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Effects of heating temperature and atmosphere on element distribution and microstructure in high-Mn/Al austenitic low-density steel
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作者 Qi Zhang Guanghui Chen +2 位作者 Yuemeng Zhu Zhengliang Xue Guang Xu 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第12期2670-2680,共11页
The elemental distribution and microstructure near the surface of high-Mn/Al austenitic low-density steel were investigated after isothermal holding at temperatures of 900-1200℃ in different atmospheres,including air... The elemental distribution and microstructure near the surface of high-Mn/Al austenitic low-density steel were investigated after isothermal holding at temperatures of 900-1200℃ in different atmospheres,including air,N_(2),and N_(2)+CO_(2).No ferrite was formed near the surface of the experimental steel during isothermal holding at 900 and 1000℃ in air,while ferrite was formed near the steel sur-face at holding temperatures of 1100 and 1200℃.The ferrite fraction was larger at 1200℃ because more C and Mn diffused to the sur-face,exuded from the steel,and then reacted with N and O to form oxidation products.The thickness of the compound scale increased owing to the higher diffusion rate at higher temperatures.In addition,after isothermal holding at 1100℃ in N_(2),the Al content near the surface slightly decreased,while the C and Mn contents did not change.Therefore,no ferrite was formed near the surface.However,the near-surface C and Al contents decreased after holding at 1100℃in the N_(2)+CO_(2)mixed atmosphere,resulting in the formation of a small amount of ferrite.The compound scale was thickest in N_(2),followed by the N_(2)+CO_(2)mixed atmosphere,and thinnest in air.Overall,the element loss and ferrite fraction were largest after holding in air at the same temperature.The differences in element loss and ferrite frac-tion between in N_(2) and N_(2)+CO_(2)atmospheres were small,but the compound scale formed in N_(2) was significantly thicker.According to these results,N_(2)+CO_(2)is the ideal heating atmosphere for the industrial production of high-Mn/Al austenitic low-density steel. 展开更多
关键词 low-density steel oxidation MICROSTRUCTURE element distribution compound scale
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Effect of perforation density distribution on production of perforated horizontal wellbore
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作者 KAREEM Hasanain J. HASINI Hasril ABDULWAHID Mohammed A. 《Petroleum Exploration and Development》 SCIE 2024年第2期464-475,共12页
To address the issue of horizontal well production affected by the distribution of perforation density in the wellbore,a numerical model for simulating two-phase flow in a horizontal well is established under two perf... To address the issue of horizontal well production affected by the distribution of perforation density in the wellbore,a numerical model for simulating two-phase flow in a horizontal well is established under two perforation density distribution conditions(i.e.increasing the perforation density at inlet and outlet sections respectively).The simulation results are compared with experimental results to verify the reliability of the numerical simulation method.The behaviors of the total pressure drop,superficial velocity of air-water two-phase flow,void fraction,liquid film thickness,air production and liquid production that occur with various flow patterns are investigated under two perforation density distribution conditions based on the numerical model.The total pressure drop,superficial velocity of the mixture and void fraction increase with the air flow rate when the water flow rate is constant.The liquid film thickness decreases when the air flow rate increases.The liquid and air productions increase when the perforation density increases at the inlet section compared with increasing the perforation density at the outlet section of the perforated horizontal wellbore.It is noted that the air production increases with the air flow rate.Liquid production increases with the bubble flow and begins to decrease at the transition point of the slug-stratified flow,then increases through the stratified wave flow.The normalized liquid flux is higher when the perforation density increases at the inlet section,and increases with the radial air flow rate. 展开更多
关键词 horizontal wellbore two-phase flow pattern perforation density wellbore pressure drop void fraction production performance
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Spatial distribution of shallow landslides caused by Typhoon Lekima in 2019 in Zhejiang Province, China 被引量:1
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作者 CUI Yulong YANG Liu +1 位作者 XU Chong ZHENG Jun 《Journal of Mountain Science》 SCIE CSCD 2024年第5期1564-1580,共17页
