期刊文献+
共找到7,923篇文章
< 1 2 250 >
每页显示 20 50 100
CsABF3-activated CsSUT1 pathway is implicated in pre-harvest water deficit inducing sucrose accumulation in citrus fruit 被引量:1
1
作者 Xiaochuan Ma Yuanyuan Chang +6 位作者 Feifei Li Junfeng Yang Li Ye Tie Zhou Yan Jin Ling Sheng Xiaopeng Lu 《Horticultural Plant Journal》 SCIE CAS CSCD 2024年第1期103-114,共12页
Pre-harvest water deficit(PHWD)plays an important role in sugar accumulation of citrus fruit.However,the mechanism is not known well.Here,it was confirmed that PHWD promoted sucrose accumulation of citrus fruit,but ha... Pre-harvest water deficit(PHWD)plays an important role in sugar accumulation of citrus fruit.However,the mechanism is not known well.Here,it was confirmed that PHWD promoted sucrose accumulation of citrus fruit,but had limited effect on fructose,glucose and total acid.A sucrose transporter,Cs SUT1,which localizes to the plasma membrane,was demonstrated to function in sucrose transport induced by PHWD.Compared to wild-type,Cs SUT1 overexpression in citrus calli stimulated sucrose,fructose and glucose accumulation,while its silencing in juice sacs reduced sucrose accumulation.Increased sugar accumulation in transgenic lines enhanced plant drought tolerance,and resulted in decreased electrolyte leakage,malondialdehyde and hydrogen peroxide contents,as well as increased superoxide dismutase activity and proline contents.An abscisic acid(ABA)-responsive transcription factor,Cs ABF3,was found with a same expression pattern with Cs SUT1 under PHWD.Yeast one-hybrid,electrophoretic mobility shift assay and dual-luciferase assays all revealed that Cs ABF3 directly bound with the Cs SUT1 promoter by ABA responsive elements.When Cs ABF3 was overexpressed in citrus calli,the sucrose,fructose and glucose concentration increased correspondingly.Further,transgenic studies demonstrated that Cs ABF3 could affect sucrose accumulation by regulating Cs SUT1.Overall,this study revealed a regulation of Cs ABF3 promoting Cs SUT1 expression and sucrose accumulation in response to PHWD.Our results provide a detail insight into the quality formation of citrus fruit. 展开更多
关键词 CITRUS Water deficit Pre-harvest SUCROSE CsABF3 CsSUT1
下载PDF
STAT3 ameliorates truncated tau-induced cognitive deficits 被引量:2
2
作者 Bingge Zhang Huali Wan +7 位作者 Maimaitijiang Maierwufu Qian Liu Ting Li Ye He Xin Wang Gongping Liu Xiaoyue Hong Qiong Feng 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第4期915-922,共8页
Proteolytic cleavage of tau by asparagine endopeptidase(AEP)creates tau-N368 fragments,which may drive the pathophysiology associated with synaptic dysfunction and memory deterioration in the brain of Alzheimer’s dis... Proteolytic cleavage of tau by asparagine endopeptidase(AEP)creates tau-N368 fragments,which may drive the pathophysiology associated with synaptic dysfunction and memory deterioration in the brain of Alzheimer’s disease patients.Nonetheless,the molecular mechanisms of truncated tau-induced cognitive deficits remain unclear.Evidence suggests that signal transduction and activator of transcription-3(STAT3)is associated with modulating synaptic plasticity,cell apoptosis,and cognitive function.Using luciferase reporter assays,electrophoretic mobility shift assays,western blotting,and immunofluorescence,we found that human tau-N368 accumulation inhibited STAT3 activity by suppressing STAT3 translocation into the nucleus.Overexpression of STAT3 improved tau-N368-induced synaptic deficits and reduced neuronal loss,thereby improving the cognitive deficits in tau-N368 mice.Moreover,in tau-N368 mice,activation of STAT3 increased N-methyl-D-aspartic acid receptor levels,decreased Bcl-2 levels,reversed synaptic damage and neuronal loss,and thereby alleviated cognitive deficits caused by tau-N368.Taken together,STAT3 plays a critical role in truncated tau-related neuropathological changes.This indicates a new mechanism behind the effect of tau-N368 on synapses and memory deficits.STAT3 can be used as a new molecular target to treat tau-N368-induced protein pathology. 展开更多
关键词 Alzheimer’s disease apoptosis cognitive deficit memory neurodegenerative disease neuron loss N-methyl-D-aspartic acid receptor STAT3 SYNAPSE tau-N368
下载PDF
Main focus of parents of children with attention deficit hyperactivity disorder and the effectiveness of early clinical screening
3
作者 Jia-Wen Li Ke Gao +1 位作者 Xiao-Yun Yang Zhi-Fei Li 《World Journal of Clinical Cases》 SCIE 2024年第19期3752-3759,共8页
