In order to collect rainwater and resist drought to enhance the utilization rate of rainfall and water resources, through project rainwater harvesting measures, the total annual rainwater harvesting amount of the six ...In order to collect rainwater and resist drought to enhance the utilization rate of rainfall and water resources, through project rainwater harvesting measures, the total annual rainwater harvesting amount of the six greenhouses was calculated according to annual average precipitation 542.2 mm, up to 1 095.7 m^3. The upper natural slopes of cultivated land were as rainwater harvesting areas, and total annual rainwater harvesting amount was 49 242 m^3 on the mountain slopes with an area of 73.37 hm^2, while total water storage amount was 39 394 m^3 in theory, so it could meet water use for the irrigation of 26.28 hm^2 of T. sinensis land. To be convenient for rainwater harvesting, irrigation and supplying water to the water-saving cellars, one pert-cut and part-fill reservoir (which was 470 m^3 in volume) was built on the mountain slopes at the right rear of the greenhouses, and their altitude difference was 50 m. The reservoir was sealed and was built with reinforced concrete. Water-saving cellars were distributed in front and the middle and at the back of two rows of greenhouses, and they were connected with each other. The reservoir could supply water to the water-saving cellars and also collect water by mountain slopes, from the lower water-saving cellars or deep wells. Two rainwater hervesting ditches that were 1 650 m in length were at the lower edge of arable land in the upper reaches of slopes to intercept rainfall runoff and make it flow into channels and then the sedimentation tanks. The total annual rainwater harvesting amount of the reservoir and water-saving cellars was 1 222.5 m^3.展开更多
Deformation and failure of high slope impact the construction and operation safety of highway in the mountainous areas. The deformation and failure are mainly caused by poor design which normally has not well combined...Deformation and failure of high slope impact the construction and operation safety of highway in the mountainous areas. The deformation and failure are mainly caused by poor design which normally has not well combined with the geological conditions and unplanned construction. Therefore, effective design and construction management should be conducted for ensuring a successful construction without damage and risk. In light of the reality of high slope construction along highway in the Huangshan area, this paper proposes a technical procedure for dynamic design and construction management of high slopes along highway in the mountainous area. The proposed construction management scheme is divided into three phases, i.e., 1) design phase, 2) preparation phase of excavation, and 3) construction phase. During the design phase, experiences and lessons learnt from the design and construction of other high slopes along highway in the same region are summarized. The number of slopes and slope height should be optimized from the aspects of route selection and route form. During the preparation phase of excavation, "Excavation Permit Management System" should be adopted, and construction scheme should be made by the construction unit, then the scientific research and design unit determine whether it guarantees slope stability and makes optimization measures. During the construction phase, the scientific research unit would make proposal of optimization design, and apply the achievements of scientific research into practice through common efforts of various units based on the understanding of excavation and investigation. The management system mentioned above is adopted to conduct dynamic design and construction management for more than 90 slopes along the Huangshan - Taling - Taolin Expressway, and successful results of application have been achieved.展开更多
The The Great-West Dyke with a length of 6.7 km, the largest sea wall in China, was completed in June, 1994. This paper introduces structure options of nibble mound sea wall on soft foundation and a new type of armour...The The Great-West Dyke with a length of 6.7 km, the largest sea wall in China, was completed in June, 1994. This paper introduces structure options of nibble mound sea wall on soft foundation and a new type of armour block-hexagon multihole block (HMB) and a new method of treatment for soft foundation by using underwater explosion. Construction practice of some projects in China shows that by using this method good effect of treatment and marked economic benefit can be achieved by using this method.展开更多
The high and large span cast-in-place reinforced concrete cantilever structure of the office building of some court, which is located I-steel at the cantilever and used steel pipe scaffold as the support, has guarante...The high and large span cast-in-place reinforced concrete cantilever structure of the office building of some court, which is located I-steel at the cantilever and used steel pipe scaffold as the support, has guaranteed the frame body and structure security by the frame body calculating, on-site test and reasonable construction order.展开更多
