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Fault detection and diagnosis of permanent-magnetic DC motors based on current analysis and BP neural networks 被引量:1
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作者 刘曼兰 朱春波 王铁成 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2005年第3期266-270,共5页
In order to guarantee quality during mass serial production of motors, a convenient approach on how to detect and diagnose the faults of a permanent-magnetic DC motor based on armature current analysis and BP neural n... In order to guarantee quality during mass serial production of motors, a convenient approach on how to detect and diagnose the faults of a permanent-magnetic DC motor based on armature current analysis and BP neural networks was presented in this paper. The fault feature vector was directly established by analyzing the armature current. Fault features were extracted from the current using various signal processing methods including Fourier analysis, wavelet analysis and statistical methods. Then an advanced BP neural network was used to finish decision-making and separate fault patterns. Finally, the accuracy of the method in this paper was verified by analyzing the mechanism of faults theoretically. The consistency between the experimental results and the theoretical analysis shows that four kinds of representative faults of low power permanent-magnetic DC motors can be diagnosed conveniently by this method. These four faults are brush fray, open circuit of components, open weld of components and short circuit between armature coils. This method needs fewer hardware instruments than the conventional method and whole procedures can be accomplished by several software packages developed in this paper. 展开更多
关键词 DC motor current analysis BP neural networks fault detection fault diagnosis
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Analysis of the Current Situation of Drug Clinical Trial Institutions in Shaanxi Province
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作者 Yurong Zhang Qi Zhang +4 位作者 Li Wang Rui Xu Lili Zhao Enze Li Xin Wang 《Journal of Clinical and Nursing Research》 2024年第1期78-87,共10页
To understand the current situation of institutional registration in Shaanxi Province after the implementation ofregistration system management in drug clinical trial institutions.Relevant information was collected on... To understand the current situation of institutional registration in Shaanxi Province after the implementation ofregistration system management in drug clinical trial institutions.Relevant information was collected on the“Announcement on the Accreditation of Drug Clinical Trial Institutions”issued by the National Medical Products Administration from 2005 to August 2022,the record management information system of drug and medical device clinical trial institutions,and the drug clinical trial registration and information publicity platform.A retrospective analysis was carried out in terms of institutional development,regional distribution,registered majors,principal investigators,and the number of drug clinical trials.After the implementation of institution registration,the number of drug clinical trial institutions in Shaanxi Province increased by 47.4%,884 principal investigators were registered,the number of registered majors expanded from 58 qualified to 117,and the professional scope increased by 50.4%.The policy of institution registration is conducive to promoting the rational use of medical resources and the development of drug clinical trial institutions and improving the healthy development of the pharmaceutical industry in Shaanxi Province. 展开更多
关键词 Drug clinical trial Institution registration Registered majors current situation analysis Professional group Shaanxi Province
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Research on the Current Situation and Countermeasures of Integrating Artificial Intelligence into Ideological and Political Teaching in Universities
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作者 Siying Zhang 《Journal of Contemporary Educational Research》 2024年第5期15-20,共6页
With the rapid development of modern science and technology,artificial intelligence(AI)technology is becoming more and more mature,which has brought a profound impact on every field of human society.The new era backgr... With the rapid development of modern science and technology,artificial intelligence(AI)technology is becoming more and more mature,which has brought a profound impact on every field of human society.The new era background provides a new teaching concept for ideological and political teaching in colleges and universities.Teachers in colleges and universities should adopt a positive attitude to face the teaching change brought by new technology,update the teaching ideas in time,and adjust the teaching strategy.This paper will analyze the current situation of the integrated development of AI and ideological and political teaching and put forward corresponding teaching strategies to help train well-developed socialist successors. 展开更多
