BACKGROUND John Henryism(JH)is a strategy for dealing with chronic psychological stress characterized by high levels of physical effort and work.Cynicism is a belief that people are motivated primarily by self-interes...BACKGROUND John Henryism(JH)is a strategy for dealing with chronic psychological stress characterized by high levels of physical effort and work.Cynicism is a belief that people are motivated primarily by self-interest.High scores on the JH scale and cynicism measures correlate with an increased risk of cardiovascular disease.High cynicism is also a hallmark of burnout syndrome,another known risk factor for heart disease.AIM To evaluate possible interactions between JH and cynicism hoping to clarify risk factors of burnout.METHODS We analyzed genetic and psychological data available from the Database of Genotypes and Phenotypes for genome-wide associations with these traits.We split the total available samples and used plink to perform the association studies on the discovery set(n=1852,80%)and tested for replication using the validation set(n=465).We used scikit-learn to perform supervised machine learning for developing genetic risk algorithms.RESULTS We identified 2,727,and 204 genetic associations for scores on the JH,cynicism and cynical distrust(CD)scales,respectively.We also found 173 associations with high cynicism,109 with high CD,but no associations with high JH.We also produced polygenic classifiers for high cynicism using machine learning with areas under the receiver operator characteristics curve greater than 0.7.CONCLUSION We found significant genetic components to these traits but no evidence of an interaction.Therefore,while there may be a genetic risk,JH is not likely a burnout risk factor.展开更多
目的研究儿科重症监护病房(pediatric intensive care unit,PICU)住院医师职业倦怠的现状,探索降低职业倦怠的方法。方法2019年1月—2021年12月,采用问卷调查法、统计学分析方法对上海某三甲医院PICU住院医师的职业倦怠进行分析。结果...目的研究儿科重症监护病房(pediatric intensive care unit,PICU)住院医师职业倦怠的现状,探索降低职业倦怠的方法。方法2019年1月—2021年12月,采用问卷调查法、统计学分析方法对上海某三甲医院PICU住院医师的职业倦怠进行分析。结果回收有效问卷71份。研究对象职业倦怠量表中“情绪衰竭”“玩世不恭”“个人成就感低”三个维度得分分别为(3.55±0.94)分、(2.45±1.10)分、(2.90±0.65)分,有77.5%的医师存在中度职业倦怠,21.1%的医师存在重度职业倦怠。职业倦怠的两个分量表(情绪衰竭、玩世不恭)与内在工作满意度、外在工作满意度、总体工作满意度差异有统计学意义(P<0.05)。学历、年龄、工作时间、收入与PICU住院医生职业倦怠得分的差异有统计学意义(P<0.05)。其中研究生学历者、每周工作时间≥50小时者“情绪衰竭”得分更高,年龄≥30岁者、年收入<10万元者“个人成就感低”得分更高。结论PICU住院医师职业倦怠水平高,职业倦怠与工作满意度呈负相关,学历、年龄、工作时间、收入可影响职业倦怠水平,应采取措施降低职业倦怠,稳定医疗队伍。展开更多
文摘BACKGROUND John Henryism(JH)is a strategy for dealing with chronic psychological stress characterized by high levels of physical effort and work.Cynicism is a belief that people are motivated primarily by self-interest.High scores on the JH scale and cynicism measures correlate with an increased risk of cardiovascular disease.High cynicism is also a hallmark of burnout syndrome,another known risk factor for heart disease.AIM To evaluate possible interactions between JH and cynicism hoping to clarify risk factors of burnout.METHODS We analyzed genetic and psychological data available from the Database of Genotypes and Phenotypes for genome-wide associations with these traits.We split the total available samples and used plink to perform the association studies on the discovery set(n=1852,80%)and tested for replication using the validation set(n=465).We used scikit-learn to perform supervised machine learning for developing genetic risk algorithms.RESULTS We identified 2,727,and 204 genetic associations for scores on the JH,cynicism and cynical distrust(CD)scales,respectively.We also found 173 associations with high cynicism,109 with high CD,but no associations with high JH.We also produced polygenic classifiers for high cynicism using machine learning with areas under the receiver operator characteristics curve greater than 0.7.CONCLUSION We found significant genetic components to these traits but no evidence of an interaction.Therefore,while there may be a genetic risk,JH is not likely a burnout risk factor.
文摘目的研究儿科重症监护病房(pediatric intensive care unit,PICU)住院医师职业倦怠的现状,探索降低职业倦怠的方法。方法2019年1月—2021年12月,采用问卷调查法、统计学分析方法对上海某三甲医院PICU住院医师的职业倦怠进行分析。结果回收有效问卷71份。研究对象职业倦怠量表中“情绪衰竭”“玩世不恭”“个人成就感低”三个维度得分分别为(3.55±0.94)分、(2.45±1.10)分、(2.90±0.65)分,有77.5%的医师存在中度职业倦怠,21.1%的医师存在重度职业倦怠。职业倦怠的两个分量表(情绪衰竭、玩世不恭)与内在工作满意度、外在工作满意度、总体工作满意度差异有统计学意义(P<0.05)。学历、年龄、工作时间、收入与PICU住院医生职业倦怠得分的差异有统计学意义(P<0.05)。其中研究生学历者、每周工作时间≥50小时者“情绪衰竭”得分更高,年龄≥30岁者、年收入<10万元者“个人成就感低”得分更高。结论PICU住院医师职业倦怠水平高,职业倦怠与工作满意度呈负相关,学历、年龄、工作时间、收入可影响职业倦怠水平,应采取措施降低职业倦怠,稳定医疗队伍。
