Life′s Simple 7干预减轻Her⁃2阳性乳腺癌患者化疗相关心血管系统损害的研究

目的探讨Life′s Simple 7(LS7)干预减轻Her⁃2阳性乳腺癌患者根治术后化疗相关心血管系统损害的作用。方法将120例Her⁃2阳性并接受标准化乳腺癌化疗的患者随机等量分为对照组及LS7组,对照组为标准化疗方案,LS7组为对照组基础上给予LS7干预12个月,后续通过比较两组治疗前后心血管系统损伤程度、焦虑、抑郁及生活质量等指标评价其对心血管系统损害的改善作用。结果相较于对照组,LS7组LS7总评分及7项心血管健康指标均优于对照组(P<0.05),LS7组LVEF较高(P<0.05)、NT⁃proBNP较低(P<0.05),焦虑和抑郁评分较低(P<0.05)、生活质量评分较高(P<0.05)。结论LS7干预可显著减轻Her⁃2阳性乳腺癌化疗相关心血管系统损害并改善乳腺癌患者的心理状况和生活质量,值得在临床推广。

基于断裂力学的腐蚀钢丝疲劳S-N曲线研究

高强冷拔钢丝因其优异的力学性能被广泛应用于缆索承重结构,服役过程中钢丝腐蚀与断裂威胁着结构安全。钢丝腐蚀后表面的蚀坑因应力集中效应易产生疲劳裂纹,因此腐蚀钢丝剩余疲劳寿命主要取决于裂纹的扩展阶段,且裂纹扩展受到腐蚀程度(初始损伤)的显著影响。精确表征腐蚀程度并准确评估服役期钢丝腐蚀后的剩余寿命,仍是亟待解决的维修难题。首先采用蚀坑最大深度表征钢丝腐蚀程度,以应力强度因子幅作为裂纹扩展驱动力指标,基于断裂力学的Paris公式建立受拉钢丝裂纹扩展理论模型,进而推导腐蚀钢丝的疲劳S-N曲线。大量既有的腐蚀钢丝疲劳试验结果与理论预测值的比较验证了所提理论模型及疲劳S-N曲线的合理性和有效性。含多个蚀坑的钢丝裂纹扩展有限元模拟表明,等效单裂纹适用于多腐蚀坑钢丝疲劳寿命的简化分析。参数分析表明,蚀坑深度和腐蚀环境是腐蚀钢丝疲劳强度的关键影响因素,而应力比和疲劳加载频率影响较小,所提出的S-N曲线在钢丝常规服役条件下适用于评估其剩余寿命,可得到合理的预测结果。基于断裂力学所提的理论方法和疲劳S-N曲线可为腐蚀钢丝的疲劳强度和寿命评估提供参考。

液压成形对液体火箭发动机多层增强S型波纹管结构疲劳寿命的影响

完善液体火箭发动机燃气摇摆装置中增强S型波纹管组件的疲劳寿命评估方法,提高其疲劳寿命预测精度,是发展可重复使用液体火箭发动机的重要课题之一。针对多层增强S型波纹管,为了计算其液压成形后的实际寿命数据,了解成形工艺对其疲劳寿命的影响,提出一种充分考虑成形制备过程对结构不同区域几何构型和材料力学性能造成差异化影响后的波纹管疲劳寿命分析方法。该方法基于成形仿真和材料拉伸试验结果,构建实际波纹管有限元模型并进行三维仿真分析,得到其在高内压和不同摆动工况下结构危险点的循环载荷信息,并根据波纹管结构的低周疲劳失效特点采用子午向应力应变数据,以及经过平均应力应变修正的Manson-Coffin(M-C)公式对波纹管的循环寿命进行估算和对比分析。结果表明:波纹管疲劳寿命薄弱点位置和大小均与循环摆角有关;在预测计算中考虑液压成形作用影响更接近实际场景,所得结构疲劳寿命大小和所在区域均与理论模型值存在差异,在结构设计、优化和健康监测中不应忽视其影响。

Factors influencing quality of life in Chinese patients with dementia: a systematic review