关键词 Artificial intelligence Ideological and political education current situation analysis Countermeasure analysis
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NUMERICAL ANALYSIS AND EXPERI-MENT OF UNSTEADY THERMAL FIELD OF ROTOR PLATE FOR EDDY CURRENT RETARDER 被引量:10
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作者 LIU Chengye HE Ren 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2008年第4期71-75,共5页
The physical model based on heat transfer theory and virtual boundary method for analyzing unsteady thermal field of rotor plate for eddy current retarder used in automobile is established and boundary conditions are ... The physical model based on heat transfer theory and virtual boundary method for analyzing unsteady thermal field of rotor plate for eddy current retarder used in automobile is established and boundary conditions are also defined. The finite element governing equation is derived by Galerkin method. The time differential item is discrete based on Galerkin format that is stable at any condition. And a new style of varying time step method is used in iteration process. The thermal field on the rotor plate at the radial and axle directions is analyzed and varying temperature at appointed points on two side-surfaces is measured. The testing and analytical data are uniform approximately. Finite element method can be used for estimating thermal field of the rotor plate at initial design stage of eddy current retarder. 展开更多
关键词 Eddy current retarder Thermal field Numerical analysis Varying time step method
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Testing and Analysis of Induction Motor Electrical Faults Using Current Signature Analysis 被引量:1
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作者 K. Prakasam S. Ramesh 《Circuits and Systems》 2016年第9期2651-2662,共13页
The proposed method deals with the emerging technique called as Motor Current Signature Analysis (MCSA) to diagnosis the stator faults of Induction Motors. The performance of the proposed method deals with the emergin... The proposed method deals with the emerging technique called as Motor Current Signature Analysis (MCSA) to diagnosis the stator faults of Induction Motors. The performance of the proposed method deals with the emerging technique called as Motor Current Signature Analysis (MCSA) and the Zero-Sequence Voltage Component (ZSVC) to diagnose the stator faults of Induction Motors. The unalleviated study of the robustness of the industrial appliances is obligatory to verdict the fault of the machines at precipitate stages and thwart the machine from brutal damage. For all kinds of industry, a machine failure escorts to a diminution in production and cost increases. The Motor Current Signature Analysis (MCSA) is referred as the most predominant way to diagnose the faults of electrical machines. Since the detailed analysis of the current spectrum, the method will portray the typical fault state. This paper aims to present dissimilar stator faults which are classified under electrical faults using MCSA and the comparison of simulation and hardware results. The magnitude of these fault harmonics analyzes in detail by means of Finite-Element Method (FEM). The anticipated method can effectively perceive the trivial changes too during the operation of the motor and it shows in the results. 展开更多
关键词 Three Phase Induction Motor Motor current Signature analysis (MCSA) ZSVC Fault Diagnosis current Spectrum analysis
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Industrial Fault Signals Propagation and Current Signature Analysis
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作者 Alireza Gheitasi Adnan AI-Anbuky 《Journal of Energy and Power Engineering》 2013年第2期361-369,共9页
Motor current signature analysis provides good results in laboratory environment. In real life situation, electrical machines usually share voltage and current from common terminals and would easily influence each oth... Motor current signature analysis provides good results in laboratory environment. In real life situation, electrical machines usually share voltage and current from common terminals and would easily influence each other. This will result in considerable amount of interferences among motors and doubt in identity of fault signals. Therefore, estimating the mutual influence of motors will help identifying the original signal from the environmental noise. This research aims at modelling the propagation of signals that are caused by faults of induction motors in power networks. Estimating the propagation pattern of fault signal leads to a method to discriminate and identify the original source of major events in industrial networks. Simulation results show that source of fault could be identified using this approach with a higher certainty than anticipated output coming of any individual diagnosis. 展开更多
关键词 Motor current signature analysis signal interference decision making signal propagation.
