Parkinson＇s disease （PD） is a common progressive neurological disorder and is composed of motor and nonmotor symptoms. Sleep disturbances are frequent problems for patients with PD. The relationship between sleep d...Parkinson＇s disease （PD） is a common progressive neurological disorder and is composed of motor and nonmotor symptoms. Sleep disturbances are frequent problems for patients with PD. The relationship between sleep disturbances with Hoehn and Yahr （H＆Y） staging have been demonstrated. However, the relationship between sleep disorders and H＆Y is still unclear in patients with PD without dementia in Chinese PD patients. In this study, we interviewed 487 non-demented PD patients of Chinese Han descents by H＆Y classification. We found that night sleep quality was significantly associated with the severity of PD （P=0.008）. Panic disorder severity scale （PDSS） total scores were correlated with PD non-motor symptoms scale （PDNMS） scores （r=-0.528, P〈0.001）, the Hamilton depression scale （HAMD） scores （r=-0.545, P〈0.001） and the Hamilton anxiety scale （HAMA） scores （r=-0.498, P〈0.001）. Our results indicated that sleep quality deteriorated with the advancing of PD in Chinese non-demented patients with PD. Depression and anxiety may partly explain sleep disturbances in nondemented patients with PD.展开更多
Quality of life (QOL) is an important topic in social and medical sciences, it has a multidimensional nature and is influenced by many factors. Aim of the Work: In this study we want to assess the impact of cognitive ...Quality of life (QOL) is an important topic in social and medical sciences, it has a multidimensional nature and is influenced by many factors. Aim of the Work: In this study we want to assess the impact of cognitive impairment on the health related quality of life (HR-QOL) of community dwelling non demented elderly. Subject and Method: 115 non demented elderly, 60 years and older recruited from outpatient geriatric clinic at Al Mansoura General Hospital, Dakahlia, Egypt. Each participant underwent, comprehensive geriatric assessment, assessing cognitive function using the mini-mental state examination (MMSE) and montreal cognitive function test, assessing the health related quality of life (HR-QOL) by the RAND-36 health survey. Results: We found that the elderly with impaired cognition by both MMSE and Montreal test were significantly older;the ones with lower education, with more depressive symptoms, had more functional impairment and had lower HR-QOL scores than the elderly with normal cognitive function, after controlling for confounders still cognition was a determinant of HR-QOL. Also by linear correlation coefficient a significant correlation between HR-QOL and age, function, cognition and depression was found. Conclusion: Cognition affects significantly HR-QOL of the elderly, so we can say that interventions targeting cognition in the elderly can significantly improve their QOL.展开更多
Thiamine metabolism is critical for glucose metabolism and also vital for brain function, which is susceptible to decline in the elderly. This study aimed to investigate whether thiamine metabolites correlate with cog...Thiamine metabolism is critical for glucose metabolism and also vital for brain function, which is susceptible to decline in the elderly. This study aimed to investigate whether thiamine metabolites correlate with cognitive function in the non-demented elderly and their impact factors. Volunteers 〉60 years old were recruited and their blood thiamine metabolites and Mini-Mental State Examination （MMSE） scores were measured. The apolipoprotein E （APOE） genotype, routine blood parameters, liver and kidney function, and levels of fasting blood glucose and triglycerides were also measured. The results showed that the thiamine diphosphate （TDP） level weakly correlated with MMSE score in the non-demented elderly. Participants with high TDP levels performed better in Recall and Attention and Calculation than those with low TDP. TDP levels were associated with the APOE E2 allele, body mass index, hemoglobin level, fasting blood glucose, and triglycerides. Our results suggest that TDP, which is easily affected by many factors, impacts cognitive function in the elderly.展开更多