In recent years, the coastal region of Southeast China has witnessed a significant increase in the frequency and intensity of extreme rainfall events associated with landfalling typhoons. The hilly and mountainous ter... In recent years, the coastal region of Southeast China has witnessed a significant increase in the frequency and intensity of extreme rainfall events associated with landfalling typhoons. The hilly and mountainous terrain of this area, combined with rapid rainfall accumulation, has led to a surge in flash floods and severe geological hazards. On August 10, 2019, Typhoon Lekima made landfall in Zhejiang Province, China, and its torrential rainfall triggered extensive landslides, resulting in substantial damage and economic losses. Utilizing high-resolution satellite images, we compiled a landslide inventory of the affected area, which comprises a total of 2,774 rainfallinduced landslides over an area of 2965 km2. The majority of these landslides were small to mediumsized and exhibited elongated, clustered patterns. Some landslides displayed characteristics of high-level initiation, obstructing or partially blocking rivers, leading to the formation of debris dams. We used the inventory to analyze the distribution pattern of the landslides and their relationship with topographical, geological, and hydrological factors. The results showed that landslide abundance was closely related to elevation, slope angle, faults, and road density. The landslides were predominantly located in hilly and low mountainous areas, with elevations ranging from 150 to 300 m, slopes of 20 to 30 degrees, and a NE-SE aspect. Notably, we observed the highest Landslide Number Density(LND) and Landslide Area Percentage(LAP) in the rhyolite region. Landslides were concentrated within approximately 4 km on either side of fault zones, with their size and frequency negatively correlated with distances to faults, roads, and river systems. Furthermore, under the influence of typhoons, regions with denser vegetation cover exhibited higher landslide density, reaching maximum values in shrubland areas. In areas experiencing significantly increased concentrated rainfall, landslide density also showed a corresponding rise. In terms of spatial distribution, the rainfall-triggered landslides primarily occurred in the northeastern part of the study area, particularly in regions characterized by complex topography such as Shanzao Village in Yantan Town, Xixia Township, and Shangzhang Township. The research findings offer crucial data on the rainfallinduced landslides triggered by Typhoon Lekima, shedding light on their spatial distribution patterns. These findings provide valuable references for mitigating risks and planning reconstruction in typhoon-affected area. 展开更多
关键词 Typhoon rainfall Landslide characteristics Spatial distribution Southeast coastal region
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FPGA-based position reconstruction method for neutron beam flux spatial distribution measurement in BNCT 被引量:1
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作者 Wei Jiang Ping Cao +5 位作者 Yi-Ming Wu Xian-Ke Liu Zhu-Jun Fang Zhi-Yong Zhang Bin Shi Jun Chen 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第3期96-108,共13页
A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas detector.To address the issue of long process... A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas detector.To address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber principle.This method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined RAM.The performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data transmission.The experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 mm.The beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction method.The online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT. 展开更多
关键词 Position reconstruction FPGA Readout electronics Neutron flux spatial distribution
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Federated Learning Model for Auto Insurance Rate Setting Based on Tweedie Distribution 被引量:1
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作者 Tao Yin Changgen Peng +2 位作者 Weijie Tan Dequan Xu Hanlin Tang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第1期827-843,共17页
In the assessment of car insurance claims,the claim rate for car insurance presents a highly skewed probability distribution,which is typically modeled using Tweedie distribution.The traditional approach to obtaining ... In the assessment of car insurance claims,the claim rate for car insurance presents a highly skewed probability distribution,which is typically modeled using Tweedie distribution.The traditional approach to obtaining the Tweedie regression model involves training on a centralized dataset,when the data is provided by multiple parties,training a privacy-preserving Tweedie regression model without exchanging raw data becomes a challenge.To address this issue,this study introduces a novel vertical federated learning-based Tweedie regression algorithm for multi-party auto insurance rate setting in data silos.The algorithm can keep sensitive data locally and uses privacy-preserving techniques to achieve intersection operations between the two parties holding the data.After determining which entities are shared,the participants train the model locally using the shared entity data to obtain the local generalized linear model intermediate parameters.The homomorphic encryption algorithms are introduced to interact with and update the model intermediate parameters to collaboratively complete the joint training of the car insurance rate-setting model.Performance tests on two publicly available datasets show that the proposed federated Tweedie regression algorithm can effectively generate Tweedie regression models that leverage the value of data fromboth partieswithout exchanging data.The assessment results of the scheme approach those of the Tweedie regressionmodel learned fromcentralized data,and outperformthe Tweedie regressionmodel learned independently by a single party. 展开更多