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Analysis of Charge-Exchange Spectrum during Lower Hybrid Current Drive on HT-7 Tokamak
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作者 刘胜侠 万宝年 +8 位作者 匡光力 高翔 胡立群 秦品健 姚爱玲 龚先祖 石跃江 陈磊 李健刚 《Plasma Science and Technology》 SCIE EI CAS CSCD 2000年第6期523-527,共5页
A perpendicular neutral particle analyzer (NPA) is used on HT-7 tokamak experiment to provide the measurements of neutral particle flux and ion temperature. The measured results were compared with calculated data by ... A perpendicular neutral particle analyzer (NPA) is used on HT-7 tokamak experiment to provide the measurements of neutral particle flux and ion temperature. The measured results were compared with calculated data by Monte-carlo method for ohmic heating. In lower hybrid current drive (LHCD) experiments, the ion heating of LHCD was identified. The chargeexchange neutral particle flux enhanced was observed. The energy spectrum clearly showed a high-energy ions tail. The bulk ion temperature increased by 0.4-0.5 keV after the onset of LHCD. Efficient ion heating of 1 eV. kW-1 was obtained. 展开更多
关键词 LHCD analysis of Charge-Exchange Spectrum during Lower Hybrid current Drive on HT-7 Tokamak HT
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Information visualization analysis on Advances in Psychological Science:1983-2014 被引量:1
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作者 xiao-Jie pan Hui-Ning Zhao +5 位作者 Mi-Mi Li Li-Hong Hou Yan-Qing Guo Xiao Zheng Ya-Qing Xue Chi-Chen Zhang 《Chinese Nursing Research》 CAS 2017年第3期124-129,共6页
Objective: To describe the revolution and research status of Advances in Psychological Science. Methods: A total of 3060 articles published in Advances in Psychological Science from 1983 to 2014 were analyzed with t... Objective: To describe the revolution and research status of Advances in Psychological Science. Methods: A total of 3060 articles published in Advances in Psychological Science from 1983 to 2014 were analyzed with the information visualization method using Citespace software from the aspects of pub- lications, cited frequency and downloads, funding, organizations, authors and keywords. Results: The results showed that the amount of literature published annually had an upward tendency, and 49.4% of the papers were supported by national or provincial projects. Institutions such as the Chinese Academy of Sciences (CAS) and the normal universities were rated in the forefront of the sci- entific research output. Xiting Huang, Hong Li and Yuejia Luo were at the top of the list of prolific authors. Conclusions: A new pattern of cooperative development of the theory and application in the field of psychological research is forming. 展开更多
关键词 Advances in psychological science Bibliometrics Citespace Visualization analysis Scientific knowledge map current research state Research hotspot
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Spatial Distribution Characteristics of Surface Tidal Currents in the Southwest of Taiwan Strait 被引量:1
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作者 SHEN Zhiben WU Xiongbin +3 位作者 LIN Hang CHEN Xiaofeng XU Xing’an LI Lun 《Journal of Ocean University of China》 SCIE CAS 2014年第6期971-978,共8页
This study was conducted on the spatial distribution characteristics of surface tidal currents in the southwestern Taiwan Strait based on the quasi-harmonic analysis of current data obtained by two high frequency surf... This study was conducted on the spatial distribution characteristics of surface tidal currents in the southwestern Taiwan Strait based on the quasi-harmonic analysis of current data obtained by two high frequency surface wave radar(HFSWR) systems. The analysis shows that the tidal current pattern in the southwestern Taiwan Strait is primarily semi-diurnal and influenced significantly by shallow water constituents. The spatial distribution of tidal current ellipses of M2 is probably affected by the interaction between two different systems of tide wave, one from the northern mouth of Taiwan Strait and the other from the Bashi Channel. The directions of the major axes of M2 tidal current ellipses coincide roughly with the axis of the Taiwan Strait. The spatial distribution of the magnitudes of the probable maximum current velocity(PMCS) shows gradual increase of the velocity from northeast to southwest, which is in accordance with the spatial distribution of the measured maximum current velocity(MMCS). The directions of the residual currents are in accordance with the direction of the prevailing monsoon wind at the Taiwan Strait and the direction of the Taiwan warm current during summer. The bathymetry also shows a significant effect on the spatial distribution characteristics of tidal currents. 展开更多
