As one of the most simple and effective single image dehazing methods, the dark channel prior(DCP) algorithm has been widely applied. However, the algorithm does not work for pixels similar to airlight(e.g., snowy gro...As one of the most simple and effective single image dehazing methods, the dark channel prior(DCP) algorithm has been widely applied. However, the algorithm does not work for pixels similar to airlight(e.g., snowy ground or a white wall), resulting in underestimation of the transmittance of some local scenes. To address that problem, we propose an image dehazing method by incorporating Markov random field(MRF) with the DCP. The DCP explicitly represents the input image observation in the MRF model obtained by the transmittance map. The key idea is that the sparsely distributed wrongly estimated transmittance can be corrected by properly characterizing the spatial dependencies between the neighboring pixels of the transmittances that are well estimated and those that are wrongly estimated. To that purpose, the energy function of the MRF model is designed. The estimation of the initial transmittance map is pixel-based using the DCP, and the segmentation on the transmittance map is employed to separate the foreground and background, thereby avoiding the block effect and artifacts at the depth discontinuity. Given the limited number of labels obtained by clustering, the smoothing term in the MRF model can properly smooth the transmittance map without an extra refinement filter. Experimental results obtained by using terrestrial and underwater images are given.展开更多
The blurred image restoration method can dramatically highlight the image details and enhance the global contrast, which is of benefit to improvement of the visual effect during practical ap- plications. This paper is...The blurred image restoration method can dramatically highlight the image details and enhance the global contrast, which is of benefit to improvement of the visual effect during practical ap- plications. This paper is based on the dark channel prior principle and aims at the prior information absent blurred image degradation situation. A lot of improvements have been made to estimate the transmission map of blurred images. Since the dark channel prior principle can effectively restore the blurred image at the cost of a large amount of computation, the total variation (TV) and image morphology transform (specifically top-hat transform and bottom- hat transform) have been introduced into the improved method. Compared with original transmission map estimation methods, the proposed method features both simplicity and accuracy. The es- timated transmission map together with the element can restore the image. Simulation results show that this method could inhibit the ill-posed problem during image restoration, meanwhile it can greatly improve the image quality and definition.展开更多
Focusing on the degradation of foggy images, a restora- tion approach from a single image based on spatial correlation of dark channel prior is proposed. Firstly, the transmission of each pixel is estimated by the spa...Focusing on the degradation of foggy images, a restora- tion approach from a single image based on spatial correlation of dark channel prior is proposed. Firstly, the transmission of each pixel is estimated by the spatial correlation of dark channel prior. Secondly, a degradation model is utilized to restore the foggy image. Thirdly, the final recovered image, with enhanced contrast, is obtained by performing a post-processing technique based on just-noticeable difference. Experimental results demonstrate that the information of a foggy image can be recovered perfectly by the proposed method, even in the case of the abrupt depth changing scene.展开更多
In the field of computer and machine vision, haze and fog lead to image degradation through various degradation mechanisms including but not limited to contrast attenuation, blurring and pixel distortions. This limits...In the field of computer and machine vision, haze and fog lead to image degradation through various degradation mechanisms including but not limited to contrast attenuation, blurring and pixel distortions. This limits the efficiency of machine vision systems such as video surveillance, target tracking and recognition. Various single image dark channel dehazing algorithms have aimed to tackle the problem of image hazing in a fast and efficient manner. Such algorithms rely upon the dark channel prior theory towards the estimation of the atmospheric light which offers itself as a crucial parameter towards dehazing. This paper studies the state-of-the-art in this area and puts forwards their strengths and weaknesses. Through experiments the efficiencies and shortcomings of these algorithms are shared. This information is essential for researchers and developers in providing a reference for the development of applications and future of the research field.展开更多
To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be elucidated.Here,Piezo1 channel was identified as a key iron transporter in response to mechanica...To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be elucidated.Here,Piezo1 channel was identified as a key iron transporter in response to mechanical stress.Piezo1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron gatekeeper.Furthermore,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical stress.Moreover,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases.展开更多
The concentration difference in the near-surface region of lithium metal is the main cause of lithium dendrite growth.Resolving this issue will be key to achieving high-performance lithium metal batteries(LMBs).Herein...The concentration difference in the near-surface region of lithium metal is the main cause of lithium dendrite growth.Resolving this issue will be key to achieving high-performance lithium metal batteries(LMBs).Herein,we construct a lithium nitrate(LiNO_(3))-implanted electroactiveβphase polyvinylidene fluoride-co-hexafluoropropylene(PVDF-HFP)crystalline polymorph layer(PHL).The electronegatively charged polymer chains attain lithium ions on the surface to form lithium-ion charged channels.These channels act as reservoirs to sustainably release Li ions to recompense the ionic flux of electrolytes,decreasing the growth of lithium dendrites.The stretched molecular channels can also accelerate the transport of Li ions.The combined effects enable a high Coulombic efficiency of 97.0%for 250 cycles in lithium(Li)||copper(Cu)cell and a stable symmetric plating/stripping behavior over 2000 h at 3 mA cm^(-2)with ultrahigh Li utilization of 50%.Furthermore,the full cell coupled with PHL-Cu@Li anode and Li Fe PO_(4) cathode exhibits long-term cycle stability with high-capacity retention of 95.9%after 900 cycles.Impressively,the full cell paired with LiNi_(0.87)Co_(0.1)Mn_(0.03)O_(2)maintains a discharge capacity of 170.0 mAh g^(-1)with a capacity retention of 84.3%after 100 cycles even under harsh condition of ultralow N/P ratio of 0.83.This facile strategy will widen the potential application of LiNO_(3)in ester-based electrolyte for practical high-voltage LMBs.展开更多
