Model transformation is one of the prominent features and the rising research area of Model Driven Engineering (MDE). MDE promotes models to primary artifacts that drive the whole development process. This paper prese...Model transformation is one of the prominent features and the rising research area of Model Driven Engineering (MDE). MDE promotes models to primary artifacts that drive the whole development process. This paper presents the model transformation approach for textual model oriented programs Umple (UML Programming Language) to generate android applications (apps). The proposed approach improved the generation of android source code by using Drools transformation rules and introducing new concern in model driven mobile engineering. The major objective of proposed transformation approach intends to address consistency between source and target model and also intends to handle productivity issues in model driven software development. The main results of model transformation approach are Java class for model layer, XML file for view layer and android activity class for controller layer. Results show that proposed approach achieves high consistency between source and target model and also improves model transformation productivity.展开更多
The author constructed a transformer Scp4 of functional programs. The transformer uses the technology known as Turchin's supercompilation. Scp4 was implemented in a functional language Refal 5. The input language...The author constructed a transformer Scp4 of functional programs. The transformer uses the technology known as Turchin's supercompilation. Scp4 was implemented in a functional language Refal 5. The input language for Scp4 is also Refal 5. In the present paper we give an outline of the supercompiler and consider a number of tools of the transformer in details. The tools can be formally thought of as quasi distributive laws.展开更多
Induction of tumor cell senescence has become a promising strategy for anti-tumor immunotherapy,but fibrotic matrix severely blocks senescence inducers penetration and immune cells infiltration.Herein,we designed a ca...Induction of tumor cell senescence has become a promising strategy for anti-tumor immunotherapy,but fibrotic matrix severely blocks senescence inducers penetration and immune cells infiltration.Herein,we designed a cancer-associated fibroblasts(CAFs)triggered structure-transformable nano-assembly(HSD-P@V),which can directionally deliver valsartan(Val,CAFs regulator)and doxorubicin(DOX,senescence inducer)to the specific targets.In detail,DOX is conjugated with hyaluronic acid(HA)via diselenide bonds(Se-Se)to form HSD micelles,while CAFs-sensitive peptide is grafted onto the HSD to form a hydrophilic polymer,which is coated on Val nanocrystals(VNs)surface for improving the stability and achieving responsive release.Once arriving at tumor microenvironment and touching CAFs,HSD-P@V disintegrates into VNs and HSD micelles due to sensitive peptide detachment.VNs can degrade the extracellularmatrix,leading to the enhanced penetration of HSD.HSD targets tumor cells,releases DOX to induce senescence,and recruits effector immune cells.Furthermore,senescent cells are cleared by the recruited immune cells to finish the integrated anti-tumor therapy.In vitro and in vivo results show that the nanoassembly remarkably inhibits tumor growth as well as lungmetastasis,and extends tumorbearing mice survival.This work provides a promising paradigm of programmed delivering multi-site nanomedicine for cancer immunotherapy.展开更多
This paper studied an integrative fault diagnostic system on the power transformer. On-line monitor items were grounded current of iron core, internal partial discharge and oil dissolved gas. Diagnostic techniques wer...This paper studied an integrative fault diagnostic system on the power transformer. On-line monitor items were grounded current of iron core, internal partial discharge and oil dissolved gas. Diagnostic techniques were simple rule-based judgment, fuzzy logistic reasoning and neural network distinguishing. Considering that much faults information was interactional, intellectualized diagnosis was implemented based on integrating the neural network with the expert system. Hologamous integrating strategies were materialized by information-based integrating monitor devices, shared information database on several levels and fusion diagnosis software along thought patterns. The expert system practiced logic thought by logistic reasoning. The neural network realized image thought by model matching. Creative conclusion was educed by their integrating. The diagnosis example showed that the integrative diagnostic system was reasonable and practical.展开更多