Background:Dementia is a group of nervous system diseases characterized by progressive cognitive decline,leading to a loss of self-care ability and a decline in well-being.This places a significant burden on the global healthcare system,with Chinese patients accounting for approximately one-quarter of the world’s dementia cases.Therefore,it is crucial to identify factors that impact the quality of life(QOL)among elderly Chinese individuals with dementia.Method:To achieve this,we conducted a comprehensive search of several databases,including PubMed,Embase,Web of Science,the Cochrane Library,China National Knowledge Infrastructure,Wanfang Data,China VIP Database and China Biomedical Literature Database.We reviewed cross-sectional studies from the inception of these databases until March 27,2022.QOL outcomes were assessed using standardized scales in the studies included in this review.Results:The search yielded a total of 1,235 relevant articles,from which we finally included 21 cross-sectional studies and one longitudinal study after rigorous quality assessment.Among these,10 studies were classified as high quality,while 12 were classified as fair quality.Through our analysis,we identified 28 patient-rated QOL factors and 14 caregiver-rated QOL factors.These factors were categorized into three groups:patient,disease-related and caregiver.Factors commonly found to influence patient-rated QOL included age,education,marital status,depression,self-care ability,dementia severity,cognitive function,behavioral and psychological symptoms of dementia and caregiver burden.Similarly,factors commonly influencing caregiver-rated QOL included economic status,depression,self-care ability,dementia severity,cognitive function,behavioral and psychological symptoms of dementia and caregiving time.Conclusion:This review clarifies the factors that influence the QOL of Chinese individuals with dementia.When implementing interventions,it is crucial to consider the differences between patient-rated QOL and caregiver-proxy-rated QOL,as well as their respective influencing factors.

具有稚虫迁徙机制的S型自适应混沌蜉蝣算法

针对蜉蝣优化算法(MA)全局搜索能力较弱,对子代优秀个体有效信息利用不够充分的缺点,以及在计算中后期易陷入局部收敛,进而影响优化效果的问题,提出一种具有稚虫迁徙机制的S型自适应混沌蜉蝣优化算法(S-AMA)。S-AMA算法首先采用Logistic混沌映射产生蜉蝣种群,增加算法初期种群的多样性;随后,将蜉蝣生命周期进行数学建模,并引入S型生命系数替换原有的重力惯性系数,动态调整算法探索能力和开发能力间的平衡性;最后,根据蜉蝣在缺氧环境下的种群活动,引入稚虫迁徙机制强化子代优秀个体摆脱局部最优的能力,进而更加充分地搜索最优解附近的区域,以增强算法的收敛精度。实验部分将S-AMA应用于标准函数测试集,并分别进行优化对比实验、Wilcoxon秩和检验。结果表明:与对比算法相比,S-AMA算法具有更好的寻优能力、收敛速度及鲁棒性。

Expectations and Level of Satisfaction of the Patient with Parkinson’s Disease Undergoing Deep Brain Stimulation Surgery at the National Institute of Neurology and Neurosurgery

Background: Deep brain stimulation (DBS) is an established treatment for patients with advanced Parkinson’s disease (PD). Reports show continued patient satisfaction after surgery despite not maintaining clinical improvement as measured by evolution scales. Objectives: The present study sought to explore expectations and level of satisfaction in patients after DBS surgery with a semi-structured questionnaire and subsequent correlation with functional scales, Quality of Life (QoL), and motor and non-motor symptoms. Methods: We performed descriptive statistics to represent demographic data, Wilcoxon rank tests to determine significant differences, and Spearman correlation between the applied scales. Results: We evaluated 20 patients with a history of DBS surgery. 45% were female, with a mean age of 55.7 ± 14.15 years, a mean disease duration of 13.42 ± 8.3 years, and a mean time after surgery of 3.18 ± 1.86 years. Patients reported surgery meeting expectations in 85.5% and continued satisfaction in 92%. These two variables showed a significant correlation. Conclusions: This sample of patients remained satisfied after DBS surgery, although we found no differences in motor and non-motor clinimetric scales. Further studies are needed to confirm the importance of assessing quality of life in patients with DBS.

基于B/S架构的军校教材管理系统分析与设计

近年来,军校教材呈现爆发式增长,旧的教材管理系统已不能有效进行信息化管理,工作效率低。根据军校对教材管理的特定需求,对系统和技术可行性进行客观分析,提出一种基于B/S架构的军校教材管理系统设计,并探讨系统运行性能指标,对系统的拓扑结构、运行环境、功能实现等进行全面设计,充分利用军校现有的校园网络系统实现每册教材的全生命周期管理。

基于ABAQUS的汽车转向拉杆心轴疲劳失效分析及改进

转向拉杆是汽车转向机构中的重要零件,它在转向系中起着传递运动的作用,直接影响汽车操纵的稳定性、运行的安全性和轮胎的使用寿命。运用ABAQUS对某车型转向拉杆外球节心轴进行CAE分析并结合其材料的S-N曲线验证第一次根据经验设计出的产品的不合理性,然后通过CAE有限元分析方法设计出符合客户疲劳寿命要求的产品,并通过实验验证。

