In this work,we aim to introduce some modifications to the Anam-Net deep neural network(DNN)model for segmenting optic cup(OC)and optic disc(OD)in retinal fundus images to estimate the cup-to-disc ratio(CDR).The CDR i...In this work,we aim to introduce some modifications to the Anam-Net deep neural network(DNN)model for segmenting optic cup(OC)and optic disc(OD)in retinal fundus images to estimate the cup-to-disc ratio(CDR).The CDR is a reliable measure for the early diagnosis of Glaucoma.In this study,we developed a lightweight DNN model for OC and OD segmentation in retinal fundus images.Our DNN model is based on modifications to Anam-Net,incorporating an anamorphic depth embedding block.To reduce computational complexity,we employ a fixed filter size for all convolution layers in the encoder and decoder stages as the network deepens.This modification significantly reduces the number of trainable parameters,making the model lightweight and suitable for resource-constrained applications.We evaluate the performance of the developed model using two publicly available retinal image databases,namely RIM-ONE and Drishti-GS.The results demonstrate promising OC segmentation performance across most standard evaluation metrics while achieving analogous results for OD segmentation.We used two retinal fundus image databases named RIM-ONE and Drishti-GS that contained 159 images and 101 retinal images,respectively.For OD segmentation using the RIM-ONE we obtain an f1-score(F1),Jaccard coefficient(JC),and overlapping error(OE)of 0.950,0.9219,and 0.0781,respectively.Similarly,for OC segmentation using the same databases,we achieve scores of 0.8481(F1),0.7428(JC),and 0.2572(OE).Based on these experimental results and the significantly lower number of trainable parameters,we conclude that the developed model is highly suitable for the early diagnosis of glaucoma by accurately estimating the CDR.展开更多
Background:The incidence of lumbar disc herniation(LDH)is notably high.Consensus among experts highlights non-surgical treatments as the primary therapeutic approach for LDH.Contemporary medicine frequently employs ph...Background:The incidence of lumbar disc herniation(LDH)is notably high.Consensus among experts highlights non-surgical treatments as the primary therapeutic approach for LDH.Contemporary medicine frequently employs pharmacotherapy and epidural injections in such treatments,which are associated with numerous adverse effects.Prolonged use can severely impair the liver and kidney functions of patients.Hence,the role of safe and effective traditional Chinese medicine techniques becomes pivotal.Among various traditional Chinese medicine approaches for treating LDH,fire dragon cupping,renowned for its remarkable efficacy,cost-effectiveness,and ease of application,is extensively utilised in clinical settings for managing LDH.Nonetheless,there is a scarcity of systematic and standardised evidence from evidence-based medicine studies.Therefore,conducting a meta-analysis is imperative.Methods:A comprehensive computerised search was conducted in databases including China National Knowledge Infrastructure,WanFang Data,VIP,China Biology Medicine disc,PubMed,EMbase,The Cochrane Library,Web of Science,and CINAHL.The search aimed to gather randomised controlled trials on fire dragon cupping therapy for LDH,spanning from the inception of these databases until December 2023.Two researchers independently screened the literature according to inclusion and exclusion criteria,extracted data,and assessed the methodological quality of the studies included,utilising RevMan 5.3 software for meta-analysis.Results:The results show that the fire dragon cupping therapy group had better clinical effectiveness(relative risk=1.23,95%confidence interval(CI)(1.14,1.33),P<0.00001),less pain(standardized mean difference=–1.33,95%CI(–1.49,–1.16),P<0.00001),and some improvement in lumbar function(Japanese Orthopaedic Association scores:mean difference=3.37,95%CI(2.31,4.43),P<0.00001.Conclusion:The fire dragon cupping therapy significantly alleviates LDH,warranting its extensive application.However,considering the limitations in the number and quality of studies included,the aforementioned conclusion necessitates further validation through more high-quality research.展开更多