Diabetes has become a growing concern in Japan, both medically and financially. The medical cost of diabetes was estimated at 1215 billion yen for fiscal year 2011. We analyzed the length of stay (LOS) in a hospital f...Diabetes has become a growing concern in Japan, both medically and financially. The medical cost of diabetes was estimated at 1215 billion yen for fiscal year 2011. We analyzed the length of stay (LOS) in a hospital for type 2 diabetes mellitus patients who participated in educational programs to determine factors affecting LOS. Data on 991 patients obtained from 28 Red Cross hospitals in 2008 were used. For the analysis, we used the Box-Cox transformation model and Hausman test. The results revealed that patients aged 75 years and above and those with comorbidities and complications were prone to longer LOS. The analysis also revealed significant differences in LOS across the hospitals, even after controlling for patient characteristics. Finally, we applied the least squares method to determine the effects of hospital and regional factors and revealed that patients’ LOS was affected by the region’s average LOS. Regional corporations and networks appeared to be important in improving educational programs.展开更多
This paper proposed the reclosing method in distribution system with battery energy storage system(BESS)using wavelet transform(WT).The proposed method performs the WT of load current and then calculates the absolute ...This paper proposed the reclosing method in distribution system with battery energy storage system(BESS)using wavelet transform(WT).The proposed method performs the WT of load current and then calculates the absolute value of slope of detail coefficient.The mother wavelet used is db4of level6.The fault clearing is detected using the rapid increase of this value.After the detection of fault clearing,the reclosing is performed.To verify the proposed method,various simulations according to the fault clearing times,fault resistances,and fault lengths are performed using EMTP.The simulation results show that fault clearing can be detected using proposed absolute value of slope of detail coefficient and hence the reclosing can be performed successfully.展开更多
The simplest normal form of resonant double Hopf bifurcation was studied based on Lie operator. The coefficients of the simplest normal forms of resonant double Hopf bifurcation and the nonlinear transformations in te...The simplest normal form of resonant double Hopf bifurcation was studied based on Lie operator. The coefficients of the simplest normal forms of resonant double Hopf bifurcation and the nonlinear transformations in terms of the original system coefficients were given explicitly. The nonlinear transformations were used for reducing the lower- and higher-order normal forms, and the rank of system matrix was used to determine the coefficient of normal form which could be reduced. These make the gained normal form simpler than the traditional one. A general program was compiled with Mathematica. This program can compute the simplest normal form of resonant double Hopf bifurcation and the non-resonant form up to the 7th order.展开更多
Generalized Partial Computation (GPC) is a program transformation method utilizing partial information about input data, properties of auxiliary functions and the logical structure of a source program. GPC uses both a...Generalized Partial Computation (GPC) is a program transformation method utilizing partial information about input data, properties of auxiliary functions and the logical structure of a source program. GPC uses both an inference engine such as a theorem prover and a classical partial evaluator to optimize programs. Therefore, GPC is more powerful than classical partial evaluators but harder to implement and control. We have implemented an experimental GPC system called WSDFU (Waseda Simplify Distribute Fold Unfold). This paper discusses the power of the program transformation system, its theorem prover and future works.展开更多
A global variable in C/C++ is one that is declared outside a function, and whose scope extends the lifetime of the entire program. Global variables cause problems for program dependability, maintainability, extensibil...A global variable in C/C++ is one that is declared outside a function, and whose scope extends the lifetime of the entire program. Global variables cause problems for program dependability, maintainability, extensibility, verification, and thread-safety. However, global variables can also make coding more convenient and improve program performance. We have found the use of global variables to remain unabated and extensive in real-world software. In this paper we present a source-to-source refactoring tool to automatically detect and localize global variables in a program. We implement a compiler based transformation to find the best location to redefine each global variable as a local. For each global, our algorithm initializes the corresponding new local variable, passes it as an argument to necessary functions, and updates the source lines that used the global to now instead use the corresponding local or argument. We also characterize the use of global variables in standard benchmark programs. We study the effect of our transformation on static program properties, such as change in the number of function arguments and program state visibility. Additionally, we quantify dynamic program features, including memory and runtime performance, before and after our localizing transformation.展开更多