关键词 high frequency surface wave radar quasi-harmonic analysis spatial distribution characteristic surface tidal current Taiwan Strait
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Investigation and Analysis of Continuing Nursing Education Status and Needs of In-Service Nurses in Tibet
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作者 Haihua Zou Lihong Liu +1 位作者 Lijuan Dong Weiju Chen 《Open Journal of Internal Medicine》 2020年第2期223-231,共9页
<strong>Objective:</strong> To investigate and analyze the current status of continuing nursing education (CNE) of in-service nurses in Tibet and their demand for continuing education. <strong>Method... <strong>Objective:</strong> To investigate and analyze the current status of continuing nursing education (CNE) of in-service nurses in Tibet and their demand for continuing education. <strong>Methods:</strong> 663 active nurses in Tibet were taken as the research objects, and the self-developed questionnaire was used to investigate the current status and needs of CNE, and the correlation between the CNE needs of active nurses and their personal conditions was analyzed. <strong>Results:</strong> This study shows that 65.61% (435/663) of active nurses have not participated in any CNE, and 91.86% (609/663) of active nurses believe that they need to participate in CNE. The problems faced by active nurses in participating in CNE include funding restrictions, time limitation and ability limitation. Logistic stepwise regression analysis reveals that the age of active nurses and working years of nurses are negatively correlated with the funding restrictions for participating in CNE (P < 0.05). It is relatively more difficult for young nurses with less working experience to obtain funding for participating in CNE. Moreover, there is a negative correlation between age, educational level and the ability of nurses to participate in CNE (P < 0.05). Younger nurses with lower educational level are more difficult to participate in CNE due to personal ability. There is a positive correlation between the length of working experience and the time limitation faced to participate in CNE (P < 0.05). Senior nurses are too busy with their work to participate in CNE due to limited time. <strong>Conclusion:</strong> The problems faced by active nurses in Tibet in participating in CNE come from funding, time and ability. Young nurses with limited working experience cannot participate in CNE resulting from limited ability and funds;while senior nurses are mainly restricted by time. It is recommended that hospitals and nursing management in Tibet should solve these problems faced by nurses in participating in CNE by implementing a flexible scheduling system, and providing funding or implementing an incentive system, to enhance the confidence of active nurses in participating in CNE. 展开更多
关键词 TIBET In-Service Nurses Continuing Education current Situation analysis Facing Problems SOLUTIONS
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Current Situation and Approaches Relating to Construction of Agricultural Production and Operation Development Capacity for Rural Households in Hubei Province
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作者 Jing ZENG 《Asian Agricultural Research》 2018年第6期18-22,共5页
The main body of household operation in the rural household contract responsibility system of our country has developed to the present stage,and has formed the situation that three kinds of rural households coexist,na... The main body of household operation in the rural household contract responsibility system of our country has developed to the present stage,and has formed the situation that three kinds of rural households coexist,namely,ordinary rural households,major professional households and family farms. The agricultural production and operation of three kinds of household plays an important role in supporting the rapid development of modern agriculture in China. Under the new situation of deepening the rural reform and realizing the goal of well-off society in an all-round way,it is of great practical significance to make a thorough investigation and study on the present situation and approaches relating to the construction of the agricultural production and operation capacity for the three kinds of rural households. 展开更多
关键词 Rural households Agricultural production and operation development capacity analysis of current situation Construction approaches
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Difficulty Analysis of HVAC Construction and Key Analysis of Improved Technology
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作者 Xiaolong Ruan Yisong Yin 《Journal of Architectural Research and Development》 2020年第3期43-46,共4页
