In this paper, we report the synthesis of a potential anti-cancer agent: Cyclo[Val-Lys(DMQ-MA)-Gaba]. The cytotoxic agent conjugated to the N-terminal and the xi -amino group of lysine of the tripeptide is 2,6-dimetho...In this paper, we report the synthesis of a potential anti-cancer agent: Cyclo[Val-Lys(DMQ-MA)-Gaba]. The cytotoxic agent conjugated to the N-terminal and the xi -amino group of lysine of the tripeptide is 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). By employing the rhodamine B degradation method and ESR spectra, we testify the reactive oxygen species - hydroxyl radicals produced by the drug.展开更多
基金the National Natural Science Foundation of China and Provincial Natural Foundation of Shanxi.
文摘In this paper, we report the synthesis of a potential anti-cancer agent: Cyclo[Val-Lys(DMQ-MA)-Gaba]. The cytotoxic agent conjugated to the N-terminal and the xi -amino group of lysine of the tripeptide is 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). By employing the rhodamine B degradation method and ESR spectra, we testify the reactive oxygen species - hydroxyl radicals produced by the drug.
