In the field of developmental neurobiology, accurate and ordered regulation of the cell cycle and apoptosis are crucial factors contributing to the normal formation of the neural tube. Preliminary studies identified s...In the field of developmental neurobiology, accurate and ordered regulation of the cell cycle and apoptosis are crucial factors contributing to the normal formation of the neural tube. Preliminary studies identified several genes involved in the development of neural tube defects. In this study, we established a model of developmental neural tube defects by administration of retinoic acid to pregnant rats. Gene chip hybridization analysis showed that genes related to the cell cycle and apoptosis, signal transduction, transcription and translation regulation, energy and metabolism, heat shock, and matrix and cytoskeletal proteins were all involved in the formation of developmental neural tube defects. Among these, cell cycle-related genes were predominant. Retinoic acid treat-ment caused differential expression of three cell cycle-related genes p57kip2, Cdk5 and Spin, the expression levels of which were downregulated by retinoic acid and upregulated during normal neural tube formation. The results of this study indicate that cell cycle-related genes play an im-portant role in the formation of neural tube defects. P57kip2, Cdk5 and Spin may be critical genes in the pathogenesis of neural tube defects.展开更多
This paper presents a global methodology to compute wind flow in complex urban areas in order to assess wind pedestrian comfort, wind energy, wind safety or natural ventilation potential. The numerical tool presented ...This paper presents a global methodology to compute wind flow in complex urban areas in order to assess wind pedestrian comfort, wind energy, wind safety or natural ventilation potential. The numerical tool presented here is composed of a CFD soft-ware suite covering both regional scale (20 km) and urban scale (1km), and able to model the wind in any complex terrains and in large urban environments. Examples are presented in the paper in order to show the advantages of the methodology for urban designers.展开更多
基金supported by the Science and Technology Key Program of Sichuan Provincial Health Ministry,No.080128
文摘In the field of developmental neurobiology, accurate and ordered regulation of the cell cycle and apoptosis are crucial factors contributing to the normal formation of the neural tube. Preliminary studies identified several genes involved in the development of neural tube defects. In this study, we established a model of developmental neural tube defects by administration of retinoic acid to pregnant rats. Gene chip hybridization analysis showed that genes related to the cell cycle and apoptosis, signal transduction, transcription and translation regulation, energy and metabolism, heat shock, and matrix and cytoskeletal proteins were all involved in the formation of developmental neural tube defects. Among these, cell cycle-related genes were predominant. Retinoic acid treat-ment caused differential expression of three cell cycle-related genes p57kip2, Cdk5 and Spin, the expression levels of which were downregulated by retinoic acid and upregulated during normal neural tube formation. The results of this study indicate that cell cycle-related genes play an im-portant role in the formation of neural tube defects. P57kip2, Cdk5 and Spin may be critical genes in the pathogenesis of neural tube defects.
文摘This paper presents a global methodology to compute wind flow in complex urban areas in order to assess wind pedestrian comfort, wind energy, wind safety or natural ventilation potential. The numerical tool presented here is composed of a CFD soft-ware suite covering both regional scale (20 km) and urban scale (1km), and able to model the wind in any complex terrains and in large urban environments. Examples are presented in the paper in order to show the advantages of the methodology for urban designers.
