Examining the retinal tissue has the potential to provide a unique method and technique to quantify Alzheimer’s disease-related changes in participants at various stages of the disease.In this metaanalysis,we aimed t...Examining the retinal tissue has the potential to provide a unique method and technique to quantify Alzheimer’s disease-related changes in participants at various stages of the disease.In this metaanalysis,we aimed to investigate the association of various optical coherence tomography parameters with Alzheimer’s disease and whether retinal measurements can be used to diffe rentiate between Alzheimer’s disease and control subjects.Scientific databases including Google Schola r,Web of Science,and PubMed were systematically searched for published articles that evaluated retinal nerve fiber layer thickness and retinal microvascular network in Alzheimer’s disease and control subjects.Seventy-three studies(5850 participants,including 2249 Alzheimer’s disease patients and 3601controls) were included in this meta-analysis.Relative to controls,Alzheimer’s disease patients had a significantly lower global retinal nerve fiber layer thickness(standardized mean difference [SMD]=-0.79,95% confidence intervals [CI]:-1.03 to-0.54,P <0.00001) as well as each quadrant being thinner in Alzheimer’s disease versus controls.Regarding macular paramete rs,values measured by optical coherence tomography were significantly lower in Alzheimer’s disease than controls for macular thickness(pooled SMD:-0.44,95% CI:-0.67 to-0.20,P=0.0003),foveal thickness(pooled SMD=-0.39,95% CI:-0.58 to-0.19,P <0.0001),ganglion cell inner plexiform layer(SMD=-1.26,95% CI:-2.24 to-0.27,P=0.01) and macular volume(pooled SMD=-0.41,95% CI-0.76 to-0.07,P=0.02).Analysis using optical coherence tomography angiography parameters revealed mixed results between Alzheimer’s disease and controls.Superficial vessel density(pooled SMD=-0.42,95% CI:-0.68 to-0.17,P=0.0001) and deep vessel density(pooled SMD=-0.46,95% CI:-0.75 to-0.18,P=0.001) were found to be thinner in Alzheimer’s disease patients whereas the foveal avascular zone(SMD=0.84,95% CI:0.17-1.51,P=0.01) was larger in controls.Vascular density and thickness of various retinal laye rs were decreased in Alzheimer’s disease patients compared to controls.Our results provide evidence for optical coherence tomography technology having the potential to detect retinal and microvascular changes in patients diagnosed with Alzheimer’s disease and aid in monito ring and early diagnosis methods.展开更多
1研究背景。广东拥有超高密度的高层建筑群、现代化的综合交通运输体系、世界级港口群、空港群,高速公路、铁路、城市轨道交通总里程位居全国前列,具有人口密度高,经济体量大,社会影响广的特点。同时,广东经济最为发达的珠江三角洲地区...1研究背景。广东拥有超高密度的高层建筑群、现代化的综合交通运输体系、世界级港口群、空港群,高速公路、铁路、城市轨道交通总里程位居全国前列,具有人口密度高,经济体量大,社会影响广的特点。同时,广东经济最为发达的珠江三角洲地区位于华南沿海地震带中段的构造断陷盆地,盆地内部及边缘区NE向、NW向以及NEE向断裂互相切割且具有多期活动的特点(林纪曾等,1980;Lee and Lawver,1995;魏柏林等,2001);广东近海展布着曾发生多次强震的滨海断裂带,滨海断裂带是南海北部的重要控震构造和发震构造(刘以宣等,1981;赵明辉等,2003,2004;徐辉龙等,2006;孙金龙等,2012;曹敬贺等,2014),2015年发布的《中国地震动参数区划图》曾将珠江口列为7.5级潜在震源区。展开更多
基金National Health and Medical Research Council (NHMRC) Australia (to VG)。
文摘Examining the retinal tissue has the potential to provide a unique method and technique to quantify Alzheimer’s disease-related changes in participants at various stages of the disease.In this metaanalysis,we aimed to investigate the association of various optical coherence tomography parameters with Alzheimer’s disease and whether retinal measurements can be used to diffe rentiate between Alzheimer’s disease and control subjects.Scientific databases including Google Schola r,Web of Science,and PubMed were systematically searched for published articles that evaluated retinal nerve fiber layer thickness and retinal microvascular network in Alzheimer’s disease and control subjects.Seventy-three studies(5850 participants,including 2249 Alzheimer’s disease patients and 3601controls) were included in this meta-analysis.Relative to controls,Alzheimer’s disease patients had a significantly lower global retinal nerve fiber layer thickness(standardized mean difference [SMD]=-0.79,95% confidence intervals [CI]:-1.03 to-0.54,P <0.00001) as well as each quadrant being thinner in Alzheimer’s disease versus controls.Regarding macular paramete rs,values measured by optical coherence tomography were significantly lower in Alzheimer’s disease than controls for macular thickness(pooled SMD:-0.44,95% CI:-0.67 to-0.20,P=0.0003),foveal thickness(pooled SMD=-0.39,95% CI:-0.58 to-0.19,P <0.0001),ganglion cell inner plexiform layer(SMD=-1.26,95% CI:-2.24 to-0.27,P=0.01) and macular volume(pooled SMD=-0.41,95% CI-0.76 to-0.07,P=0.02).Analysis using optical coherence tomography angiography parameters revealed mixed results between Alzheimer’s disease and controls.Superficial vessel density(pooled SMD=-0.42,95% CI:-0.68 to-0.17,P=0.0001) and deep vessel density(pooled SMD=-0.46,95% CI:-0.75 to-0.18,P=0.001) were found to be thinner in Alzheimer’s disease patients whereas the foveal avascular zone(SMD=0.84,95% CI:0.17-1.51,P=0.01) was larger in controls.Vascular density and thickness of various retinal laye rs were decreased in Alzheimer’s disease patients compared to controls.Our results provide evidence for optical coherence tomography technology having the potential to detect retinal and microvascular changes in patients diagnosed with Alzheimer’s disease and aid in monito ring and early diagnosis methods.
文摘1研究背景。广东拥有超高密度的高层建筑群、现代化的综合交通运输体系、世界级港口群、空港群,高速公路、铁路、城市轨道交通总里程位居全国前列,具有人口密度高,经济体量大,社会影响广的特点。同时,广东经济最为发达的珠江三角洲地区位于华南沿海地震带中段的构造断陷盆地,盆地内部及边缘区NE向、NW向以及NEE向断裂互相切割且具有多期活动的特点(林纪曾等,1980;Lee and Lawver,1995;魏柏林等,2001);广东近海展布着曾发生多次强震的滨海断裂带,滨海断裂带是南海北部的重要控震构造和发震构造(刘以宣等,1981;赵明辉等,2003,2004;徐辉龙等,2006;孙金龙等,2012;曹敬贺等,2014),2015年发布的《中国地震动参数区划图》曾将珠江口列为7.5级潜在震源区。
