Overall Image Design of Small Townships in Guangxi

Since the 21st century, the construction of small towns in Guangxi Zhuang Autonomous Region has been accelerated obviously and has already taken shape, but there are still some problems such as old towns not being well protected, new towns constructed in unified style, regional culture not being excavated and town features without characteristics. Thus, this paper analyzed some actual cases in Guangxi which are successful in designing the overall image of small towns, including Cendou Xincun, Xing'an County and Yangshuo Dongling, found that all constructions show rich elements of traditional houses, characteristics of local houses and distinctive cultures of folk houses, and concluded that tradition was the source to construct the features of small towns, innovation was the basis to develop small towns and culture was the core to sublimate the features of small towns. It was considered that traditional architectures could only be integrated with modern architectures by fully excavating cultural characteristics of regional architectures, combining with regional tourism industry and motivating local people to participate in reconstruction, to enhance local styles and national features, and create a beautiful, comfortable and harmonious living environment, so the overall regional styles and features of small towns can be represented and proceeded, comprehensive competitiveness and strong vitality can be given to those towns.

Ecological Compensation Design of Residential Environment in Small Towns

In view of the current situation of the residential environment in small towns,some methods of ecological compensation design were discussed,such as the improvement of planting quality,the selection of suitable tree species,reasonable construction and management methods,expansion of space and so on.Meanwhile,some rational suggestions were put forward on strengthening the ecological and cultural construction of residential areas and enhancing residents' awareness of environmental protection.

Design and Experiment of ф-type-knots Knotters on Chinese Small Square Balers

Since the knotters on the Chinese rectangular balers are imported from outside of the country, Chinese knotters with independent intellectual property rights is far away from being closed. In order to harvest a large quantity of straw in a short period on the small-scale lands of China, basic requirements on the knotters are summarized. Mathematical model of the knotter is also determined uniquely. Furthermore, the ^-type-knots knotter equipped on the Chinese square baler to form the ~ type knots is designed. Knotting rate experiments of the qb-type-knots knotter on the test bench and in the wheat/maize straws covered fields are carried out to check the knotting performances of the knotter. The parameters of the formed knots are also tested. The experiments results show that the knotting rate of the qb-type-knots knotter reaches 100.0% on the test bench without straws, while reaches 99.6% in the wheat straws covered field and 100.0% in the maize straws covered field. The average maximum force in the knotting process is 194.7 N in the lab experiment. The length out of the knots formed in lab is 15.9%-20.6% lower than the knots formed in the field experiment. The breaking force of the knots formed in the field is 115.9%-167.2% higher than the knots formed in lab due to the higher preload and interactions with the compacted bales. Highly relevant relationships exist between the breaking force of the formed knots and the maximum force in the forming process of the knots in the lab experiment. The designed knotter breaks out the embarrassing situation of the domestic knotters which don＇t have independent intellectual property rights, and promotes the development of Chinese knotter technology, and the mathematical model is helpful for designing new type of knotters.

Molecular Design of Conjugated Small Molecule Nanoparticles for Synergistically Enhanced PTT/PDT

Simultaneous photothermal therapy(PTT)and photodynamic therapy(PDT)is beneficial for enhanced cancer therapy due to the synergistic effect.Conventional materials developed for synergistic PTT/PDT are generally multicomponent agents that need complicated preparation procedures and be activated by multiple laser sources.The emerging monocomponent diketopyrrolopyrrole(DPP)-based conjugated small molecular agents enable dual PTT/PDT under a single laser irradiation,but suffer from low singlet oxygen quantum yield,which severely restricts the therapeutic efficacy.Herein,we report acceptor-oriented molecular design of a donor-acceptor-donor(D-A-D)conjugated small molecule(IID-ThTPA)-based phototheranostic agent,with isoindigo(IID)as selective acceptor and triphenylamine(TPA)as donor.The strong D-A strength and narrow singlet-triplet energy gap endow IID-ThTPA nanoparticles(IID-ThTPA NPs)high mass extinction coefficient(18.2 L g^-1 cm^-1),competitive photothermal conversion efficiency(35.4%),and a dramatically enhanced singlet oxygen quantum yield(84.0%)comparing with previously reported monocomponent PTT/PDT agents.Such a high PTT/PDT performance of IID-ThTPA NPs achieved superior tumor cooperative eradicating capability in vitro and in vivo.

Design of Small Stone Asphalt Mixture based on Anti-skidding Performance

Small stone asphalt mixture（SSAM） was designed by Bailey method and coarse aggregate voids-filling method.The optimum asphalt content was determined by Marshal test.Surface texture depth for SSAM with different voidage,and the BPN of SSAM and SMA before after wet track abrasion were measured.The experimental results indicate that the surface texture depth increases with the decreasing of asphalt aggregate ratio.The SSAM with the optimal asphalt content has a good skid resistance.BPN of asphalt mixture decreases with the increasing of wearing time,but the extent of reduction is different.The reduction rate of BPN for SSAM is smaller than that of SMA,indicating that SSAM has a good skid resistance attenuation capacity.Finally,the other properties of SSAM are also evaluated,showing that the splitting strength and modulus and SSAM are higher than those of SMA,and the other properties of SSAM,such as high-temperature performance and water stability can also satisfy the technical requirements.