Purpose: The aim of this study is early detection of increased cup to disc ratio and a survey study of cup-disc ratio in Egyptian children age group less than 15 years. Methods: Three hundred and eighty-two (382) chil...Purpose: The aim of this study is early detection of increased cup to disc ratio and a survey study of cup-disc ratio in Egyptian children age group less than 15 years. Methods: Three hundred and eighty-two (382) children were enrolled in this study. They were classified into three age groups;infants’ Group (1) from 0-2 years, preschool Group (2) from 2-6 years and school children Group (3) from 6-15 years old. C/D ratio was measured for each child. Results: In Group (1), normal C/D ratio ranged from 0 to 0.1. The C/D ratio > 0.3 or a binocular difference of >0.2 could be regarded as one of the criteria of newborn glaucoma. Group (2): the normal ratio ranged from 0.1-0.2. Group (3): the normal ratio ranged from 0.2-0.3. The highest ratio 0.7 was found in two eyes. An asymmetry of 0.2 or more in the C/D ratios of the eyes was found in 4.8% of the children. Conclusion: C/D ratio > 0.3 and asymmetry of 0.2 is suggestive of glaucoma especially in infants of lower age group.展开更多
Brazilian disc tests were undertaken on a number of red sandstone samples with different water absorption ratios.The tensile strength of the red sandstone decreases as the water absorption ratio increases.The fracture...Brazilian disc tests were undertaken on a number of red sandstone samples with different water absorption ratios.The tensile strength of the red sandstone decreases as the water absorption ratio increases.The fracture surfaces of failed red sandstone discs were scanned by Talysurf CLI 2000.With the aid of Talymap Gold software,based on ISO25178,a set of statistical parameters was obtained for the fracture surfaces.The maximum peak height(S_p),maximum pit height(S_v) and maximum height(S_z) of the fracture surfaces exhibited the same decreasing trend with increasing water absorption.Sa and Sku values for the fracture surfaces showed a downward trend as the water absorption ratio increased.The fractal dimensions of fracture surfaces were calculated and found to decrease as the water absorption ratio increased.Through analysis of PSD curves,the smallest dominant wavelength was observed to reflect the roughness of the fracture surfaces.Additionally,the results suggest that the roughness of fracture surfaces becomes small as the water absorption ratio increases.展开更多
Objective:To explore the relationship between the polymorphism of optic disc related genes and the susceptibility to primary open angle glaucoma(POAG)in Inner Mongolia.Methods:A retrospective study was adopted to incl...Objective:To explore the relationship between the polymorphism of optic disc related genes and the susceptibility to primary open angle glaucoma(POAG)in Inner Mongolia.Methods:A retrospective study was adopted to include 108 patients who were diagnosed as POAG in six hospitals in Hohhot and Baotou from January of 2014 to December of 2016(POAG group).At the same time,120 healthy examinees were included in the control group.1-2 ml of whole blood was collected by use of EDTA anticoagulation tubes from each patient in these two groups.It was required to fully mix EDTA with whole blood in order to extract genomic DNA and place it in the-20℃ refrigerator.Mass spectrometry was used to identify the genotype of single nucleotide polymorphism(SNP)of RFTN1(rs690037),ATOH7(rs7916697,rs3858145),CDC7(rs1192415),CDKN2B(rs1063192)and SIX(rs10483727)in 108 POAG patients and 120 normal controls.χ^(2) test and binary logistic regression were used to analyze the relationship between the genetic polymorphism and the occurrence of POAG.Results:The frequency of G allele at CDKN2B(rs1063192)in POAG group was significantly higher than that in the control group(27%vs.17%),and the difference was of statistical significance[odds ratio(OR)=1.824,95%confidence interval(CI):1.163-2.861,p=.008];As to the comparison in the frequency of allele at the other 7 SNPs between the two groups,the differences were statistically significant(all p>.05).Additive and dominant models at rs1063192 indicated that the individuals with G allele were more susceptible to POAG,and the difference was of statistical significance(p<.05),and recessive models showed that the risk in the individuals with A allele was not significantly reduced,and the difference was of no statistical significance(p>.05).There was no statistically significant difference in the distribution of genotypes at other SNPs between POAG group and the control group(p>.05).Conclusions:The genetic polymorphism of CDKN2B(rs1063192)is associated with the susceptibility to POAG,and G allele may increase the risk for POAG.展开更多
基金funded byResearchers Supporting Project Number(RSPD2024R 553),King Saud University,Riyadh,Saudi Arabia.