The great potentials of massive Multiple-Input Multiple-Output(MIMO)in Frequency Division Duplex(FDD)mode can be fully exploited when the downlink Channel State Information(CSI)is available at base stations.However,th...The great potentials of massive Multiple-Input Multiple-Output(MIMO)in Frequency Division Duplex(FDD)mode can be fully exploited when the downlink Channel State Information(CSI)is available at base stations.However,the accurate CsI is difficult to obtain due to the large amount of feedback overhead caused by massive antennas.In this paper,we propose a deep learning based joint channel estimation and feedback framework,which comprehensively realizes the estimation,compression,and reconstruction of downlink channels in FDD massive MIMO systems.Two networks are constructed to perform estimation and feedback explicitly and implicitly.The explicit network adopts a multi-Signal-to-Noise-Ratios(SNRs)technique to obtain a single trained channel estimation subnet that works well with different SNRs and employs a deep residual network to reconstruct the channels,while the implicit network directly compresses pilots and sends them back to reduce network parameters.Quantization module is also designed to generate data-bearing bitstreams.Simulation results show that the two proposed networks exhibit excellent performance of reconstruction and are robust to different environments and quantization errors.展开更多
Low Earth Orbit(LEO)multibeam satellites will be widely used in the next generation of satellite communication systems,whose inter-beam interference will inevitably limit the performance of the whole system.Nonlinear ...Low Earth Orbit(LEO)multibeam satellites will be widely used in the next generation of satellite communication systems,whose inter-beam interference will inevitably limit the performance of the whole system.Nonlinear precoding such as Tomlinson-Harashima precoding(THP)algorithm has been proved to be a promising technology to solve this problem,which has smaller noise amplification effect compared with linear precoding.However,the similarity of different user channels(defined as channel correlation)will degrade the performance of THP algorithm.In this paper,we qualitatively analyze the inter-beam interference in the whole process of LEO satellite over a specific coverage area,and the impact of channel correlation on Signal-to-Noise Ratio(SNR)of receivers when THP is applied.One user grouping algorithm is proposed based on the analysis of channel correlation,which could decrease the number of users with high channel correlation in each precoding group,thus improve the performance of THP.Furthermore,our algorithm is designed under the premise of co-frequency deployment and orthogonal frequency division multiplexing(OFDM),which leads to more users under severe inter-beam interference compared to the existing research on geostationary orbit satellites broadcasting systems.Simulation results show that the proposed user grouping algorithm possesses higher channel capacity and better bit error rate(BER)performance in high SNR conditions relative to existing works.展开更多
Identification of the ice channel is the basic technology for developing intelligent ships in ice-covered waters,which is important to ensure the safety and economy of navigation.In the Arctic,merchant ships with low ...Identification of the ice channel is the basic technology for developing intelligent ships in ice-covered waters,which is important to ensure the safety and economy of navigation.In the Arctic,merchant ships with low ice class often navigate in channels opened up by icebreakers.Navigation in the ice channel often depends on good maneuverability skills and abundant experience from the captain to a large extent.The ship may get stuck if steered into ice fields off the channel.Under this circumstance,it is very important to study how to identify the boundary lines of ice channels with a reliable method.In this paper,a two-staged ice channel identification method is developed based on image segmentation and corner point regression.The first stage employs the image segmentation method to extract channel regions.In the second stage,an intelligent corner regression network is proposed to extract the channel boundary lines from the channel region.A non-intelligent angle-based filtering and clustering method is proposed and compared with corner point regression network.The training and evaluation of the segmentation method and corner regression network are carried out on the synthetic and real ice channel dataset.The evaluation results show that the accuracy of the method using the corner point regression network in the second stage is achieved as high as 73.33%on the synthetic ice channel dataset and 70.66%on the real ice channel dataset,and the processing speed can reach up to 14.58frames per second.展开更多
Due to the interdependency of frame synchronization(FS)and channel estimation(CE),joint FS and CE(JFSCE)schemes are proposed to enhance their functionalities and therefore boost the overall performance of wireless com...Due to the interdependency of frame synchronization(FS)and channel estimation(CE),joint FS and CE(JFSCE)schemes are proposed to enhance their functionalities and therefore boost the overall performance of wireless communication systems.Although traditional JFSCE schemes alleviate the influence between FS and CE,they show deficiencies in dealing with hardware imperfection(HI)and deterministic line-of-sight(LOS)path.To tackle this challenge,we proposed a cascaded ELM-based JFSCE to alleviate the influence of HI in the scenario of the Rician fading channel.Specifically,the conventional JFSCE method is first employed to extract the initial features,and thus forms the non-Neural Network(NN)solutions for FS and CE,respectively.Then,the ELMbased networks,named FS-NET and CE-NET,are cascaded to capture the NN solutions of FS and CE.Simulation and analysis results show that,compared with the conventional JFSCE methods,the proposed cascaded ELM-based JFSCE significantly reduces the error probability of FS and the normalized mean square error(NMSE)of CE,even against the impacts of parameter variations.展开更多