Plant Landscape Design Language of Small Street Parks in Tropical Coastal Regions:A Case Study of Zhanjiang City

Small urban street parks play an irreplaceable role in protecting ecological environment of cities and beautifying living spaces of citizens, in these parks plant is an essential landscaping element that can not only improve environmental quality, but also provide visual enjoyment for viewers. There are many small street parks in Zhanjiang City, however, plant landscapes in such parks lack in regional characteristics because of blind copy and random planting. By analyzing plant landscapes in typical street parks in Zhanjiang, and borrowing the theoretical research framework of linguistics, this paper concluded the vocabulary, sentence,chapter and grammatical rules of plant landscape design, in order to explore new methods for the plant landscape design of small parks in tropical coastal regions.

Design and Comparative Analysis of Small Modular Reactors for Nuclear Marine Propulsion of a Ship

The fast growth in the size and difficulty of nuclear power plant in the 1970s produced an interest in smaller, modest designs that are intrinsically safe over the usage of design features. With the development of nuclear technology, there is the need for revolution in the Maritime sector, especially the advance marine propulsion. In current years, numerous reactor manufacturers are dynamically improving small modular reactor designs with even superior use of safety features. Several designs integrate the ultimate in greater safety. They totally remove specific accident initiators from the design. Other design features benefit to reduce different types of accident or help to mitigate the accident’s consequences. Although some safety features are mutual to maximum SMR designs, irrespective of the coolant technology, other features are specific to liquid-metal cooled, water, gas, or SMR designs. Results: There have been more reactor concepts investigated in the marine propulsion area by different assemblies and research laboratories than in the power generation field, and much can be learned from their experience for land applications. The extensive use of safety features in SMRs potential to make these power plants extremely vigorous, protecting both the public and the investor. Conclusion: For these two considerations, it is recognized that a nuclear reactor is the ideal engine for naval advanced propulsion. The paper will present the work to analyze the concept design of SMRs and design a modular vessel consisting of a propulsion module.

Landscape Planning & Design of Small Townlet in Ethnic Area

In this study, the overall planning of Ji Townlet in Jianshan Town, Tujia-Miao Autonomous Prefecture was analyzed. The landscape planning & design of small townlets combined with the natural environment, humanist resources and ethnic features in ethnic area were discussed.

Codebook design for uplink of densely small cells

The shrinking of cell-size brings significant changes to the wireless uplink of densely small cells （DSCs）. A codebook design is proposed that utilizes the strong line of sight （LOS） chan- nel component existing in a DSC system for uplink of the DSC system. To further improve the uplink performance, the high-rank codebook is designed based on singular value decomposition （SVD） due to the unnecessary preservation of strict constant modulus in the DSC system. And according to the simulation result, the proposed codebook leads to significant sum-rate gain and appreciable block error rate （BLER） performance improvement in the DSC system.

Design of the small microstrip antenna based on the WLAN/UWB wireless communication system

The antenna,as the component of receiving and sending signals in the front end of the wireless communication system,plays an important role in the communication quality,and is often the main obstacle to the development of the miniaturization of the wireless communication system.The microstrip antenna is composed of a metal radiation patch which can be pasted on the dielectric substrate.The choice of the shape of the metal patch can be arbitrary.The conventional shape is usually chosen as the metal patch to simplify the analysis and prediction of its performance.The dielectric constant of the microstrip antenna substrate is relatively low in order to enhance the field intensity of the edge radiation field.However,the dielectric constant of the substrate needs to be greater than 5 in order to meet the needs of other performance of the microstrip antenna,so that the radiation edge effect cannot be enhanced,resulting in the greater contradictions.

Analysis of Key Technologies in the Design of Small and Medium Span Basket Type Steel Box Tied Arch Bridge

In order to ensure the construction quality and safety of small and medium span basket type steel box tied arch bridge,this paper takes a practical project as an example to analyze the key technologies in its design process.It is hoped that this analysis can provide corresponding reference for the design and construction of this kind of arch bridge.

Plant Landscape Design of Residential Court

Courtyard is a signifi cant component of architectural design because it is an important living place that plays a positive role in improving the living environment. This paper reviewed basic principles of small courtyard landscape design, and analyzed the way of integrating plants and other landscape elements in small courtyards.