基于nCode Design-Life的某车架疲劳可靠性分析

针对某型半挂牵引车车架局部出现裂纹或者断裂现象,通过有限元理论和疲劳分析理论相结合进行了车架的有限元分析和疲劳可靠性分析。首先对该车架进行了建模和有限元静态特性分析,然后定义了特定的时间载荷序列数据和材料参数,选用了S-N疲劳设计和静态疲劳分析方法,利用疲劳分析软件nCode Design-Life对该车架进行疲劳可靠性分析,得出该车架的疲劳结果云图和各节点的疲劳寿命,并从相关云图中确定出车架容易破坏的位置和其寿命之后再进行样车实验验证。

基于B-S分布的智能电能表寿命预计方法研究

针对目前智能电能表寿命预计普遍采用Weibull分布的情况,文中介绍了概率物理方法中一个重要的失效模型:B-S疲劳寿命分布及其可靠性分析,并推导出两参数B-S分布的极大似然估计值及近似区间。B-S分布适合描述失效产品的寿命规律,主要应用于疲劳失效以及电子产品性能退化失效的分析研究。文中将两参数B-S分布引入智能电能表寿命预计,对寿命数据是否来自两参数B-S分布总体的样本进行了拟合检验,采用极大似然法和最小二乘法对两参数B-S分布进行了参数估计,建立了基于B-S分布的寿命预计方法,通过实际算例验证了B-S分布寿命预计方法的实用性。文中研究内容对于电能表寿命预计、轮换周期的确定提供了一种新方法,同时对于电能表可靠性评价提供了新思路。

四川泸定M_(S)6.8地震灾害主要特征分析

四川泸定6.8级地震是继2013年芦山7.0级地震至今,四川境内遭受灾害面积最大、死亡人数最多的一次地震,造成了一定程度的房屋和基础设施损坏,诱发了大量的地质灾害,具有明显的区域特点.本文基于四川省抗震救灾指挥部和地震现场工作队的一手资料,从灾情获取的时间序列、震害的空间分布、生命损失、建筑物破坏、地震地质灾害的强度等方面开展了本次地震的灾害特征分析.初步得到如下认识:①黑箱期时间为1.5h,死亡人数统计比小于1%,24h获得了半数以上伤亡信息,符合中强地震灾情渐进式获取的一般规律;②本次地震影响面较广,有感面积为816194km^(2),烈度Ⅵ度区域以上面积为19089km^(2),Ⅸ度区面积为280km^(2),与一次7级地震受灾范围相当;③地震灾害重且破坏集中,截至2022年9月11日17时共造成93人死亡,25人失联,导致房屋垮塌415间,严重损坏5566间,一般损坏19890间,新增有威胁对象的地震地质灾害点565处,其中,约92%的死亡人员地点、68%的地震地质灾害点、多数的毁坏及严重破坏房屋位置,集中分布在Ⅷ度和Ⅸ度区;④滑坡、崩塌等次生地质灾害是造成本次地震人员死亡最主要的原因,占总死亡(含失联)人数的86%.

基于nCode Design-Life的电动客车车架疲劳寿命分析

针对某型电动客车车架疲劳及寿命问题,本文以有限元理论和疲劳分析理论相结合的方法,对电动客车车架进行静强度分析和疲劳寿命校核,建立有限元模型并进行受力分析,定义特定的载荷谱和材料疲劳数据;同时利用S-N静态疲劳设计方法,选用疲劳分析软件nCode Design-Life对该车架进行疲劳可靠性分析。分析结果表明,该车架的疲劳寿命为1.558×106次,许用行驶里程为650 000km,与公交客运车行驶里程参考值约为400 000km相比,结果满足要求。该研究实现了电动车减重节能,增加了续驶里程,为车架优化设计及寿命模型的建立提供了理论依据。

基于nCode Design-Life的重型起重设备疲劳寿命预测研究

为研究重型起重设备的疲劳损伤和寿命,以门式起重机为算例建立有限元模型,通过有限元静力学分析,最大等效应力位于跨中受拉区,得出门式起重机强度和刚度满足要求。采用nCode Design-Life疲劳仿真软件利用S-N疲劳设计方法对有限元静力学特性和疲劳损伤进行分析,得到门式起重机疲劳寿命分布云图和疲劳损伤云图,其最小寿命满足工程要求。为了研究载荷变化对起重机寿命的影响,通过改变载荷缩放因子来改变时间载荷序列的大小,对比分析载荷变化后的寿命情况,得出随机载荷减小门式起重机寿命大大增加,过载对门式起重机的疲劳寿命有显著的影响。