关键词 Rate setting Tweedie distribution generalized linear models federated learning homomorphic encryption
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Predicting the probability distribution of Martian rocks mechanical property based on microscale rock mechanical experiments and accurate grain-based modeling 被引量:1
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作者 Shuohui Yin Yingjie Wang Jingang Liu 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第9期1327-1339,共13页
The exploration of Mars would heavily rely on Martian rocks mechanics and engineering technology.As the mechanical property of Martian rocks is uncertain,it is of utmost importance to predict the probability distribut... The exploration of Mars would heavily rely on Martian rocks mechanics and engineering technology.As the mechanical property of Martian rocks is uncertain,it is of utmost importance to predict the probability distribution of Martian rocks mechanical property for the success of Mars exploration.In this paper,a fast and accurate probability distribution method for predicting the macroscale elastic modulus of Martian rocks was proposed by integrating the microscale rock mechanical experiments(micro-RME),accurate grain-based modeling(AGBM)and upscaling methods based on reliability principles.Firstly,the microstructure of NWA12564 Martian sample and elastic modulus of each mineral were obtained by micro-RME with TESCAN integrated mineral analyzer(TIMA)and nanoindentation.The best probability distribution function of the minerals was determined by Kolmogorov-Smirnov(K-S)test.Secondly,based on best distribution function of each mineral,the Monte Carlo simulations(MCS)and upscaling methods were implemented to obtain the probability distribution of upscaled elastic modulus.Thirdly,the correlation between the upscaled elastic modulus and macroscale elastic modulus obtained by AGBM was established.The accurate probability distribution of the macroscale elastic modulus was obtained by this correlation relationship.The proposed method can predict the probability distribution of Martian rocks mechanical property with any size and shape samples. 展开更多
关键词 Probability distribution Martian rocks Microscale rock mechanic experiment Nanoindentation Accurate grain-based modeling
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Synergetic optimization operation method for distribution network based on SOP and PV 被引量:1
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作者 Lei Chen Ning Zhang +4 位作者 Xingfang Yang Wei Pei Zhenxing Zhao Yinan Zhu Hao Xiao 《Global Energy Interconnection》 EI CSCD 2024年第2期130-141,共12页
The integration of distributed generation brings in new challenges for the operation of distribution networks,including out-of-limit voltage and power flow control.Soft open points(SOP)are new power electronic devices... The integration of distributed generation brings in new challenges for the operation of distribution networks,including out-of-limit voltage and power flow control.Soft open points(SOP)are new power electronic devices that can flexibly control active and reactive power flows.With the exception of active power output,photovoltaic(PV)devices can provide reactive power compensation through an inverter.Thus,a synergetic optimization operation method for SOP and PV in a distribution network is proposed.A synergetic optimization model was developed.The voltage deviation,network loss,and ratio of photovoltaic abandonment were selected as the objective functions.The PV model was improved by considering the three reactive power output modes of the PV inverter.Both the load fluctuation and loss of the SOP were considered.Three multi-objective optimization algorithms were used,and a compromise optimal solution was calculated.Case studies were conducted using an IEEE 33-node system.The simulation results indicated that the SOP and PVs complemented each other in terms of active power transmission and reactive power compensation.Synergetic optimization improves power control capability and flexibility,providing better power quality and PV consumption rate. 展开更多
关键词 Synergetic optimization Soft open point(SOP) Photovoltaic(PV) distribution network
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Coseismic deformation and fault slip distribution of the 2023 M_(W)7.8 and M_(W)7.6 earthquakes in Türkiye 被引量:1
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作者 Weikang Li Lijiang Zhao +4 位作者 Kai Tan Xiaofei Lu Caihong Zhang Chengtao Li Shuaishuai Han 《Earthquake Science》 2024年第3期263-276,共14页