It is avery important field for educational researcher to use collaborative educational platform to manage and educate students. With the development of the Internet and the popularization of computers, cooperative ed...It is avery important field for educational researcher to use collaborative educational platform to manage and educate students. With the development of the Internet and the popularization of computers, cooperative education is becoming increasingly important. In consideration of the immature stage of the current domestic collaborative education platform, in order to promote the communication among students, teachers and parents, and to facilitate the collaborative supervision and management of teachers and parents, we design and construct the family-school collaborative education platform.展开更多
This paper mainly introduces the designand construction of the multi-flue chimneysof Beilungang Power Plant, ShidongkouSecond Power Plant and Waigaoqiao PowerPlant which have been used in East Chinaarea. This paper co...This paper mainly introduces the designand construction of the multi-flue chimneysof Beilungang Power Plant, ShidongkouSecond Power Plant and Waigaoqiao PowerPlant which have been used in East Chinaarea. This paper contains the generalsituation of construction, material selection,lifting scheme of steel inner flue, designfeatures and construction method. It could bereferential to concerned design andconstruction companies.展开更多
The design method of a 6-axis force robot's transducer based on the Stewartplatform is detailed. For this purpose, the sensitivity isotropy evaluation criteria of thetransducer are defined, and by the aid of compu...The design method of a 6-axis force robot's transducer based on the Stewartplatform is detailed. For this purpose, the sensitivity isotropy evaluation criteria of thetransducer are defined, and by the aid of computer, the relationships between the criteria and theparameters of all the transducers based on the Stewart platform are investigated within thegeometric model of the solution space, which can provide the theoretical background for the optimalconstruction design of the 6-axis force transducer related to the sensitivity isotropy.展开更多
In this paper, the author gives a brief introduction to the evolution of FIDIC conditions of contract, particularly the background of the 1999 new editions. A detailed discussion is made of the applying prospects refe...In this paper, the author gives a brief introduction to the evolution of FIDIC conditions of contract, particularly the background of the 1999 new editions. A detailed discussion is made of the applying prospects referring to the new editions of FIDIC Conditions of Contract in China in 6 aspects: revisions of the existing model contract forms; finding solutions to the payment delay problem; advocating the Design/Build and EPC turnkey project delivery system; clarifying the roles of supervising engineers and opening up the new regions of their work. This paper also prepares a short form model contract for small projects in China, improving the settlement of construction disputes.展开更多
Chimeric antigen receptor T cell denoted as CAR-T therapy has realized incredible therapeutic advancements for B cell malignancy treatment.However,its therapeutic validity has yet to be successfully achieved in solid ...Chimeric antigen receptor T cell denoted as CAR-T therapy has realized incredible therapeutic advancements for B cell malignancy treatment.However,its therapeutic validity has yet to be successfully achieved in solid tumors.Different from hematological cancers,solid tumors are characterized by dysregulated blood vessels,dense extracellular matrix,and filled with immunosuppressive signals,which together result in CAR-T cells’insufficient infiltration and rapid dysfunction.The insufficient recognition of tumor cells and tumor heterogeneity eventually causes cancer reoccurrences.In addition,CAR-T therapy also raises safety concerns,including potential cytokine release storm,on-target/off-tumor toxicities,and neuro-system side effects.Here we comprehensively review various targeting aspects,including CAR-T cell design,tumor modulation,and delivery strategy.We believe it is essential to rationally design a combinatory CAR-T therapy via constructing optimized CAR-T cells,directly manipulating tumor tissue microenvironments,and selecting the most suitable delivery strategy to achieve the optimal outcome in both safety and efficacy.展开更多
The architecture,engineering,and construction(AEC)industry is undergoing a substantial change,and the tech-nological advancements are shaping the future of this industry.Over years,numerous tools have been developed b...The architecture,engineering,and construction(AEC)industry is undergoing a substantial change,and the tech-nological advancements are shaping the future of this industry.Over years,numerous tools have been developed based on building information modeling(BIM)and the Internet of Things(IoT)to manage a variety of tasks and activities within different construction and operational phases in the AEC industry.Recently,with the advent of novel internet-enabled technologies in providing the ability of real-time connectivity,researchers have started to develop virtual design and construction(VDC)and digital twin approaches to remotely monitor,control,and optimize different work progresses and activities in real-time at any work level in the AEC industry.This paper presents a reference model to illustrates the main advantages and applications of VDC and digital twin,and to demonstrate