation despite the many fields to which it applies. While scalar Riccati equation has been studied thoroughly, matrix Riccati equation of which scalar Riccati equations is a particular case, is much less investigated. This article proposes a change of variable that allows to find explicit solution of the Matrix Riccati equation. We then apply this solution to Optimal Control.展开更多
Contrastive learning is a significant research direction in the field of deep learning.However,existing data augmentation methods often lead to issues such as semantic drift in generated views while the complexity of ...Contrastive learning is a significant research direction in the field of deep learning.However,existing data augmentation methods often lead to issues such as semantic drift in generated views while the complexity of model pre-training limits further improvement in the performance of existing methods.To address these challenges,we propose the Efficient Clustering Network based on Matrix Factorization(ECN-MF).Specifically,we design a batched low-rank Singular Value Decomposition(SVD)algorithm for data augmentation to eliminate redundant information and uncover major patterns of variation and key information in the data.Additionally,we design a Mutual Information-Enhanced Clustering Module(MI-ECM)to accelerate the training process by leveraging a simple architecture to bring samples from the same cluster closer while pushing samples from other clusters apart.Extensive experiments on six datasets demonstrate that ECN-MF exhibits more effective performance compared to state-of-the-art algorithms.展开更多
BACKGROUND Frey syndrome,also known as ototemporal nerve syndrome or gustatory sweating syndrome,is one of the most common complications of parotid gland surgery.This condition is characterized by abnormal sensations ...BACKGROUND Frey syndrome,also known as ototemporal nerve syndrome or gustatory sweating syndrome,is one of the most common complications of parotid gland surgery.This condition is characterized by abnormal sensations in the facial skin accompanied by episodes of flushing and sweating triggered by cognitive processes,visual stimuli,or eating.AIM To investigate the preventive effect of acellular dermal matrix(ADM)on Frey syndrome after parotid tumor resection and analyzed the effects of Frey syndrome across various surgical methods and other factors involved in parotid tumor resection.METHODS Retrospective data from 82 patients were analyzed to assess the correlation between sex,age,resection sample size,operation time,operation mode,ADM usage,and occurrence of postoperative Frey syndrome.RESULTS Among the 82 patients,the incidence of Frey syndrome was 56.1%.There were no significant differences in sex,age,or operation time between the two groups(P>0.05).However,there was a significant difference between ADM implantation and occurrence of Frey syndrome(P<0.05).ADM application could reduce the variation in the incidence of Frey syndrome across different operation modes.CONCLUSION ADM can effectively prevent Frey syndrome and delay its onset.展开更多
Autograft or metal implants are routinely used in skeletal repair.However,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering alternative.The use of native human...Autograft or metal implants are routinely used in skeletal repair.However,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering alternative.The use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor tissueregeneration.Thus,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMSCs)to proliferate and differentiate along the osteogenic lineage.In this study,we engineered a novel material ink(LAB)by blending human bone-ECM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based deposition.The inclusion of the nanofiller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMSCs viability upon printing.The composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)model.The inclusion of bone morphogenetic protein-2(BMP-2)with the HBMSCs further enhanced vascularization and mineralization after only seven days.This study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.展开更多
BACKGROUND Abdominal wall deficiencies or weakness are a common complication of tem-porary ostomies,and incisional hernias frequently develop after colostomy or ileostomy takedown.The use of synthetic meshes to reinfo...BACKGROUND Abdominal wall deficiencies or weakness are a common complication of tem-porary ostomies,and incisional hernias frequently develop after colostomy or ileostomy takedown.The use of synthetic meshes to reinforce the abdominal wall has reduced hernia occurrence.Biologic meshes have also been used to enhance healing,particularly in contaminated conditions.Reinforced tissue matrices(R-TMs),which include a biologic scaffold of native extracellular matrix and a syn-thetic component for added strength/durability,are designed to take advantage of aspects of both synthetic and biologic materials.To date,RTMs have not been reported to reinforce the abdominal wall following stoma reversal.METHODS Twenty-eight patients were selected with a parastomal and/or incisional hernia who had received a temporary ileostomy or colostomy for fecal diversion after rectal cancer treatment or trauma.Following hernia repair and proximal stoma closure,RTM(OviTex®1S permanent or OviTex®LPR)was placed to reinforce the abdominal wall using a laparoscopic,robotic,or open surgical approach.Post-operative follow-up was performed at 1 month and 1 year.Hernia recurrence was determined by physical examination and,when necessary,via computed tomo-graphy scan.Secondary endpoints included length of hospital stay,time to return to work,and hospital readmissions.Evaluated complications of the wound/repair site included presence of surgical site infection,seroma,hematoma,wound dehiscence,or fistula formation.RESULTS The observational