Transient receptor potential(TRP)channels are strongly associated with colon cancer development and progression.This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TR...Transient receptor potential(TRP)channels are strongly associated with colon cancer development and progression.This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature,with further validation of signature in real world samples from our hospital treated patient samples.Kaplan-Meier(K-M)survival analysis and receiver operating characteristic(ROC)curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts,respectively.Additionally,the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional implications.The support vector machine algorithm was applied to evaluate the signature’s potential in predicting chemotherapy outcomes.The findings unveiled a novel three TRP channels-related gene signature(MCOLN1,TRPM5,and TRPV4)in colon adenocarcinoma(COAD).The ROC and K-M survival curves in the training dataset(AUC=0.761;p=1.58e-05)and testing dataset(AUC=0.699;p=0.004)showed the signature’s robust predictive capability for the overall survival of COAD patients.Analysis of the immune infiltration landscape associated with the signature revealed higher immune infiltration,especially an increased presence of M2 macrophages,in high-risk group patients compared to their low-risk counterparts.High-risk score patients also exhibited potential responsiveness to immune checkpoint inhibitor therapy,evident through increased CD86 and PD-1 expression profiles.Moreover,the TRPM5 gene within the signature was highly expressed in the chemoresistance group(p=0.00095)and associated with poor prognosis(p=0.036)in COAD patients,highlighting its role as a hub gene of chemoresistance.Ultimately,this signature emerged as an independent prognosis factor for COAD patients(p=6.48e-06)and expression of model gene are validated by public data and real-world patients.Overall,this bioinformatics study provides valuable insights into the prognostic implications and potential chemotherapy resistance mechanisms associated with TRPs-related genes in colon cancer.展开更多
In this paper,the channel impulse response matrix(CIRM)can be expressed as a sum of couplings between the steering vectors at the base station(BS)and the eigenbases at the mobile station(MS).Nakagami distribution was ...In this paper,the channel impulse response matrix(CIRM)can be expressed as a sum of couplings between the steering vectors at the base station(BS)and the eigenbases at the mobile station(MS).Nakagami distribution was used to describe the fading of the coupling between the steering vectors and the eigenbases.Extensive measurements were carried out to evaluate the performance of this proposed model.Furthermore,the physical implications of this model were illustrated and the capacities are analyzed.In addition,the azimuthal power spectrum(APS)of several models was analyzed.Finally,the channel hardening effect was simulated and discussed.Results showed that the proposed model provides a better fit to the measured results than the other CBSM,i.e.,Weichselberger model.Moreover,the proposed model can provide better tradeoff between accuracy and complexity in channel synthesis.This CIRM model can be used for massive MIMO design in the future communication system design.展开更多
Visible light communication(VLC)has attracted much attention in the research of sixthgeneration(6G)systems.Furthermore,channel modeling is the foundation for designing efficient and robust VLC systems.In this paper,we...Visible light communication(VLC)has attracted much attention in the research of sixthgeneration(6G)systems.Furthermore,channel modeling is the foundation for designing efficient and robust VLC systems.In this paper,we present extensive VLC channel measurement campaigns in indoor environments,i.e.,an office and a corridor.Based on the measured data,the large-scale fading characteristics and multipath-related characteristics,including omnidirectional optical path loss(OPL),K-factor,power angular spectrum(PAS),angle spread(AS),and clustering characteristics,are analyzed and modeled through a statistical method.Based on the extracted statistics of the above-mentioned channel characteristics,we propose a statistical spatial channel model(SSCM)capable of modeling multipath in the spatial domain.Furthermore,the simulated statistics of the proposed model are compared with the measured statistics.For instance,in the office,the simulated path loss exponent(PLE)and the measured PLE are 1.96and 1.97,respectively.And,the simulated medians of AS and measured medians of AS are 25.94°and 24.84°,respectively.Generally,the fact that the simulated results fit well with measured results has demonstrated the accuracy of our SSCM.展开更多
Great experimental results and observations achieved by Astronomy in the last decades revealed new unexplainable phenomena. Astronomers have conclusive new evidence that a recently discovered “dark galaxy” is, in fa...Great experimental results and observations achieved by Astronomy in the last decades revealed new unexplainable phenomena. Astronomers have conclusive new evidence that a recently discovered “dark galaxy” is, in fact, an object the size of a galaxy, made entirely of dark matter. They found that the speed of the Earth’s rotation varies randomly each day. 115 years ago, the Tunguska Event was observed, and astronomers still do not have an explanation of It. Main results of the present article are: 1) Dark galaxies explained by the spinning of their Dark Matter Cores with the surface speed at equator less than the escape velocity. Their Rotational Fission is not happening. Extrasolar systems do not emerge;2) 21-cm Emission explained by the self-annihilation of Dark Matter particles XIONs (5.3 μeV);3) Sun-Earth-Moon Interaction explained by the influence of the Sun’s and the Moon’s magnetic field on the electrical currents of the charged Geomagma (the 660-km layer), and, as a result, the Earth’s daylength varies;4) Tunguska Event explained by a huge atmospheric explosion of the Superbolide, which was a stable Dark Matter Bubble before entering the Earth’s atmosphere.展开更多