Trend term removal is a key step in Fourier transform infrared spectroscopy(FTIR)data pre-processing.The most commonly used least squares(LS)method,although satisfying the real-time requirement,has many problems such ...Trend term removal is a key step in Fourier transform infrared spectroscopy(FTIR)data pre-processing.The most commonly used least squares(LS)method,although satisfying the real-time requirement,has many problems such as highly correlated initial values of the expression parameters,the need to pre-estimate the trend term shape,and poor fitting accuracy at low signal-to-noise ratios.In order to achieve real-time and robust trend term removal,a new trend term removal method using genetic programming(GP)in symbolic regression is constructed in this paper,and the FTIR simulation interference results and experimental measurement data for common volatile organic compounds(VOCs)gases are analyzed.The results show that the genetic programming algorithm can both reduce the initial value requirement and greatly improve the trend term accuracy by 20%-30% in three evaluation indicators,which is suitable for gas FTIR detection in complex scenarios.展开更多
The basis graph \%G\% for a linear programming consists of all bases under pivot transformations. A degenerate optimal basis graph G * is a subgraph of \%G\% induced by all optimal bases at a degenerate optimal verte...The basis graph \%G\% for a linear programming consists of all bases under pivot transformations. A degenerate optimal basis graph G * is a subgraph of \%G\% induced by all optimal bases at a degenerate optimal vertex x 0. In this paper, several conditions for the characterization of G * are presented.展开更多
The study deals with the multi-choice mathematical programming problem, where the right hand side of the constraints is multi-choice in nature. However, the problem of multi-choice linear programming cannot be solved ...The study deals with the multi-choice mathematical programming problem, where the right hand side of the constraints is multi-choice in nature. However, the problem of multi-choice linear programming cannot be solved directly by standard linear or nonlinear programming techniques. The aim of this paper is to transform such problems to a standard mathematical linear programming problem. For each constraint, exactly one parameter value is selected out of a multiple number of parameter values. This process of selection can be established in different ways. In this paper, we present a new simple technique enabling us to handle such problem as a mixed integer linear programming problem and consequently solve them by using standard linear programming software. Our main aim depends on inserting a specific number of binary variables and using them to construct a linear combination which gives just one parameter among the multiple choice values for each choice of the values of the binary variables. A numerical example is presented to illustrate our analysis.展开更多
Lines plan of a ship related to resistance,structural strength,and economic benefit,is a complicated system engineering.Especially for the catamaran-stern hull,the designers have to modify the lines plan of the ship,i...Lines plan of a ship related to resistance,structural strength,and economic benefit,is a complicated system engineering.Especially for the catamaran-stern hull,the designers have to modify the lines plan of the ship,in order to combine the catamaran-stern with the main ship hull.This paper use trigonometric function method to achieve the local transformation of catamaran-stern hull;on the other hand,making it programmed can effectively shorten the cycle of shipbuilding.展开更多
文摘Model transformation is one of the prominent features and the rising research area of Model Driven Engineering (MDE). MDE promotes models to primary artifacts that drive the whole development process. This paper presents the model transformation approach for textual model oriented programs Umple (UML Programming Language) to generate android applications (apps). The proposed approach improved the generation of android source code by using Drools transformation rules and introducing new concern in model driven mobile engineering. The major objective of proposed transformation approach intends to address consistency between source and target model and also intends to handle productivity issues in model driven software development. The main results of model transformation approach are Java class for model layer, XML file for view layer and android activity class for controller layer. Results show that proposed approach achieves high consistency between source and target model and also improves model transformation productivity.
文摘The author constructed a transformer Scp4 of functional programs. The transformer uses the technology known as Turchin's supercompilation. Scp4 was implemented in a functional language Refal 5. The input language for Scp4 is also Refal 5. In the present paper we give an outline of the supercompiler and consider a number of tools of the transformer in details. The tools can be formally thought of as quasi distributive laws.