study cohort included 16 male and 12 female patients with average age of 58.5 years±16.3 years and average body mass index of 26.2 kg/m^(2)±4.1 kg/m^(2).Patients presented with a parastomal hernia(75.0%),in-cisional hernia(14.3%),or combined parastomal/incisional hernia(10.7%).Using a laparoscopic(53.6%),robotic(35.7%),or open(10.7%)technique,RTMs(OviTex®LPR:82.1%,OviTex®1S:17.9%)were placed using sublay(82.1%)or intraperitoneal onlay(IPOM;17.9%)mesh positioning.At 1-month and 1-year follow-ups,there were no hernia recurrences(0%).Average hospital stays were 2.1 d±1.2 d and return to work occurred at 8.3 post-operative days±3.0 post-operative days.Three patients(10.7%)were readmitted before the 1-month follow up due to mesh infection and/or gastrointestinal issues.Fistula and mesh infection were observed in two patients each(7.1%),leading to partial mesh removal in one patient(3.6%).There were no complications between 1 month and 1 year(0%).CONCLUSION RTMs were used successfully to treat parastomal and incisional hernias at ileostomy reversal,with no hernia recurrences and favorable outcomes after 1-month and 1-year.展开更多
In regard to unconventional oil reservoirs,the transient dual-porosity and triple-porosity models have been adopted to describe the fluid flow in the complex fracture network.It has been proven to cause inaccurate pro...In regard to unconventional oil reservoirs,the transient dual-porosity and triple-porosity models have been adopted to describe the fluid flow in the complex fracture network.It has been proven to cause inaccurate production evaluations because of the absence of matrix-macrofracture communication.In addition,most of the existing models are solved analytically based on Laplace transform and numerical inversion.Hence,an approximate analytical solution is derived directly in real-time space considering variable matrix blocks and simultaneous matrix depletion.To simplify the derivation,the simultaneous matrix depletion is divided into two parts:one part feeding the macrofractures and the other part feeding the microfractures.Then,a series of partial differential equations(PDEs)describing the transient flow and boundary conditions are constructed and solved analytically by integration.Finally,a relationship between oil rate and production time in real-time space is obtained.The new model is verified against classical analytical models.When the microfracture system and matrix-macrofracture communication is neglected,the result of the new model agrees with those obtained with the dual-porosity and triple-porosity model,respectively.Certainly,the new model also has an excellent agreement with the numerical model.The model is then applied to two actual tight oil wells completed in western Canada sedimentary basin.After identifying the flow regime,the solution suitably matches the field production data,and the model parameters are determined.Through these output parameters,we can accurately forecast the production and even estimate the petrophysical properties.展开更多
In the case of massive data,matrix operations are very computationally intensive,and the memory limitation in standalone mode leads to the system inefficiencies.At the same time,it is difficult for matrix operations t...In the case of massive data,matrix operations are very computationally intensive,and the memory limitation in standalone mode leads to the system inefficiencies.At the same time,it is difficult for matrix operations to achieve flexible switching between different requirements when implemented in hardware.To address this problem,this paper proposes a matrix operation accelerator based on reconfigurable arrays in the context of the application of recommender systems(RS).Based on the reconfigurable array processor(APR-16)with reconfiguration,a parallelized design of matrix operations on processing element(PE)array is realized with flexibility.The experimental results show that,compared with the proposed central processing unit(CPU)and graphics processing unit(GPU)hybrid implementation matrix multiplication framework,the energy efficiency ratio of the accelerator proposed in this paper is improved by about 35×.Compared with blocked alternating least squares(BALS),its the energy efficiency ratio has been accelerated by about 1×,and the switching of matrix factorization(MF)schemes suitable for different sparsity can be realized.展开更多
In recent years,the allergy rate of oysters has surged,and daily food processing methods make it hard to reduce heat resistance and digestive allergy such as tropomyosin(TM).In this study,the Maillard reaction with xy...In recent years,the allergy rate of oysters has surged,and daily food processing methods make it hard to reduce heat resistance and digestive allergy such as tropomyosin(TM).In this study,the Maillard reaction with xylose significantly reduced the IgE binding capacity of Alectryonella plicatula food matrix(AFM),that reduced by(77.81±2.68)%.The study found the Maillard reaction changes the structure of the AFM,in which the content ofα-helix decreased by(24.64±1.46)%.Structural transformation further explains why the Maillard reaction alters the immunobinding activity of AFM.In addition,the Maillard reaction reduces the digestive stability of the AFM and makes TM in the A.plicatula food matrix Maillard reaction products(AFM-MRPs)more easily digested.Based on the above research,10 amino acids on the 7 IgE epitopes of TM were modified.This result indicates that the Maillard reaction reduces the immunobinding activity of the AFM by changing the structure and modifying the amino acids on the epitope.展开更多