The cosmological constant, Λ, represents dark energy. The dark energy hypothesis (DEH) replaces Λ with a variable quantity, the cosmological parameter: Λ=1a2η2In this formula, “a” is the scale factor and η the ...The cosmological constant, Λ, represents dark energy. The dark energy hypothesis (DEH) replaces Λ with a variable quantity, the cosmological parameter: Λ=1a2η2In this formula, “a” is the scale factor and η the conformal time: adη = cdt. A companion paper (DEH II) develops and explores a cosmological model with this variable parameter. This paper portrays the origin of the cosmological parameter in the uncoupling of time and space in the early universe from a prior state in which the comoving coordinates x0 = η and x1 = χ, the cosmic latitude, are coupled. In this hypothesis dark matter is a co-product of the decoupling, but its nature remains mysterious.展开更多
The article develops a cosmological model based on a hypothesis that dark energy is a cosmological variable rather than a constant. A companion paper (DEH I) derives a formula for this variable cosmological parameter ...The article develops a cosmological model based on a hypothesis that dark energy is a cosmological variable rather than a constant. A companion paper (DEH I) derives a formula for this variable cosmological parameter as well as an argument that the early universe produces it and dark matter. The developed model leads to a series of self-consistent results including a prediction that provides a test for it. The results include comparisons of the DEH and the ΛCDM theory.展开更多
In this paper, we discuss a Many Worlds Interpretation (MWI) of Dark Energy and Dark Matter. The universe is viewed cosmologically as a fermionic fluid with a hydrostatic pressure from “Zitterbewegung”, the quantum ...In this paper, we discuss a Many Worlds Interpretation (MWI) of Dark Energy and Dark Matter. The universe is viewed cosmologically as a fermionic fluid with a hydrostatic pressure from “Zitterbewegung”, the quantum “zig-zagging” of Dirac particles. At each point in space-time, the pressure from all possible velocity states existing in the Many Worlds sums to provide a dark energy. This provides a ratio of matter energy to pressure energy close to that observed experimentally. Visible matter is the matter observed or measured in a particular velocity state and dark matter is then considered as the unobserved fermion contributions from different orthogonal spatial directions.展开更多
The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central n...The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be used to treat these disorders. We concluded that there are few clinical drugs that can improve the pathology these diseases by acting on potassium or calcium ions. Although a few novel ion-channelspecific modulators have been discovered, meaningful therapies have largely not yet been realized. The lack of target-specific drugs, their requirement to cross the blood–brain barrier, and their exact underlying mechanisms all need further attention. This review aims to explain the urgent problems that need research progress and provide comprehensive information aiming to arouse the research community's interest in the development of ion channel-targeting drugs and the identification of new therapeutic targets for that can increase the cure rate of nervous system diseases and reduce the occurrence of adverse reactions in other systems.展开更多
The article considers a conceptual universe model as a periodic lattice (network) with nodes defined by the wave function in a background-independent Hamiltonian based on their relations and interactions. This model g...The article considers a conceptual universe model as a periodic lattice (network) with nodes defined by the wave function in a background-independent Hamiltonian based on their relations and interactions. This model gives rise to energy bands, similar to those in semiconductor solid-state models. In this context, valence band holes are described as dark matter particles with a heavy effective mass. The conducting band, with a spontaneously symmetry-breaking energy profile, contains particles with several times lighter effective mass, which can represent luminous matter. Some possible analogies with solid-state physics, such as the comparison between dark and luminous matter, are discussed. Additionally, tiny dark energy, as intrinsic lattice Casimir energy, is calculated for a lattice with a large number of lattice nodes.展开更多
基金supported by the National Natural Science Foundation of China (No.61571407)。
文摘As one of the most simple and effective single image dehazing methods, the dark channel prior(DCP) algorithm has been widely applied. However, the algorithm does not work for pixels similar to airlight(e.g., snowy ground or a white wall), resulting in underestimation of the transmittance of some local scenes. To address that problem, we propose an image dehazing method by incorporating Markov random field(MRF) with the DCP. The DCP explicitly represents the input image observation in the MRF model obtained by the transmittance map. The key idea is that the sparsely distributed wrongly estimated transmittance can be corrected by properly characterizing the spatial dependencies between the neighboring pixels of the transmittances that are well estimated and those that are wrongly estimated. To that purpose, the energy function of the MRF model is designed. The estimation of the initial transmittance map is pixel-based using the DCP, and the segmentation on the transmittance map is employed to separate the foreground and background, thereby avoiding the block effect and artifacts at the depth discontinuity. Given the limited number of labels obtained by clustering, the smoothing term in the MRF model can properly smooth the transmittance map without an extra refinement filter. Experimental results obtained by using terrestrial and underwater images are given.
