Effects of WIN 55,212-2 on I_K Current in Cultured Trigeminal Ganglion Neurons of Rat

Summary: To investigate the effects of WIN 55,212-2 on I K in cultured rat trigeminal ganglion (TG) neurons, whole-cell patch clamp techniques were used to record the I K before and after WIN 55,212-2 perfusion at different concentrations. 30 μmol/L WIN 55,212-2 markedly (35 7 %± 7 3 %, P<0.01, n=8) inhibited I K currents, and the currents were partially recovered after washing. 30 μmol/L WIN 55,212-2 also induced a significant depolarizing shift in conductance-voltage parameters (control: V 0 5=10 43 ± 4.25 mV, k=16 27±3 86; WIN 55,212-2: V 0.5=24.71±3.91 mV, k =16.69±2.75; n = 8, P<0.01 for V 0.5). 0.01 μmol/L WIN 55,212-2 slightly (27.0 %± 7.9 %, P<0.05, n=7) increased I K currents, but had no significant change in conductance–voltage parameters (control: V 0.5=10.74±5.27 mV, k=17.33±2.96; WIN 55,212-2: V 0.5=11.06±2.05 mV, k=19.69±6.60; n=7, P>0.05 for V 0.5 and k). These results suggested that WIN 55,212-2 has dual action, which might be through different receptors.

A, ■-Ω METHOD FOR 3-D EDDY CURRENT ANALYSIS

After the field equations and the snonumuoo conditions between the interfaces for 3D eddy current problems Under various gauges were discussed, it was pointed cut in this paper that using the magnetic vector potential A. the electric scalar potential and Coulomb gauge △ .A = 0 in eddy current regions and using the magntetic scalar potential Ω in the non-conducting regions are more suitable. All field equations, the boundary conditions, the interface continuity conditions and the corresponding variational principle of this method are also given

Exact Traveling Wave Solutions of Nano-Ionic Solitons and Nano-Ionic Current of MTs Using the exp(-φ (ξ ))-Expansion Method

In this work, the exp(-φ (ξ )) -expansion method is used for the first time to investigate the exact traveling wave solutions involving parameters of nonlinear evolution equations. When these parameters are taken to be special values, the solitary wave solutions are derived from the exact traveling wave solutions. The validity and reliability of the method are tested by its applications to Nano-ionic solitons wave’s propagation along microtubules in living cells and Nano-ionic currents of MTs which play an important role in biology.

Effects of Angiotensin Ⅱ and ACE Inhibitor,Captopril on L-type Calcium Current and Sodium Current of Single Guinea Myocytes

Objectives To investigate effect of Angll, captopril on single guinea myocytes on L - type calcium current and sodium current. Methods Membrane patch clamp whole cell recording technique was used to investigate effect of angll, captopril on L - Ca maximum current density and sodium maximum current density. Resutls Angll increased the maximum current density compared with control after perfused 5 min, 357. 7 ±219. 7 Vs 279. 5± 240. 5 PA/PF, increase rate is 27. 9 %, the shape of current - voltage relationship curve was unchanged, peaked at + 10 mv, indicated that angll increased L - Ca current density in voltage - dependent. After perfused with captopril, captopril + angll 3, 5 min, L - Ca current was recorded, results suggest L - Ca maximum current density decreased significantly compared with control, in captopril group, 128. 4 ± 92. 6Vs286. 2 ± 89. 7, 66. 7±68. 3Vs 286. 2 ± 89. 7, respectively, rate of inhibition is 55. 1 %, 76. 6 %, respectively. L - Ca current further decreased in captopril perfused 5 min compared with 3 min, 66. 7 ± 68. 3 Vs 128. 4 ± 92. 6, in captopril + angll group, L - Ca current decreased greatly in 3, 5 min than control, 143. 4±117. 6Vs 267. 7±141. 4, 96. 4±82. 5 Vs 267. 7±141. 4, respectively, rate of inhibition is 46. 4 % , 63. 9 % respectively. We also investigated effect of captopril on Na current, which decreased significantly in 1 min and 3 min compared with control, 939. 1 ±319. 1 Vs 1398. 0±144. 6 PA/PF, 469. 95 ± 314. 9 Vs 1398. 0 ±144. 6 PA/PF, respectively, rate of inhibition is 32. 8 % , 66. 3 % , respectively. Na current density decreased significantly in 3 min compared with 1 min, 469. 9±314. 9 Vs 939. 1±319. 1PA/PF, rate of inhibition is 49. 9 % . Conclusions Angiotensin Ⅱexerts increased maximum current density of L - Ca in voltage dependent, captopril decreased maximum current density of L - Ca in voltage dependent, decreased sodium maximum current density, which is the prominently antiarrhythmia mechanisms through inhibition of angiotensin Ⅱ evoked calcium dependent transient inward current and calcium overload.