Magnesium(Mg)alloys are gaining great consideration as body implant materials due to their high biodegradability and biocompatibility.However,they suffer from low corrosion resistance and antibacterial activity.In thi...Magnesium(Mg)alloys are gaining great consideration as body implant materials due to their high biodegradability and biocompatibility.However,they suffer from low corrosion resistance and antibacterial activity.In this research,semi-powder metallurgy followed by hot extrusion was utilized to produce the magnesium oxide@graphene nanosheets/magnesium(MgO@GNS/Mg)composite to improve mechanical,corrosion and cytocompatibility characteristics.Investigations have revealed that the incorporation of MgO@GNS nanohybrids into Mg-based composite enhanced microhardness and compressive strength.In vitro,osteoblast cell culture tests show that using MgO@GNS nanohybrid fillers enhances osteoblast adhesion and apatite mineralization.The presence of MgO@GNS nanoparticles in the composites decreased the opening defects,micro-cracks and micro-pores of the composites thus preventing the penetration of the corrosive solution into the matrix.Studies demonstrated that the MgO@GNS/Mg composite possesses excellent antibacterial properties because of the combination of the release of MgO and physical damage to bacterium membranes caused by the sharp edges of graphene nanosheets that can effectively damage the cell wall thereby facilitating penetration into the bacterial lipid bilayer.Therefore,the MgO@GNS/Mg composite with high mechanical strength,antibacterial activity and corrosion resistance is considered to be a promising material for load-bearing implant applications.展开更多
For the reduction of bovine serum proteins from wastewater,a novel mixed matrix membrane was prepared by functionalizing the substrate material polyaryletherketone(PAEK),followed by carboxyl groups(C-SPAEKS),and then ...For the reduction of bovine serum proteins from wastewater,a novel mixed matrix membrane was prepared by functionalizing the substrate material polyaryletherketone(PAEK),followed by carboxyl groups(C-SPAEKS),and then adding amino-functionalized UiO-66-NH_(2)(Am-UiO-66-NH_(2)).Aminofunctionalization of UiO-66 was accomplished by melamine,followed by an amidation reaction to immobilize Am-UiO-66-NH_(2),which was immobilized on the surface of the membrane as well as in the pore channels,which enhanced the hydrophilicity of the membrane surface while increasing the negative potential of the membrane surface.This nanoparticle-loaded ultrafiltration membrane has good permeation performance,with a pure water flux of up to 482.3 L·m^(-2)·h^(-1) for C-SPAEKS/AmUiO-66-NH_(2) and a retention rate of up to 98.7%for bovine serum albumin(BSA)-contaminated solutions.Meanwhile,after several hydrophilic modifications,the flux recovery of BSA contaminants by this series of membranes increased from 56.2%to 80.55%of pure membranes.The results of ultra-filtration flux time tests performed at room temperature showed that the series of ultrafiltration membranes remained relatively stable over a test time of 300 min.Thus,the newly developed mixed matrix membrane showed potential for high efficiency and stability in wastewater treatment containing bovine serum proteins.展开更多
Spatial covariance matrix(SCM) is essential in many multi-antenna systems such as massive multiple-input multiple-output(MIMO). For multi-antenna systems operating at millimeter-wave bands, hybrid analog-digital struc...Spatial covariance matrix(SCM) is essential in many multi-antenna systems such as massive multiple-input multiple-output(MIMO). For multi-antenna systems operating at millimeter-wave bands, hybrid analog-digital structure has been widely adopted to reduce the cost of radio frequency chains.In this situation, signals received at the antennas are unavailable to the digital receiver, and as a consequence, traditional sample average approach cannot be used for SCM reconstruction in hybrid multi-antenna systems. To address this issue, beam sweeping algorithm(BSA) which can reconstruct the SCM effectively for a hybrid uniform linear array, has been proposed in our previous works. However, direct extension of BSA to a hybrid uniform circular array(UCA)will result in a huge computational burden. To this end, a low-complexity approach is proposed in this paper. By exploiting the symmetry features of SCM for the UCA, the number of unknowns can be reduced significantly and thus the complexity of reconstruction can be saved accordingly. Furthermore, an insightful analysis is also presented in this paper, showing that the reduction of the number of unknowns can also improve the accuracy of the reconstructed SCM. Simulation results are also shown to demonstrate the proposed approach.展开更多
Objective This study aimed to explore the association of single nucleotide polymorphisms(SNP)in the matrix metalloproteinase 2(MMP-2)signaling pathway and the risk of vascular senescence(VS).Methods In this cross-sect...Objective This study aimed to explore the association of single nucleotide polymorphisms(SNP)in the matrix metalloproteinase 2(MMP-2)signaling pathway and the risk of vascular senescence(VS).Methods In this cross-sectional study,between May and November 2022,peripheral venous blood of151 VS patients(case group)and 233 volunteers(control group)were collected.Fourteen SNPs were identified in five genes encoding the components of the MMP-2 signaling pathway,assessed through carotid-femoral pulse wave velocity(cf PWV),and analyzed using multivariate logistic regression.The multigene influence on the risk of VS was assessed using multifactor dimensionality reduction(MDR)and generalized multifactor dimensionality regression(GMDR)modeling.Results Within the multivariate logistic regression models,four SNPs were screened to have significant associations with VS:chemokine(C-C motif)ligand 2(CCL2)rs4586,MMP2 rs14070,MMP2rs7201,and MMP2 rs1053605.Carriers of the T/C genotype of MMP2 rs14070 had a 2.17-fold increased risk of developing VS compared with those of the C/C genotype,and those of the T/T genotype had a19.375-fold increased risk.CCL2 rs4586 and MMP-2 rs14070 exhibited the most significant interactions.Conclusion CCL2 rs4586,MMP-2 rs14070,MMP-2 rs7201,and MMP-2 rs1053605 polymorphisms were significantly associated with the risk of VS.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.11275186,91024026,and FOM2014OF001)the University of Shanghai for Science and Technology(USST)of Humanities and Social Sciences,China(Grant Nos.USST13XSZ05 and 11YJA790231)
