Background In-stent restenosis （ISR） has become one of the most challenging problems in patients with coronary heart disease. At present, using non-invasive methods to assess ISR is a hot topic. In this investigatio...Background In-stent restenosis （ISR） has become one of the most challenging problems in patients with coronary heart disease. At present, using non-invasive methods to assess ISR is a hot topic. In this investigation we attempted to explore the potential of magnetocardiography （MCG） in diagnosis of in-stent restenosis. Methods MCG was analyzed in 52 patients with coronary artery disease for three times： before stenting, one month and 7 months after successful intracoronary stenting. Results The average classification of total maps （ACTM） and the ratio of abnormal maps （RAM） were lower in 1 month after intracoronary stenting compared with that obtained before stent planting （2.91 vs 2.52, 65.74% vs 42.80%, P〈0.01）, while complex ventricular excitation index （CVEI） increased from -42.63 to -20.05 （P〈0.01）. In ISR subgroup （n=16）, RAM decreased in 1 month after intracoronary stenting compared to it before stenting （68.99% vs 45.26%, P〈0.05）. ACTM increased in 7 months compared to that obtained in 1 month after stenting （3.15 vs 2.51, P〈0.05）. According to the ROC curve, ACTM showed its unique diagnostic value in restenosis patients. The sensitivity and specificity of ACTM were 80.0%, 69.40%, respectively. Its positive predictive value and negative predictive value were 54.6% and 88.5%, respectively. Conclusions After successful intracoronary stenting, most parameters of MCG were improved. ACTM was of prognostic value in diagnosing ISR.展开更多
文摘Background In-stent restenosis （ISR） has become one of the most challenging problems in patients with coronary heart disease. At present, using non-invasive methods to assess ISR is a hot topic. In this investigation we attempted to explore the potential of magnetocardiography （MCG） in diagnosis of in-stent restenosis. Methods MCG was analyzed in 52 patients with coronary artery disease for three times： before stenting, one month and 7 months after successful intracoronary stenting. Results The average classification of total maps （ACTM） and the ratio of abnormal maps （RAM） were lower in 1 month after intracoronary stenting compared with that obtained before stent planting （2.91 vs 2.52, 65.74% vs 42.80%, P〈0.01）, while complex ventricular excitation index （CVEI） increased from -42.63 to -20.05 （P〈0.01）. In ISR subgroup （n=16）, RAM decreased in 1 month after intracoronary stenting compared to it before stenting （68.99% vs 45.26%, P〈0.05）. ACTM increased in 7 months compared to that obtained in 1 month after stenting （3.15 vs 2.51, P〈0.05）. According to the ROC curve, ACTM showed its unique diagnostic value in restenosis patients. The sensitivity and specificity of ACTM were 80.0%, 69.40%, respectively. Its positive predictive value and negative predictive value were 54.6% and 88.5%, respectively. Conclusions After successful intracoronary stenting, most parameters of MCG were improved. ACTM was of prognostic value in diagnosing ISR.
