Two new C-glucoside flavonoids, namely 8-C-b-D-(2-O-acetyl) glucofuranosyl apigenin and 3-O-acetylvitexin, were isolated from leaves of Crataegus pinnatifida Bge. var. major N. E. Br.. Their structures were elucidated...Two new C-glucoside flavonoids, namely 8-C-b-D-(2-O-acetyl) glucofuranosyl apigenin and 3-O-acetylvitexin, were isolated from leaves of Crataegus pinnatifida Bge. var. major N. E. Br.. Their structures were elucidated by the spectroscopic means and chemical evidence.展开更多
Hepatitis C virus(HCV) replication is associated with the endoplasmic reticulum, where the virus can induce cellular stress. Oxidative cell damage plays an important role in HCV physiopathology. Oxidative stress is tr...Hepatitis C virus(HCV) replication is associated with the endoplasmic reticulum, where the virus can induce cellular stress. Oxidative cell damage plays an important role in HCV physiopathology. Oxidative stress is triggered when the concentration of oxygen species in the extracellular or intracellular environment exceeds antioxidant defenses. Cells are protected and modulate oxidative stress through the interplay of intracellular antioxidant agents, mainly glutathione system(GSH) and thioredoxin; and antioxidant enzyme systems such as superoxide dismutase, catalase, GSH peroxidase, and heme oxygenase-1. Also, the use of natural and synthetic antioxidants(vitamin C and E, N-acetylcysteine, glycyrrhizin, polyenylphosphatidyl choline, mitoquinone, quercetin, S-adenosylmethionine and silymarin) has already shown promising results as co-adjuvants in HCV therapy. Despite all the available information, it is not known how different agents with antiviral activity can interfere with the modulation of the cell redox state induced by HCV and decrease viral replication. This review describes an evidence-based consensus on molecular mechanisms involved in HCV replication and their relationship with cell damage induced by oxidative stress generated by the virus itself and cell antiviral machinery. It also describes some molecules that modify the levels of oxidative stress in HCV-infected cells.展开更多
It has been made a proposal of new ideal cycle for power plants which is working by a turbine gas, for both closed and open systems. It has been designed a special device for adding heat at constant volume. The aim of...It has been made a proposal of new ideal cycle for power plants which is working by a turbine gas, for both closed and open systems. It has been designed a special device for adding heat at constant volume. The aim of special device is to decrease the amount of added heat for the new cycle. We have made a comparison between the simple gas turbine cycle & the new cycle. The results has been shown, that the efficiency of new cycle is greater than the simple cycle of gas turbine.展开更多
In order to reasonably explain the phenomenon of cell bioelectricity,we proposed the conservation law of cell membrane area,established the ion inequality equation,and therefore paid attention to the mystery of“θ-τ...In order to reasonably explain the phenomenon of cell bioelectricity,we proposed the conservation law of cell membrane area,established the ion inequality equation,and therefore paid attention to the mystery of“θ-τ”.We researched and analyzed the“θ-τ”mystery,discussed the parity non-conservation in weak interactions,suggested possible experiments to test the parity non-conservation in weak interactions,and gave our research and analysis conclusions:The parity non-conservation in weak interactions,is still a“conjecture”;The experimental scheme suggested in the papers by C.N.Yang et al.cannot determine whether the weak interaction can separate left and right,and it is impossible to directly answer whetherθandτin the“θ-τ”mystery are the same particle;The