文摘In this work,we aim to introduce some modifications to the Anam-Net deep neural network(DNN)model for segmenting optic cup(OC)and optic disc(OD)in retinal fundus images to estimate the cup-to-disc ratio(CDR).The CDR is a reliable measure for the early diagnosis of Glaucoma.In this study,we developed a lightweight DNN model for OC and OD segmentation in retinal fundus images.Our DNN model is based on modifications to Anam-Net,incorporating an anamorphic depth embedding block.To reduce computational complexity,we employ a fixed filter size for all convolution layers in the encoder and decoder stages as the network deepens.This modification significantly reduces the number of trainable parameters,making the model lightweight and suitable for resource-constrained applications.We evaluate the performance of the developed model using two publicly available retinal image databases,namely RIM-ONE and Drishti-GS.The results demonstrate promising OC segmentation performance across most standard evaluation metrics while achieving analogous results for OD segmentation.We used two retinal fundus image databases named RIM-ONE and Drishti-GS that contained 159 images and 101 retinal images,respectively.For OD segmentation using the RIM-ONE we obtain an f1-score(F1),Jaccard coefficient(JC),and overlapping error(OE)of 0.950,0.9219,and 0.0781,respectively.Similarly,for OC segmentation using the same databases,we achieve scores of 0.8481(F1),0.7428(JC),and 0.2572(OE).Based on these experimental results and the significantly lower number of trainable parameters,we conclude that the developed model is highly suitable for the early diagnosis of glaucoma by accurately estimating the CDR.
基金supported by the 2022 study on the effectiveness of Fire Dragon Cupping in treating cold-dampness obstructive type shoulder stiffness,funded by the Bao'an District Healthcare Research Project in Shenzhen(Shen Bao Ke[2023]No.13,Project No.2022JD237)2023 study on the therapeutic observation and mechanism exploration of Fire Dragon Cupping in cold-dampness obstructive type acute gout,funded by the Guangdong Provincial Administration of Traditional Chinese Medicine(Yue Zhong Yi Han[2023]No.205,Project No.20242077)+1 种基金National Clinical Key Specialty(Traditional Chinese Medicine)Construction Project(2013-239)Sanming Project of Medicine in Shenzhen(No.SZZYSM202206014).
文摘Background:The incidence of lumbar disc herniation(LDH)is notably high.Consensus among experts highlights non-surgical treatments as the primary therapeutic approach for LDH.Contemporary medicine frequently employs pharmacotherapy and epidural injections in such treatments,which are associated with numerous adverse effects.Prolonged use can severely impair the liver and kidney functions of patients.Hence,the role of safe and effective traditional Chinese medicine techniques becomes pivotal.Among various traditional Chinese medicine approaches for treating LDH,fire dragon cupping,renowned for its remarkable efficacy,cost-effectiveness,and ease of application,is extensively utilised in clinical settings for managing LDH.Nonetheless,there is a scarcity of systematic and standardised evidence from evidence-based medicine studies.Therefore,conducting a meta-analysis is imperative.Methods:A comprehensive computerised search was conducted in databases including China National Knowledge Infrastructure,WanFang Data,VIP,China Biology Medicine disc,PubMed,EMbase,The Cochrane Library,Web of Science,and CINAHL.The search aimed to gather randomised controlled trials on fire dragon cupping therapy for LDH,spanning from the inception of these databases until December 2023.Two researchers independently screened the literature according to inclusion and exclusion criteria,extracted data,and assessed the methodological quality of the studies included,utilising RevMan 5.3 software for meta-analysis.Results:The results show that the fire dragon cupping therapy group had better clinical effectiveness(relative risk=1.23,95%confidence interval(CI)(1.14,1.33),P<0.00001),less pain(standardized mean difference=–1.33,95%CI(–1.49,–1.16),P<0.00001),and some improvement in lumbar function(Japanese Orthopaedic Association scores:mean difference=3.37,95%CI(2.31,4.43),P<0.00001.Conclusion:The fire dragon cupping therapy significantly alleviates LDH,warranting its extensive application.However,considering the limitations in the number and quality of studies included,the aforementioned conclusion necessitates further validation through more high-quality research.