BACKGROUND Attention deficit hyperactivity disorder(ADHD)is a common mental and behavioral disorder among children.AIM To explore the focus of attention deficit hyperactivity disorder parents and the effectiveness of ... BACKGROUND Attention deficit hyperactivity disorder(ADHD)is a common mental and behavioral disorder among children.AIM To explore the focus of attention deficit hyperactivity disorder parents and the effectiveness of early clinical screening METHODS This study found that the main directions of parents seeking medical help were short attention time for children under 7 years old(16.6%)and poor academic performance for children over 7 years old(12.1%).We employed a two-stage experiment to diagnose ADHD.Among the 5683 children evaluated from 2018 to 2021,360 met the DSM-5 criteria.Those diagnosed with ADHD underwent assessments for letter,number,and figure attention.Following the exclusion of ADHD-H diagnoses,the detection rate rose to 96.0%,with 310 out of 323 cases identified.RESULTS This study yielded insights into the primary concerns of parents regarding their children's symptoms and validated the efficacy of a straightforward diagnostic test,offering valuable guidance for directing ADHD treatment,facilitating early detection,and enabling timely intervention.Our research delved into the predominant worries of parents across various age groups.Furthermore,we showcased the precision of the simple exclusion experiment in discerning between ADHD-I and ADHD-C in children.CONCLUSION Our study will help diagnose and guide future treatment directions for ADHD. 展开更多
关键词 Attention deficit hyperactivity disorder CHILDREN PARENTS Direction of attention Simple test
下载PDF
Exploring the impact of high density planting system and deficit irrigation in cotton(Gossypium hirsutum L.):a comprehensive review
4
作者 MANIBHARATHI Sekar SOMASUNDARAM Selvaraj +3 位作者 PARASURAMAN Panneerselvam SUBRAMANIAN Alagesan RAVICHANDRAN Veerasamy MANIKANDA BOOPATHI Narayanan 《Journal of Cotton Research》 CAS 2024年第3期302-317,共16页
Lessons learned from past experiences push for an alternate way of crop production.In India,adopting high density planting system(HDPS)to boost cotton yield is becoming a growing trend.HDPS has recently been considere... Lessons learned from past experiences push for an alternate way of crop production.In India,adopting high density planting system(HDPS)to boost cotton yield is becoming a growing trend.HDPS has recently been considered a replacement for the current Indian production system.It is also suitable for mechanical harvesting,which reducing labour costs,increasing input use efficiency,timely harvesting timely,maintaining cotton quality,and offering the potential to increase productivity and profitability.This technology has become widespread in globally cotton growing regions.Water management is critical for the success of high density cotton planting.Due to the problem of freshwater availability,more crops should be produced per drop of water.In the high-density planting system,optimum water application is essential to control excessive vegetative growth and improve the translocation of photoassimilates to reproductive organs.Deficit irrigation is a tool to save water without compromising yield.At the same time,it consumes less water than the normal evapotranspiration of crops.This review comprehensively documents the importance of growing cotton under a high-density planting system with deficit irrigation.Based on the current research and combined with cotton production reality,this review discusses the application and future development of deficit irrigation,which may provide theoretical guidance for the sustainable advancement of cotton planting systems. 展开更多
关键词 deficit irrigation High density planting system Ultra narrow row Cost saving Mechanical harvesting Yield optimization
下载PDF
Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy
5
作者 Bismark Gatica-Garcia Michael J.Bannon +14 位作者 Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-Fong 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期2057-2067,共11页
Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,... Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-synucleinopathy.As Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 post-transfection.This study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced neuropathology.Accordingly,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the striatum.In addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia nigra.These effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor behavior.Our results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor deficits.Increased neurotrophic astrocytes and brain-derived neurotrophic factor can mediate the rNurr1-V5 effect,supporting its potential clinical use in the treatment of Parkinson’s disease. 展开更多
关键词 A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates
下载PDF
MicroRNAs as potential biomarkers for diagnosis of attention deficit hyperactivity disorder
6
作者 Bridget Martinez Philip V.Peplow 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期557-562,共6页