their trends and anticipated cost savings in the AEC industry at a global level.These technological advancements along with augmented reality(AR)and virtual reality(VR)can offer the unique benefit of real-time monitoring of the current status as well as predicting the future of any physical structure at any level of work.The global demand and usage of these technological advancements will lead to great cost savings in the AEC industry which would be US$950 million in design and construction and US$400 million in operation and maintenance phases in the non-residential AEC industry in 2025.This paper also discusses the future challenges of VDC and digital twin in the industry.As a main line of future research,these technologies can simultaneously be utilized with artificial intelligence to enable human-centered decision making to automate and optimize work progresses.Such integrations of VDC,digital twin,artificial intelligence,and human-centered approaches will shape the future of the AEC industry and provide numerous research opportunities in this domain.展开更多
Healthcare facilities are among the most complicated facilities to plan,design,construct and operate.A new breed of hospitals is considering the impact of the built environment on healthcare worker productivity and pa...Healthcare facilities are among the most complicated facilities to plan,design,construct and operate.A new breed of hospitals is considering the impact of the built environment on healthcare worker productivity and patient recovery in their design,construction,and operation.A crucial subset of healthcare facilities are children’s hospitals where the consequences of poor building system design and performance have the potential to seriously impact young lives with compromised health.Green facilities are not always pursued:they are perceived as difficult to build and costing more than equivalent conventional hospitals.This study explored the design process of the Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center(UPMC)and Penn State’s Hershey Medical Center Children’s Hospital to understand the critical steps and processes for green children’s hospital design.Producing a series of process maps that identify the key characteristics in the complex design requirements of a green children’s hospital,this paper reveals the importance of design process to design quality.More broadly,this research will help future project teams meet the complex design requirements of green children’s hospitals.展开更多
The construction industry is embracing sustainable building practices that boost the“triple bottom line”,namely the building’s ecological,social,and financial performance.Since more than 55 million US students spen...The construction industry is embracing sustainable building practices that boost the“triple bottom line”,namely the building’s ecological,social,and financial performance.Since more than 55 million US students spend a significant part of their day in K-12 schools,it is vital that these facilities should provide healthy,comfortable,and productive learning environments.Here we present an in-depth literature review of how educational facilities affect student school performance,comfort,and health,and we examine the role of sustainable design and construction strategies in influencing the physical learning environment in schools.Significant barriers to implementing sustainable strategies are examined,particularly the first cost premium of a sustainable building.A systematic decision strategy is described that incorporates sustainable design strategies,lowering energy consumption and improving indoor environments.A case study describes the process of incorporating sustainable strategies in a K-12 education facility in North Carolina to lower annual energy consumption and greenhouse gas emissions.Ways to reduce the first cost premium and minimize operating costs over the facility’s life while providing healthy and comfortable learning environments for students and teachers are discussed.The case study school also functions as an experimental learning tool for teaching sustainability to K-12 students,having the potential to improve their attitudes and behavior with respect to sustainability.展开更多
Design is a goal-oriented planning activity for creating products,processes,and systems with desired functions through specifications.It is a decision-making exploration:the design outcome may vary greatly depending o...Design is a goal-oriented planning activity for creating products,processes,and systems with desired functions through specifications.It is a decision-making exploration:the design outcome may vary greatly depending on the designer’s knowledge and philosophy.Integrated design is one type of design philosophy that takes an interdisciplinary and holistic approach.In civil engineering,structural design is such an activity for creating buildings and infrastructures.Recently,structural design in many countries has emphasized a performance-based philosophy that simultaneously considers a structure’s safety,durability,serviceability,and sustainability.Consequently,integrated design in civil engineering has become more popular,useful,and important.Material-oriented integrated design and construction of structures(MIDCS)combine materials engineering and structural engineering in the design stage:it fully utilizes the strengths of materials by selecting the