Treatment of denudatine 1 with 10％ HCl soln. at 30-40℃ for 1 day leads to another rearrangement product 3 along with a pair of epimers 2A and 2B. Upon adding a little EtOH in the reaction solution, only a pair of ep...Treatment of denudatine 1 with 10％ HCl soln. at 30-40℃ for 1 day leads to another rearrangement product 3 along with a pair of epimers 2A and 2B. Upon adding a little EtOH in the reaction solution, only a pair of epimers 4A and 4B were obtained along with the unchanged starting material.展开更多
Treatment of denudatine 1 with 10% HCl soln. at 45-50℃ for 3 days leads to a pair of epimers 4A and 4B, Structures of 4A and 4B have been elucidated on the basis of chemical and spectral methods.
The reactions of denudatine 1 and diacetyldenudatine 2 with NBS-50% HOAc soln. afforded 4 and 6, respectively, in high yields.Treatment of 6 with (Ac)_2CO-Pyr. gives 7. The structures of 3,6 and 7 were deduced on the ...The reactions of denudatine 1 and diacetyldenudatine 2 with NBS-50% HOAc soln. afforded 4 and 6, respectively, in high yields.Treatment of 6 with (Ac)_2CO-Pyr. gives 7. The structures of 3,6 and 7 were deduced on the basis of spectral and chemical methods.展开更多
Two new denudatine-type C20-diterpenoid alkaloids, named sinomontanidines A （1） and B （2）, were isolated from the roots ofAconitum sinomontanum Nakai. Their structures were elucidated by extensive analysis of 1D, ...Two new denudatine-type C20-diterpenoid alkaloids, named sinomontanidines A （1） and B （2）, were isolated from the roots ofAconitum sinomontanum Nakai. Their structures were elucidated by extensive analysis of 1D, 2D NMR, and MS data.展开更多
文摘Treatment of denudatine 1 with 10％ HCl soln. at 30-40℃ for 1 day leads to another rearrangement product 3 along with a pair of epimers 2A and 2B. Upon adding a little EtOH in the reaction solution, only a pair of epimers 4A and 4B were obtained along with the unchanged starting material.
文摘Treatment of denudatine 1 with 10% HCl soln. at 45-50℃ for 3 days leads to a pair of epimers 4A and 4B, Structures of 4A and 4B have been elucidated on the basis of chemical and spectral methods.
文摘The reactions of denudatine 1 and diacetyldenudatine 2 with NBS-50% HOAc soln. afforded 4 and 6, respectively, in high yields.Treatment of 6 with (Ac)_2CO-Pyr. gives 7. The structures of 3,6 and 7 were deduced on the basis of spectral and chemical methods.
基金financially supported by the National Natural Science Foundation of China (No. 81273387)
文摘Two new denudatine-type C20-diterpenoid alkaloids, named sinomontanidines A （1） and B （2）, were isolated from the roots ofAconitum sinomontanum Nakai. Their structures were elucidated by extensive analysis of 1D, 2D NMR, and MS data.
