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Dendritic cell subsets in cancer immunity and tumor antigen sensing 被引量:9
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作者 Annalisa Del Prete Valentina Salvil +4 位作者 Alessandra Soriani Mattia Laffranchi Francesca Sozio Daniela Bosisio Silvano Sozzani 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2023年第5期432-447,共16页
Dendritic cells(DCs)exhibit a specialized antigen-presenting function and play crucial roles in both innate and adaptive immune responses.Due to their ability to cross-present tumor cell-associated antigens to naï... Dendritic cells(DCs)exhibit a specialized antigen-presenting function and play crucial roles in both innate and adaptive immune responses.Due to their ability to cross-present tumor cell-associated antigens to naïve T cells,DCs are instrumental in the generation of specific T-cell-mediated antitumor effector responses in the control of tumor growth and tumor cell dissemination.Within an immunosuppressive tumor microenvironment,DC antitumor functions can,however,be severely impaired.In this review,we focus on the mechanisms of DC capture and activation by tumor cell antigens and the role of the tumor microenvironment in shaping DC functions,taking advantage of recent studies showing the phenotype acquisition,transcriptional state and functional programs revealed by scRNA-seq analysis.The therapeutic potential of DC-mediated tumor antigen sensing in priming antitumor immunity is also discussed. 展开更多
关键词 dendritic cell subsets Tumor microenvironment MIGRATION Innate immune sensing Immune cell death Tumor-derived extracellularvesicles
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