针-板电极空气隙直流放电光信息采集

为研究气体击穿的放电机理,采集直流电压下针-板电极空气隙流注放电击穿瞬间的光信号,实验设计了气体放电光学采集装置.利用光纤,光谱仪和ICCD组成光信号检测系统,其中ICCD单独使用可以捕捉光现象,配合光谱仪可采集光谱.实验中采用具有高速触发脉冲的外部触发方式操作控制器,进行图像及光谱的采集,并对采集到的结果进行分析和讨论.

度量空间中Current的某些特征

作者从代数观念出发研究了Current的表示定理．对于完备不变Current,利用构建的极小三元组技巧,给出了一个类似的Radon-Nikodym定理．

Effects of alternating current interference on corrosion of X60 pipeline steel

With rapid economic development in China, demand for energy and transportation is growing. Due to the limitations of factors such as terrain and traffic, a large number of buried oil and gas pipelines are parallel to high- voltage transmission lines and electrified railways over long distances. Alternating pipelines is very serious in laboratory experiments were current （AC） corrosion of such cases. In this work, carried out with an electrochemical method in a simulated soil solution at various AC current densities from 0 to 200 A]m2 and AC frequencies from 10 to 200 Hz. Experimental results indicated that with an increase in the AC current density, the corrosion po- tential of an X60 steel electrode shifted negatively, the anodic current density increased significantly, and the corrosion rate increased. Moreover, with an increase in the AC frequency, the corrosion potential of the X60 electrode shifted positively and the anodic current density decreased, which led to a decrease in the corrosion rate. Furthermore, the morphology of X60 electrodes indicated that uniform corrosion occurred at a low AC current density; while corrosion pits were found on the X60 electrode surface at a high AC current density, and deep corrosion pits seriously damaged the pipelines and might lead to leakage.

一种模拟3 V锂电池供电的DC-DC设计

微光像增强器采用3 V锂电池供电,随着电池电压下降,直流工作点变化或调整可能引起其内部高压电源输出异常,导致像管出现闪烁、熄灭或高亮等故障。通常使用具有“电池模拟功能”的直流电源进行供电特性验证,该类设备功率大,功能多,价格也昂贵,像增强器功率小,若采用这种设备则利用率低以至于研发成本高。基于恒流源控制LDO输出,设计一种模拟1.4 V^3.4 V锂电池充放电的DC-DC电路,经仿真和实测验证,输出电压能够线性上升或下降且速率可在数十毫秒至数小时内可调,具备模拟电池供电功能,该电路成本较低,其改进线路还可用于其它领域功率产品作直流扫描分析验证。

On the horizontal distribution of algal-bloom in Chaohu Lake and its formation process

Based on the remote sensing images of algae, the present work analyzes the horizontal distribution characteristics of algal blooms in Chaohu Lake, China, which also reveals the frequency of algal blooms under different wind directions. Further, an unstructured-grid, three-dimensional finite-volume coastal ocean model （FVCOM） is applied to investigate the wind-induced currents and the transport pro- cess to explain the reason why algal blooms occur at the detected places. We first deduce the primary distribution of biomass from overlaid satellite images, and explain the formation mechanism by analyzing the pollution sources, and simulating the flow field and transportation process under prevailing wind over Chaohu Lake. And then, we consider the adjustment action of the wind on the corresponding day and develop a two-time scale approach to describe the whole formation process of algae horizontal distribution in Chaohu Lake. That is, on the longer time scale, i.e., during bloom season, prevailing wind determines the primary distribution of biomass by inducing the characteristic flow field; on the shorter time scale, i.e., on the day when bloom occurs, the wind force adjusts the primary distribution of biomass to form the final distribution of algal bloom.

Formation of epitaxial Tl_2Ba_2Ca_2Cu_3O_(10) superconducting films by dc-magnetron sputtering and triple post-annealing method

For obtaining pure phase T12Ba2Ca2Cu3O10 （T1-2223） films with good superconducting properties, the growth technique is improved by dc magnetron sputtering and a triple post-annealing process. The triple post-annealing process comprises annealing twice in argon and once in oxygen at different temperatures. In the first low-temperature annealing phase in argon, T12Ba2CaCu2O8 （T1-2212） is obtained to effectively minimize evaporation in the next step. With the increase of temperature in the second annealing stage in argon, the previously prepared T1-2212 inter-phase is converted into T1-2223 phase. An additional annealing in oxygen is also adopted to improve the properties of T1-2223 films, each containing an optimal oxygen content value. The results of X-ray diffraction （XRD） θ-2θ scans, 09 scans and rotational φ scans show that each of the T1-2223 films has a high phase purity and an epitaxial structure. Smooth films are observed by scanning electron microscopy （SEM）. The critical temperatures Tc of the films are measured to be about 120 K and the critical current densities Jc can reach 4.0 MA/cm2 at 77 K at self field.