基金was supported by National Natural Science Foundation of China(81972893,82172719)Natural Science Foundation of Henan(212300410071)Training program for young key teachers in Henan Province(2020GGJS019).
文摘Induction of tumor cell senescence has become a promising strategy for anti-tumor immunotherapy,but fibrotic matrix severely blocks senescence inducers penetration and immune cells infiltration.Herein,we designed a cancer-associated fibroblasts(CAFs)triggered structure-transformable nano-assembly(HSD-P@V),which can directionally deliver valsartan(Val,CAFs regulator)and doxorubicin(DOX,senescence inducer)to the specific targets.In detail,DOX is conjugated with hyaluronic acid(HA)via diselenide bonds(Se-Se)to form HSD micelles,while CAFs-sensitive peptide is grafted onto the HSD to form a hydrophilic polymer,which is coated on Val nanocrystals(VNs)surface for improving the stability and achieving responsive release.Once arriving at tumor microenvironment and touching CAFs,HSD-P@V disintegrates into VNs and HSD micelles due to sensitive peptide detachment.VNs can degrade the extracellularmatrix,leading to the enhanced penetration of HSD.HSD targets tumor cells,releases DOX to induce senescence,and recruits effector immune cells.Furthermore,senescent cells are cleared by the recruited immune cells to finish the integrated anti-tumor therapy.In vitro and in vivo results show that the nanoassembly remarkably inhibits tumor growth as well as lungmetastasis,and extends tumorbearing mice survival.This work provides a promising paradigm of programmed delivering multi-site nanomedicine for cancer immunotherapy.
文摘This paper studied an integrative fault diagnostic system on the power transformer. On-line monitor items were grounded current of iron core, internal partial discharge and oil dissolved gas. Diagnostic techniques were simple rule-based judgment, fuzzy logistic reasoning and neural network distinguishing. Considering that much faults information was interactional, intellectualized diagnosis was implemented based on integrating the neural network with the expert system. Hologamous integrating strategies were materialized by information-based integrating monitor devices, shared information database on several levels and fusion diagnosis software along thought patterns. The expert system practiced logic thought by logistic reasoning. The neural network realized image thought by model matching. Creative conclusion was educed by their integrating. The diagnosis example showed that the integrative diagnostic system was reasonable and practical.
文摘Diabetes has become a growing concern in Japan, both medically and financially. The medical cost of diabetes was estimated at 1215 billion yen for fiscal year 2011. We analyzed the length of stay (LOS) in a hospital for type 2 diabetes mellitus patients who participated in educational programs to determine factors affecting LOS. Data on 991 patients obtained from 28 Red Cross hospitals in 2008 were used. For the analysis, we used the Box-Cox transformation model and Hausman test. The results revealed that patients aged 75 years and above and those with comorbidities and complications were prone to longer LOS. The analysis also revealed significant differences in LOS across the hospitals, even after controlling for patient characteristics. Finally, we applied the least squares method to determine the effects of hospital and regional factors and revealed that patients’ LOS was affected by the region’s average LOS. Regional corporations and networks appeared to be important in improving educational programs.
文摘This paper proposed the reclosing method in distribution system with battery energy storage system(BESS)using wavelet transform(WT).The proposed method performs the WT of load current and then calculates the absolute value of slope of detail coefficient.The mother wavelet used is db4of level6.The fault clearing is detected using the rapid increase of this value.After the detection of fault clearing,the reclosing is performed.To verify the proposed method,various simulations according to the fault clearing times,fault resistances,and fault lengths are performed using EMTP.The simulation results show that fault clearing can be detected using proposed absolute value of slope of detail coefficient and hence the reclosing can be performed successfully.
基金Supported by National Natural Science Foundation of China(No. 10372068).
