期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Screening primary racemic amines for enantioseparation by derivatized polysaccharide and cyclofructan columns
1
作者 Yeeun Lim Zachary S.Breitbach +1 位作者 Daniel W.Armstrong Alain Berthod 《Journal of Pharmaceutical Analysis》 SCIE CAS 2016年第6期345-355,共11页
It is a challenge to separate the enantiomers of native chiral amines prone to deleterious silanol interactions. Aset of 39 underivatized chiral primary amines was screened for enantiomeric separation. Seven recentlyi... It is a challenge to separate the enantiomers of native chiral amines prone to deleterious silanol interactions. Aset of 39 underivatized chiral primary amines was screened for enantiomeric separation. Seven recentlyintroduced commercial chiral columns were tested. They included six polysaccharide based chiral stationaryphases (CSP) with bonded derivatives, ChiralPak? IA, IB, IC, ID, IE and IF columns and a cyclofructanderivatized CSP, Larihc? CF6-P column. Both the normal phase (NP) mode with heptane/alcohol mobile phasesand the polar organic (PO) mode with acetonitrile/alcohol were evaluated. It was found that the cyclofructanbased CSP demonstrated the highest success rate in separating primary amines in the PO mode with only onechiral amine not resolved. It is shown that, when screening the columns, there is no standard optimal condition;an excellent mobile phase composition for one column may be poorly suited to another one. Althoughbutylamine was a good mobile phase additive for the polysaccharide columns in both PO and NP modes, it wasdetrimental to the enantio-recognition capability of the cyclofructan column. Triethylamine was the appropriatesilanol screening agent for this latter column. 展开更多
关键词 Chiral PRIMARY AMINES Cyclofructan Bonded POLYSACCHARIDE Enantiomeric separation
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部