On February 6,2023,a devastating earthquake with a moment magnitude of M_(W)7.8 struck the town of Pazarcik in south-central Türkiye,followed by another powerful earthquake with a moment magnitude of M_(W)7.6 tha... On February 6,2023,a devastating earthquake with a moment magnitude of M_(W)7.8 struck the town of Pazarcik in south-central Türkiye,followed by another powerful earthquake with a moment magnitude of M_(W)7.6 that struck the nearby city of Elbistan 9 h later.To study the characteristics of surface deformation caused by this event and the influence of fault rupture,this study calculated the static coseismic deformation of 56 stations and dynamic displacement waveforms of 15 stations using data from the Turkish national fixed global navigation satellite system(GNSS)network.A maximum static coseismic displacement of 0.38 m for the M_(W)7.8 Kahramanmaras earthquake was observed at station ANTE,36 km from the epicenter,and a maximum dynamic coseismic displacement of 4.4 m for the M_(W)7.6 Elbistan earthquake was observed at station EKZ1,5 km from the epicenter.The rupture-slip distributions of the two earthquakes were inverted using GNSS coseismic deformation as a constraint.The results showed that the Kahramanmaras earthquake rupture segment was distinct and exposed on the ground,resulting in significant rupture slip along the Amanos and Pazarcik fault segments of the East Anatolian Fault.The maximum slip in the Pazarcik fault segment was 10.7 m,and rupture occurred at depths of 0–15 km.In the Cardak fault region,the Elbistan earthquake caused significant ruptures at depths of 0–12 km,with the largest amount of slip reaching 11.6 m.The Coulomb stress change caused by the Kahramanmaras earthquake rupture along the Cardak fault segment was approximately 2 bars,and the area of increased Coulomb stress corresponded to the subsequent rupture region of the M_(W)7.6 earthquake.Thus,it is likely that the M_(W)7.8 earthquake triggered or promoted the M_(W)7.6 earthquake.Based on the cumulative stress impact of the M_(W)7.8 and M_(W)7.6 events,the southwestern segment of the East Anatolian Fault,specifically the Amanos fault segment,experienced a Coulomb rupture stress change exceeding 2 bars,warranting further attention to assess its future seismic hazard risk. 展开更多
关键词 2023 Türkiye earthquake GNSS observation coseismic deformation field slip distribution
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Integrative biogeography: Validating hypotheses of species distribution 被引量:1
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作者 Zhong-E Hou Shu-Qiang Li 《Zoological Research(Diversity and Conservation)》 2024年第1期86-88,共3页
DEAR EDITOR,Biogeography is a scientific field dedicated to the investigation of the origins and distribution patterns of organisms,as well as predicting future alterations in their geographical distributions(Cox&... DEAR EDITOR,Biogeography is a scientific field dedicated to the investigation of the origins and distribution patterns of organisms,as well as predicting future alterations in their geographical distributions(Cox&Moore,2005).However,the majority of conclusions drawn within the field of biogeography are hypothetical.Rigorous testing of these biogeographic hypotheses remains a considerable challenge.This paper presents the concept of“integrative biogeography”,which emphasizes the experimental testing of biogeographic hypotheses through studies on geological history,as well as biotic and abiotic factors(Figure 1). 展开更多
关键词 BIOGEOGRAPHY distribution DATING
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Extended wet sieving method for determination of complete particle size distribution of general soils 被引量:1
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作者 Shengnan Ma Yi Song +2 位作者 Jiawei Liu Xingyu Kang Zhongqi Quentin Yue 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第1期242-257,共16页
The traditional standard wet sieving method uses steel sieves with aperture?0.063 mm and can only determine the particle size distribution(PSD)of gravel and sand in general soil.This paper extends the traditional meth... The traditional standard wet sieving method uses steel sieves with aperture?0.063 mm and can only determine the particle size distribution(PSD)of gravel and sand in general soil.This paper extends the traditional method and presents an extended wet sieving method.The extended method uses both the steel sieves and the nylon filter cloth sieves.The apertures of the cloth sieves are smaller than 0.063 mm and equal 0.048 mm,0.038 mm,0.014 mm,0.012 mm,0.0063 mm,0.004 mm,0.003 mm,0.002 mm,and 0.001 mm,respectively.The extended method uses five steps to separate the general soil into many material sub-groups of gravel,sand,silt and clay with known particle size ranges.The complete PSD of the general soil is then calculated from the dry masses of the individual material sub-groups.The extended method is demonstrated with a general soil of completely decomposed granite(CDG)in Hong Kong,China.The silt and clay materials with different particle size ranges are further examined,checked and verified using stereomicroscopic observation,physical and chemical property tests.The results further confirm the correctness of the extended wet sieving method. 展开更多
关键词 Particle size distribution(PSD) General soil SILT CLAY Wet sieving Physical and chemical properties
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Spatial distribution characteristics and influence factor analysis of landslides——case study of the Hanwang area in Qinba Mountains
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作者 Jikai Zhang Yanbo Cao +4 位作者 Wen Fan Wenbo Zheng Zequan Wang Chengcheng He Hongquan Teng 《Earthquake Research Advances》 CSCD 2024年第3期55-65,共11页