基金supported by the National Natural Science Foundation of China(61301095)the Chinese University Scientific Fund(HEUCF130807)the Chinese Defense Advanced Research Program of Science and Technology(10J3.1.6)
文摘The blurred image restoration method can dramatically highlight the image details and enhance the global contrast, which is of benefit to improvement of the visual effect during practical ap- plications. This paper is based on the dark channel prior principle and aims at the prior information absent blurred image degradation situation. A lot of improvements have been made to estimate the transmission map of blurred images. Since the dark channel prior principle can effectively restore the blurred image at the cost of a large amount of computation, the total variation (TV) and image morphology transform (specifically top-hat transform and bottom- hat transform) have been introduced into the improved method. Compared with original transmission map estimation methods, the proposed method features both simplicity and accuracy. The es- timated transmission map together with the element can restore the image. Simulation results show that this method could inhibit the ill-posed problem during image restoration, meanwhile it can greatly improve the image quality and definition.
基金supported by "the Twelfth Five-year Civil Aerospace Technologies Pre-Research Program"(D040201)
文摘Focusing on the degradation of foggy images, a restora- tion approach from a single image based on spatial correlation of dark channel prior is proposed. Firstly, the transmission of each pixel is estimated by the spatial correlation of dark channel prior. Secondly, a degradation model is utilized to restore the foggy image. Thirdly, the final recovered image, with enhanced contrast, is obtained by performing a post-processing technique based on just-noticeable difference. Experimental results demonstrate that the information of a foggy image can be recovered perfectly by the proposed method, even in the case of the abrupt depth changing scene.
文摘In the field of computer and machine vision, haze and fog lead to image degradation through various degradation mechanisms including but not limited to contrast attenuation, blurring and pixel distortions. This limits the efficiency of machine vision systems such as video surveillance, target tracking and recognition. Various single image dark channel dehazing algorithms have aimed to tackle the problem of image hazing in a fast and efficient manner. Such algorithms rely upon the dark channel prior theory towards the estimation of the atmospheric light which offers itself as a crucial parameter towards dehazing. This paper studies the state-of-the-art in this area and puts forwards their strengths and weaknesses. Through experiments the efficiencies and shortcomings of these algorithms are shared. This information is essential for researchers and developers in providing a reference for the development of applications and future of the research field.
基金supported in part by the National Nature Science Foundation(81874022 and 82172483 to Xinyu Liu,82102522 to Lianlei Wang,82072478 to Yunpeng Zhao,82072435 to Qiang Yang,82073437 to Weiwei Li,81930070 to Shiqing Feng,82272548 to Lei Cheng)Key R&D Project of Shandong Province(2022CXGC010503 to Xinyu Liu)+1 种基金Shandong Natural Science Foundation(ZR202102210113 to Lianlei Wang,ZR2020YQ54 to Yunpeng Zhao)Shandong Province Taishan Scholar Project(tsqn202211317 to Lianlei Wang).The authors thank the Translational Medicine Core Facility of Shandong University for the consultation and instrument availability that supported this work.
文摘To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be elucidated.Here,Piezo1 channel was identified as a key iron transporter in response to mechanical stress.Piezo1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron gatekeeper.Furthermore,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical stress.Moreover,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases.
基金the financial support from the National Natural Science Foundation of China(Nos.22205191 and 52002346)the Science and Technology Innovation Program of Hunan Province(No.2021RC3109)+1 种基金the Natural Science Foundation of Hunan Province,China(No.2022JJ40446)Guangxi Key Laboratory of Low Carbon Energy Material(No.2020GXKLLCEM01)。
文摘The concentration difference in the near-surface region of lithium metal is the main cause of lithium dendrite growth.Resolving this issue will be key to achieving high-performance lithium metal batteries(LMBs).Herein,we construct a lithium nitrate(LiNO_(3))-implanted electroactiveβphase polyvinylidene fluoride-co-hexafluoropropylene(PVDF-HFP)crystalline polymorph layer(PHL).The electronegatively charged polymer chains attain lithium ions on the surface to form lithium-ion charged channels.These channels act as reservoirs to sustainably release Li ions to recompense the ionic flux of electrolytes,decreasing the growth of lithium dendrites.The stretched molecular channels can also accelerate the transport of Li ions.The combined effects enable a high Coulombic efficiency of 97.0%for 250 cycles in lithium(Li)||copper(Cu)cell and a stable symmetric plating/stripping behavior over 2000 h at 3 mA cm^(-2)with ultrahigh Li utilization of 50%.Furthermore,the full cell coupled with PHL-Cu@Li anode and Li Fe PO_(4) cathode exhibits long-term cycle stability with high-capacity retention of 95.9%after 900 cycles.Impressively,the full cell paired with LiNi_(0.87)Co_(0.1)Mn_(0.03)O_(2)maintains a discharge capacity of 170.0 mAh g^(-1)with a capacity retention of 84.3%after 100 cycles even under harsh condition of ultralow N/P ratio of 0.83.This facile strategy will widen the potential application of LiNO_(3)in ester-based electrolyte for practical high-voltage LMBs.
