A spatiotemporal deep learning method for excavation-induced wall deflections

Data-driven approaches such as neural networks are increasingly used for deep excavations due to the growing amount of available monitoring data in practical projects.However,most neural network models only use the data from a single monitoring point and neglect the spatial relationships between multiple monitoring points.Besides,most models lack flexibility in providing predictions for multiple days after monitoring activity.This study proposes a sequence-to-sequence(seq2seq)two-dimensional(2D)convolutional long short-term memory neural network(S2SCL2D)for predicting the spatiotemporal wall deflections induced by deep excavations.The model utilizes the data from all monitoring points on the entire wall and extracts spatiotemporal features from data by combining the 2D convolutional layers and long short-term memory(LSTM)layers.The S2SCL2D model achieves a long-term prediction of wall deflections through a recursive seq2seq structure.The excavation depth,which has a significant impact on wall deflections,is also considered using a feature fusion method.An excavation project in Hangzhou,China,is used to illustrate the proposed model.The results demonstrate that the S2SCL2D model has superior prediction accuracy and robustness than that of the LSTM and S2SCL1D(one-dimensional)models.The prediction model demonstrates a strong generalizability when applied to an adjacent excavation.Based on the long-term prediction results,practitioners can plan and allocate resources in advance to address the potential engineering issues.

Theoretical Analysis on Deflection and Bearing Capacity of Prestressed Bamboo-Steel Composite Beams

A theoretical analysis of upward deflection and midspan deflection of prestressed bamboo-steel composite beams is presented in this study.The deflection analysis considers the influences of interface slippage and shear deformation.Furthermore,the calculation model for flexural capacity is proposed considering the two stages of loading.The theoretical results are verified with 8 specimens considering different prestressed load levels,load schemes,and prestress schemes.The results indicate that the proposed theoretical analysis provides a feasible prediction of the deflection and bearing capacity of bamboo-steel composite beams.For deflection analysis,the method considering the slippage and shear deformation provides better accuracy.The theoretical method for bearing capacity matches well with the test results,and the relative errors in the serviceability limit state and ultimate limit state are 4.95%and 5.85%,respectively,which meet the accuracy requirements of the engineered application.

NUDT5 promotes the growth,metastasis,and Warburg effect of IDH wild-type glioblastoma multiforme cells by upregulating TRIM47

Objective:To explore the regulatory mechanism of NUDT5 in glioblastoma multiforme(GBM).Methods:GEPIA database was used to predict the expressions of NUDT5 and tripartite motif family proteins 47(TRIM47)in GBM patients.RT-qPCR and Western blot analyses were performed to examine NUDT5 expression in GBM cells.LN-229 cell proliferation,migration as well as invasion were estimated by CCK-8,colony formation,wound healing,and Transwell assays following interference with NUDT5.ECAR assay,L-lactic acid kit,glucose detection kit,and ATP detection kit were applied for the detection of glycolysis-related indexes.Co-immunoprecipitation experiment was carried out to verify the relationship between NUDT5 and TRIM47.Results:GEPIA database showed that NUDT5 expression was significantly increased in GBM patients.Inhibiting the expression of NUDT5 in GBM cells significantly suppressed the viability,proliferation,invasion,migration,and glycolysis of GBM cells.Moreover,TRIM47 was highly expressed in GBM cells and interacted with NUDT5.Overexpression of TRIM47 partially reversed the inhibitory effect of NUDT5 downregulation on the proliferation,metastasis,and glycolysis of GBM cells.Conclusions:NUDT5 promotes the growth,metastasis,and Warburg effect of GBM cells by upregulating TRIM47.Both NUDT5 and TRIM47 can be used as targets for GMB treatment.

Identification prognostic features related to sphingolipid metabolism and experimental validation of TRIM47 in hepatocellular carcinoma

