OBJECTIVE:To explore the characteristics of blood glucose excursions of type 2 diabetes mellitus patients with three different Traditional Chinese Medicine(TCM) syndromes.METHODS:One hundred and nine patients with typ...OBJECTIVE:To explore the characteristics of blood glucose excursions of type 2 diabetes mellitus patients with three different Traditional Chinese Medicine(TCM) syndromes.METHODS:One hundred and nine patients with type 2 diabetes mellitus were recruited from the Department of Endocrinology and the Department of TCM of the Sixth People's Hospital affiliated to Shanghai Jiao Tong University.Subjects were divided into three groups according to TCM syndrome:intrinsic Damp(n- 42),Yin deficiency and internal Heat(n = 25),and Qi and Yin deficiency(n- 42).Subcutaneous interstitial glucose was monitored with a continuous glucose monitoring system for 3consecutive days to investigate the glycemic profile in each group.Plasma C-peptide levels were measured,and an arginine test was taken in 10 patients randomly selected from each group.Glucose data and glycemic variability were analyzed to investigate the differences among the groups.The change in C-peptide levels and the results from arginine trial were used to evaluate β cell function.RESULTS:Indicators reflecting blood glucose level were the highest in subjects with Yin deficiency and internal Heat syndrome,and parameters reflecting glycemic variability were the lowest in those with Qi and Yin deficiency syndrome.The change in C-peptide levels showed that subjects with Qi and Yin deficiency syndrome had the best βcell function among the three groups;this was confirmed by the arginine trial.CONCLUSION:Patients with Qi and Yin deficiency syndrome had a more stable blood glucose profile,as glycemic variability was higher in those with intrinsic Damp syndrome and those with Yin deficiency and internal Heat syndrome.展开更多
目的探讨血糖波动与早期糖尿病肾病微量白蛋白尿之间的关系。方法对40例尿白蛋白排泄率(UAER)≤20μg/min(正常白蛋白尿组)及40例UAER 20-199μg/min(微量白蛋白尿组)的2型糖尿病患者进行动态血糖监测(CGMS),然后比较两组患者的平均血...目的探讨血糖波动与早期糖尿病肾病微量白蛋白尿之间的关系。方法对40例尿白蛋白排泄率(UAER)≤20μg/min(正常白蛋白尿组)及40例UAER 20-199μg/min(微量白蛋白尿组)的2型糖尿病患者进行动态血糖监测(CGMS),然后比较两组患者的平均血糖、平均血糖波动振幅(MAGE)及血糖标准差(SDBG)。结果两组患者的平均血糖水平(11.07±1.94 mmol/L vs 10.45±1.90 mmol/L)无统计学差异;微量白蛋白尿组,血糖标准差(3.14±0.94 mmol/L vs 2.21±0.64 mmol/L)、平均血糖波动振幅(6.2±0.6 mmol/L vs 3.4±0.4 mmol/L)均高于正常白蛋白尿组,差异有统计学意义。结论血糖水平控制相当的2型糖尿病患者(糖化血红蛋白、平均血糖水平相当)中,合并早期糖尿病肾病-微量白蛋白尿组其血糖标准差、平均血糖波动振幅均大于正常白蛋白尿组。展开更多
基金Supported by the State Administration of Traditional Chinese Medicine plan projects:Base Construction of Traditional Chinese Medicine Clinical Research(No.JDZX2012129)Shanghai Science and Technology Commitment plan projects:Science and Technology Support Project(No.12401905000)
文摘OBJECTIVE:To explore the characteristics of blood glucose excursions of type 2 diabetes mellitus patients with three different Traditional Chinese Medicine(TCM) syndromes.METHODS:One hundred and nine patients with type 2 diabetes mellitus were recruited from the Department of Endocrinology and the Department of TCM of the Sixth People's Hospital affiliated to Shanghai Jiao Tong University.Subjects were divided into three groups according to TCM syndrome:intrinsic Damp(n- 42),Yin deficiency and internal Heat(n = 25),and Qi and Yin deficiency(n- 42).Subcutaneous interstitial glucose was monitored with a continuous glucose monitoring system for 3consecutive days to investigate the glycemic profile in each group.Plasma C-peptide levels were measured,and an arginine test was taken in 10 patients randomly selected from each group.Glucose data and glycemic variability were analyzed to investigate the differences among the groups.The change in C-peptide levels and the results from arginine trial were used to evaluate β cell function.RESULTS:Indicators reflecting blood glucose level were the highest in subjects with Yin deficiency and internal Heat syndrome,and parameters reflecting glycemic variability were the lowest in those with Qi and Yin deficiency syndrome.The change in C-peptide levels showed that subjects with Qi and Yin deficiency syndrome had the best βcell function among the three groups;this was confirmed by the arginine trial.CONCLUSION:Patients with Qi and Yin deficiency syndrome had a more stable blood glucose profile,as glycemic variability was higher in those with intrinsic Damp syndrome and those with Yin deficiency and internal Heat syndrome.
文摘目的探讨血糖波动与早期糖尿病肾病微量白蛋白尿之间的关系。方法对40例尿白蛋白排泄率(UAER)≤20μg/min(正常白蛋白尿组)及40例UAER 20-199μg/min(微量白蛋白尿组)的2型糖尿病患者进行动态血糖监测(CGMS),然后比较两组患者的平均血糖、平均血糖波动振幅(MAGE)及血糖标准差(SDBG)。结果两组患者的平均血糖水平(11.07±1.94 mmol/L vs 10.45±1.90 mmol/L)无统计学差异;微量白蛋白尿组,血糖标准差(3.14±0.94 mmol/L vs 2.21±0.64 mmol/L)、平均血糖波动振幅(6.2±0.6 mmol/L vs 3.4±0.4 mmol/L)均高于正常白蛋白尿组,差异有统计学意义。结论血糖水平控制相当的2型糖尿病患者(糖化血红蛋白、平均血糖水平相当)中,合并早期糖尿病肾病-微量白蛋白尿组其血糖标准差、平均血糖波动振幅均大于正常白蛋白尿组。