most suitable structural forms and construction methodologies.This paper will explore real-world examples of MIDCS,including the realization of MIDCS in timber seismic-resistant structures,masonry arch structures,long-span steel bridges,prefabricated/on-site extruded light-weight steel structures,fiber-reinforced cementitious composites structures,and fiber-reinforced polymer bridge decks.Additionally,advanced material design methods such as bioinspired design and structure construction technology of additive manufacturing are briefly reviewed and discussed to demonstrate how MIDCS can combine materials and structures.A unified strengthdurability design theory is also introduced,which is a human-centric,interdisciplinary,and holistic approach to the description and development of any civil infrastructure and includes all processes directly involved in the life cycle of the infrastructure.Finally,this paper lays out future research directions for further development in the field.展开更多
基金Supported by Key Technology R&D Program Project of Shijiazhuang City(141520208A)~~
文摘In order to collect rainwater and resist drought to enhance the utilization rate of rainfall and water resources, through project rainwater harvesting measures, the total annual rainwater harvesting amount of the six greenhouses was calculated according to annual average precipitation 542.2 mm, up to 1 095.7 m^3. The upper natural slopes of cultivated land were as rainwater harvesting areas, and total annual rainwater harvesting amount was 49 242 m^3 on the mountain slopes with an area of 73.37 hm^2, while total water storage amount was 39 394 m^3 in theory, so it could meet water use for the irrigation of 26.28 hm^2 of T. sinensis land. To be convenient for rainwater harvesting, irrigation and supplying water to the water-saving cellars, one pert-cut and part-fill reservoir (which was 470 m^3 in volume) was built on the mountain slopes at the right rear of the greenhouses, and their altitude difference was 50 m. The reservoir was sealed and was built with reinforced concrete. Water-saving cellars were distributed in front and the middle and at the back of two rows of greenhouses, and they were connected with each other. The reservoir could supply water to the water-saving cellars and also collect water by mountain slopes, from the lower water-saving cellars or deep wells. Two rainwater hervesting ditches that were 1 650 m in length were at the lower edge of arable land in the upper reaches of slopes to intercept rainfall runoff and make it flow into channels and then the sedimentation tanks. The total annual rainwater harvesting amount of the reservoir and water-saving cellars was 1 222.5 m^3.
文摘Deformation and failure of high slope impact the construction and operation safety of highway in the mountainous areas. The deformation and failure are mainly caused by poor design which normally has not well combined with the geological conditions and unplanned construction. Therefore, effective design and construction management should be conducted for ensuring a successful construction without damage and risk. In light of the reality of high slope construction along highway in the Huangshan area, this paper proposes a technical procedure for dynamic design and construction management of high slopes along highway in the mountainous area. The proposed construction management scheme is divided into three phases, i.e., 1) design phase, 2) preparation phase of excavation, and 3) construction phase. During the design phase, experiences and lessons learnt from the design and construction of other high slopes along highway in the same region are summarized. The number of slopes and slope height should be optimized from the aspects of route selection and route form. During the preparation phase of excavation, "Excavation Permit Management System" should be adopted, and construction scheme should be made by the construction unit, then the scientific research and design unit determine whether it guarantees slope stability and makes optimization measures. During the construction phase, the scientific research unit would make proposal of optimization design, and apply the achievements of scientific research into practice through common efforts of various units based on the understanding of excavation and investigation. The management system mentioned above is adopted to conduct dynamic design and construction management for more than 90 slopes along the Huangshan - Taling - Taolin Expressway, and successful results of application have been achieved.
文摘The The Great-West Dyke with a length of 6.7 km, the largest sea wall in China, was completed in June, 1994. This paper introduces structure options of nibble mound sea wall on soft foundation and a new type of armour block-hexagon multihole block (HMB) and a new method of treatment for soft foundation by using underwater explosion. Construction practice of some projects in China shows that by using this method good effect of treatment and marked economic benefit can be achieved by using this method.
文摘The high and large span cast-in-place reinforced concrete cantilever structure of the office building of some court, which is located I-steel at the cantilever and used steel pipe scaffold as the support, has guaranteed the frame body and structure security by the frame body calculating, on-site test and reasonable construction order.