Background:The specific impact of sphingolipid metabolism on developing hepatocellular Carcinoma(HCC)remains unclear.This study aims to explore the relationship between sphingolipid metabolism and HCC prognosis,immune response,and drug sensitivity.Methods:Data were obtained from The Cancer Genome Atlas(TCGA)-Hepatocellular Carcinoma(LIHC)and Gene Expression Omnibus(GEO,GSE14520 datasets).47 sphingolipid metabolism genes were obtained from the Kyoto Encyclopedia of Genes and Genomes(KEGG)database.After classifying HCC samples using the Non-negative Matrix Factorization(NMF)clustering method,differentially expressed genes were screened.Then,8 risk genes were obtained by univariate analysis,survival random forest reduction and lasso analysis.The expression of 8 risk genes was verified in vitro.Results:8 risk genes were used to construct the Sphingolipid score model.High-Sphingolipid score predicted poor prognosis of HCC patients.Sphingolipid score was associated with immune checkpoints(IL-1B,TLR4,TGFB1,and IL-10),immune cells(Th2,Treg,MDSC,Neutrophil,Fibroblasts and macrophage),and MAPK Cascade.In the High-Sphingolipid score group,a significantly higher proportion of patients with TP53(p53)mutations was significantly higher(56%).Furthermore,patients with a high-Sphingolipid score were predicted to have a higher sensitivity to chemotherapy drugs.In vitro validation showed that compared with normal liver cells LX-2,TRIM47,and S100A9 significantly increased in liver cancer cells Hep G2,MHCC-97H,and Hep3B2.1-7,while SLC1A7,LPCAT1,and CFHR4 significantly decreased.Silencing TRIM47 reduced the proliferation and promoted apoptosis.The levels of ceramide synthesis-related indexes(CERS1,CERS6,CERS5,and SPTLC2)increased,and the ACER3 related to catalytic hydrolysis decreased.Conclusion:We constructed a sphingolipid metabolism-related prognostic signature(Sphingolipid score)based on 8 risk genes.TRIM47 may affect the development of liver cancer by regulating the relevant indicators of ceramide synthesis and catalytic hydrolysis.

组蛋白去甲基化酶KDM5A通过LncRNA TRIM52-AS1调控急性髓系白血病的发生和发展

目的初步探索组蛋白去甲基化酶赖氨酸特异性去甲基化酶5(KDM5A)通过长链非编码RNA(LncRNA)TRIM52-AS1调控急性髓系白血病(AML)发生、发展的机制。方法通过逆转录定量聚合酶链式反应(qRT-PCR)和蛋白质印迹(Western blot)检测白血病患者血清和各种白血病细胞中的KDM5A、TRIM52-AS1的表达。采用双荧光素酶报告实验检测KDM5A和TRIM52-AS1的靶向关系。通过CCK8实验检测KDM5A和TRIM52-AS1对HL-60细胞增殖的影响。通过Transwell实验检测KDM5A和TRIM52-AS1对HL-60细胞迁移的影响。结果KDM5A在白血病患者血清和各种白血病细胞中高表达,TRIM52-AS1在白血病患者血清和各种白血病细胞中低表达(P<0.05)。KDM5A可以靶向抑制TRIM52-AS1。过表达TRIM52-AS1可以抑制白血病细胞的增殖和迁移,KDM5A可以通过抑制TRIM52-AS1进而抑制白血病细胞的增殖和迁移(P<0.05)。结论组蛋白去甲基化酶KDM5A可通过抑制LncRNA TRIM52-AS1进而抑制AML的发生、发展。

Disordered Multi-view Registration Method Based on the Soft Trimmed Deep Network

Compared with the pair-wise registration of point clouds,multi-view point cloud registration is much less studied.In this dissertation,a disordered multi-view point cloud registration method based on the soft trimmed deep network is proposed.In this method,firstly,the expression ability of feature extraction module is improved and the registration accuracy is increased by enhancing feature extraction network with the point pair feature.Secondly,neighborhood and angle similarities are used to measure the consistency of candidate points to surrounding neighborhoods.By combining distance consistency and high dimensional feature consistency,our network introduces the confidence estimation module of registration,so the point cloud trimmed problem can be converted to candidate for the degree of confidence estimation problem,achieving the pair-wise registration of partially overlapping point clouds.Thirdly,the results from pair-wise registration are fed into the model fusion to achieve the rough registration of multi-view point clouds.Finally,the hierarchical clustering is used to iteratively optimize the clustering center model by gradually increasing the number of clustering categories and performing clustering and registration alternately.This method achieves rough point cloud registration quickly in the early stage,improves the accuracy of multi-view point cloud registration in the later stage,and makes full use of global information to achieve robust and accurate multi-view registration without initial value.