Inappropriate levels of hyperactivity,impulsivity,and inattention characterize attention deficit hyperactivity disorder,a common childhood-onset neuropsychiatric disorder.The cognitive function and learning ability of... Inappropriate levels of hyperactivity,impulsivity,and inattention characterize attention deficit hyperactivity disorder,a common childhood-onset neuropsychiatric disorder.The cognitive function and learning ability of children with attention deficit hyperactivity disorder are affected,and these symptoms may persist to adulthood if they are not treated.The diagnosis of attention deficit hyperactivity disorder is only based on symptoms and objective tests for attention deficit hyperactivity disorder are missing.Treatments for attention deficit hyperactivity disorder in children include medications,behavior therapy,counseling,and education services which can relieve many of the symptoms of attention deficit hyperactivity disorder but cannot cure it.There is a need for a molecular biomarker to distinguish attention deficit hyperactivity disorder from healthy subjects and other neurological conditions,which would allow for an earlier and more accurate diagnosis and appropriate treatment to be initiated.Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of attention deficit hyperactivity disorder.The recent studies reviewed had performed microRNA profiling in whole blood,white blood cells,blood plasma,and blood serum of children with attention deficit hyperactivity disorder.A large number of microRNAs were dysregulated when compared to healthy controls and with some overlap between individual studies.From the studies that had included a validation set of patients and controls,potential candidate biomarkers for attention deficit hyperactivity disorder in children could be miR-140-3p,let-7g-5p,-30e-5p,-223-3p,-142-5p,-486-5p,-151a-3p,-151a-5p,and-126-5p in total white blood cells,and miR-4516,-6090,-4763-3p,-4281,-4466,-101-3p,-130a-3p,-138-5p,-195-5p,and-106b-5p in blood serum.Further studies are warranted with children and adults with attention deficit hyperactivity disorder,and consideration should be given to utilizing rat models of attention deficit hyperactivity disorder.Animal studies could be used to confirm microRNA findings in human patients and to test the effects of targeting specific microRNAs on disease progression and behavior. 展开更多
关键词 ADULTS attention deficit hyperactivity disorder biomarkers blood plasma blood serum CHILDREN MICRORNA total white blood cells whole blood
下载PDF
Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder
7
作者 Renee J Dufault Katherine M Adler +2 位作者 David O Carpenter Steven G Gilbert Raquel A Crider 《World Journal of Psychiatry》 SCIE 2024年第1期159-178,共20页
BACKGROUND Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations,creating conditions for the neurodevelopmental disorders... BACKGROUND Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations,creating conditions for the neurodevelopmental disorders known as autism and attention deficit/hyperactivity disorder(ADHD).Children with these disorders have difficulty metabolizing and excreting heavy metals from their bloodstream,and the severity of their symptoms correlates with the heavy metal levels measured in their blood.Psychiatrists may play a key role in helping parents reduce their ultra-processed food and dietary heavy metal intake by providing access to effective nutritional epigenetics education.AIM To test the efficacy of nutritional epigenetics instruction in reducing parental ultra-processed food intake.METHODS The study utilized a semi-randomized test and control group pretest-posttest pilot study design with participants recruited from parents having a learning-disabled child with autism or ADHD.Twenty-two parents who met the inclusion criteria were randomly selected to serve in the test(n=11)or control(n=11)group.The test group participated in the six-week online nutritional epigenetics tutorial,while the control group did not.The efficacy of the nutritional epigenetics instruction was determined by measuring changes in parent diet and attitude using data derived from an online diet survey administered to the participants during the pre and post intervention periods.Diet intake scores were derived for both ultra-processed and whole/organic foods.Paired sample t-tests were conducted to determine any differences in mean diet scores within each group.RESULTS There was a significant difference in the diet scores of the test group between the pre-and post-intervention periods.The parents in the test group significantly reduced their intake of ultra-processed foods with a preintervention diet score of 70(mean=5.385,SD=2.534)and a post-intervention diet score of 113(mean=8.692,SD=1.750)and the paired t-test analysis showing a significance of P<0.001.The test group also significantly increased their consumption of whole and/or organic foods with a pre-intervention diet score of 100(mean=5.882,SD=2.472)and post-intervention diet score of 121(mean=7.118,SD=2.390)and the paired t-test analysis showing a significance of P<0.05.CONCLUSION Here we show nutritional epigenetics education can be used to reduce ultra-processed food intake and improve attitude among parents having learning-disabled children with autism or ADHD. 展开更多