The geological hazards of landslides in Hanwang Town, Ziyang County, Ankang City, Shaanxi Province, have emerged. Yet, the current understanding of the spatial distribution characteristics and influencing factors of l... The geological hazards of landslides in Hanwang Town, Ziyang County, Ankang City, Shaanxi Province, have emerged. Yet, the current understanding of the spatial distribution characteristics and influencing factors of landslides in this area remains unclear. Combining the results of remote sensing interpretation and field investigation, seven influencing factors, namely, elevation, slope direction, slope gradient, distance from rivers, distance from faults, engineering geologic lithology, and distance from roads, are selected for the study. The distribution characteristics of landslides in each influencing factor and the influence of the resolution of the Digital Elevation Model(DEM) on the results are statistically and analytically analyzed. Furthermore, two highrisk landslides within the study area were subjected to comprehensive analysis, integrating the findings from drilling and other field investigations in order to examine their deformation mechanisms. Based on this analysis,the following conclusions were derived:(1) 34 landslides in the study area, mainly small earth landslides, with a distribution density of 0.42/km~2, threatening 414 people and property of about 55.87 million Yuan.(2)The landslides in the study area easily occur in the <400 m elevation range;the landslides are developed in all slope directions, the gradient is mainly concentrated in the range of 10°–40°, the distribution density of the landslides is higher in the closer distance from the river and the faults(0–200 m), the landslide-prone strata are mainly the softer and weaker metamorphic rocks, and the landslides are mainly around roads.(3) The resolution of the DEM should be selected based on the specific conditions of the study area, the requirements of the investigation, and the scale of the landslide. Opting for an appropriate DEM resolution is advantageous for understanding the patterns of landslides and conducting risk assessments in the region.(4) The Zhengjiabian landslide is a traction Landslide. The landslide body is a binary structure of gravel soil and slate weathering layer, and the damage process can be divided into three stages:(1)damage to the leading edge and stress release,(2)continuous creep and cracking,(3)rainfall infiltration and damage. The predominant slope material in the Brickyard landslide comprises clay, and the landslide is triggered by a combination of the traction effect resulting from the excavation at the slope's base and the nudging effect caused by the stacking load of the brick factory. Additionally, the Brickyard landslide exhibits persistent creep deformation. The study results provide a scientific basis for disaster prevention and mitigation in the Hanwang Township area. 展开更多
关键词 LANDSLIDE Spatial distribution Influence factor Landslide density Deformation mechanism DEM
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Hydrocarbon accumulation and orderly distribution of whole petroleum system in marine carbonate rocks of Sichuan Basin,SW China 被引量:1
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作者 GUO Xusheng HUANG Renchun +3 位作者 ZHANG Dianwei LI Shuangjian SHEN Baojian LIU Tianjia 《Petroleum Exploration and Development》 SCIE 2024年第4期852-869,共18页
Based on the situation and progress of marine oil/gas exploration in the Sichuan Basin,SW China,the whole petroleum system is divided for marine carbonate rocks of the basin according to the combinations of hydrocarbo... Based on the situation and progress of marine oil/gas exploration in the Sichuan Basin,SW China,the whole petroleum system is divided for marine carbonate rocks of the basin according to the combinations of hydrocarbon accumulation elements,especially the source rock.The hydrocarbon accumulation characteristics of each whole petroleum system are analyzed,the patterns of integrated conventional and unconventional hydrocarbon accumulation are summarized,and the favorable exploration targets are proposed.Under the control of multiple extensional-convergent tectonic cycles,the marine carbonate rocks of the Sichuan Basin contain three sets of regional source rocks and three sets of regional cap rocks,and can be divided into the Cambrian,Silurian and Permian whole petroleum systems.These whole petroleum systems present mainly independent hydrocarbon accumulation,containing natural gas of affinity individually.Locally,large fault zones run through multiple whole petroleum systems,forming a fault-controlled complex whole petroleum system.The hydrocarbon accumulation sequence of continental shelf facies shale gas accumulation,marginal platform facies-controlled gas reservoirs,and intra-platform fault-and facies-controlled gas reservoirs is common in the whole petroleum system,with a stereoscopic accumulation and orderly distribution pattern.High-quality source rock is fundamental to the formation of large gas fields,and natural gas in a whole petroleum system is generally enriched near and within the source rocks.The development and maintenance of large-scale reservoirs are essential for natural gas enrichment,multiple sources,oil and gas transformation,and dynamic adjustment are the characteristics of marine petroleum accumulation,and good preservation conditions are critical to natural gas accumulation.Large-scale marginal-platform reef-bank facies zones,deep shale gas,and large-scale lithological complexes related to source-connected faults are future marine hydrocarbon exploration targets in the Sichuan Basin. 展开更多