Height connection across sea by using satellite altimetry data sets,ellipsoidal heights,astrogeodetic deflections of the vertical,and an Earth Gravity Model

Islands and the mainland are separated by seas,and the distances between them might be so long that the height on the mainland cannot be exactly translated to the islands,resulting in different height systems on the mainland and the islands.In this study,we used astrogeodetic deflections of the vertical and ellipsoidal heights of points on the mainland and island near their coastlines to implement height connection across sea areas.First,the modeled gravity and modeled astrogeodetic vertical deflections of segmentation points along connecting routes over the sea between the mainland and the island were determined by Earth Gravity Model(EGM),and the ellipsoidal heights of segmentation points were determined by the satellite altimetry data sets.Second,we used a linear interpolation model to increase the precision of the vertical deflections of segmentation points.Third,we computed the geopotential difference of points between the mainland and the island using a method derived from geopotential theory and the astronomical leveling principle.Finally,we estimated the normal height of the point on the island using the geopotential-difference iterative computation approach.Using observed data of normal heights,ellipsoidal heights,and astrogeodetic vertical deflections referring to height sites in Qingdao,Shandong Province,we conducted a numerical experiment involving the normal height connection across sea regions.We determined the data of the ellipsoidal heights and gravity of segmentation points along the connecting route across the water in the numerical experiment using DTU10.The distance of the height connection across the sea was approximately 10.5 km.According to China's official leveling specifications,the experimental results met the criterion of third-class leveling precision.

Distributed Trimmed Hill Estimator

Proceeded from trimmed Hill estimators and distributed inference, a new distributed version of trimmed Hill estimator for heavy tail index is proposed. Considering the case where the number of observations involved in each machine can be either the same or different and either fixed or varying to the total sample size, its consistency and asymptotic normality are discussed. Simulation studies are particularized to show the new estimator performs almost in line with the trimmed Hill estimator.

Considerations of Area Parameter of the Deflection Basin on the Structural Evaluation of Flexible Pavements

By using the concept of modified structural number(SNC)and deflection measurements,a simplified calculation methodology,that permits the structural condition evaluation of an existing pavement,is being proposed.The values of SNC and the curvature parameters were first determined through simulations using the ELSYM-5 software.Deflection measurements were carried out in experimental segments of Brazilian highways.The resilient moduli of each layer were determined from backcalculation using the ELMOD program for a three-layer system.Theoretical correlation models between SNC and the basin deformation parameter were determined and later,calibrated with the results of experimental sections.Utilizing the studied models,a good correlation was found between SNC,area parameter and maximum deflection,enabling the determination of SNC through deflection measurements and assisting in the diagnostic of structural condition of asphalt pavements.

Effect of the Wick Deflection Angles on Heat Transfer Characteristics for the Flat LHP

Loop Heat Pipe(LHP)is an efficient two-phase heat transfer device,which can be used in waste heat recovery,electronics cooling,aerospace and other fields.The wick,the core component of LHP,plays an important role in its start-up and operation.In this paper,the wick fabricated by 3D printing technology had uniform and interconnected pores.In the experiment,the position of the parallel vapor removal grooves was always fixed towards the vapor outlet.When the cylindrical wick was placed in the evaporator,the rotation angle relative to its central axis could be changed,thus changing the number and shape of the pores facing the vapor removal grooves.The wick deflection angle represented its change in spatial position relative to the fixed vapor removal grooves.The effect of the wick deflection angles on the heat transfer characteristics of the flat LHP was experimentally investigated.It was found that with the change of deflection angle,the number of pores in the evaporation-oriented zone would also change,which had a significant impact on the start-up process and heat transfer performance of LHP.When the deflection angle was 30°,LHP could start fastest at a low heat load of 20 W and operate stable at a high heat load of 180 W.

Determination of the Critical Value of Deflection for Embedded Cylindrical Structures

An embedded cylinder is a large-diameter cylinder embedded in a soil foundation. The state of failure of such an embedded cylindrical structure shows large deflection instead of slide and overturn of the traditional gravity type of structure placed on a rubble base or foundation base. The critical value of deflection of the embedded cylindrical structure, which is the maximum allowable deflection for stability calculation of the cylinder, is a vital control value. Through investigation on deflection and soil pressures on an embedded cylinder by model experiments, the variations of the angle of rotation θ of a cylinder with effective anti-overturning ratio η and moment MH of thrust are discussed. On the basis of experimental study, the critical value of deflection of the cylindrical structure is proposed in the paper. Meanwhile, the formulas for calculating deflection of cylinders are derived.