关键词 EPIGENOMICS Parenteral nutrition AUTISM Attention deficit/hyperactivity disorder Ultra-processed foods Heavy metals
下载PDF
Spatial Heterogeneity of Embedded Water Consumption from the Perspective of Virtual Water Surplus and Deficit in the Yellow River Basin,China
8
作者 MA Weijing LI Xiangjie +1 位作者 KOU Jingwen LI Chengyi 《Chinese Geographical Science》 SCIE CSCD 2024年第2期311-326,共16页
Virtual water trade(VWT)provides a new perspective for alleviating water crisis and has thus attracted widespread attention.However,the heterogeneity of virtual water trade inside and outside the river basin and its i... Virtual water trade(VWT)provides a new perspective for alleviating water crisis and has thus attracted widespread attention.However,the heterogeneity of virtual water trade inside and outside the river basin and its influencing factors remains further study.In this study,for better investigating the pattern and heterogeneity of virtual water trade inside and outside provincial regions along the Yellow River Basin in 2015 using the input-output model(MRIO),we proposed two new concepts,i.e.,virtual water surplus and virtual water deficit,and then used the Logarithmic Mean Divisia Index(LMDI)model to identify the inherent mechanism of the imbalance of virtual water trade between provincial regions along the Yellow River Basin and the other four regions in China.The results show that:1)in provincial regions along the Yellow River Basin,the less developed the economy was,the larger the contribution of the agricultural sector in virtual water trade,while the smaller the contribution of the industrial sector.2)Due to the large output of agricultural products,the upstream and midstream provincial regions of the Yellow River Basin had a virtual water surplus,with a net outflow of virtual water of 2.7×10^(8) m^(3) and 0.9×10^(8) m^(3),respectively.3)provincial regions along the Yellow River Basin were in a virtual water deficit with the rest of China,and the decisive factor was the active degree of trade with the outside.This study would be beneficial to illuminate the trade-related water use issues in provincial regions along the Yellow River Basin,which has farreaching practical signific-ance for alleviating water scarcity. 展开更多
关键词 virtual water trade(VWT) input-output model(MRIO) virtual water surplus virtual water deficit Yellow River Basin China
下载PDF
Clipping Effect on Growth and Plant Water Use Response to Diurnal Variation of Vapor Pressure Deficit in Cenchrus biflorus Roxb
9
作者 Moussa Oumarou Abdoulaye Issoufou Hassane Bil-Assanou +1 位作者 Soulé Moussa Mainassara Zaman-Allah 《Journal of Agricultural Chemistry and Environment》 2024年第2期183-191,共9页
Cenchrus biflorus called Karangiya in the Hausa language is an annual pastoral grass which is a valuable herbaceous fodder in dry land region in the context of climate change. However, little is known about the plant ... Cenchrus biflorus called Karangiya in the Hausa language is an annual pastoral grass which is a valuable herbaceous fodder in dry land region in the context of climate change. However, little is known about the plant water use under the effects of cut in West Africa Sahel like Niger where the plant is a multipurpose grass species. Therefore, this study investigated the impact of grazing (simulated by shoot cuts) on biomass production. Cenchrus biflorus Roxb was grown on field plots and in pots and subjected to shoot cuts at different levels (3 cm and 5 cm from soil surface). The effect of shoot cuts on drought tolerance was evaluated by assessing the response of transpiration to the diurnal variation of vapor pressure deficit (VPD). Results showed that the biomass production varied in response to shoot cuts depending on the culture system, and the level or frequency of cuts. The mean biomass production increased significantly especially in field plots for 5 cm cuts compared to those at 3 cm and the control treatment. In addition, transpiration was highly increased in response to the VPD increase. Shoot cuts significantly reduced transpiration, whatever the level, largely because they reduced leaf surface. We concluded that moderate grazing (cuts to 5cm) can improve biomass production and allow better adaptation to water deficit as they significantly reduced water loss through transpiration. The study recommends the cropping of the Cenchrus biflorus as climate solution as it performs better under water deficit for improving grazing resilience in Niger. 展开更多
关键词 Cenchrus biflorus BIOMASS Vapor Pressure deficit CUTTING GRAZING
下载PDF
Influence of vapor pressure deficit on vegetation growth in China 被引量:1
10
作者 LI Chuanhua ZHANG Liang +3 位作者 WANG Hongjie PENG Lixiao YIN Peng MIAO Peidong 《Journal of Arid Land》 SCIE CSCD 2024年第6期779-797,共19页