关键词 Sichuan Basin margin oil/gas whole petroleum system carbonate hydrocarbon accumulation hydrocarbon distribution law hydrocarbon exploration target
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Influence of Topography on the Distribution and Structure of Woody Plants in the Senegalese Sahel (Sandy Ferlo)
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作者 Moustapha Bassimbe Sagna Aïssatou Ndong Thiam +5 位作者 Khoudia Niang Oumar Sarr Aly Diallo Sekouna Diatta Daouda Ngom Aliou Guissé 《American Journal of Plant Sciences》 CAS 2024年第1期14-28,共15页
This study describes the floristic composition and structure of a woody stand in the Senegalese Sahel, paying particular attention to the edaphic factors of its floristic composition. A stratified inventory considerin... This study describes the floristic composition and structure of a woody stand in the Senegalese Sahel, paying particular attention to the edaphic factors of its floristic composition. A stratified inventory considering the different relief units was adopted. Woody vegetation was surveyed using a dendrometric approach. The results obtained show that the flora is dominated by a few species adapted to drought, such as Balanites aegyptiaca (L.) Del., Calotropis procera Ait. and Boscia senegalensis (Pers.). The distribution of this flora and the structure of the ligneous plants are linked to the topography. In the lowlands, the flora is more diversified and the ligneous plants reach their optimum level of development compared with the higher relief areas. In the lowlands, there are a few woody species which, in the past, were indicative of better climatic conditions. These are Anogeissus leiocarpus (DC.), Commiphora africana (A. Rich.), Feretia apodanthera Del., Loeseneriella africana (A. Smith), Mitragyna inermis (Willd.) and Sclerocarya birrea (A. Rich). It is important that their reintroduction into reforestation projects takes account of their edaphic preference. 展开更多
关键词 Woody Plants distribution TOPOGRAPHY Ferlo Senegal
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Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease 被引量:1
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作者 Bo Li Yujie Chen +10 位作者 Yan Zhou Xuanran Feng Guojun Gu Shuang Han Nianhao Cheng Yawen Sun Yiming Zhang Jiahui Cheng Qi Zhang Wei Zhang Jianhui Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1593-1601,共9页
Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheime... Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a whole.Here,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial distribution.Additionally,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse model.Our findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-βproduction.Thus,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial biogenesis.In addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis. 展开更多
关键词 Alzheimer’s disease mitochondrial biogenesis neural stem cell-derived exosome SIRT1-PGC1α regional brain distribution whole brain clearing and imaging
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Diversity of Orchids in Terms of Their Distribution, Uses and Conservation in Annapurna Conservation Area of Nepal
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作者 Babu Lal Tiruwa Basu Dev Neupane +2 位作者 Rabin Kadariya Chiranjibi Prasad Pokheral Bijaya Pant 《American Journal of Plant Sciences》 CAS 2024年第6期422-440,共19页
The Annapurna Conservation Area (ACA), the first conservation area and the largest protected area (PA) in Nepal, is incredibly rich in biodiversity. Notwithstanding this, orchids in the ACA have not been explored enou... The Annapurna Conservation Area (ACA), the first conservation area and the largest protected area (PA) in Nepal, is incredibly rich in biodiversity. Notwithstanding this, orchids in the ACA have not been explored enough yet thus making the need for ambitious research to be carried out. Previous study only included 81 species of orchids within ACA. This study aims to update the record of species and genera richness in the ACA. In total 198 species of orchids, belonging to 67 genera (40% and 62% of the total recorded orchid species and genera in Nepal) has been recorded in ACA. This represents an increase of 144% in species and 56% in genera over the previous data. Out of the 198 species, 99 were epiphytes, 6 were holomycotrophic and 93 were terrestrial. Among the 67 genera, Bulbophyllum (17) species were dominant, followed by Dendrobium (16), Herminium (10), Coelogyne, Plantanthera (9 each), Eria, Habenaria, Oberonia (8 each), Calanthe (7), and Liparis (6). Fifty-six species were found to be ornamentally significant and 85 species medicinally significant. 展开更多
关键词 ORCHIDS Annapurna Conservation Area DIVERSITY distribution USES
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Boosting Adversarial Training with Learnable Distribution
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作者 Kai Chen Jinwei Wang +2 位作者 James Msughter Adeke Guangjie Liu Yuewei Dai 《Computers, Materials & Continua》 SCIE EI 2024年第3期3247-3265,共19页