文摘Purpose: The aim of this study is early detection of increased cup to disc ratio and a survey study of cup-disc ratio in Egyptian children age group less than 15 years. Methods: Three hundred and eighty-two (382) children were enrolled in this study. They were classified into three age groups;infants’ Group (1) from 0-2 years, preschool Group (2) from 2-6 years and school children Group (3) from 6-15 years old. C/D ratio was measured for each child. Results: In Group (1), normal C/D ratio ranged from 0 to 0.1. The C/D ratio > 0.3 or a binocular difference of >0.2 could be regarded as one of the criteria of newborn glaucoma. Group (2): the normal ratio ranged from 0.1-0.2. Group (3): the normal ratio ranged from 0.2-0.3. The highest ratio 0.7 was found in two eyes. An asymmetry of 0.2 or more in the C/D ratios of the eyes was found in 4.8% of the children. Conclusion: C/D ratio > 0.3 and asymmetry of 0.2 is suggestive of glaucoma especially in infants of lower age group.
基金Project(E21527)supported by Open Research Fund Program of Hunan Provincial Key Laboratory of Shale Gas Resource Utilization,Hunan University of Science and Technology,ChinaProjects(51174088,51174228)supported by the National Natural Science Foundation of China+1 种基金Project(2013CB035401)supported by the National Basic Research Program of ChinaProject(2015zzts077)supported by the Fundamental Research Funds for the Central Universities,China
文摘Brazilian disc tests were undertaken on a number of red sandstone samples with different water absorption ratios.The tensile strength of the red sandstone decreases as the water absorption ratio increases.The fracture surfaces of failed red sandstone discs were scanned by Talysurf CLI 2000.With the aid of Talymap Gold software,based on ISO25178,a set of statistical parameters was obtained for the fracture surfaces.The maximum peak height(S_p),maximum pit height(S_v) and maximum height(S_z) of the fracture surfaces exhibited the same decreasing trend with increasing water absorption.Sa and Sku values for the fracture surfaces showed a downward trend as the water absorption ratio increased.The fractal dimensions of fracture surfaces were calculated and found to decrease as the water absorption ratio increased.Through analysis of PSD curves,the smallest dominant wavelength was observed to reflect the roughness of the fracture surfaces.Additionally,the results suggest that the roughness of fracture surfaces becomes small as the water absorption ratio increases.
文摘Objective:To explore the relationship between the polymorphism of optic disc related genes and the susceptibility to primary open angle glaucoma(POAG)in Inner Mongolia.Methods:A retrospective study was adopted to include 108 patients who were diagnosed as POAG in six hospitals in Hohhot and Baotou from January of 2014 to December of 2016(POAG group).At the same time,120 healthy examinees were included in the control group.1-2 ml of whole blood was collected by use of EDTA anticoagulation tubes from each patient in these two groups.It was required to fully mix EDTA with whole blood in order to extract genomic DNA and place it in the-20℃ refrigerator.Mass spectrometry was used to identify the genotype of single nucleotide polymorphism(SNP)of RFTN1(rs690037),ATOH7(rs7916697,rs3858145),CDC7(rs1192415),CDKN2B(rs1063192)and SIX(rs10483727)in 108 POAG patients and 120 normal controls.χ^(2) test and binary logistic regression were used to analyze the relationship between the genetic polymorphism and the occurrence of POAG.Results:The frequency of G allele at CDKN2B(rs1063192)in POAG group was significantly higher than that in the control group(27%vs.17%),and the difference was of statistical significance[odds ratio(OR)=1.824,95%confidence interval(CI):1.163-2.861,p=.008];As to the comparison in the frequency of allele at the other 7 SNPs between the two groups,the differences were statistically significant(all p>.05).Additive and dominant models at rs1063192 indicated that the individuals with G allele were more susceptible to POAG,and the difference was of statistical significance(p<.05),and recessive models showed that the risk in the individuals with A allele was not significantly reduced,and the difference was of no statistical significance(p>.05).There was no statistically significant difference in the distribution of genotypes at other SNPs between POAG group and the control group(p>.05).Conclusions:The genetic polymorphism of CDKN2B(rs1063192)is associated with the susceptibility to POAG,and G allele may increase the risk for POAG.