侦察星座优化是天基信息体系建设的关键问题。为弥补以往研究大多只采用少量性能指标进行侦察星座优化的不足,提出了一种综合考虑5项性能指标的侦察星座优化模型。在解算优化模型过程中,为解决传统基于Pareto支配的进化算法出现的选择...侦察星座优化是天基信息体系建设的关键问题。为弥补以往研究大多只采用少量性能指标进行侦察星座优化的不足,提出了一种综合考虑5项性能指标的侦察星座优化模型。在解算优化模型过程中,为解决传统基于Pareto支配的进化算法出现的选择压力与多样性不足的问题,提出了TOPSIS-MOPSO(Technique for Order Preference by Similarity to an Ideal Solution-Multi-Objective Particle Swarm Optimization)算法,将多属性决策领域的TOPSIS引入进化算法中,并与SPD(Strengthened Pareto Dominate)相结合,得到一种能够同时增强种群收敛性与多样性的环境选择策略。提出了基于Harmonic距离的全局最优粒子选择策略,加快种群收敛速度,保护种群多样性;提出了自适应进化算子选择策略,帮助算法摆脱局部最优解。将TOPSIS-MOPSO算法应用在侦察星座优化问题上,并与MOPSO、DGEA、AR-MOEA 3种经典方法进行实验对比分析,实验结果显示,所提算法比其他3种算法在Δ*、IGD和HV上的最优指标值分别提升了19.76%、89.07%和28.2%。展开更多
A new favorable iterative algorithm named as PBiCGSTAB （preconditioned bi-conjugate gradient stabilized） algorithm is presented for solving large sparse complex systems. Based on the orthogonal list, the special tec...A new favorable iterative algorithm named as PBiCGSTAB （preconditioned bi-conjugate gradient stabilized） algorithm is presented for solving large sparse complex systems. Based on the orthogonal list, the special technique of only storing non-zero elements is carried out. The incomplete LU factorization without fill-ins is adopted to reduce the condition number of the coefficient matrix. The BiCGSTAB algorithm is extended from the real system to the complex system and it is used to solve the preconditioned complex linear equations. The locked-rotor state of a single-sided linear induction machine is simulated by the software programmed with the finite element method and the PBiCGSTAB algorithm. Then the results are compared with those from the commercial software ANSYS, showing the validation of the proposed software. The iterative steps required for the proposed algorithm are reduced to about one-third, when compared to the BiCG method, therefore the algorithm is fast.展开更多
基金supported by Medical Science and Technology Development Foundation,Nanjing Department of Health(No.ZKX12037)the Opening Project of Jiangsu Key Laboratory of Neurodegeneration,Nanjing Medical University(No.SJ11KF03)
文摘Parkinson＇s disease （PD） is a common progressive neurological disorder and is composed of motor and nonmotor symptoms. Sleep disturbances are frequent problems for patients with PD. The relationship between sleep disturbances with Hoehn and Yahr （H＆Y） staging have been demonstrated. However, the relationship between sleep disorders and H＆Y is still unclear in patients with PD without dementia in Chinese PD patients. In this study, we interviewed 487 non-demented PD patients of Chinese Han descents by H＆Y classification. We found that night sleep quality was significantly associated with the severity of PD （P=0.008）. Panic disorder severity scale （PDSS） total scores were correlated with PD non-motor symptoms scale （PDNMS） scores （r=-0.528, P〈0.001）, the Hamilton depression scale （HAMD） scores （r=-0.545, P〈0.001） and the Hamilton anxiety scale （HAMA） scores （r=-0.498, P〈0.001）. Our results indicated that sleep quality deteriorated with the advancing of PD in Chinese non-demented patients with PD. Depression and anxiety may partly explain sleep disturbances in nondemented patients with PD.