Vapor pressure deficit(VPD)plays a crucial role in determining plant physiological functions and exerts a substantial influence on vegetation,second only to carbon dioxide(CO_(2)).As a robust indicator of atmospheric ... Vapor pressure deficit(VPD)plays a crucial role in determining plant physiological functions and exerts a substantial influence on vegetation,second only to carbon dioxide(CO_(2)).As a robust indicator of atmospheric water demand,VPD has implications for global water resources,and its significance extends to the structure and functioning of ecosystems.However,the influence of VPD on vegetation growth under climate change remains unclear in China.This study employed empirical equations to estimate the VPD in China from 2000 to 2020 based on meteorological reanalysis data of the Climatic Research Unit(CRU)Time-Series version 4.06(TS4.06)and European Centre for Medium-Range Weather Forecasts(ECMWF)Reanalysis 5(ERA-5).Vegetation growth status was characterized using three vegetation indices,namely gross primary productivity(GPP),leaf area index(LAI),and near-infrared reflectance of vegetation(NIRv).The spatiotemporal dynamics of VPD and vegetation indices were analyzed using the Theil-Sen median trend analysis and Mann-Kendall test.Furthermore,the influence of VPD on vegetation growth and its relative contribution were assessed using a multiple linear regression model.The results indicated an overall negative correlation between VPD and vegetation indices.Three VPD intervals for the correlations between VPD and vegetation indices were identified:a significant positive correlation at VPD below 4.820 hPa,a significant negative correlation at VPD within 4.820–9.000 hPa,and a notable weakening of negative correlation at VPD above 9.000 hPa.VPD exhibited a pronounced negative impact on vegetation growth,surpassing those of temperature,precipitation,and solar radiation in absolute magnitude.CO_(2) contributed most positively to vegetation growth,with VPD offsetting approximately 30.00%of the positive effect of CO_(2).As the rise of VPD decelerated,its relative contribution to vegetation growth diminished.Additionally,the intensification of spatial variations in temperature and precipitation accentuated the spatial heterogeneity in the impact of VPD on vegetation growth in China.This research provides a theoretical foundation for addressing climate change in China,especially regarding the challenges posed by increasing VPD. 展开更多
关键词 vapor pressure deficit(VPD) near-infrared reflectance of vegetation(NIRv) leaf area index(LAI) gross primary productivity(GPP) Climatic Research Unit(CRU)Time-Series version 4.06(TS4.06) European Centre for Medium-Range Weather Forecasts(ECMWF)Reanalysis 5(ERA-5) climate change
下载PDF
Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents
11
作者 Irene Navarro-Lobato Mariam Masmudi-Martín +8 位作者 Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第8期1835-1841,共7页
Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for treatment.Up till now,all potential drug candidates have failed to ... Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for treatment.Up till now,all potential drug candidates have failed to produce satisfa ctory effects.Therefore,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of ORM.In this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s disease.Furthermore,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM deficits.These findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s disease.Therefore,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits. 展开更多
关键词 behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling
下载PDF
Impact of applying the theory of human becoming and self-care deficit theory of nursing on insomnia in after stroke urinary incontinence patients
12
作者 Heltty Heltty Ratna Sitorus Haryanto Haryanto 《Frontiers of Nursing》 2024年第3期259-266,共8页
Objective:To determine the impact of applying the theory of human becoming and self-care deficit theory of nursing in overcoming insomnia in patients of urinary incontinence(UI)after stroke.Insomnia is a sleep disorde... Objective:To determine the impact of applying the theory of human becoming and self-care deficit theory of nursing in overcoming insomnia in patients of urinary incontinence(UI)after stroke.Insomnia is a sleep disorder experienced by UI patients after stroke which can exacerbate problems related to brain damage and can complicate the recovery process.Methods:This study was a quasi-experimental conducted in 4 hospitals.Fifty-six patients were selected by convenience sampling and divided into 2 groups(the intervention and control group).Participants in the intervention group received“applying the theory of Human becoming and self-care deficit theory of nursing,”starting when the patient is about to go home from the hospital and continuing at the house.Measurement of insomnia is done using the Pittsburgh Sleep Quality