In recent years,various adversarial defense methods have been proposed to improve the robustness of deep neural networks.Adversarial training is one of the most potent methods to defend against adversarial attacks.How... In recent years,various adversarial defense methods have been proposed to improve the robustness of deep neural networks.Adversarial training is one of the most potent methods to defend against adversarial attacks.However,the difference in the feature space between natural and adversarial examples hinders the accuracy and robustness of the model in adversarial training.This paper proposes a learnable distribution adversarial training method,aiming to construct the same distribution for training data utilizing the Gaussian mixture model.The distribution centroid is built to classify samples and constrain the distribution of the sample features.The natural and adversarial examples are pushed to the same distribution centroid to improve the accuracy and robustness of the model.The proposed method generates adversarial examples to close the distribution gap between the natural and adversarial examples through an attack algorithm explicitly designed for adversarial training.This algorithm gradually increases the accuracy and robustness of the model by scaling perturbation.Finally,the proposed method outputs the predicted labels and the distance between the sample and the distribution centroid.The distribution characteristics of the samples can be utilized to detect adversarial cases that can potentially evade the model defense.The effectiveness of the proposed method is demonstrated through comprehensive experiments. 展开更多
关键词 Adversarial training feature space learnable distribution distribution centroid
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Simulation of Haloxylon Ammodendron Stand Basic Diameter Structure Based on Fuzzy Distribution Function
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作者 Shaohua Wang Chuanqiang Liu Ting Yang 《Agricultural Sciences》 2024年第1期132-145,共14页
Based on the investigation data of 12 Haloxylon ammodendron plots in the south edge of Gurbantunggut Desert, Fuzzy distribution was introduced into the study of Haloxylon ammodendron base diameter structure fitting ac... Based on the investigation data of 12 Haloxylon ammodendron plots in the south edge of Gurbantunggut Desert, Fuzzy distribution was introduced into the study of Haloxylon ammodendron base diameter structure fitting according to the consistency between the characteristics of Fuzzy distribution function and the distribution series of cumulative percentage of stand base diameter, and the fitting precision and effect of Fuzzy distribution function were discussed. The root mean square error RMSE and determination coefficient R<sup>2</sup> values showed that Fuzzy-Γ<sub>1</sub>, Fuzzy-Γ<sub>2</sub>, Fuzzy-Γ<sub>3</sub>, Fuzzy-Γ<sub>4</sub> had good fitting performance, among which Fuzzy-Γ<sub>1</sub> had relatively high fitting precision, and its parameters were closely related to stand age and density, Fuzzy-Γ<sub>2</sub> distribution function was the second, and Fuzzy-Γ<sub>4</sub> distribution function had the worst fitting effect. By introducing a parameter c from the similarity of four distribution function formulas, a generalized Fuzzy distribution function Fuzzy-Γ<sub>5</sub> is obtained. This function shows the highest fitting accuracy. Most of the values of parameter c are near 1 or 2, which shows that the diameter distribution is mainly approximate to Fuzzy-Γ<sub>1</sub> and Fuzzy-Γ<sub>2</sub>. 展开更多
关键词 Fuzzy distribution Function Haloxylon Ammodendron Base Diameter distribution Stand Factor
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Approximating the Radial Distribution Function of the Electron in a Hydrogen Atom by a Normal Distribution Suggests That Magnetic Confinement Fusion Would Be Less Energy Efficient than Inertial Confinement Fusion
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作者 Motohisa Osaka 《Applied Mathematics》 2024年第9期585-593,共9页
Since the position of the electron in a hydrogen atom cannot be determined, the region in which it resides is said to be determined stochastically and forms an electron cloud. The probability density function of the s... Since the position of the electron in a hydrogen atom cannot be determined, the region in which it resides is said to be determined stochastically and forms an electron cloud. The probability density function of the single electron in 1s orbit is expressed as φ2, a function of distance from the nucleus. However, the probability of existence of the electron is expressed as a radial distribution function at an arbitrary distance from the nucleus, so it is estimated as the probability of the entire spherical shape of that radius. In this study, it has been found that the electron existence probability approximates the radial distribution function by assuming that the probability of existence of the electron being in the vicinity of the nucleus follows a normal distribution for arbitrary x-, y-, and z-axis directions. This implies that the probability of existence of the electron, which has been known only from the distance information, would follow a normal distribution independently in the three directions. When the electrons’ motion is extremely restricted in a certain direction by the magnetic field of both tokamak and helical fusion reactors, the probability of existence of the electron increases with proximity to the nucleus, and as a result, it is less likely to be liberated from the nucleus. Therefore, more and more energy is required to free the nucleus from the electron in order to generate plasma. 展开更多