基金supported in part by the National Natural Science Foundation of China(NSFC)under Grants 61941104,61921004the Key Research and Development Program of Shandong Province under Grant 2020CXGC010108+1 种基金the Southeast University-China Mobile Research Institute Joint Innovation Centersupported in part by the Scientific Research Foundation of Graduate School of Southeast University under Grant YBPY2118.
文摘The great potentials of massive Multiple-Input Multiple-Output(MIMO)in Frequency Division Duplex(FDD)mode can be fully exploited when the downlink Channel State Information(CSI)is available at base stations.However,the accurate CsI is difficult to obtain due to the large amount of feedback overhead caused by massive antennas.In this paper,we propose a deep learning based joint channel estimation and feedback framework,which comprehensively realizes the estimation,compression,and reconstruction of downlink channels in FDD massive MIMO systems.Two networks are constructed to perform estimation and feedback explicitly and implicitly.The explicit network adopts a multi-Signal-to-Noise-Ratios(SNRs)technique to obtain a single trained channel estimation subnet that works well with different SNRs and employs a deep residual network to reconstruct the channels,while the implicit network directly compresses pilots and sends them back to reduce network parameters.Quantization module is also designed to generate data-bearing bitstreams.Simulation results show that the two proposed networks exhibit excellent performance of reconstruction and are robust to different environments and quantization errors.
基金supported by the Key R&D Project of the Ministry of Science and Technology of China(2020YFB1808005)。
文摘Low Earth Orbit(LEO)multibeam satellites will be widely used in the next generation of satellite communication systems,whose inter-beam interference will inevitably limit the performance of the whole system.Nonlinear precoding such as Tomlinson-Harashima precoding(THP)algorithm has been proved to be a promising technology to solve this problem,which has smaller noise amplification effect compared with linear precoding.However,the similarity of different user channels(defined as channel correlation)will degrade the performance of THP algorithm.In this paper,we qualitatively analyze the inter-beam interference in the whole process of LEO satellite over a specific coverage area,and the impact of channel correlation on Signal-to-Noise Ratio(SNR)of receivers when THP is applied.One user grouping algorithm is proposed based on the analysis of channel correlation,which could decrease the number of users with high channel correlation in each precoding group,thus improve the performance of THP.Furthermore,our algorithm is designed under the premise of co-frequency deployment and orthogonal frequency division multiplexing(OFDM),which leads to more users under severe inter-beam interference compared to the existing research on geostationary orbit satellites broadcasting systems.Simulation results show that the proposed user grouping algorithm possesses higher channel capacity and better bit error rate(BER)performance in high SNR conditions relative to existing works.
基金financially supported by the National Key Research and Development Program(Grant No.2022YFE0107000)the General Projects of the National Natural Science Foundation of China(Grant No.52171259)the High-Tech Ship Research Project of the Ministry of Industry and Information Technology(Grant No.[2021]342)。
文摘Identification of the ice channel is the basic technology for developing intelligent ships in ice-covered waters,which is important to ensure the safety and economy of navigation.In the Arctic,merchant ships with low ice class often navigate in channels opened up by icebreakers.Navigation in the ice channel often depends on good maneuverability skills and abundant experience from the captain to a large extent.The ship may get stuck if steered into ice fields off the channel.Under this circumstance,it is very important to study how to identify the boundary lines of ice channels with a reliable method.In this paper,a two-staged ice channel identification method is developed based on image segmentation and corner point regression.The first stage employs the image segmentation method to extract channel regions.In the second stage,an intelligent corner regression network is proposed to extract the channel boundary lines from the channel region.A non-intelligent angle-based filtering and clustering method is proposed and compared with corner point regression network.The training and evaluation of the segmentation method and corner regression network are carried out on the synthetic and real ice channel dataset.The evaluation results show that the accuracy of the method using the corner point regression network in the second stage is achieved as high as 73.33%on the synthetic ice channel dataset and 70.66%on the real ice channel dataset,and the processing speed can reach up to 14.58frames per second.