Index(PSQI).Results:The mean insomnia scores of participants from both groups increased in the first and third measurements.The second and third insomnia measurements found a significant difference(P<0.001).This intervention decreased the average score of insomnia by 4.11 times in the second measurement and 5.82 times in the third measurement.The most important item that decreased in the third measurement of insomnia was sleep efficiency.Conclusions:Applying the theory of human becoming and self-care deficit theory of nursing in this study significantly decreased the insomnia score of post-stroke UI patients.It can be used as a guide for nurses,patients,and families in managing insomnia.In addition,the application of nursing theory in nursing practice can systematize nursing care plans and organize the knowledge of professionals into a conceptual framework,as well as provide effective guidance for nurses on what to do. 展开更多
关键词 human becoming theory INSOMNIA self-care deficit theory STROKE urinary incontinence
下载PDF
Early Intervention Facilitates Neuropsychological Development in Children with Autism and Attention Deficit Hyperactivity Disorder
13
作者 Bei Li 《Journal of Clinical and Nursing Research》 2024年第8期1-7,共7页
Objective:This study aims to investigate the impact of early intervention on neuropsychological development in children with autism and attention deficit hyperactivity disorder(ADHD),providing effective intervention s... Objective:This study aims to investigate the impact of early intervention on neuropsychological development in children with autism and attention deficit hyperactivity disorder(ADHD),providing effective intervention strategies for clinical practice.Methods:A total of 130 children with autism and ADHD who visited the hospital between June 2023 and June 2024 were selected as study subjects and randomly divided into an intervention group and a control group,with 65 children in each group.The intervention group received a one-year early comprehensive intervention,including behavioral therapy,cognitive training,and family guidance,while the control group only received routine medical care.The neuropsychological development assessment scale was used to evaluate both groups before and after the intervention to compare changes in their neuropsychological development levels.Results:Children in the intervention group showed significant improvements in cognitive function,social skills,language ability,and attention concentration,with an average improvement score of 23.5 points.Children in the control group did not show significant improvements in these areas,with an average improvement score of only 5.8 points.The difference between the two groups was statistically significant(P<0.05).Conclusion:Early comprehensive intervention has a significant promoting effect on the neuropsychological development of children with autism and ADHD.Targeted behavioral therapy,cognitive training,and family guidance can effectively enhance children’s cognitive,social,language,and attention abilities,laying a solid foundation for their future overall development.Therefore,it is recommended to actively promote and apply early intervention strategies in clinical practice. 展开更多
关键词 Early intervention AUTISM Attention deficit hyperactivity disorder(ADHD) Neuropsychological development Comprehensive intervention strategies
下载PDF
Positive Effect of Transcranial Direct Current Stimulation on Visual Verbal Working Memory in Patients with Attention-Deficit/Hyperactivity Disorder
14
作者 Tomoko Uchida Daisuke Matsuzawa +7 位作者 Tadashi Shiohama Katsunori Fujii Akihiro Shiina Masamitsu Naka Katsuo Sugita Eiji Shimizu Naoki Shimojo Hiromichi Hamada 《Open Journal of Psychiatry》 2024年第4期334-346,共13页
Background: Working memory is an executive function that plays an important role in many aspects of daily life, and its impairment in patients with attention-deficit/hyperactivity disorder (ADHD) affects quality of li... Background: Working memory is an executive function that plays an important role in many aspects of daily life, and its impairment in patients with attention-deficit/hyperactivity disorder (ADHD) affects quality of life. The dorsolateral prefrontal cortex (DLPFC) has been a good target site for transcranial direct current stimulation (tDCS) due to its intense involvement in working memory. In our 2018 study, tDCS improved visual-verbal working memory in healthy subjects. Objective: This study examines the effects of tDCS on ADHD patients, particularly on verbal working memory. Methods: We conducted an experiment involving verbal working memory of two modalities, visual and auditory, and a sustained attention task that could affect working memory in 9 ADHD patients. Active or sham tDCS was applied to the left DLPFC in a single-blind crossover design. Results: tDCS significantly improved the accuracy of visual-verbal working memory. In contrast, tDCS did not affect auditory-verbal working memory and sustained attention. Conclusion: tDCS to the left DLPFC improved visual-verbal working memory in ADHD patients, with important implications for potential ADHD treatments. 展开更多