Co60βdecay experiment such as C.S.Wu is a pseudo-mirror experiment,whether the experimental result violates parity conservation is only based on the assumption of C.N.Yang et al.In fact,experiments such as polarized Co60 did not overturn the so-called“law of parity conservation”.The mirror image principle does not have any physical meaning,does not correspond to any physical conservation quantity,and cannot be destroyed by any physical experiment.In the process of turning“mirror symmetry”and“mirror asymmetry”into so-called physical“common sense”and scientific“facts”respectively,the methods of transformation are“stealing concepts”and“circular argumentation”.The“θ-τ”mystery is a“man-made”mystery.θandτare two different particles,which may be the result of the same precursor particle being divided into two.The work of C.N.Yang,T.D.Lee,C.S.Wu et al.has brought quantum physicists from the“small black room”to the“bigger black room”or“smaller black room”.The right and wise choice is to go back through the door that came in.With the development of science today,it is time for some contents to reform from the bottom.展开更多
在基于Mesh-under的IPv6低功耗无线个域网(IPv6over low-power wireless personal area networks,6LoWPAN)中,针对传输路径上中间节点重传缓存溢出导致重传数据分片丢失,造成网络性能下降等问题,提出一种基于Mesh-under的备用缓存机制...在基于Mesh-under的IPv6低功耗无线个域网(IPv6over low-power wireless personal area networks,6LoWPAN)中,针对传输路径上中间节点重传缓存溢出导致重传数据分片丢失,造成网络性能下降等问题,提出一种基于Mesh-under的备用缓存机制。本文所提机制根据传输路径上各节点重传缓存使用情况及数据分片剩余跳数等信息,设置动态重传缓存门限,并为超过该门限的节点从其邻居节点中挑选合适的备用缓存节点,从而完成数据分片的缓存与重传过程,达到均衡使用各节点重传缓存的目的。结果表明,所提机制能够有效避免重传缓存溢出,减小网络能耗,同时进一步提高目的端重组成功率。展开更多
现有研究集中于企业国际化节奏的作用及其影响因素,缺乏对CM N Es海外资源获取过程中国际化节奏不规律的后果及其应对机制的关注。本文采用事件路径分析方法,抽取两家典型CM N Es的海外技术与市场资源获取相关事件,基于悖论视角,分析国...现有研究集中于企业国际化节奏的作用及其影响因素,缺乏对CM N Es海外资源获取过程中国际化节奏不规律的后果及其应对机制的关注。本文采用事件路径分析方法,抽取两家典型CM N Es的海外技术与市场资源获取相关事件,基于悖论视角,分析国际化节奏不规律下技术与市场资源获取对立关系的演化趋势。根据资源获取对象和获取方式,本文提出一个海外资源获取矩阵结构,揭示了资源获取跨领域互动过程中的缓冲机制。研究结果表明,CM N Es能够分别通过桥接和支撑协调冲突,形成惯例与能动双缓冲机制,二者共同促进技术和市场领域从二元对立向相互依赖对立演化,以应对连续的国际化节奏不规律。展开更多
文摘Two new C-glucoside flavonoids, namely 8-C-b-D-(2-O-acetyl) glucofuranosyl apigenin and 3-O-acetylvitexin, were isolated from leaves of Crataegus pinnatifida Bge. var. major N. E. Br.. Their structures were elucidated by the spectroscopic means and chemical evidence.
基金Supported by The CONACYTNo.CB-2011-1-58781 to Ana M Rivas-Estilla(partially)Red CA Fisiopatología de Enfermedades Hepáticas 2015
文摘Hepatitis C virus(HCV) replication is associated with the endoplasmic reticulum, where the virus can induce cellular stress. Oxidative cell damage plays an important role in HCV physiopathology. Oxidative stress is triggered when the concentration of oxygen species in the extracellular or intracellular environment exceeds antioxidant defenses. Cells are protected and modulate oxidative stress through the interplay of intracellular antioxidant agents, mainly glutathione system(GSH) and thioredoxin; and antioxidant enzyme systems such as superoxide dismutase, catalase, GSH peroxidase, and heme oxygenase-1. Also, the use of natural and synthetic antioxidants(vitamin C and E, N-acetylcysteine, glycyrrhizin, polyenylphosphatidyl choline, mitoquinone, quercetin, S-adenosylmethionine and silymarin) has already shown promising results as co-adjuvants in HCV therapy. Despite all the available information, it is not known how different agents with antiviral activity can interfere with the modulation of the cell redox state induced by HCV and decrease viral replication. This review describes an evidence-based consensus on molecular mechanisms involved in HCV replication and their relationship with cell damage induced by oxidative stress generated by the virus itself and cell antiviral machinery. It also describes some molecules that modify the levels of oxidative stress in HCV-infected cells.