This paper expounds the concept of HVAC construction,specifically analyzes the current situation of HVAC construction in construction engineering,and focuses on the key and difficult points in HVAC construction.In ord... This paper expounds the concept of HVAC construction,specifically analyzes the current situation of HVAC construction in construction engineering,and focuses on the key and difficult points in HVAC construction.In order to provide an effective reference for improving the quality of HVAC construction in the current construction engineering,some suggestions are put forward for improvement of relevant technologies involved in key and difficult points. 展开更多
关键词 HVAC construction Key and difficult points current situation analysis Technical improvement Air duct installation
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Efficient Supply Current Control Strategies for Bridgeless Interleaved AC-DC Converter
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作者 R.Sasikala R.Seyezhai 《Computer Systems Science & Engineering》 SCIE EI 2022年第10期175-191,共17页
This paper presents an efficient supply current wave shaping technique for bridgeless interleaved Single Ended Primary Inductor Converter(SEPIC).The SEPIC converter converts an Alternating Current(AC)to Direct Current... This paper presents an efficient supply current wave shaping technique for bridgeless interleaved Single Ended Primary Inductor Converter(SEPIC).The SEPIC converter converts an Alternating Current(AC)to Direct Current(DC)with the boost converter.Power Factor Correction(PFC)is progressively significant to achieve high energy efficiency.The overall system efficiency can be increased as the bridgeless topology has less conduction losses from rectifying bridges.Also,the bridgeless and interleaved techniques are incorporated in this study to achieve better performance.The performance of the system is analyzed on both current control and sensor-less techniques.Different controllers such as Proportional Integral(PI)control,peak current control,Non-Linear Carrier(NLC)control,and sensor-less current control are integrated.All the above controllers are implemented using MATrix LABoratory(MATLAB)/SIMULINK.The performance parameter,namely Power Factor(PF),Total Harmonic Distortion(THD),is computed for both open loop and closed loop condition.The sensor-less current control method is implemented using the DsPIC30F2010 controller.The circuit performance is also verified from the simulation and hardware results.The proposed controller has inbuilt Analog-to-Digital Converter(ADC),Digital-to-Analog Converter(DAC),Pulse Width Modulation(PWM)generator,and provides fast responses. 展开更多
关键词 Light emitting diode power factor correction SEPIC converter current control method sensor-less method fast Fourier transform analysis for input current
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Parameters analysis and application of the differential excitation detection technology
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作者 于霞 张卫民 +2 位作者 陈国龙 邱忠超 曾卫琴 《Journal of Beijing Institute of Technology》 EI CAS 2015年第3期348-354,共7页
A differential excitation probe based on eddy current testing technology was designed. Sheet specimens of Q 235 steel with prefabricated micro-cracks of different widths and of aluminum with prefabricated micro-cracks... A differential excitation probe based on eddy current testing technology was designed. Sheet specimens of Q 235 steel with prefabricated micro-cracks of different widths and of aluminum with prefabricated micro-cracks of different depths were detected through the designed detection system. The characteristics of micro-cracks can be clearly showed after signals processing through the short-time Fourier transform( STFT). By changing the parameter and its value in detecting process,the factors including the excitation frequency and amplitude,the lift-off effect and the scanning direction were discussed,respectively. The results showed that the differential excitation probe was insensitive to dimension and surface state of the tested specimen,while it had a high degree of recognition for micro-crack detection. Therefore,when the differential excitation detection technology was used for inspecting micro-crack of turbine blade in aero-engine,and smoothed pseudo Wigner-Ville distribution was used for signal processing,micro-cracks of 0. 3 mm depth and 0. 1 mm width could be identified. The experimental results might be useful for further research on engineering test of turbine blades of aero-engine. 展开更多
关键词 differential excitation probe eddy current testing micro-crack defect influence parameters analysis
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An Analysis of Marketing Trend of IVD in China
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作者 Gu Chi Chen Yuwen 《Asian Journal of Social Pharmacy》 2020年第2期83-88,共6页
