This study investigated whether bone marrow mesenchymal stem cell(BMSC) transplantation protected ischemic cerebral injury by stimulating endogenous erythropoietin. The model of ischemic stroke was established in ra...This study investigated whether bone marrow mesenchymal stem cell(BMSC) transplantation protected ischemic cerebral injury by stimulating endogenous erythropoietin. The model of ischemic stroke was established in rats through transient middle cerebral artery occlusion. Twenty-four hours later, 1 × 106 human BMSCs(h BMSCs) were injected into the tail vein. Fourteen days later, we found that h BMSCs promoted the release of endogenous erythropoietin in the ischemic region of rats. Simultaneously, 3 μg/d soluble erythropoietin receptor(s EPOR) was injected into the lateral ventricle, and on the next 13 consecutive days. s EPOR blocked the release of endogenous erythropoietin. The neurogenesis in the subventricular zone was less in the h BMSCs + s EPOR group than in the h BMSCs + heat-denatured s EPOR group. The adhesive-removal test result and the modified Neurological Severity Scores(m NSS) were lower in the h BMSCs + s EPOR group than in the heat-denatured s EPOR group. The adhesive-removal test result and m NSS were similar between the h BMSCs + heat-denatured s EPOR group and the h BMSCs + s EPOR group. These findings confirm that BMSCs contribute to neurogenesis and improve neurological function by promoting the release of endogenous erythropoietin following ischemic stroke.展开更多
The epidermis is the outermost layer of skin and the first barrier against invasion.Dendritic epidermal T cells(DETCs)are a subset ofT cells and an important component of the epidermal immune microenvironment.DETCs a...The epidermis is the outermost layer of skin and the first barrier against invasion.Dendritic epidermal T cells(DETCs)are a subset ofT cells and an important component of the epidermal immune microenvironment.DETCs are involved in skin wound healing,malignancy and autoim-mune diseases.DETCs secrete insulin-like growth factor-1 and keratinocyte growth factor for skin homeostasis and re-epithelization and release inflammatory factors to adjust the inflammatory microenvironment of wound healing.Therefore,an understanding of their development,activation and correlative signalling pathways is indispensable for the regulation of DETCs to accelerate wound healing.Our review focuses on the above-mentioned molecular mechanisms to provide a general research framework to regulate and control the function of DETCs.展开更多
Major depressive disorder(MDD) is a common and devastating psychiatric disorder characterized by persistent low mood,cognitive disorder,and impaired social function. Despite its complex mechanisms,increasing evidenc...Major depressive disorder(MDD) is a common and devastating psychiatric disorder characterized by persistent low mood,cognitive disorder,and impaired social function. Despite its complex mechanisms,increasing evidence has identified the involvement of neurotrophic factors,inflammatory cytokines,the hypothalamuspituitary-adrenal axis,and glutamate receptors in the pathophysiology of this illness. The present review synthesizes recent research achievements to defi ne the network between different hypotheses of MDD and to understand which part is most pivotal for its pathogenesis. By integrating MDD-related signal pathways,we highlight brain-derived neurotrophic factor(BDNF) dysfunction and increased apoptosis as the fi nal common cascades,and new therapeutic strategies aiming to enhance BDNF function have been shown to exert a rapid and effective antidepressant action.展开更多
基金supported by the National Natural Science Foundation of China,No.81371258a grant from the TCM General Research Project of Zhejiang Province of China,No.2015ZA061a grant from the Education of Zhejiang Province of China,Y201431639
文摘This study investigated whether bone marrow mesenchymal stem cell(BMSC) transplantation protected ischemic cerebral injury by stimulating endogenous erythropoietin. The model of ischemic stroke was established in rats through transient middle cerebral artery occlusion. Twenty-four hours later, 1 × 106 human BMSCs(h BMSCs) were injected into the tail vein. Fourteen days later, we found that h BMSCs promoted the release of endogenous erythropoietin in the ischemic region of rats. Simultaneously, 3 μg/d soluble erythropoietin receptor(s EPOR) was injected into the lateral ventricle, and on the next 13 consecutive days. s EPOR blocked the release of endogenous erythropoietin. The neurogenesis in the subventricular zone was less in the h BMSCs + s EPOR group than in the h BMSCs + heat-denatured s EPOR group. The adhesive-removal test result and the modified Neurological Severity Scores(m NSS) were lower in the h BMSCs + s EPOR group than in the heat-denatured s EPOR group. The adhesive-removal test result and m NSS were similar between the h BMSCs + heat-denatured s EPOR group and the h BMSCs + s EPOR group. These findings confirm that BMSCs contribute to neurogenesis and improve neurological function by promoting the release of endogenous erythropoietin following ischemic stroke.
基金supported by grants from the General Program of National Natural Science Foundation of China(31872742 to WH,31970830 ,81630025 to JH,31800722 to ZM)the Military Medical Science and Technology Youth Cultivation Plan(20QNPY024)+3 种基金the Traditional Chinese Medicine Bureau of Guangdong Province(2018071 to JH)the Guangzhou Municipal Science and Technology Bureau(201904010090 to JH)the Health Commission of Guangdong Province(A2019520 to JH)a grant from the Tianjin Natural Science Foundation(19JCQNJC11400 to ZM).
文摘The epidermis is the outermost layer of skin and the first barrier against invasion.Dendritic epidermal T cells(DETCs)are a subset ofT cells and an important component of the epidermal immune microenvironment.DETCs are involved in skin wound healing,malignancy and autoim-mune diseases.DETCs secrete insulin-like growth factor-1 and keratinocyte growth factor for skin homeostasis and re-epithelization and release inflammatory factors to adjust the inflammatory microenvironment of wound healing.Therefore,an understanding of their development,activation and correlative signalling pathways is indispensable for the regulation of DETCs to accelerate wound healing.Our review focuses on the above-mentioned molecular mechanisms to provide a general research framework to regulate and control the function of DETCs.
基金supported by the Key Program of the National Natural Science of China (81130020)a National 12th Five Year Plan Support Project of China (2012BAI01B07)
文摘Major depressive disorder(MDD) is a common and devastating psychiatric disorder characterized by persistent low mood,cognitive disorder,and impaired social function. Despite its complex mechanisms,increasing evidence has identified the involvement of neurotrophic factors,inflammatory cytokines,the hypothalamuspituitary-adrenal axis,and glutamate receptors in the pathophysiology of this illness. The present review synthesizes recent research achievements to defi ne the network between different hypotheses of MDD and to understand which part is most pivotal for its pathogenesis. By integrating MDD-related signal pathways,we highlight brain-derived neurotrophic factor(BDNF) dysfunction and increased apoptosis as the fi nal common cascades,and new therapeutic strategies aiming to enhance BDNF function have been shown to exert a rapid and effective antidepressant action.