文摘In order to study the universality of the interactions among different markets, we analyze the cross-correlation matrix of the price of the Chinese and American bank stocks. We then find that the stock prices of the emerging market are more correlated than that of the developed market. Considering that the values of the components for the eigenvector may be positive or negative, we analyze the differences between two markets in combination with the endogenous and exogenous events which influence the financial markets. We find that the sparse pattern of components of eigenvectors out of the threshold value has no change in American bank stocks before and after the subprime crisis. However, it changes from sparse to dense for Chinese bank stocks. By using the threshold value to exclude the external factors, we simulate the interactions in financial markets.
文摘The elastic thickness parameter was estimated using the mobile correlation technique between the observed isostatic disturbance and the gravity disturbance calculated through direct gravimetric modeling. We computed the vertical flexure value of the crust for a specific elastic thickness using a given topographic dataset. The gravity disturbance due to the topography was determined after the calculation. A grid of values for the elastic thickness parameter was generated. Then, a moving correlation was performed between the observed gravity data(representing actual surface data) and the calculated data from the forward modeling. The optimum elastic thickness of the particular point corresponded to the highest correlation coefficient. The methodology was tested on synthetic data and showed that the synthetic depth closely matched the original depth, including the elastic thickness value. To validate the results, the described procedure was applied to a real dataset from the Barreirinhas Basin, situated in the northeastern region of Brazil. The results show that the obtained crustal depth is highly correlated with the depth from known models. Additionally, we noted that the elastic thickness behaves as expected, decreasing from the continent towards the ocean. Based on the results, this method has the potential to be employed as a direct estimate of crustal depth and elastic thickness for any region.
基金the National Natural Science Foundation of China(Grant Nos.51874264 and 52076200)。
文摘Rainbow particle image velocimetry(PIV)can restore the three-dimensional velocity field of particles with a single camera;however,it requires a relatively long time to complete the reconstruction.This paper proposes a hybrid algorithm that combines the fast Fourier transform(FFT)based co-correlation algorithm and the Horn–Schunck(HS)optical flow pyramid iterative algorithm to increase the reconstruction speed.The Rankine vortex simulation experiment was performed,in which the particle velocity field was reconstructed using the proposed algorithm and the rainbow PIV method.The average endpoint error and average angular error of the proposed algorithm were roughly the same as those of the rainbow PIV algorithm;nevertheless,the reconstruction time was 20%shorter.Furthermore,the effect of velocity magnitude and particle density on the reconstruction results was analyzed.In the end,the performance of the proposed algorithm was verified using real experimental single-vortex and double-vortex datasets,from which a similar particle velocity field was obtained compared with the rainbow PIV algorithm.The results show that the reconstruction speed of the proposed hybrid algorithm is approximately 25%faster than that of the rainbow PIV algorithm.
文摘This research introduces a challenge in integrating and cleaning the data,which is a crucial task in object matching.While the object is detected and then measured,the vibration at different light intensities may influence the durability and reliability of mechanical systems or structures and cause problems such as damage,abnormal stopping,and disaster.Recent research failed to improve the accuracy rate and the computation time in tracking an object and in the vibration measurement.To solve all these problems,this proposed research simplifies the scaling factor determination by assigning a known real-world dimension to a predetermined portion of the image.A novel white color sticker of the known dimensions marked with a color dot is pasted on the surface of an object for the best result in the template matching using the Improved Up-Sampled Cross-Correlation(UCC)algorithm.The vibration measurement is calculated using the Finite-Difference Algorithm(FDA),a machine vision systemfitted with a macro lens sensor that is capable of capturing the image at a closer range,which does not affect the quality of displacement measurement from the video frames.Thefield test was conducted on the TAFE(Tractors and Farm Equipment Limited)tractor parts,and the percentage of error was recorded between 30%and 50%at very low vibration values close to zero,whereas it was recorded between 5%and 10%error in most high-accelerations,the essential range for vibration analysis.Finally,the suggested system is more suitable for measuring the vibration of stationary machinery having low frequency ranges.The use of a macro lens enables to capture of image frames at very close-ups.A 30%to 50%error percentage has been reported when the vibration amplitude is very small.Therefore,this study is not suitable for Nano vibration analysis.
