Objective To review the cadaveric kidney transplantations at our center in the past 22 years and to analyze the causes and the influencing factors on death in 176 patients who died after renal transplantation. Methods...Objective To review the cadaveric kidney transplantations at our center in the past 22 years and to analyze the causes and the influencing factors on death in 176 patients who died after renal transplantation. Methods A total of 1 039 patients received cadaveric kidney graftings between October 1977 and June 1999. Patient’ s mortality was calculated by the Kaplan-Meier method. The factors which might lead to patients’ death,including age and sex of the donors and recipients, frequency of transplantation, dialysis time and transfusion volume before transplantation, cold ischemic time(CIT),delayed graft function(DGF),rejection, immunosuppressive regimen, and post-transplant complications, were analyzed by log-rank and Cox model. Results Total mortalities of the patient at 1 - ,5 - , 10 - , and 15-year were 6.9%, 19.7%, 32.1% and 34.7%, respectively. The leading causes of patients’ death were infection, cardiocerebral vascular diseases, and hepatic failure. The factors of transplant times, dialysis time展开更多
Myoglobin, myosin creatine kinase MM (CK-MM),creatine kinase BB(CK-BB) in cardiac muscle and H chain ofmyosin in atrial and ventricular muscle were studied in speci-mens from 8 patients who died of sudden nocturnal de...Myoglobin, myosin creatine kinase MM (CK-MM),creatine kinase BB(CK-BB) in cardiac muscle and H chain ofmyosin in atrial and ventricular muscle were studied in speci-mens from 8 patients who died of sudden nocturnal deathsyndrome(SNDS) by avidin-biotin complex (ABC) method toinvestigate the possible early or very early myocardial ischemiain the syndrome. Hematoxylin-eosin staining was conductedfor comparison. The results showed evident loss of CK-MM,CK-BB, myoglobin and myosin from cardiac muscle cells, indi-caring that occurrence of SNDS is closely associated withacute myocardial ischemia.展开更多
This study described the epidemiologic and clinical characteristics of patients who died from severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,and pointed out the potential risk factors associated ...This study described the epidemiologic and clinical characteristics of patients who died from severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,and pointed out the potential risk factors associated with fatal outcomes.Retrospective data from 42 death cases due to SARS-CoV-2 infection at Tongji Hospital Affiliated to Huazhong University of Science and Technology,Wuhan,China was analyzed.Demographics,clinical detection,laboratory findings,and treatments of the deceased were collected and analyzed.The average time between onset of symptoms and admission to the hospitals was 11±5 days of hospitalization.Among the deceased,60%were with co-morbidities.All of them were having fever and bilateral pneumonia on computed tomography,abnormal infection-related biomarkers,and renal impairment.Abnormal blood coagulation parameters that appeared in more than half of them,were consistent with disseminated intravascular coagulation.All of the patients were treated in the ICU.Based on the fact that SARS-CoV-2 infection carries a risk of mortality,we may infer a few older male patients with underlying comorbidities are likely to have the increased risk.Impaired consciousness level,markers of renal impairment and coagulation abnormalities may be poor prognostic factors.展开更多
文摘Objective To review the cadaveric kidney transplantations at our center in the past 22 years and to analyze the causes and the influencing factors on death in 176 patients who died after renal transplantation. Methods A total of 1 039 patients received cadaveric kidney graftings between October 1977 and June 1999. Patient’ s mortality was calculated by the Kaplan-Meier method. The factors which might lead to patients’ death,including age and sex of the donors and recipients, frequency of transplantation, dialysis time and transfusion volume before transplantation, cold ischemic time(CIT),delayed graft function(DGF),rejection, immunosuppressive regimen, and post-transplant complications, were analyzed by log-rank and Cox model. Results Total mortalities of the patient at 1 - ,5 - , 10 - , and 15-year were 6.9%, 19.7%, 32.1% and 34.7%, respectively. The leading causes of patients’ death were infection, cardiocerebral vascular diseases, and hepatic failure. The factors of transplant times, dialysis time
文摘Myoglobin, myosin creatine kinase MM (CK-MM),creatine kinase BB(CK-BB) in cardiac muscle and H chain ofmyosin in atrial and ventricular muscle were studied in speci-mens from 8 patients who died of sudden nocturnal deathsyndrome(SNDS) by avidin-biotin complex (ABC) method toinvestigate the possible early or very early myocardial ischemiain the syndrome. Hematoxylin-eosin staining was conductedfor comparison. The results showed evident loss of CK-MM,CK-BB, myoglobin and myosin from cardiac muscle cells, indi-caring that occurrence of SNDS is closely associated withacute myocardial ischemia.
基金supported by grants from the Epidemiology,Early Warning,and Response Techniques of Major Infectious Diseases in the Belt and Road Initiative(#2018ZX10101002)National Natural Science Foundation of China(#81871699)Foundation of Jilin Province Science and Technology Department(#172408GH010234983).
文摘This study described the epidemiologic and clinical characteristics of patients who died from severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,and pointed out the potential risk factors associated with fatal outcomes.Retrospective data from 42 death cases due to SARS-CoV-2 infection at Tongji Hospital Affiliated to Huazhong University of Science and Technology,Wuhan,China was analyzed.Demographics,clinical detection,laboratory findings,and treatments of the deceased were collected and analyzed.The average time between onset of symptoms and admission to the hospitals was 11±5 days of hospitalization.Among the deceased,60%were with co-morbidities.All of them were having fever and bilateral pneumonia on computed tomography,abnormal infection-related biomarkers,and renal impairment.Abnormal blood coagulation parameters that appeared in more than half of them,were consistent with disseminated intravascular coagulation.All of the patients were treated in the ICU.Based on the fact that SARS-CoV-2 infection carries a risk of mortality,we may infer a few older male patients with underlying comorbidities are likely to have the increased risk.Impaired consciousness level,markers of renal impairment and coagulation abnormalities may be poor prognostic factors.