Research progress of TRIMs protein family in tumors

The tripartite motif(TRIMs)protein family has E3 ubiquitin ligase activity among most of its members.They participate in multiple cellular processes and signaling pathways in living organisms,including cell cycle,growth,and metabolism,and mediate chromatin modification,transcriptional regulation,post-translational modification,and cellular autophagy.Previous studies have confirmed that the TRIMs protein family is involved in the development of various cancers and correlated with the prognosis of tumor patients.Here we summarize the biological roles of the TRIMs protein family in cancers.

Deflection and stress of hollow CRCP slab under concentrated vehicle load

Based on the equivalence principle of deflection and stress, the concentrated vehicle load which acts on the center of continuously reinforced concrete pavement （CRCP） is translated into the equivalent half-wave sine load by the Fourier transform. On the basis of this transform and the small deflection theory of elastic thin plates, the deflection and stress formulae of CRCP under the concentrated vehicle load with a hollow foundation are put forward. The sensitivity of parameters is analyzed. The results show that maximum deflection is directly proportional to the concentrated vehicle load and the slab width, and inversely proportional to the lateral bending stiffness and slab thickness. The effects of slab width and thickness are significant with regard to maximum deflection. Maximum stress is directly proportional to the concentrated vehicle load and the slab width as well as inversely proportional to slab thickness. The effect of slab thickness is significant with regard to maximum stress. According to the calculation results, the most effective measure to reduce maximum deflection and stress is to increase slab thickness.

Lunar deflections of the vertical and their distribution

The deflection of the vertical reflects the mass distribution and density anomaly of celestial bodies. Lunar deflections of the vertical include directional information of the Moon’s gravity field. SGM90d, recovered from SELENE mission, revealed the lunar far side gravity field for the first time in history owes to 4-way Doppler data. Lunar deflections of the vertical and their meridional and prime vertical components are calculated from SGM90d, and then their global distributions are also given in the paper. The gradients of lunar deflections of the vertical are defined and computed as well. The correlations between the lunar deflections of the vertical and the lunar terrain have been fully discussed. Many different characteristics of lunar deflections of vertical have been found between the near side and the far side of the Moon, which may be caused from the lithospheric compensation and the uplifting of mantle.

Simulation and Experiment Study on the Bridge Deflection Measuring Method Based on Secant Inclination

Deflection is the most direct indicator that reflects the bearing capacity of the bridge and the overall stiffness. There are many ways to measure the deflection of Bridges, and the inclination angle method is the most commonly used indirect method, but the existing theory of inclination angle method is relatively complicated. Based on the facts of the bridge small inclination, this article proposes the method of obtaining the bridge deflection by the inclination of the secant line constructed from the adjacent measurement points. Firstly, according to the bending deformation curve of general simply supported beam, the deflection calculation formula of each measuring point is derived based on the assumption of small deformation and the inclination Angle of measuring point. Secondly, a large commercial finite element software ANSYS 10.0 is used to carry out numerical simulation on the simply-supported beam under concentrated load in mid-span, and the deflection results of the numerical simulation are compared and verified with the theoretical results of the proposed method. Finally, the measured deflection results of the simply-supported beam model under mid-span load are compared with the theoretical results of the proposed method. The verification results show that if the actual model is consistent with the theoretical model, the proposed method has good accuracy.

lncRNA TRIM52-AS1在非小细胞肺腺癌组织中的表达及其增殖抑制作用

目的探讨lncRNA TRIM52-AS1在非小细胞肺腺癌组织中的表达及其临床意义。方法通过实时荧光定量PCR和WST-1等方法检测lncRNA TRIM52-AS1在肺腺癌组织与癌旁组织以及肺腺癌细胞株与正常支气管细胞株中的表达差异。在体外肺腺癌细胞中过表达lncRNA TRIM52-AS1,WST-1法及克隆形成实验检测其对细胞生长的影响。结果lncRNA TRIM52-AS1在肺腺癌组织中的表达水平显著低于癌旁正常组织(P<0.01);lncRNA TRIM52-AS1高表达患者的总生存期(OS)显著长于低表达患者(P<0.05);lncRNA TRIM52-AS1在肺腺癌细胞株中的表达水平显著低于正常支气管细胞株(P<0.05);过表达lncRNA TRIM52-AS1可抑制肺腺癌细胞的增殖与克隆能力(P<0.05)。结论lncRNA TRIM52-AS1具有抑制肺腺癌细胞生长的作用,可能作为治疗肺腺癌的潜在靶点之一。