基金National Natural Science Foundation of China,No.U20A20403This study was conducted in accordance with the Animal Ethics Committee of the Institute of Antler Science and Product Technology,Changchun Sci-Tech University(AEC No:CKARI202309).
文摘BACKGROUND Cartilage defects are some of the most common causes of arthritis.Cartilage lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral defects.Previous studies have shown that decellularized extracellular matrix(ECM)derived from autologous,allogenic,or xenogeneic mesenchymal stromal cells(MSCs)can effectively restore osteochondral integrity.AIM To determine whether the decellularized ECM of antler reserve mesenchymal cells(RMCs),a xenogeneic material from antler stem cells,is superior to the currently available treatments for osteochondral defects.METHODS We isolated the RMCs from a 60-d-old sika deer antler and cultured them in vitro to 70%confluence;50 mg/mL L-ascorbic acid was then added to the medium to stimulate ECM deposition.Decellularized sheets of adipocyte-derived MSCs(aMSCs)and antlerogenic periosteal cells(another type of antler stem cells)were used as the controls.Three weeks after ascorbic acid stimulation,the ECM sheets were harvested and applied to the osteochondral defects in rat knee joints.RESULTS The defects were successfully repaired by applying the ECM-sheets.The highest quality of repair was achieved in the RMC-ECM group both in vitro(including cell attachment and proliferation),and in vivo(including the simultaneous regeneration of well-vascularized subchondral bone and avascular articular hyaline cartilage integrated with surrounding native tissues).Notably,the antler-stem-cell-derived ECM(xenogeneic)performed better than the aMSC-ECM(allogenic),while the ECM of the active antler stem cells was superior to that of the quiescent antler stem cells.CONCLUSION Decellularized xenogeneic ECM derived from the antler stem cell,particularly the active form(RMC-ECM),can achieve high quality repair/reconstruction of osteochondral defects,suggesting that selection of decellularized ECM for such repair should be focused more on bioactivity rather than kinship.
基金supported by National Institute on Aging(NIH-NIA)R21 AG074152(to KMA)National Institute of Allergy and Infectious Diseases(NIAID)grant DP2 AI171150(to KMA)Department of Defense(DoD)grant AZ210089(to KMA)。
文摘The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.
文摘In this paper, the matrix Riccati equation is considered. There is no general way for solving the matrix Riccati equation despite the many fields to which it applies. While scalar Riccati equation has been studied thoroughly, matrix Riccati equation of which scalar Riccati equations is a particular case, is much less investigated. This article proposes a change of variable that allows to find explicit solution of the Matrix Riccati equation. We then apply this solution to Optimal Control.
基金supported by the Key Research and Development Program of Hainan Province(Grant Nos.ZDYF2023GXJS163,ZDYF2024GXJS014)National Natural Science Foundation of China(NSFC)(Grant Nos.62162022,62162024)+3 种基金the Major Science and Technology Project of Hainan Province(Grant No.ZDKJ2020012)Hainan Provincial Natural Science Foundation of China(Grant No.620MS021)Youth Foundation Project of Hainan Natural Science Foundation(621QN211)Innovative Research Project for Graduate Students in Hainan Province(Grant Nos.Qhys2023-96,Qhys2023-95).
文摘Contrastive learning is a significant research direction in the field of deep learning.However,existing data augmentation methods often lead to issues such as semantic drift in generated views while the complexity of model pre-training limits further improvement in the performance of existing methods.To address these challenges,we propose the Efficient Clustering Network based on Matrix Factorization(ECN-MF).Specifically,we design a batched low-rank Singular Value Decomposition(SVD)algorithm for data augmentation to eliminate redundant information and uncover major patterns of variation and key information in the data.Additionally,we design a Mutual Information-Enhanced Clustering Module(MI-ECM)to accelerate the training process by leveraging a simple architecture to bring samples from the same cluster closer while pushing samples from other clusters apart.Extensive experiments on six datasets demonstrate that ECN-MF exhibits more effective performance compared to state-of-the-art algorithms.