文摘The simplest normal form of resonant double Hopf bifurcation was studied based on Lie operator. The coefficients of the simplest normal forms of resonant double Hopf bifurcation and the nonlinear transformations in terms of the original system coefficients were given explicitly. The nonlinear transformations were used for reducing the lower- and higher-order normal forms, and the rank of system matrix was used to determine the coefficient of normal form which could be reduced. These make the gained normal form simpler than the traditional one. A general program was compiled with Mathematica. This program can compute the simplest normal form of resonant double Hopf bifurcation and the non-resonant form up to the 7th order.
文摘Generalized Partial Computation (GPC) is a program transformation method utilizing partial information about input data, properties of auxiliary functions and the logical structure of a source program. GPC uses both an inference engine such as a theorem prover and a classical partial evaluator to optimize programs. Therefore, GPC is more powerful than classical partial evaluators but harder to implement and control. We have implemented an experimental GPC system called WSDFU (Waseda Simplify Distribute Fold Unfold). This paper discusses the power of the program transformation system, its theorem prover and future works.
文摘A global variable in C/C++ is one that is declared outside a function, and whose scope extends the lifetime of the entire program. Global variables cause problems for program dependability, maintainability, extensibility, verification, and thread-safety. However, global variables can also make coding more convenient and improve program performance. We have found the use of global variables to remain unabated and extensive in real-world software. In this paper we present a source-to-source refactoring tool to automatically detect and localize global variables in a program. We implement a compiler based transformation to find the best location to redefine each global variable as a local. For each global, our algorithm initializes the corresponding new local variable, passes it as an argument to necessary functions, and updates the source lines that used the global to now instead use the corresponding local or argument. We also characterize the use of global variables in standard benchmark programs. We study the effect of our transformation on static program properties, such as change in the number of function arguments and program state visibility. Additionally, we quantify dynamic program features, including memory and runtime performance, before and after our localizing transformation.
基金supported by JKW Program(No.M102-03)National Program(No.E0F80246).
文摘Trend term removal is a key step in Fourier transform infrared spectroscopy(FTIR)data pre-processing.The most commonly used least squares(LS)method,although satisfying the real-time requirement,has many problems such as highly correlated initial values of the expression parameters,the need to pre-estimate the trend term shape,and poor fitting accuracy at low signal-to-noise ratios.In order to achieve real-time and robust trend term removal,a new trend term removal method using genetic programming(GP)in symbolic regression is constructed in this paper,and the FTIR simulation interference results and experimental measurement data for common volatile organic compounds(VOCs)gases are analyzed.The results show that the genetic programming algorithm can both reduce the initial value requirement and greatly improve the trend term accuracy by 20%-30% in three evaluation indicators,which is suitable for gas FTIR detection in complex scenarios.
基金Project supported by the National Natural Science Foundation of China!(19771075)
文摘The basis graph \%G\% for a linear programming consists of all bases under pivot transformations. A degenerate optimal basis graph G * is a subgraph of \%G\% induced by all optimal bases at a degenerate optimal vertex x 0. In this paper, several conditions for the characterization of G * are presented.
文摘The study deals with the multi-choice mathematical programming problem, where the right hand side of the constraints is multi-choice in nature. However, the problem of multi-choice linear programming cannot be solved directly by standard linear or nonlinear programming techniques. The aim of this paper is to transform such problems to a standard mathematical linear programming problem. For each constraint, exactly one parameter value is selected out of a multiple number of parameter values. This process of selection can be established in different ways. In this paper, we present a new simple technique enabling us to handle such problem as a mixed integer linear programming problem and consequently solve them by using standard linear programming software. Our main aim depends on inserting a specific number of binary variables and using them to construct a linear combination which gives just one parameter among the multiple choice values for each choice of the values of the binary variables. A numerical example is presented to illustrate our analysis.
文摘Lines plan of a ship related to resistance,structural strength,and economic benefit,is a complicated system engineering.Especially for the catamaran-stern hull,the designers have to modify the lines plan of the ship,in order to combine the catamaran-stern with the main ship hull.This paper use trigonometric function method to achieve the local transformation of catamaran-stern hull;on the other hand,making it programmed can effectively shorten the cycle of shipbuilding.