Objective To contribute to the in vitro diagnosis(IVD)industry taking a leading position and developing sustainably in the market,and to help enterprises to adopt a variety of methods to strengthen its capacity.Method... Objective To contribute to the in vitro diagnosis(IVD)industry taking a leading position and developing sustainably in the market,and to help enterprises to adopt a variety of methods to strengthen its capacity.Methods Current status of IVD industry was analyzed and some strategies for the development of IVD industry were put forward in combination with the characteristics of the industry.Then the exterior environment of IVD industry and the development of marketing were analyzed so as to help increase the market shares of Chinese IVD industry in the global market.Results and Conclusion Chinese IVD industry was analyzed comprehensively from various perspectives on the basis of study of the history of Chinese IVD industry and foreign IVD industries.Therefore,some strategies are put forward. 展开更多
关键词 IVD market current situation analysis development strategy
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Development Countermeasures of County-level Edible Fungi Industry in Hebei Province from the Perspective of Rural Revitalization
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作者 Kun TANG Ying WANG +3 位作者 Minhui ZHANG Wenjie CHEN Junhong HU Chunyan XIE 《Asian Agricultural Research》 2023年第11期15-19,23,共6页
In recent years,the edible fungi industry in Hebei Province has developed rapidly,with gradually increased cultivation scale and production output,and has become the pillar industry of the province,playing a certain r... In recent years,the edible fungi industry in Hebei Province has developed rapidly,with gradually increased cultivation scale and production output,and has become the pillar industry of the province,playing a certain role in promoting the development of rural economy and rural revitalization.Based on the in-depth analysis of the development status,future development direction and current constraints of the edible fungi industry in each typical county of Hebei Province in recent years,the paper puts forward corresponding development countermeasures,which has certain reference value for the county-level edible fungi industry of Hebei Province to promote rural revitalization. 展开更多
关键词 Hebei Edible fungi industry Rural revitalization current status analysis
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Dynamics modeling and electromechanical coupling characteristics analysis of cage induction motors
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作者 ZHOU ZiWei CHEN ZaiGang ZHAI WanMing 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2024年第3期709-724,共16页
Induction motors, as typical electromechanical energy conversion devices, have received limited attention in previous studies on electromechanical coupling vibrations, precise modeling, and the use of electromechanica... Induction motors, as typical electromechanical energy conversion devices, have received limited attention in previous studies on electromechanical coupling vibrations, precise modeling, and the use of electromechanical coupling effects for fault diagnosis and condition assessment in motor drive systems. This study proposes a comprehensive model of cage induction motors that integrates the multiple coupled circuit model with a rotor-bearing dynamics model. The model accounts for the linear increase in the magnetomotive force across the slot and incorporates the skidding characteristics of bearings in the rotor-bearing system. By calculating the time-varying mutual inductance parameters based on the air-gap distribution in the vibration environment, the electromechanical coupling vibration of the cage motor is investigated. Furthermore, this study examines the electromechanical coupling vibration characteristics influenced by various factors, including bearing clearances, radial loads, and the vertical excitation frequencies of the stators. The results show that the proposed model improves the excitation inputs for the electrical and mechanical systems of the motor compared with conventional models. Increased bearing clearance and radial load affect the current and torque similarly but have opposite effects on the slip ratio. This study provides a deeper understanding of electromechanical coupling mechanisms and facilitates the use of such phenomena for fault diagnosis and condition assessment in motor-driven systems. 展开更多
关键词 cage induction motors rotor-bearing dynamics mutual inductance electromechanical testing current signal analysis
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Review of Dietary Therapy Development in Ming and Qing Dynasties
