Faster and better wound healing is a critical medical issue.Because the repair process of wounds is closely related to revascularization,accurate early assessment and postoperative monitoring are very important for es...Faster and better wound healing is a critical medical issue.Because the repair process of wounds is closely related to revascularization,accurate early assessment and postoperative monitoring are very important for establishing an optimal treatment plan.Herein,we present an extended depth-of-field photoacoustic microscopy system(E-DOF-PAM)that can achieve a constant spatial resolution and relatively uniform excitation efficiency over a long axial range.The superior performance of the system was verified by phantom and in vivo experiments.Furthermore,the system was applied to the imaging of normal and trauma sites of volunteers,and the experimental results accurately revealed the morphological differences between the normal and traumatized skin of the epidermis and dermis.These results demonstrated that the E-DOF-PAM is a powerful tool for observing and understanding the pathophysiology of cutaneous wound healing.展开更多
This paper presents an efficient method to trace secondary rays in depth-of-field （DOF） rendering, which significantly enhances realism. Till now, the effects by secondary rays have been little addressed in real-tim...This paper presents an efficient method to trace secondary rays in depth-of-field （DOF） rendering, which significantly enhances realism. Till now, the effects by secondary rays have been little addressed in real-time/interactive DOF rendering, because secondary rays have less coherence than primary rays, making them very difficult to handle. We propose novel measures to cluster secondary rays, and take a virtual viewpoint to construct a layered image-based representation for the objects that would be intersected by a cluster of secondary rays respectively. Therefore, we can exploit coherence of secondary rays in the clusters to speed up tracing secondary rays in DOF rendering. Results show that, we can interactively achieve DOF rendering effects with reflections or refractions on a commodity graphics card.展开更多
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.61822505,11774101,61627827,and 81630046)the Science and Technology Planning Project of Guangdong Province,China(No.2015B020233016)the Science and Technology Program of Guangzhou(No.2019050001).
文摘Faster and better wound healing is a critical medical issue.Because the repair process of wounds is closely related to revascularization,accurate early assessment and postoperative monitoring are very important for establishing an optimal treatment plan.Herein,we present an extended depth-of-field photoacoustic microscopy system(E-DOF-PAM)that can achieve a constant spatial resolution and relatively uniform excitation efficiency over a long axial range.The superior performance of the system was verified by phantom and in vivo experiments.Furthermore,the system was applied to the imaging of normal and trauma sites of volunteers,and the experimental results accurately revealed the morphological differences between the normal and traumatized skin of the epidermis and dermis.These results demonstrated that the E-DOF-PAM is a powerful tool for observing and understanding the pathophysiology of cutaneous wound healing.
基金supported by the National Natural Science Foundation of China under Grant Nos. 60773026 and 60833007the Knowledge Innovation Program of the Chinese Academy of Sciences
文摘This paper presents an efficient method to trace secondary rays in depth-of-field （DOF） rendering, which significantly enhances realism. Till now, the effects by secondary rays have been little addressed in real-time/interactive DOF rendering, because secondary rays have less coherence than primary rays, making them very difficult to handle. We propose novel measures to cluster secondary rays, and take a virtual viewpoint to construct a layered image-based representation for the objects that would be intersected by a cluster of secondary rays respectively. Therefore, we can exploit coherence of secondary rays in the clusters to speed up tracing secondary rays in DOF rendering. Results show that, we can interactively achieve DOF rendering effects with reflections or refractions on a commodity graphics card.