文摘BACKGROUND Frey syndrome,also known as ototemporal nerve syndrome or gustatory sweating syndrome,is one of the most common complications of parotid gland surgery.This condition is characterized by abnormal sensations in the facial skin accompanied by episodes of flushing and sweating triggered by cognitive processes,visual stimuli,or eating.AIM To investigate the preventive effect of acellular dermal matrix(ADM)on Frey syndrome after parotid tumor resection and analyzed the effects of Frey syndrome across various surgical methods and other factors involved in parotid tumor resection.METHODS Retrospective data from 82 patients were analyzed to assess the correlation between sex,age,resection sample size,operation time,operation mode,ADM usage,and occurrence of postoperative Frey syndrome.RESULTS Among the 82 patients,the incidence of Frey syndrome was 56.1%.There were no significant differences in sex,age,or operation time between the two groups(P>0.05).However,there was a significant difference between ADM implantation and occurrence of Frey syndrome(P<0.05).ADM application could reduce the variation in the incidence of Frey syndrome across different operation modes.CONCLUSION ADM can effectively prevent Frey syndrome and delay its onset.
基金supported by grants from the Biotechnology and Biological Sciences Research Council(Nos.BBSRC LO21071/and BB/L00609X/1)UK Regenerative Medicine Platform Hub Acellular Approaches for Therapeutic Delivery(No.MR/K026682/1)+3 种基金Acellular Hub,SMART Materials 3D Architecture(No.MR/R015651/1)the UK Regenerative Medicine Platform(No.MR/L012626/1 Southampton Imaging)to ROCOMRCAMED Regenerative Medicine and Stem Cell Research Initiative(No.MR/V00543X/1)to JID,ROCO and YHKGC acknowledges funding from AIRC Aldi Fellowship under grant agreement No.25412.
文摘Autograft or metal implants are routinely used in skeletal repair.However,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering alternative.The use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor tissueregeneration.Thus,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMSCs)to proliferate and differentiate along the osteogenic lineage.In this study,we engineered a novel material ink(LAB)by blending human bone-ECM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based deposition.The inclusion of the nanofiller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMSCs viability upon printing.The composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)model.The inclusion of bone morphogenetic protein-2(BMP-2)with the HBMSCs further enhanced vascularization and mineralization after only seven days.This study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.
基金This study was reviewed and approved by the UT Health Houston Institutional Review Board(approval No.HSC-MS-23-0471).
文摘BACKGROUND Abdominal wall deficiencies or weakness are a common complication of tem-porary ostomies,and incisional hernias frequently develop after colostomy or ileostomy takedown.The use of synthetic meshes to reinforce the abdominal wall has reduced hernia occurrence.Biologic meshes have also been used to enhance healing,particularly in contaminated conditions.Reinforced tissue matrices(R-TMs),which include a biologic scaffold of native extracellular matrix and a syn-thetic component for added strength/durability,are designed to take advantage of aspects of both synthetic and biologic materials.To date,RTMs have not been reported to reinforce the abdominal wall following stoma reversal.METHODS Twenty-eight patients were selected with a parastomal and/or incisional hernia who had received a temporary ileostomy or colostomy for fecal diversion after rectal cancer treatment or trauma.Following hernia repair and proximal stoma closure,RTM(OviTex®1S permanent or OviTex®LPR)was placed to reinforce the abdominal wall using a laparoscopic,robotic,or open surgical approach.Post-operative follow-up was performed at 1 month and 1 year.Hernia recurrence was determined by physical examination and,when necessary,via computed tomo-graphy scan.Secondary endpoints included length of hospital stay,time to return to work,and hospital readmissions.Evaluated complications of the wound/repair site included presence of surgical site infection,seroma,hematoma,wound dehiscence,or fistula formation.RESULTS The observational study cohort included 16 male and 12 female patients with average age of 58.5 years±16.3 years and average body mass index of 26.2 kg/m^(2)±4.1 kg/m^(2).Patients presented with a parastomal hernia(75.0%),in-cisional hernia(14.3%),or combined parastomal/incisional hernia(10.7%).Using a laparoscopic(53.6%),robotic(35.7%),or open(10.7%)technique,RTMs(OviTex®LPR:82.1%,OviTex®1S:17.9%)were placed using sublay(82.1%)or intraperitoneal onlay(IPOM;17.9%)mesh positioning.At 1-month and 1-year follow-ups,there were no hernia recurrences(0%).Average hospital stays were 2.1 d±1.2 d and return to work occurred at 8.3 post-operative days±3.0 post-operative days.Three patients(10.7%)were readmitted before the 1-month follow up due to mesh infection and/or gastrointestinal issues.Fistula and mesh infection were observed in two patients each(7.1%),leading to partial mesh removal in one patient(3.6%).There were no complications between 1 month and 1 year(0%).CONCLUSION RTMs were used successfully to treat parastomal and incisional hernias at ileostomy reversal,with no hernia recurrences and favorable outcomes after 1-month and 1-year.