文摘Quality of life (QOL) is an important topic in social and medical sciences, it has a multidimensional nature and is influenced by many factors. Aim of the Work: In this study we want to assess the impact of cognitive impairment on the health related quality of life (HR-QOL) of community dwelling non demented elderly. Subject and Method: 115 non demented elderly, 60 years and older recruited from outpatient geriatric clinic at Al Mansoura General Hospital, Dakahlia, Egypt. Each participant underwent, comprehensive geriatric assessment, assessing cognitive function using the mini-mental state examination (MMSE) and montreal cognitive function test, assessing the health related quality of life (HR-QOL) by the RAND-36 health survey. Results: We found that the elderly with impaired cognition by both MMSE and Montreal test were significantly older;the ones with lower education, with more depressive symptoms, had more functional impairment and had lower HR-QOL scores than the elderly with normal cognitive function, after controlling for confounders still cognition was a determinant of HR-QOL. Also by linear correlation coefficient a significant correlation between HR-QOL and age, function, cognition and depression was found. Conclusion: Cognition affects significantly HR-QOL of the elderly, so we can say that interventions targeting cognition in the elderly can significantly improve their QOL.
基金supported by the National Basic Research Development Program (973 Program) of China (2011CBA00400)the National Natural Science Foundation of China (91332201)+1 种基金the Natural Science Foundation of Shanghai Municipality, China (13JC1401501)the Fund for Medical Emerging Cutting-edge Technology of Shanghai Municipality, China (SHDC12012114)
文摘Thiamine metabolism is critical for glucose metabolism and also vital for brain function, which is susceptible to decline in the elderly. This study aimed to investigate whether thiamine metabolites correlate with cognitive function in the non-demented elderly and their impact factors. Volunteers 〉60 years old were recruited and their blood thiamine metabolites and Mini-Mental State Examination （MMSE） scores were measured. The apolipoprotein E （APOE） genotype, routine blood parameters, liver and kidney function, and levels of fasting blood glucose and triglycerides were also measured. The results showed that the thiamine diphosphate （TDP） level weakly correlated with MMSE score in the non-demented elderly. Participants with high TDP levels performed better in Recall and Attention and Calculation than those with low TDP. TDP levels were associated with the APOE E2 allele, body mass index, hemoglobin level, fasting blood glucose, and triglycerides. Our results suggest that TDP, which is easily affected by many factors, impacts cognitive function in the elderly.
文摘侦察星座优化是天基信息体系建设的关键问题。为弥补以往研究大多只采用少量性能指标进行侦察星座优化的不足,提出了一种综合考虑5项性能指标的侦察星座优化模型。在解算优化模型过程中,为解决传统基于Pareto支配的进化算法出现的选择压力与多样性不足的问题,提出了TOPSIS-MOPSO(Technique for Order Preference by Similarity to an Ideal Solution-Multi-Objective Particle Swarm Optimization)算法,将多属性决策领域的TOPSIS引入进化算法中,并与SPD(Strengthened Pareto Dominate)相结合,得到一种能够同时增强种群收敛性与多样性的环境选择策略。提出了基于Harmonic距离的全局最优粒子选择策略,加快种群收敛速度,保护种群多样性;提出了自适应进化算子选择策略,帮助算法摆脱局部最优解。将TOPSIS-MOPSO算法应用在侦察星座优化问题上,并与MOPSO、DGEA、AR-MOEA 3种经典方法进行实验对比分析,实验结果显示,所提算法比其他3种算法在Δ*、IGD和HV上的最优指标值分别提升了19.76%、89.07%和28.2%。
文摘A new favorable iterative algorithm named as PBiCGSTAB （preconditioned bi-conjugate gradient stabilized） algorithm is presented for solving large sparse complex systems. Based on the orthogonal list, the special technique of only storing non-zero elements is carried out. The incomplete LU factorization without fill-ins is adopted to reduce the condition number of the coefficient matrix. The BiCGSTAB algorithm is extended from the real system to the complex system and it is used to solve the preconditioned complex linear equations. The locked-rotor state of a single-sided linear induction machine is simulated by the software programmed with the finite element method and the PBiCGSTAB algorithm. Then the results are compared with those from the commercial software ANSYS, showing the validation of the proposed software. The iterative steps required for the proposed algorithm are reduced to about one-third, when compared to the BiCG method, therefore the algorithm is fast.