Beam and image experiment of beam deflection electron gun for distributed X-ray sources

Distributed X-ray sources comprise a single vacuum chamber containing multiple X-ray sources that are triggered and emit X-rays at a specific time and location. This process facilitates an application for innovative system concepts in X-ray and computer tomography. This paper proposes a novel electron beam focusing, shaping,and deflection electron gun for distributed X-ray sources.The electron gun uses a dispenser cathode as an electron emitter, a mesh grid to control emission current, and two electrostatic lenses for beam shaping, focusing, and deflection. Novel focusing and deflecting electrodes were designed to increase the number of focal spots in the distributed source. Two identical half-rectangle opening electrodes are controlled by adjusting the potential of the two electrodes to control the electron beam trajectory, and then, multifocal spots are obtained on the anode target. The electron gun can increase the spatial density of the distributed X-ray sources, thereby improving the image quality. The beam experimental results show that the focal spot sizes of the deflected(deflected amplitude 10.5 mm)and non-deflected electron beams at full width at half maximum are 0.80 mm 90.50 mm and 0.55 mm 90.40 mm, respectively(anode voltage 160 kV; beam current 30 mA). The imaging experimental results demonstrate the excellent spatial resolution and time resolution of an imaging system built with the sources, which has an excellent imaging effect on a field-programmable gate array chip and a rotating metal disk.

Variational analysis of mid-span deflection of gantry cranes

In practical application, it is very important to master the influence of structure parameters on the mid-span deflection quantificationally. For large-span and heavy-duty gantry cranes, the influence of the rigid leg and the soft leg on mid-span deflection has not been considered in the past. In the paper, the mathematical model is established for universal large-span and heavy-duty gantry cranes. The analytical solution for the mid-span deflection of gantry-frame structure girder is derived and obtained based on the variation principle by considering the coupling effect of the bending moments of girder and legs, the axial force and the secondary bending moments. The relation between the load and the deflection on the mid-span of the gantry-frame structure girder is known. Then, the experimental model is designed according to dimensional analysis method. And experiments were performed on the WEW-600 B type testing machine. Hackling experimental data, the regular of the load and deflection on the girder mid-span is obtained, namely, the deformation of the gantry-frame structure resists the external load to do work. The validity of the nonlinear analytical solution of the girder deflection is verified. Experimental results show that the analytical solution of the gantry-frame structure deflection has much higher calculation accuracy than previous calculation method. This work provides a theoretical basis for the design and inspection of gantry-frame structures.

SECOND ORDER APPROXIMATION SOLUTION OF NONLINEAR LARGE DEFLECTION PROBLEMS OF YONGJIANG RAILWAY BRIDGE IN NINGBO

The solution and computational aspects on nonlinear deflection of Yongjiang Railway Bridge in Ningbo were investigated. An approximate iteration algorithm on nonlinear governing equation was presented, and the obtained results show that, if altitude difference and span of the riverbanks are taken as 5 meters and 100 meters, respectively, the maximum gradient in the middle of the bridge exceeds 5%, much larger than maximum allowance gradient in railway design code. Therefore, a new solution scheme for decreasing gradient of the bridge is put forward, that is, the altitude difference between two riverbanks can be decreased to about 1/10 of the initial magnitude by building roadbeds with 0.5% gradient and 1 kilometer length at two riverbanks. As a direct result, the deflection gradient of the railway bridge is much reduced and the value is between 0.5% similar to 0.6%.

Investigation on behavior of crack penetration/deflection at interfaces in intelligent coating system

Based on the three-phase model, the propagation behavior of a matrix crack in an intelligent coating system is investigated by an energy criterion. The effect of the elastic mismatch parameters and the thickness of the interface layer on the ratio of the energy release rate for infinitesimal deflected and penetrated crack is evaluated with the finite element method. The results show that the ratio of the energy release rates strongly depends on the elastic mismatch al between the substrate and the driving layer. It also strongly depends on the elastic mismatch a2 between the driving layer and the sensing layer for a thinner driving layer when a primary crack reaches an interface between the substrate and the driving layer. Moreover, with the increase in the thickness of the driving layer, the dependence on a2 gradually decreases. The experimental observation on aluminum alloys monitored with intelligent coating shows that the established model can better explain the behavior of matrix crack penetration and can be used in optimization design of intelligent coating.