文摘It has been made a proposal of new ideal cycle for power plants which is working by a turbine gas, for both closed and open systems. It has been designed a special device for adding heat at constant volume. The aim of special device is to decrease the amount of added heat for the new cycle. We have made a comparison between the simple gas turbine cycle & the new cycle. The results has been shown, that the efficiency of new cycle is greater than the simple cycle of gas turbine.
文摘In order to reasonably explain the phenomenon of cell bioelectricity,we proposed the conservation law of cell membrane area,established the ion inequality equation,and therefore paid attention to the mystery of“θ-τ”.We researched and analyzed the“θ-τ”mystery,discussed the parity non-conservation in weak interactions,suggested possible experiments to test the parity non-conservation in weak interactions,and gave our research and analysis conclusions:The parity non-conservation in weak interactions,is still a“conjecture”;The experimental scheme suggested in the papers by C.N.Yang et al.cannot determine whether the weak interaction can separate left and right,and it is impossible to directly answer whetherθandτin the“θ-τ”mystery are the same particle;The Co60βdecay experiment such as C.S.Wu is a pseudo-mirror experiment,whether the experimental result violates parity conservation is only based on the assumption of C.N.Yang et al.In fact,experiments such as polarized Co60 did not overturn the so-called“law of parity conservation”.The mirror image principle does not have any physical meaning,does not correspond to any physical conservation quantity,and cannot be destroyed by any physical experiment.In the process of turning“mirror symmetry”and“mirror asymmetry”into so-called physical“common sense”and scientific“facts”respectively,the methods of transformation are“stealing concepts”and“circular argumentation”.The“θ-τ”mystery is a“man-made”mystery.θandτare two different particles,which may be the result of the same precursor particle being divided into two.The work of C.N.Yang,T.D.Lee,C.S.Wu et al.has brought quantum physicists from the“small black room”to the“bigger black room”or“smaller black room”.The right and wise choice is to go back through the door that came in.With the development of science today,it is time for some contents to reform from the bottom.
文摘在基于Mesh-under的IPv6低功耗无线个域网(IPv6over low-power wireless personal area networks,6LoWPAN)中,针对传输路径上中间节点重传缓存溢出导致重传数据分片丢失,造成网络性能下降等问题,提出一种基于Mesh-under的备用缓存机制。本文所提机制根据传输路径上各节点重传缓存使用情况及数据分片剩余跳数等信息,设置动态重传缓存门限,并为超过该门限的节点从其邻居节点中挑选合适的备用缓存节点,从而完成数据分片的缓存与重传过程,达到均衡使用各节点重传缓存的目的。结果表明,所提机制能够有效避免重传缓存溢出,减小网络能耗,同时进一步提高目的端重组成功率。
文摘现有研究集中于企业国际化节奏的作用及其影响因素,缺乏对CM N Es海外资源获取过程中国际化节奏不规律的后果及其应对机制的关注。本文采用事件路径分析方法,抽取两家典型CM N Es的海外技术与市场资源获取相关事件,基于悖论视角,分析国际化节奏不规律下技术与市场资源获取对立关系的演化趋势。根据资源获取对象和获取方式,本文提出一个海外资源获取矩阵结构,揭示了资源获取跨领域互动过程中的缓冲机制。研究结果表明,CM N Es能够分别通过桥接和支撑协调冲突,形成惯例与能动双缓冲机制,二者共同促进技术和市场领域从二元对立向相互依赖对立演化,以应对连续的国际化节奏不规律。