Faecal incontinence and health related quality of life in inflammatory bowel disease patients: Findings from a tertiary care center in South Asia

AIM: To analyze the frequency and severity of faecal incontinence(FI) and its effect on the quality of life(QOL) in inflammatory bowel disease(IBD) patients. METHODS: All patients who attended surgical and medical gastroenterology outpatient clinics in a tertiary care center with an established diagnosis of either ulcerative colitis(UC) or Crohn's disease(CD) over a period of 10 mo were included in this study. Before enrollment into the study, the patients were explained about the study and informed consent was obtained. The patients with unidentified colitis were excluded. The data on demographics, disease characteristics, FI(Vaizey score), and quality of life(IBD-Q) were collected. Data were analyzed using SPSS version 21.RESULTS: There were 184 patients(women = 101, 54.9%; UC = 153, 83.2%) with a female preponderance for UC(male/female ratio = 1:1.5) and a male preponderance for CD(male/female = 2:1). Forty-eight(26%) patients reported symptoms of FI. Among the patients with FI, 70.8% were women(n = 34) and 29.2% were men(n = 14) with an average age of 52.7 years(range, 20-78 years). Average age of onset of FI was 48.6(range, 22-74) years. Ten percent(n = 5) reported regular FI. Incontinence to flatus was seen in 33.3%(n = 16), to liquid faeces in 56.2%(n = 27), to solid faeces in 6.2%(n = 3) and to all three in 4.1%(n = 2). Twenty-one percent(n = 10) complained of disruption of their physical and social activity. There was no association between FI and type of IBD. Significant associations were found between FI and age(P = 0.005) and gender(P < 0.001). QOL in our cohort of patients was significantly affected by FI.CONCLUSION: In our study, nearly a quarter of patients reported FI. There was a significant correlation between FI and QOL. Therefore, enquiring about FI in IBD patients can lead to identification of this debilitating condition. This will enable early referral for continence care in this group of patients.

Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil

BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil.

Addressing quality of life in the patient with interstitial cystitis/bladder pain syndrome

Interstitial cystitis/bladder pain syndrome(IC/BPS)is a debilitating,chronic condition characterized by chronic pelvic pain,urinary urgency,and frequency and is well-known to be associated with a decrease in work productivity,emotional changes,sleep,sexual dysfunction,and mobility.Many metrics of quality of life(QoL)in this patient population have been developed;however,a unified,standardized approach to QoL in these patients has not been determined.The effects of IC/BPS and co-morbid conditions on QoL are described using current validated metrics.Next,data regarding successful treatment of IC/BPS in terms of QoL improvement are reviewed.While QoL is the single most important clinical measure of success in the treatment of patients suffering from IC/BPS,addressing QoL in this patient population remains a significant challenge,as its effects on QoL are highly variable and unable to be differentiated from the effects of comorbid conditions on QoL,including depression,poor sleep,and inability to work.Future studies will need to address treatment efficacy on the basis of IC/BPS specific QoL metrics,and multi-modal assessment and therapy to address comorbid disease will also play an important role in the future to ensure comprehensive management of these patients.

Evolution from Primitive Life to Homo sapiens Based on Visible Genome Structures: The Amino Acid World

It is not too much to say that molecular biology, including genome research, has progressed based on the determination of nucleotide or amino acid sequences. However, these ap-proaches are limited to the analysis of relatively small numbers of the same genes among spe-cies. On the other hand, by graphical presenta-tion of the ratios of the numbers of amino acids present to the total numbers of amino acids presumed from the target gene(s) or genome or those of the numbers of nucleotides present to the total numbers of nucleotides calculated from the target gene(s) or genome, we can readily draw conclusions from extraordinarily huge data sets integrated by human intelli-gence. 1) Assuming polymerization of amino acids or nucleotides in a simulation analysis based on a random choice, proteins were formed by simple amino acid polymerization, while nucleotide polymerization to form nucleic acids encoding specific proteins needed certain specific control. These results proposed that protein formation chronologically preceded codon formation during the establishment of primitive life forms. In the prebiotic phase, amino acid composition was a dominant factor that determined protein characteristics;the “Amino Acid World”. 2) The genome is constructed homogeneou- sly from putative small units displaying similar codon usages and coding for similar amino acid compositions;the unit is a gene assembly en-coding 3,000 - 7,000 amino acid residues and this unit size is independent not only of genome size, but also of species. 3) In codon evolution, all nucleotide alterna-tions are correlated, not only in coding regions, but also in non-coding regions;the correlations can be expressed by linear formulas;y = ax + b, where “y” and “x” represent nucleotide con-tents, and “a” and “b” are constant. 4) The basic pattern of cellular amino acid compositions obtained from whole cell lysates is conserved from bacteria to Homo sapiens, and resembles that calculated from complete genomes. This basic pattern is characterized by a “star-shape” that changes slightly among species, and changes in amino acid composi-tion seem to reflect biological evolution. 5) Organisms can essentially be classified according to two codon patterns. Biological evolution due to nucleotide sub-stitutions can be expressed by simple linear formulas based on mathematical principles, while natural selection must affect species pre- servation after nucleotide alternations. There-fore, although Darwin’s natural selection is not directly involved in nucleotide alternations, it contributes obviously to the selection of nu-cleotide alternations. Thus, Darwin’s natural selection is doubtless an important factor in biological evolution.