关键词 Working Memory Attention-deficit/Hyperactivity Disorder Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation
下载PDF
Eco-environment Evolution and Its Sustainable Development Strategies in Western China 被引量:7
15
作者 张巧显 柯兵 +2 位作者 刘昕 刘国华 吴钢 《Agricultural Science & Technology》 CAS 2010年第1期176-181,共6页
Natural condition in Western China is relatively poor and regional economy level is low. The ecological environment has been seriously damaged by population growth and over-exploitation of natural resources. It is ver... Natural condition in Western China is relatively poor and regional economy level is low. The ecological environment has been seriously damaged by population growth and over-exploitation of natural resources. It is very important for coordinating the regional development and safeguarding ecological security to discuss the eco-environment evolution trend and its sustainable development strategies in Western China. Based on analyzing documents and relative research,the changes of main ecological and environmental problems in the western region,such as degradation of forest and grassland ecosystems,shrinkage of wetland,desertification,water and soil erosion,etc. were synthetically discussed. Then,according to the development trend,some countermeasures for eco-environment protection and rehabilitation and sustainable development were proposed. 展开更多
关键词 eco-environment evolution Ecological degradation Sustainable development Western China
下载PDF
Effects of Southward Flow of Yellow River on Eco-environment of Xu-Huai River Basin 被引量:8
16
作者 李高金 韩宝平 钱程 《Agricultural Science & Technology》 CAS 2010年第1期15-18,共4页
Based on the historical records,the flood disasters in Xu-Huai River Basin caused by southward flow of Yellow River were studied,while its effects on Xu-Huai regional economic,transportation and eco-environment were a... Based on the historical records,the flood disasters in Xu-Huai River Basin caused by southward flow of Yellow River were studied,while its effects on Xu-Huai regional economic,transportation and eco-environment were also highlighted,and finally historical natural disasters were presented in this study. 展开更多
关键词 Southward flow of Yellow River eco-environment Xu-Huai River Basin
下载PDF
Eco-Environment Status of the Bohai Bay and the Impact of Coastal Exploitation 被引量:3
17
作者 聂红涛 陶建华 《Marine Science Bulletin》 CAS 2009年第2期81-96,共16页
With the rapid economic development in the surrounding coastal zone, more and more wastewater has been discharged into the Bohai Bay. And with the scale of coastal exploitation being expanded year by year, the eco-env... With the rapid economic development in the surrounding coastal zone, more and more wastewater has been discharged into the Bohai Bay. And with the scale of coastal exploitation being expanded year by year, the eco-environment of the Bohai Bay has been confronted with great pressure. In this paper, the main problems in the eco-environment of the Bohai Bay were summarized firstly. Red tides occurred more frequently and more seriously; salinity rose in inshore area, the fishery resources degenerated; all the above indicate that the eco-environment of the Bohai Bay is under a severe situation Next, to make a concrete study of the existing status of the Bohai Bay, the eco-environment index system was set up. Then the principal components analytic method and grey relation method were adopted to carry on a comprehensive analysis on the status. The results show that serious pollution of inorganic nitrogen and active phosphate, and poor species diversity are the main presentations of the bad quality of the inshore aquatic eco-environment of the Bohai Bay, which is mainly induced by the massive discharge of pollutant from land and the overexploitation in the surrounding coastal zone. At last, the variations of hydrodynamic characteristics and the pollutant transport caused by coastal exploitations such as reclamation and seawater desalination are analyzed. The results show that reclamation in coastal water not only decreases the tidal prism and weakens the tidal current action, but also influences the pollution distribution in the coastal water. The seawater desalination project would cause tremendous influence to the aquatic eco-environment of the Bohai Bay as the pollutant's pulse impact. Much more attention would be paid to the reasonable use of the coastal zone resources and the control of pollution from land-based sources. 展开更多
关键词 Bohai Bay aquatic eco-environment indicator system RECLAMATION seawater desalination
下载PDF
Impact of Agricultural Eco-environment on the Architectural Form of Vernacular Dwellings
18
作者 徐震 《Journal of Landscape Research》 2010年第10期80-82,共3页