基金supported in part by the Sichuan Science and Technology Program(Grant No.2023YFG0316)the Industry-University Research Innovation Fund of China University(Grant No.2021ITA10016)+1 种基金the Key Scientific Research Fund of Xihua University(Grant No.Z1320929)the Special Funds of Industry Development of Sichuan Province(Grant No.zyf-2018-056).
文摘Due to the interdependency of frame synchronization(FS)and channel estimation(CE),joint FS and CE(JFSCE)schemes are proposed to enhance their functionalities and therefore boost the overall performance of wireless communication systems.Although traditional JFSCE schemes alleviate the influence between FS and CE,they show deficiencies in dealing with hardware imperfection(HI)and deterministic line-of-sight(LOS)path.To tackle this challenge,we proposed a cascaded ELM-based JFSCE to alleviate the influence of HI in the scenario of the Rician fading channel.Specifically,the conventional JFSCE method is first employed to extract the initial features,and thus forms the non-Neural Network(NN)solutions for FS and CE,respectively.Then,the ELMbased networks,named FS-NET and CE-NET,are cascaded to capture the NN solutions of FS and CE.Simulation and analysis results show that,compared with the conventional JFSCE methods,the proposed cascaded ELM-based JFSCE significantly reduces the error probability of FS and the normalized mean square error(NMSE)of CE,even against the impacts of parameter variations.
基金the Ethics Committee of University Magdeburg(Ethical code:33/0119.03.2001).
文摘Transient receptor potential(TRP)channels are strongly associated with colon cancer development and progression.This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature,with further validation of signature in real world samples from our hospital treated patient samples.Kaplan-Meier(K-M)survival analysis and receiver operating characteristic(ROC)curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts,respectively.Additionally,the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional implications.The support vector machine algorithm was applied to evaluate the signature’s potential in predicting chemotherapy outcomes.The findings unveiled a novel three TRP channels-related gene signature(MCOLN1,TRPM5,and TRPV4)in colon adenocarcinoma(COAD).The ROC and K-M survival curves in the training dataset(AUC=0.761;p=1.58e-05)and testing dataset(AUC=0.699;p=0.004)showed the signature’s robust predictive capability for the overall survival of COAD patients.Analysis of the immune infiltration landscape associated with the signature revealed higher immune infiltration,especially an increased presence of M2 macrophages,in high-risk group patients compared to their low-risk counterparts.High-risk score patients also exhibited potential responsiveness to immune checkpoint inhibitor therapy,evident through increased CD86 and PD-1 expression profiles.Moreover,the TRPM5 gene within the signature was highly expressed in the chemoresistance group(p=0.00095)and associated with poor prognosis(p=0.036)in COAD patients,highlighting its role as a hub gene of chemoresistance.Ultimately,this signature emerged as an independent prognosis factor for COAD patients(p=6.48e-06)and expression of model gene are validated by public data and real-world patients.Overall,this bioinformatics study provides valuable insights into the prognostic implications and potential chemotherapy resistance mechanisms associated with TRPs-related genes in colon cancer.
基金supported by the Key R&D Project of Jiangsu Province(Modern Agriculture)under Grant BE2022322 the"Pilot Plan"Internet of Things special project(China Institute of Io T(wuxi)and Wuxi Internet of Things Innovation Promotion Center)under Grant 2022SP-T16-Bin part by the 111 Project under Grant B12018+2 种基金in part by the Six talent peaks project in Jiangsu Provincein part by the open foundation of Key Laboratory of Wireless Sensor Network and Communication,Shanghai Institute of Microsystem and Information Technology,Chinese Academy of Sciences under Grant 20190917in part by the open research fund of Key Lab of Broadband Wireless Communication and Sensor Network Technology(Nanjing University of Posts and Telecommunications,Ministry of Education)。
文摘In this paper,the channel impulse response matrix(CIRM)can be expressed as a sum of couplings between the steering vectors at the base station(BS)and the eigenbases at the mobile station(MS).Nakagami distribution was used to describe the fading of the coupling between the steering vectors and the eigenbases.Extensive measurements were carried out to evaluate the performance of this proposed model.Furthermore,the physical implications of this model were illustrated and the capacities are analyzed.In addition,the azimuthal power spectrum(APS)of several models was analyzed.Finally,the channel hardening effect was simulated and discussed.Results showed that the proposed model provides a better fit to the measured results than the other CBSM,i.e.,Weichselberger model.Moreover,the proposed model can provide better tradeoff between accuracy and complexity in channel synthesis.This CIRM model can be used for massive MIMO design in the future communication system design.