基金This study was supported by Basic Research Project from Jiangmen Science and Technology Bureau(Grant No.2220002000356)China University of Petroleum(Beijing)(Grand No.2462023BJRC007)The Guangdong Basic and Applied Basic Research Foundation(No.2022A1515110376).
文摘In regard to unconventional oil reservoirs,the transient dual-porosity and triple-porosity models have been adopted to describe the fluid flow in the complex fracture network.It has been proven to cause inaccurate production evaluations because of the absence of matrix-macrofracture communication.In addition,most of the existing models are solved analytically based on Laplace transform and numerical inversion.Hence,an approximate analytical solution is derived directly in real-time space considering variable matrix blocks and simultaneous matrix depletion.To simplify the derivation,the simultaneous matrix depletion is divided into two parts:one part feeding the macrofractures and the other part feeding the microfractures.Then,a series of partial differential equations(PDEs)describing the transient flow and boundary conditions are constructed and solved analytically by integration.Finally,a relationship between oil rate and production time in real-time space is obtained.The new model is verified against classical analytical models.When the microfracture system and matrix-macrofracture communication is neglected,the result of the new model agrees with those obtained with the dual-porosity and triple-porosity model,respectively.Certainly,the new model also has an excellent agreement with the numerical model.The model is then applied to two actual tight oil wells completed in western Canada sedimentary basin.After identifying the flow regime,the solution suitably matches the field production data,and the model parameters are determined.Through these output parameters,we can accurately forecast the production and even estimate the petrophysical properties.
基金the National Key R&D Program of China(No.2022ZD0119001)the National Natural Science Foundation of China(No.61834005)+3 种基金the Shaanxi Province Key R&D Plan(No.2022GY-027)the Key Scientific Research Project of Shaanxi Department of Education(No.22JY060)the Education Research Project of Xi'an University of Posts and Telecommunications(No.JGA202108)the Graduate Student Innovation Fund of Xi’an University of Posts and Telecommunications(No.CXJJYL2022035).
文摘In the case of massive data,matrix operations are very computationally intensive,and the memory limitation in standalone mode leads to the system inefficiencies.At the same time,it is difficult for matrix operations to achieve flexible switching between different requirements when implemented in hardware.To address this problem,this paper proposes a matrix operation accelerator based on reconfigurable arrays in the context of the application of recommender systems(RS).Based on the reconfigurable array processor(APR-16)with reconfiguration,a parallelized design of matrix operations on processing element(PE)array is realized with flexibility.The experimental results show that,compared with the proposed central processing unit(CPU)and graphics processing unit(GPU)hybrid implementation matrix multiplication framework,the energy efficiency ratio of the accelerator proposed in this paper is improved by about 35×.Compared with blocked alternating least squares(BALS),its the energy efficiency ratio has been accelerated by about 1×,and the switching of matrix factorization(MF)schemes suitable for different sparsity can be realized.
基金supported by the National Natural Scientific Foundation of China(32072336,31871720)the National Key R&D Program of China(2019YFD0901703).
文摘In recent years,the allergy rate of oysters has surged,and daily food processing methods make it hard to reduce heat resistance and digestive allergy such as tropomyosin(TM).In this study,the Maillard reaction with xylose significantly reduced the IgE binding capacity of Alectryonella plicatula food matrix(AFM),that reduced by(77.81±2.68)%.The study found the Maillard reaction changes the structure of the AFM,in which the content ofα-helix decreased by(24.64±1.46)%.Structural transformation further explains why the Maillard reaction alters the immunobinding activity of AFM.In addition,the Maillard reaction reduces the digestive stability of the AFM and makes TM in the A.plicatula food matrix Maillard reaction products(AFM-MRPs)more easily digested.Based on the above research,10 amino acids on the 7 IgE epitopes of TM were modified.This result indicates that the Maillard reaction reduces the immunobinding activity of the AFM by changing the structure and modifying the amino acids on the epitope.
文摘Magnesium(Mg)alloys are gaining great consideration as body implant materials due to their high biodegradability and biocompatibility.However,they suffer from low corrosion resistance and antibacterial activity.In this research,semi-powder metallurgy followed by hot extrusion was utilized to produce the magnesium oxide@graphene nanosheets/magnesium(MgO@GNS/Mg)composite to improve mechanical,corrosion and cytocompatibility characteristics.Investigations have revealed that the incorporation of MgO@GNS nanohybrids into Mg-based composite enhanced microhardness and compressive strength.In vitro,osteoblast cell culture tests show that using MgO@GNS nanohybrid fillers enhances osteoblast adhesion and apatite mineralization.The presence of MgO@GNS nanoparticles in the composites decreased the opening defects,micro-cracks and micro-pores of the composites thus preventing the penetration of the corrosive solution into the matrix.Studies demonstrated that the MgO@GNS/Mg composite possesses excellent antibacterial properties because of the combination of the release of MgO and physical damage to bacterium membranes caused by the sharp edges of graphene nanosheets that can effectively damage the cell wall thereby facilitating penetration into the bacterial lipid bilayer.Therefore,the MgO@GNS/Mg composite with high mechanical strength,antibacterial activity and corrosion resistance is considered to be a promising material for load-bearing implant applications.