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作者 宋阳 刘理想 赵凯维 《World Journal of Integrated Traditional and Western Medicine》 2023年第2期37-45,共9页
In the Ming and Qing Dynasties,with the development of politics,economy and culture,the development of health maintenance of traditional Chinese medicine entered a heyday.Food therapy is an important part of the healt... In the Ming and Qing Dynasties,with the development of politics,economy and culture,the development of health maintenance of traditional Chinese medicine entered a heyday.Food therapy is an important part of the health theory of traditional Chinese medicine.In the 5,000 years of Chinese civilization,you can see the record of food therapy everywhere.It can be said that food therapy of traditional Chinese medicine develops together with traditional Chinese medicine.As a treasure in the treasure-house of Chinese medicine,food therapy has a long history and rich practice.Based on the current research,further research on relevant theories remains to be carried out.Focusing on the historical period of Ming and Qing dynasties,this paper takes the works related to food,nutrition and therapy(including general works and monographs on diet),the health thoughts and practice characteristics of representative health practitioners as the research perspective,and sorts out the above research contents in the past 20 years,analyzes the research overview and trend.It is found that in the study of food nourishing in Ming and Qing dynasties,there are few studies on the contents of diet nourishing in the general works.This suggests that when we study the development of diet nourishing in Ming and Qing Dynasties,we should not only study the monograph of diet nourishing and the thoughts of doctors,but also pay attention to the diet nourishing thought reflected in the general works.The study of diet monographs in Ming Dynasty mainly focused on the textual research of wild plants,and the study of diet monographs in Qing Dynasty mainly focused on the application.The study on the health care thought of doctors in Ming and Qing Dynasties mainly focused on the views of food nourishing and personal health care.These studies are summarized in order to provide reference for further theoretical research and provide reference for contemporary research on food nourishing diet. 展开更多
关键词 Dietary therapy development analysis of current situation The Ming and Qing Dynasties
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Activation of G551D-CFTR by Bicyclooctane Compounds Is cAMP-dependent and Exhibits Low Sensitivity to Thiazolidinone CFTR Inhibitor CFTRinh-172
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作者 WANGYing ZHAOLu +2 位作者 HECheng-yan XULi-na YANGHong 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2005年第2期183-186,共4页
The G551D-CFTR mutation causing cystic fibrosis(CF) results from a missense mutation at codon 551(G551D) in the gene encoding of the cystic fibrosis transmembrane conductance regulator(CFTR). The G551D mutation in CFT... The G551D-CFTR mutation causing cystic fibrosis(CF) results from a missense mutation at codon 551(G551D) in the gene encoding of the cystic fibrosis transmembrane conductance regulator(CFTR). The G551D mutation in CFTR results in a reduced functional channel but G551D-CFTR is appropriately inserted in the apical membrane. In previous studies we discovered a class of high-affinity bicyclooctane(BCO) G551D-CFTR activators(G551D_ BCOs) with K_d down to 1 μmol/L. In this study, we analyzed the pharmacological activation of G551D-CFTR by the G551D_ BCOs by means of short circuit current analysis and cell-based fluorescence quenching assay. The G551D_ BCOs-induced G551D-CFTR activation is cAMP-dependent and is less sensitive to thiazolidinone CFTR inhibitor CFTRinh-172. These data suggest that (1) the phosphorylation of G551D-CFTR by protein kinase A is required for the activation by G551D_ BCOs; (2) G551D_ BCOs and CFTRinh-172 may act at the same site on the G551D-CFTR molecule. 展开更多
关键词 Cystic fibrosis(CF) Cystic fibrosis transmembrane conductance regulator(CFTR) Short circuit current analysis Pharmacological activation
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基于4~20 mA输出的温湿度传感器设计 被引量:4
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作者 任勇峰 朱泽珲 贾兴中 《电子设计工程》 2021年第16期110-114,共5页
基于工业现场温湿度信号的测量,为解决温湿度传感器测量信号远距离传输时受噪声干扰、线路阻抗等的影响,利用4~20 mA电流环的抗干扰特性,采用电流进行信号传输,使电路的传输性能大大提高。设计采用SHT15作为测温、测湿的敏感元件,利用C8... 基于工业现场温湿度信号的测量,为解决温湿度传感器测量信号远距离传输时受噪声干扰、线路阻抗等的影响,利用4~20 mA电流环的抗干扰特性,采用电流进行信号传输,使电路的传输性能大大提高。设计采用SHT15作为测温、测湿的敏感元件,利用C8051F410单片机的IDAC功能,将测得的温湿度数字量转化成模拟量。再经过适当调理转换电路,并通过软件程序设计改善测量信号的线性度,实现4~20 mA的电流输出。最后利用标准温湿度测量设备进行测试试验分析,验证温湿度传感器的4~20 mA电路可以实现高精度的温湿度测量。 展开更多
关键词 4~20 mA电流环 SHT15 IDAC 调理转换电路 试验分析
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