Multi-train modeling and simulation integrated with traction power supply solver using simplified Newton–Raphson method

Multi-train modeling and simulation plays a vital role in railway electrification during operation and planning phase. Study of peak power demand and energy consumed by each traction substation needs to be deter- mined to verify that electrical energy flowing in its railway power feeding system is appropriate or not. Gauss-Seidel, conventional Newton-Raphson, and current injection methods are well-known and widely accepted as a tool for electrical power network solver in DC railway power supply study. In this paper, a simplified Newton-Raphson method has been proposed. The proposed method employs a set of current-balance equations at each electrical node instead of the conventional power-balance equation used in the conventional Newton-Raphson method. This concept can remarkably reduce execution time and computing complexity for multi-train simulation. To evaluate its use, Sukhumvit line of Bangkok transit system （BTS） of Thai- land with 21.6-km line length and 22 passenger stopping stations is set as a test system. The multi-train simulation integrated with the proposed power network solver is developed to simulate 1-h operation service of selected 5-min headway. From the obtained results, the proposed method is more efficient with approximately 18 % faster than the conventional Newton-Raphson method and just over 6 % faster than the current injection method.

Tides and short-term variabilities in the Kuroshio west of Yonakuni-jima

Direct current measurements at the mooring station M southwest of Yonakuni-jima are carried out from May 18 to June 1, 1996. The Observed Kuroshio Current at 290 and 594 m depths of the mooring station M is quite steady ddring the pened of Observation. The rotary spectral estimates of the current data by the maximum entropy method show that there are prominent diurnal and semidiurnal spectral peaks. The semidiurnal tide is predominant at 290 m depth while there is the current fluctuation with the inertial period except for the tidal oscillation at 594 m depth. There are also peaks at the pened of 4-7 d. There is a significant coherence between two time series of currents at 290 and 594 m depths in the pened range of 3 - 5 d. The Japan Meteorological Agency (JMA) wind data during the same period as the oceanic measurement are used in comparison with the current meter data. Rotary spectral estimates for the wind data show significant peaks at the period of 3 - 5 d. It is concluded from the cross spectra between the wind and the current that the current fluctuation of 3 - 5 d period at 290 m depth response to the wind fluctuation of the same periods with time lags smaller than 1 d.

LOW TEMPERATURE ALUMINUM FLOATING ELECTROLYSIS IN HEAVY ELECTROLYTE Na_3AlF_6-AlF_3-BaC1_2-NaCl BATH SYSTEM

Multiple regression equations of liquidus temperature, electrical conductivity and bath density of the Na_3AlF_6-AlF_3-BaC1_2-NaCl system were obtained from experiments by using orthogonal regression method. The experiments were carried out in 100A cell with low melting point electrolyte, the influences of cathodic current density, electrolytic temperature, density differences of bath and liquid aluminum on current efficiency (CE) were studied; when the electrolyte cryolite ratio was 2.5, w(BaC1_2) and w(NaCl) were 48% and 10%, respectively, CE reached 90% and specific energy consumption was 10.97k Wb/kg/kg. Because of the fact that aluminum metal obtained floated on the surface of molten electrolyte, this electrolysis method was then defined as low temperature aluminum floating electrolysis. The results showed that the new low temperature aluminum electrolysis process in the Na_3AlF_6-AlF_3-BaC1_2-NaCl bath system was practical and promising.

Solar Flare Activity and Variability of Electric Current Helicity

Recent study using Huairou vector magnetograph data shows that durlug flare activity, the current helicity exhibits rapid and substantial variations and, in some cases, a recovering phase. We considered various representative the magnetic configurations. First, interacting twisted magnetic flux tubes are analyzed separately for positive, negative and mixed-sign helicity regions. The results show that the helicity during flares decreases in positive-sign, and increases in negative-sign regions. Then, flaring arcade also shows that the magnitude of the helicity decreases after flares. We also investigated current sheets formed by sheared magnetic field and showed that the current helicity (with either positive and negative signs) vanishes after reconnection. The emergence of twisted flux tubes which can trigger flares may be another source of flare-associated variability of current helicity. We demonstrate the relevance of current helicity to the description of flare activity by comparing its variation with that of shear angle in the active region AR 6891.