基金financial support of this work by Natural Science Foundation of China(22075031,51673030,51603017 and 51803011)Jilin Provincial Science&Technology Department(20220201105GX)Chang Bai Mountain Scholars Program of Jilin Province.
文摘For the reduction of bovine serum proteins from wastewater,a novel mixed matrix membrane was prepared by functionalizing the substrate material polyaryletherketone(PAEK),followed by carboxyl groups(C-SPAEKS),and then adding amino-functionalized UiO-66-NH_(2)(Am-UiO-66-NH_(2)).Aminofunctionalization of UiO-66 was accomplished by melamine,followed by an amidation reaction to immobilize Am-UiO-66-NH_(2),which was immobilized on the surface of the membrane as well as in the pore channels,which enhanced the hydrophilicity of the membrane surface while increasing the negative potential of the membrane surface.This nanoparticle-loaded ultrafiltration membrane has good permeation performance,with a pure water flux of up to 482.3 L·m^(-2)·h^(-1) for C-SPAEKS/AmUiO-66-NH_(2) and a retention rate of up to 98.7%for bovine serum albumin(BSA)-contaminated solutions.Meanwhile,after several hydrophilic modifications,the flux recovery of BSA contaminants by this series of membranes increased from 56.2%to 80.55%of pure membranes.The results of ultra-filtration flux time tests performed at room temperature showed that the series of ultrafiltration membranes remained relatively stable over a test time of 300 min.Thus,the newly developed mixed matrix membrane showed potential for high efficiency and stability in wastewater treatment containing bovine serum proteins.
基金supported by National Key Research and Development Program of China under Grant 2020YFB1804901State Key Laboratory of Rail Traffic Control and Safety(Contract:No.RCS2022ZT 015)Special Key Project of Technological Innovation and Application Development of Chongqing Science and Technology Bureau(cstc2019jscx-fxydX0053).
文摘Spatial covariance matrix(SCM) is essential in many multi-antenna systems such as massive multiple-input multiple-output(MIMO). For multi-antenna systems operating at millimeter-wave bands, hybrid analog-digital structure has been widely adopted to reduce the cost of radio frequency chains.In this situation, signals received at the antennas are unavailable to the digital receiver, and as a consequence, traditional sample average approach cannot be used for SCM reconstruction in hybrid multi-antenna systems. To address this issue, beam sweeping algorithm(BSA) which can reconstruct the SCM effectively for a hybrid uniform linear array, has been proposed in our previous works. However, direct extension of BSA to a hybrid uniform circular array(UCA)will result in a huge computational burden. To this end, a low-complexity approach is proposed in this paper. By exploiting the symmetry features of SCM for the UCA, the number of unknowns can be reduced significantly and thus the complexity of reconstruction can be saved accordingly. Furthermore, an insightful analysis is also presented in this paper, showing that the reduction of the number of unknowns can also improve the accuracy of the reconstructed SCM. Simulation results are also shown to demonstrate the proposed approach.
基金supported by the Construction of Prevention and Treatment System of Geriatric Syndromes Focusing on Disability and Dementia(No.21-1-2-2-zyyd-nsh)。
文摘Objective This study aimed to explore the association of single nucleotide polymorphisms(SNP)in the matrix metalloproteinase 2(MMP-2)signaling pathway and the risk of vascular senescence(VS).Methods In this cross-sectional study,between May and November 2022,peripheral venous blood of151 VS patients(case group)and 233 volunteers(control group)were collected.Fourteen SNPs were identified in five genes encoding the components of the MMP-2 signaling pathway,assessed through carotid-femoral pulse wave velocity(cf PWV),and analyzed using multivariate logistic regression.The multigene influence on the risk of VS was assessed using multifactor dimensionality reduction(MDR)and generalized multifactor dimensionality regression(GMDR)modeling.Results Within the multivariate logistic regression models,four SNPs were screened to have significant associations with VS:chemokine(C-C motif)ligand 2(CCL2)rs4586,MMP2 rs14070,MMP2rs7201,and MMP2 rs1053605.Carriers of the T/C genotype of MMP2 rs14070 had a 2.17-fold increased risk of developing VS compared with those of the C/C genotype,and those of the T/T genotype had a19.375-fold increased risk.CCL2 rs4586 and MMP-2 rs14070 exhibited the most significant interactions.Conclusion CCL2 rs4586,MMP-2 rs14070,MMP-2 rs7201,and MMP-2 rs1053605 polymorphisms were significantly associated with the risk of VS.