文摘It is avery important field for educational researcher to use collaborative educational platform to manage and educate students. With the development of the Internet and the popularization of computers, cooperative education is becoming increasingly important. In consideration of the immature stage of the current domestic collaborative education platform, in order to promote the communication among students, teachers and parents, and to facilitate the collaborative supervision and management of teachers and parents, we design and construct the family-school collaborative education platform.
文摘This paper mainly introduces the designand construction of the multi-flue chimneysof Beilungang Power Plant, ShidongkouSecond Power Plant and Waigaoqiao PowerPlant which have been used in East Chinaarea. This paper contains the generalsituation of construction, material selection,lifting scheme of steel inner flue, designfeatures and construction method. It could bereferential to concerned design andconstruction companies.
基金This project is supported by National 863 plan(No.512-9804-02)Robotics Laboratory,Chinese Academy of Sciences Foundation, China
文摘The design method of a 6-axis force robot's transducer based on the Stewartplatform is detailed. For this purpose, the sensitivity isotropy evaluation criteria of thetransducer are defined, and by the aid of computer, the relationships between the criteria and theparameters of all the transducers based on the Stewart platform are investigated within thegeometric model of the solution space, which can provide the theoretical background for the optimalconstruction design of the 6-axis force transducer related to the sensitivity isotropy.
文摘In this paper, the author gives a brief introduction to the evolution of FIDIC conditions of contract, particularly the background of the 1999 new editions. A detailed discussion is made of the applying prospects referring to the new editions of FIDIC Conditions of Contract in China in 6 aspects: revisions of the existing model contract forms; finding solutions to the payment delay problem; advocating the Design/Build and EPC turnkey project delivery system; clarifying the roles of supervising engineers and opening up the new regions of their work. This paper also prepares a short form model contract for small projects in China, improving the settlement of construction disputes.
基金support from the National Key R&D Program of China(2021YFA0909900)the National Natural Science Foundation of China(52173142,82072650)+1 种基金the Key Research and Development Program of Zhejiang Province(2021C03121)the grants from the Startup Package of Zhejiang University.
文摘Chimeric antigen receptor T cell denoted as CAR-T therapy has realized incredible therapeutic advancements for B cell malignancy treatment.However,its therapeutic validity has yet to be successfully achieved in solid tumors.Different from hematological cancers,solid tumors are characterized by dysregulated blood vessels,dense extracellular matrix,and filled with immunosuppressive signals,which together result in CAR-T cells’insufficient infiltration and rapid dysfunction.The insufficient recognition of tumor cells and tumor heterogeneity eventually causes cancer reoccurrences.In addition,CAR-T therapy also raises safety concerns,including potential cytokine release storm,on-target/off-tumor toxicities,and neuro-system side effects.Here we comprehensively review various targeting aspects,including CAR-T cell design,tumor modulation,and delivery strategy.We believe it is essential to rationally design a combinatory CAR-T therapy via constructing optimized CAR-T cells,directly manipulating tumor tissue microenvironments,and selecting the most suitable delivery strategy to achieve the optimal outcome in both safety and efficacy.
基金This work was supported by a grant from the Office of Research and Creative Activity at Western Kentucky University.
文摘The architecture,engineering,and construction(AEC)industry is undergoing a substantial change,and the tech-nological advancements are shaping the future of this industry.Over years,numerous tools have been developed based on building information modeling(BIM)and the Internet of Things(IoT)to manage a variety of tasks and activities within different construction and operational phases in the AEC industry.Recently,with the advent of novel internet-enabled technologies in providing the ability of real-time connectivity,researchers have started to develop virtual design and construction(VDC)and digital twin approaches to remotely monitor,control,and optimize different work progresses and activities in real-time at any work level in the AEC industry.This paper presents a reference model to illustrates the main advantages and applications of VDC and digital twin,and to demonstrate their trends and anticipated cost savings in the AEC industry at a global level.These technological advancements along with augmented reality(AR)and virtual reality(VR)can offer the unique benefit of real-time monitoring of the current status as well as predicting the future of any physical structure at any level of work.The global demand and usage of these technological advancements will lead to great cost savings in the AEC industry which would be US$950 million in design and construction and US$400 million in operation and maintenance phases in the non-residential AEC industry in 2025.This paper also discusses the future challenges of VDC and digital twin in the industry.As a main line of future research,these technologies can simultaneously be utilized with artificial intelligence to enable human-centered decision making to automate and optimize work progresses.Such integrations of VDC,digital twin,artificial intelligence,and human-centered approaches will shape the future of the AEC industry and provide numerous research opportunities in this domain.