Acceptance Sampling Plans with Truncated Life Tests for the Length-Biased Weighted Lomax Distribution

In this paper,we considered the Length-biased weighted Lomax distribution and constructed new acceptance sampling plans(ASPs)where the life test is assumed to be truncated at a pre-assigned time.For the new suggested ASPs,the tables of the minimum samples sizes needed to assert a specific mean life of the test units are obtained.In addition,the values of the corresponding operating characteristic function and the associated producer’s risks are calculated.Analyses of two real data sets are presented to investigate the applicability of the proposed acceptance sampling plans;one data set contains the first failure of 20 small electric carts,and the other data set contains the failure times of the air conditioning system of an airplane.Comparisons are made between the proposed acceptance sampling plans and some existing acceptance sampling plans considered in this study based on the minimum sample sizes.It is observed that the samples sizes based on the proposed acceptance sampling plans are less than their competitors considered in this study.The suggested acceptance sampling plans are recommended for practitioners in the field.

Association between Caregiver Quality of Life and the Care Provided to Persons with Alzheimer’s Disease: Systematic Review

We reviewed the literature to examine whether an association exists between the quality of life (QoL) of primary informal Alzheimer's disease (AD) caregivers and the level and quality of care that these caregivers provide to their loved ones with AD. We obtained studies focusing on the care that these caregivers provide for their family members with AD. Our outcome of interest was level or quality of care and the independent variable was caregiver QoL. We extracted data in tabular form and used a narrative synthesis approach to describe our findings. Only one relevant study was included in the review. Overall, the evidence was equivocal regarding the associations between caregiver QoL and the level/quality of care in AD.

Virtual games and quality of life in Parkinson’s disease: A randomised controlled trial

Objective: To evaluate the efficacy of Nintendo Wii training in quality of life in Parkinson’s disease (PD) patients when compared to traditional physical therapy (PT). Methods: A randomized, single-blinded trial with 2 parallel arms was performed in a referral center for movement disorders in North-eastern, Brazil. Forty-four PD outpatients that fulfilled the eligibility criteria with mild to moderate motor impairment were randomized. Both groups executed a warm up session for 10 minutes that consisted of trunk flexion, extension and rotation, associated with upper and lower limbs stretching. The PT group followed a program that consisted of trunk and limb mobilisation, balance, muscle strengthening, rhythmic movement, postural alignment, double-task execution, bimanual tasks, and gait training. The Nintendo Wii group executed a sequence of tasks according to a previously established protocol, with similar training exercises. Duration of exercises was 40 minutes per session, 3 days per week for 4 weeks. The primary endpoint was the total score obtained in the Parkinson’s disease quality of life questionnaire (PDQ-39) translated from English to Brazilian Portuguese by Oxford outcomes. Secondary endpoints were the scores achieved by each group in the following domains of PDQ-39 scale: mobility, activities of daily living (ADL), emotional well-being, stigma, social support, cognition, communication and bodily discomfort. Assessments were performed before and after intervention in both groups with subjects in the “on” period. Results: Subjects in the Nintendo Wii group showed greater improvement in the PDQ-39 total score when compared to PT group (p = 0.01). Also, significant differences were observed in ADL, stigma, social support and communication when comparing subjects before and after intervention in the Nintendo Wii group (p < 0.05). Conclusions: The results achieved in this trial suggest that rehabilitation using Nintendo Wii may have beneficial effects in quality of life of PD subjects, when compared to traditional PT. Further larger randomised controlled-trials are necessary to reassure these results.