A chiral stationary phase （CSP） was prepared by chemically bonding carboxymethyl-β-cyclodextrin （CM- β-CD） onto 3-aminopropyl silica gel through amidation reaction in water solution and was characterized by Four...A chiral stationary phase （CSP） was prepared by chemically bonding carboxymethyl-β-cyclodextrin （CM- β-CD） onto 3-aminopropyl silica gel through amidation reaction in water solution and was characterized by Fourier transform infrared spectroscopy （FT-IR）, element analysis （EA） and thermal gravimetry analysis （TGA）. The chromatographic performance was evaluated with 24 racemates under reversedphase conditions, The effect of salt, organic modifier, mobile phase pH and structures of analytes were discussed. In comparison with native β-CD bonded column, CYCLOBOND 12000, CM-β-CD CSP exhibited enhanced enantioseparation.展开更多
The separation of enantiomers of a series of eighteen novel nitrogen mustard linked phosphoryl diamide derivatives was investigated on the prepared phenyl carbamate derivative β-cy-clodextrin bonded phase in normal-p...The separation of enantiomers of a series of eighteen novel nitrogen mustard linked phosphoryl diamide derivatives was investigated on the prepared phenyl carbamate derivative β-cy-clodextrin bonded phase in normal-phase HPLC. Some of the enantiomers could be separated in baseline. The chiral recognition mechanism was also suggested for the separation of chiral phosphorus organic compounds.展开更多
文摘A chiral stationary phase （CSP） was prepared by chemically bonding carboxymethyl-β-cyclodextrin （CM- β-CD） onto 3-aminopropyl silica gel through amidation reaction in water solution and was characterized by Fourier transform infrared spectroscopy （FT-IR）, element analysis （EA） and thermal gravimetry analysis （TGA）. The chromatographic performance was evaluated with 24 racemates under reversedphase conditions, The effect of salt, organic modifier, mobile phase pH and structures of analytes were discussed. In comparison with native β-CD bonded column, CYCLOBOND 12000, CM-β-CD CSP exhibited enhanced enantioseparation.
基金Project supported by the Fundation of National Laboratory of Elemento-Organic Chemistry, Nankai University.
文摘The separation of enantiomers of a series of eighteen novel nitrogen mustard linked phosphoryl diamide derivatives was investigated on the prepared phenyl carbamate derivative β-cy-clodextrin bonded phase in normal-phase HPLC. Some of the enantiomers could be separated in baseline. The chiral recognition mechanism was also suggested for the separation of chiral phosphorus organic compounds.