Observational Features of Large-Scale Structures as Revealed by the Catastrophe Model of Solar Eruptions

Large-scale magnetic structures are the main carrier of major eruptions in the solar atmosphere. These structures are rooted in the photosphere and are driven by the unceasing motion of the photospheric material through a series of equilibrium configurations. The motion brings energy into the coronal magnetic field until the system ceases to be in equilibrium. The catastrophe theory for solar eruptions indicates that loss of mechanical equilibrium constitutes the main trigger mechanism of major eruptions, usually shown up as solar flares, eruptive prominences, and coronal mass ejections （CMEs）. Magnetic reconnection which takes place at the very beginning of the eruption as a result of plasma instabilities/turbulence inside the current sheet, converts magnetic energy into heating and kinetic energy that are responsible for solar flares, and for accelerating both plasma ejecta （flows and CMEs） and energetic particles. Various manifestations are thus related to one another, and the physics behind these relationships is catastrophe and magnetic reconnection. This work reports on recent progress in both theoretical research and observations on eruptive phenomena showing the above manifestations. We start by displaying the properties of large-scale structures in the corona and the related magnetic fields prior to an eruption, and show various morphological features of the disrupting magnetic fields. Then, in the framework of the catastrophe theory, we look into the physics behind those features investigated in a succession of previous works, and discuss the approaches they used.

自动门控像增强器温度补偿技术研究

针对匹配自动门控电源的超二代像增强器高低温条件下亮度增益和最大输出亮度产生漂移的问题,分析了温度补偿原理,设计了温度补偿方案,通过实验确定了温度补偿系数,验证了该温度补偿方案的合理性。实验结果表明,低照条件(输入照度低于5×10^(-4)lx),通过将MCP电压降低14.7 V能够将低温(-45℃)亮度增益从121%降低到105%以内,通过将MCP电压增加16.5 V能够将高温(55℃)亮度增益从77%提高到99%以上;高照条件(输入照度高于5×10^(-4)lx),通过将阳极电流设定值降低14%能够将低温最大输出亮度从114%降低到104%以内,通过将阳极电流设定值增加12.6%能够将高温最大输出亮度从87%提高到91%以上。因此,采用本文所述温度补偿技术能够有效提高自动门控像增强器高低温条件下亮度增益和最大输出亮度的一致性。

MCP增益与首次碰撞时电子能量关系的试验研究

首次碰撞时电子的能量对微通道板的增益产生影响。为了揭示它们之间的变化关系,分别测试了标准型和高性能6μm孔径的微通道板的电流增益和电子增益随首次碰撞时电子能量的变化关系曲线,讨论了两者在微光像增强器中的相对优势,预示高性能MCP使用于微光像增强器中的技术潜力。

铝电解槽电流强化与高效节能综合技术的开发及应用

提出了"五低三窄一高"新工艺技术,并开发了与新工艺技术相配套的智能多环协同优化与控制技术。应用该新技术对郑州龙祥铝业有限公司原设计容量为154kA的铝电解系列134台电解槽进行技术升级,在无需改变现有铝电解槽结构的条件下,成功地将其升级为一个高效节能型180kA级铝电解系列,为期9个月的工业应用表明,平均槽电压降低到3.83V^3.88V,阳极效应系数降低到0.02次/(槽.日),平均电流效率提升到93.5%,吨铝节电1183kWh。

200kA预焙槽强化电流过程中发生电解质粘度增加的实践探讨

通过分析200kA预焙槽在强化电流条件下电解质粘度增大的原因及对电解生产的影响,提出了规范电解生产作业制度及处理电解质粘度过大的建议,以实现降低工人劳动强度,达到工艺参数优化和提高电流效率的目的。

阴极脉冲占空比与荧光屏电流关系研究

自动门控电源作为微光像增强器的能量来源,其阴极脉冲占空比与荧光屏电流的关系对完善自动门控电源的自动亮度控制(ABC)电路设计具有重要意义。从自动门控电源与微光像增强器的匹配应用方面分析了阴极脉冲占空比对荧光屏电流的影响,又从自动门控电源ABC电路设计方面分析了阴极脉冲占空比如何跟随荧光屏电流变化,才能确保微光像增强器荧光屏亮度的基本恒定,给出了自动门控电源阴极脉冲占空比与荧光屏电流的曲线图。