基金supported by the National Science Fund for Distinguished Young Scholars(No.61925102)the National Natural Science Foundation of China(No.62201086,92167202,62201087,62101069)BUPT-CMCC Joint Innovation Center,and State Key Laboratory of IPOC(BUPT)(No.IPOC2023ZT02),China。
文摘Visible light communication(VLC)has attracted much attention in the research of sixthgeneration(6G)systems.Furthermore,channel modeling is the foundation for designing efficient and robust VLC systems.In this paper,we present extensive VLC channel measurement campaigns in indoor environments,i.e.,an office and a corridor.Based on the measured data,the large-scale fading characteristics and multipath-related characteristics,including omnidirectional optical path loss(OPL),K-factor,power angular spectrum(PAS),angle spread(AS),and clustering characteristics,are analyzed and modeled through a statistical method.Based on the extracted statistics of the above-mentioned channel characteristics,we propose a statistical spatial channel model(SSCM)capable of modeling multipath in the spatial domain.Furthermore,the simulated statistics of the proposed model are compared with the measured statistics.For instance,in the office,the simulated path loss exponent(PLE)and the measured PLE are 1.96and 1.97,respectively.And,the simulated medians of AS and measured medians of AS are 25.94°and 24.84°,respectively.Generally,the fact that the simulated results fit well with measured results has demonstrated the accuracy of our SSCM.
文摘Great experimental results and observations achieved by Astronomy in the last decades revealed new unexplainable phenomena. Astronomers have conclusive new evidence that a recently discovered “dark galaxy” is, in fact, an object the size of a galaxy, made entirely of dark matter. They found that the speed of the Earth’s rotation varies randomly each day. 115 years ago, the Tunguska Event was observed, and astronomers still do not have an explanation of It. Main results of the present article are: 1) Dark galaxies explained by the spinning of their Dark Matter Cores with the surface speed at equator less than the escape velocity. Their Rotational Fission is not happening. Extrasolar systems do not emerge;2) 21-cm Emission explained by the self-annihilation of Dark Matter particles XIONs (5.3 μeV);3) Sun-Earth-Moon Interaction explained by the influence of the Sun’s and the Moon’s magnetic field on the electrical currents of the charged Geomagma (the 660-km layer), and, as a result, the Earth’s daylength varies;4) Tunguska Event explained by a huge atmospheric explosion of the Superbolide, which was a stable Dark Matter Bubble before entering the Earth’s atmosphere.
文摘The cosmological constant, Λ, represents dark energy. The dark energy hypothesis (DEH) replaces Λ with a variable quantity, the cosmological parameter: Λ=1a2η2In this formula, “a” is the scale factor and η the conformal time: adη = cdt. A companion paper (DEH II) develops and explores a cosmological model with this variable parameter. This paper portrays the origin of the cosmological parameter in the uncoupling of time and space in the early universe from a prior state in which the comoving coordinates x0 = η and x1 = χ, the cosmic latitude, are coupled. In this hypothesis dark matter is a co-product of the decoupling, but its nature remains mysterious.
文摘The article develops a cosmological model based on a hypothesis that dark energy is a cosmological variable rather than a constant. A companion paper (DEH I) derives a formula for this variable cosmological parameter as well as an argument that the early universe produces it and dark matter. The developed model leads to a series of self-consistent results including a prediction that provides a test for it. The results include comparisons of the DEH and the ΛCDM theory.
文摘In this paper, we discuss a Many Worlds Interpretation (MWI) of Dark Energy and Dark Matter. The universe is viewed cosmologically as a fermionic fluid with a hydrostatic pressure from “Zitterbewegung”, the quantum “zig-zagging” of Dirac particles. At each point in space-time, the pressure from all possible velocity states existing in the Many Worlds sums to provide a dark energy. This provides a ratio of matter energy to pressure energy close to that observed experimentally. Visible matter is the matter observed or measured in a particular velocity state and dark matter is then considered as the unobserved fermion contributions from different orthogonal spatial directions.
基金supported by the National Natural Science Foundation of China,Nos.81901098(to TC),82201668(to HL)Fujian Provincial Health Technology Project,No.2021QNA072(to HL)。
文摘The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be used to treat these disorders. We concluded that there are few clinical drugs that can improve the pathology these diseases by acting on potassium or calcium ions. Although a few novel ion-channelspecific modulators have been discovered, meaningful therapies have largely not yet been realized. The lack of target-specific drugs, their requirement to cross the blood–brain barrier, and their exact underlying mechanisms all need further attention. This review aims to explain the urgent problems that need research progress and provide comprehensive information aiming to arouse the research community's interest in the development of ion channel-targeting drugs and the identification of new therapeutic targets for that can increase the cure rate of nervous system diseases and reduce the occurrence of adverse reactions in other systems.
文摘The article considers a conceptual universe model as a periodic lattice (network) with nodes defined by the wave function in a background-independent Hamiltonian based on their relations and interactions. This model gives rise to energy bands, similar to those in semiconductor solid-state models. In this context, valence band holes are described as dark matter particles with a heavy effective mass. The conducting band, with a spontaneously symmetry-breaking energy profile, contains particles with several times lighter effective mass, which can represent luminous matter. Some possible analogies with solid-state physics, such as the comparison between dark and luminous matter, are discussed. Additionally, tiny dark energy, as intrinsic lattice Casimir energy, is calculated for a lattice with a large number of lattice nodes.