文摘Healthcare facilities are among the most complicated facilities to plan,design,construct and operate.A new breed of hospitals is considering the impact of the built environment on healthcare worker productivity and patient recovery in their design,construction,and operation.A crucial subset of healthcare facilities are children’s hospitals where the consequences of poor building system design and performance have the potential to seriously impact young lives with compromised health.Green facilities are not always pursued:they are perceived as difficult to build and costing more than equivalent conventional hospitals.This study explored the design process of the Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center(UPMC)and Penn State’s Hershey Medical Center Children’s Hospital to understand the critical steps and processes for green children’s hospital design.Producing a series of process maps that identify the key characteristics in the complex design requirements of a green children’s hospital,this paper reveals the importance of design process to design quality.More broadly,this research will help future project teams meet the complex design requirements of green children’s hospitals.
文摘The construction industry is embracing sustainable building practices that boost the“triple bottom line”,namely the building’s ecological,social,and financial performance.Since more than 55 million US students spend a significant part of their day in K-12 schools,it is vital that these facilities should provide healthy,comfortable,and productive learning environments.Here we present an in-depth literature review of how educational facilities affect student school performance,comfort,and health,and we examine the role of sustainable design and construction strategies in influencing the physical learning environment in schools.Significant barriers to implementing sustainable strategies are examined,particularly the first cost premium of a sustainable building.A systematic decision strategy is described that incorporates sustainable design strategies,lowering energy consumption and improving indoor environments.A case study describes the process of incorporating sustainable strategies in a K-12 education facility in North Carolina to lower annual energy consumption and greenhouse gas emissions.Ways to reduce the first cost premium and minimize operating costs over the facility’s life while providing healthy and comfortable learning environments for students and teachers are discussed.The case study school also functions as an experimental learning tool for teaching sustainability to K-12 students,having the potential to improve their attitudes and behavior with respect to sustainability.
基金This work was supported by the Science and Technology Development Fund,Macao SAR(0083/2018/A2)Multi-Year Research Grant(MYRG2019-00135-IAPME)Research&Development Grant for Chair Professor(CPG2020-00002-IAPME).
文摘Design is a goal-oriented planning activity for creating products,processes,and systems with desired functions through specifications.It is a decision-making exploration:the design outcome may vary greatly depending on the designer’s knowledge and philosophy.Integrated design is one type of design philosophy that takes an interdisciplinary and holistic approach.In civil engineering,structural design is such an activity for creating buildings and infrastructures.Recently,structural design in many countries has emphasized a performance-based philosophy that simultaneously considers a structure’s safety,durability,serviceability,and sustainability.Consequently,integrated design in civil engineering has become more popular,useful,and important.Material-oriented integrated design and construction of structures(MIDCS)combine materials engineering and structural engineering in the design stage:it fully utilizes the strengths of materials by selecting the most suitable structural forms and construction methodologies.This paper will explore real-world examples of MIDCS,including the realization of MIDCS in timber seismic-resistant structures,masonry arch structures,long-span steel bridges,prefabricated/on-site extruded light-weight steel structures,fiber-reinforced cementitious composites structures,and fiber-reinforced polymer bridge decks.Additionally,advanced material design methods such as bioinspired design and structure construction technology of additive manufacturing are briefly reviewed and discussed to demonstrate how MIDCS can combine materials and structures.A unified strengthdurability design theory is also introduced,which is a human-centric,interdisciplinary,and holistic approach to the description and development of any civil infrastructure and includes all processes directly involved in the life cycle of the infrastructure.Finally,this paper lays out future research directions for further development in the field.