Through analyzing the form, materials, building techniques of vernacular dwellings in Jinzhai County, Anhui Province, this study tries to explore the influence of agricultural eco-environment on the form of folk house... Through analyzing the form, materials, building techniques of vernacular dwellings in Jinzhai County, Anhui Province, this study tries to explore the influence of agricultural eco-environment on the form of folk houses, points out that vernacular dwellings are fully combined with local traditional agricultural environment from site selection, spatial form, architectural style, building materials and detail designs, which unifies the economic and environmental benefits of vernacular dwellings. 展开更多
关键词 VERNACULAR DWELLINGS in north ANHUI AGRICULTURAL eco-environment ARCHITECTURAL form
下载PDF
Exploration of Water and Soil Conservation's Function in Construction of Eco-environment 被引量:2
19
作者 张丰良 冯兴平 《Agricultural Science & Technology》 CAS 2015年第7期1544-1551,共8页
Eco-environment lays foundation for human existence and development, and social and economy evolvement. Therefore, it is a fundamental principle to pro- tact and construct eco-environment and achieve sustainable devel... Eco-environment lays foundation for human existence and development, and social and economy evolvement. Therefore, it is a fundamental principle to pro- tact and construct eco-environment and achieve sustainable development. With ur- ban development, and destruction on natural environment, however, the issue of water and soil losses has become a serious problem, affecting people's life and production. The research, therefore, explored the role of water and soil conservation in ecological civilization construction, including bomprehensive treatment of water storage and sand reduction, improving agricultural structure and advancing rural econ- omy, relieving the conflict between supply and demand of water resources, improv- ing eco-environment in mountainous regions and accelerating eco-construction. 展开更多
关键词 Water and soil conservation eco-environment Fundamental national policy
下载PDF
A Theoretical Analysis of Interactive Coercing Effects Between Urbanization and Eco-environment 被引量:42
20
作者 FANG Chuanglin WANG Jing 《Chinese Geographical Science》 SCIE CSCD 2013年第2期147-162,共16页
Objectively, a complex interactive coercing relationship exists between urbanization and eco-environment, and the research of this relationship is primarily divided into three schools, i.e., interactive coercion theor... Objectively, a complex interactive coercing relationship exists between urbanization and eco-environment, and the research of this relationship is primarily divided into three schools, i.e., interactive coercion theory, interactive promotion theory and coupling symbiosis theory. Harmonizing the relationship between urbanization and eco-environment is not only an important proposition for the national development plan but also the only way to promote healthy urbanization. Based on an analysis of urbanization process and its relationship with the eco-environment, this article analyzes interactive coercing effects between urbanization and eco-environment from three perspectives of population urbanization, economic urbanization and spatial urbanization, respectively, and analyzes risk effects of the interactive coercion. Further, it shows six basic laws followed by interactive coercion between urbanization and eco-environment, namely, coupling fission law, dynamic hierarchy law, stochastic fluctuation law, non-linear synergetic law, threshold value law and forewarning law, and divides the interactive coercing process into five stages, namely, low-level coordinate, antagonistic, break-in, ameliorative and high-grade coordinate. Based on the geometric derivation, the interactive coercing relationship between urbanization and eco-environment is judged to be non-linear and it can be explained by a double-exponential function formed by the combination of power and exponential functions. Then, the evolutionary types of the interactive coercing relationship are divided into nine ones: rudimentary coordinating, ecology-dominated, synchronal coordinating, urbanization lagging, stepwise break-in, exorbitant urbanization, fragile ecology, rudimentary break-in and unsustainable types. Finally, based on an interactive coercion model, the degree of interactive coercion can be examined, and then, an evolutionary cycle can be divided into four phases, namely rudimentary symbiosis, harmonious development, utmost increasing and spiral type rising. The study results offer a scientific decision-making of healthy urbanization for achieving the goal of eco-environment protection and promoting urbanization. 展开更多
关键词 urbanization process eco-environment interactive coercing relationship interactive coercing rules interactive coercingdegree
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部