关键词 Electron Cloud Radial distribution Function Nuclear Fusion TOKAMAK Laser
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Reactive jet density distribution effect on its penetration behavior
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作者 Huan-guo Guo Cheng-hai Su +3 位作者 Yi-qiang Cai Suo He Qing-bo Yu Haifu Wang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第6期190-202,共13页
In this paper,the penetration mechanism of reactive jet with non-uniform density distribution is studied.The simulations show that the density deficit occurs in the whole reactive jet,and the density increases from th... In this paper,the penetration mechanism of reactive jet with non-uniform density distribution is studied.The simulations show that the density deficit occurs in the whole reactive jet,and the density increases from the jet tip to tail.The density of jet tip is approximately 1.5 g/cm3,which is lower than that of the reactive liner materials.The X-ray experiments show similar results with the simulations.The density decreasing effect of jet tip has a significant influence on the penetration behavior when the reactive jet impacts steel plate.According to the simulation results,this paper assumes that the density gradient in the jet section has linear distribution.Then,the deflagration pressure generated by each jet element at the bottom of crater is introduced into the Bernoulli equation.Based on the virtual origin model and Szendrei-Held equation,the analytical models for penetration depth and radial cratering of reactive jet with the density reduction are obtained.Moreover,to further prove the validity of analytical models,the penetration experiments of the reactive liner shaped charge against steel plate under different standoffs are carried out.There is a convergence between the analytical crater profiles and experimental results when reactive jets penetrate steel plates under different standoffs,especially at standoff of 1.5 and 2.0charge diameters. 展开更多
关键词 Shaped charge Reactive jet density distribution Jet penetration Virtual origin
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An Algorithm for Short-Circuit Current Interval in Distribution Networks with Inverter Type Distributed Generation Based on Affine Arithmetic
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作者 Yan Zhang Bowen Du +3 位作者 Benren Pan GuannanWang Guoqiang Xie Tong Jiang 《Energy Engineering》 EI 2024年第7期1903-1920,共18页
During faults in a distribution network,the output power of a distributed generation(DG)may be uncertain.Moreover,the output currents of distributed power sources are also affected by the output power,resulting in unc... During faults in a distribution network,the output power of a distributed generation(DG)may be uncertain.Moreover,the output currents of distributed power sources are also affected by the output power,resulting in uncertainties in the calculation of the short-circuit current at the time of a fault.Additionally,the impacts of such uncertainties around short-circuit currents will increase with the increase of distributed power sources.Thus,it is very important to develop a method for calculating the short-circuit current while considering the uncertainties in a distribution network.In this study,an affine arithmetic algorithm for calculating short-circuit current intervals in distribution networks with distributed power sources while considering power fluctuations is presented.The proposed algorithm includes two stages.In the first stage,normal operations are considered to establish a conservative interval affine optimization model of injection currents in distributed power sources.Constrained by the fluctuation range of distributed generation power at the moment of fault occurrence,the model can then be used to solve for the fluctuation range of injected current amplitudes in distributed power sources.The second stage is implemented after a malfunction occurs.In this stage,an affine optimization model is first established.This model is developed to characterizes the short-circuit current interval of a transmission line,and is constrained by the fluctuation range of the injected current amplitude of DG during normal operations.Finally,the range of the short-circuit current amplitudes of distribution network lines after a short-circuit fault occurs is predicted.The algorithm proposed in this article obtains an interval range containing accurate results through interval operation.Compared with traditional point value calculation methods,interval calculation methods can provide more reliable analysis and calculation results.The range of short-circuit current amplitude obtained by this algorithm is slightly larger than those obtained using the Monte Carlo algorithm and the Latin hypercube sampling algorithm.Therefore,the proposed algorithm has good suitability and does not require iterative calculations,resulting in a significant improvement in computational speed compared to the Monte Carlo algorithm and the Latin hypercube sampling algorithm.Furthermore,the proposed algorithm can provide more reliable analysis and calculation results,improving the safety and stability of power systems. 展开更多
关键词 Short circuit calculation inverter type distributed power supplies affine arithmetic distribution network
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