Performance Investigation of Three Combined Airfoils Bladed Small Scale Horizontal Axis wind Turbine by BEM and CFD Analysis

The present work is based on the comparative study between “Blade-Element- Momentum” (BEM) analysis and “Computational-Fluid-Dynamics” (CFD) analysis of small-scale horizontal axis wind turbine blade. In this study, the pitch is considered as fixed and rotor speed is variable. Firstly, the aerodynamic characteristics of three different specialized airfoils were analyzed to get optimum design parameters of wind turbine blade. Then BEM was performed with the application of the open source wind turbine design and performance computation software Q-Blade v0.6. After that, CFD simulation was done by Ansys CFX software. Here, k-ω “Shear-Stress-Transport” (SST) model was conducted for three-dimensional visualization of turbine performance. However, the best coefficient of performance was observed at 6o angle of attack. At this angle of attack, in the case of BEM, the highest coefficient of performance was 0.47 whereby CFD analysis, it was 0.43. Both studies showed good performance prediction which was a positive step to accelerate the continuous revolution in wind energy sector.

Prospective Development of Small Molecule Targets to Oncogenic Ras Proteins

Abnormal expression or mutations in Ras proteins has been found in up to 30% of cancer cell types, making them excellent protein models to probe structure-function relationships of cell-signaling processes that mediate cell transformtion. Yet, there has been very little development of therapies to help tackle Ras-related diseased states. The development of small molecules to target Ras proteins to potentially inhibit abnormal Ras-stimulated cell signaling has been conceptualized and some progress has been made over the last 16 or so years. Here, we briefly review studies characterizing Ras protein-small molecule interactions to show the importance and potential that these small molecules may have for Ras-related drug discovery. We summarize recent results, highlighting small molecules that can be directly targeted to Ras using Structure-Based Drug Design (SBDD) and Fragment-Based Lead Discovery (FBLD) methods. The inactivation of Ras oncogenic signaling in vitro by small molecules is currently an attractive hurdle to try to and leap over in order to attack the oncogenic state. In this regard, important features of previously characterized properties of small molecule Ras targets, as well as a current understanding of conformational and dynamics changes seen for Ras-related mutants, relative to wild type, must be taken into account as newer small molecule design strategies towards Ras are developed.

Feasibility neutronic design for the reactor core configurations of a 5 MWth transportable block-type HTR

Small long-life transportable high temperature gas-cooled reactors(HTRs) are interesting because they can safely provide electricity or heat in remote areas or to industrial users in developed or developing countries.This paper presents the neutronic design of the U-Battery,which is a 5 MWth block-type HTR with a fuel lifetime of 5–10 years.Assuming a reactor pressure vessel diameter of less than 3.7 m,some possible reactor core configurations of the 5 MWth U-Battery have been investigated using the TRITON module in SCALE 6.The neutronic analysis shows that Layout 12×2B,a scattering core containing 2 layers of 12 fuel blocks each with 20% enriched235U,reaches a fuel lifetime of 10 effective full power years(EFPYs).When the diameter of the reactor pressure vessel is reduced to 1.8 m,a fuel lifetime of 4 EFPYs will be achieved for the 5 MWth U-Battery with a 25-cm thick graphite side reflector.Layouts 6×3 and 6×4 with a 25-cm thick BeO side reflector achieve a fuel lifetime of 7 and 10 EFPYs,respectively.The comparison of the different core configurations shows that,keeping the number of fuel blocks in the reactor core constant,the annular and scattering core configurations have longer fuel lifetimes and lower fuel cost than the cylindrical ones.Moreover,for the 5 MWth U-Battery,reducing the fuel inventory in the reactor core by decreasing the diameter of fuel kernels and packing fraction of TRISO particles is more effective to lower the fuel cost than decreasing the 235U enrichment.

Structural Design Optimization of a Vertical Axis Wind Turbine for Seismic Qualification and Lightweight

Recently, there is a growing interest in seismic qualification of ridges, buildings and mechanical equipment worldwide due to increase of accidents caused by earthquake. Severe earthquake can bring serious problems in the wind turbines and eventually lead to an interruption to their electric power supply. To overcome and prevent these undesirable problems, structural design optimization of a small vertical axis wind turbine has performed, in this study, for seismic qualification and lightweight by using a Genetic Algorithm (GA) subject to some design constraints such as the maximum stress limit, maximum deformation limit, and seismic acceleration gain limit. Also, the structural design optimizations were conducted for the four different initial design variable sets to confirm robustness of the optimization algorithm used. As a result, all the optimization results for the 4 different initial designs showed good agreement with each other properly. Thus the structural design optimization of a small vertical-axis wind turbine could be successfully accomplished.

Environmental Integration of Small Hydropower Development

On the basis of cooperative research with European professionals, problems relating to environmental and ecological protection were discussed while small hydropower development in China currently was introduced in this paper. Guidelines of small hydropower development dealing with environmental protection were sug- gested hereby. Various specific technical environmental solutions focusing on small hydropower development applied in European and other developed countries were also introduced in this paper. Main environmental solutions are discussed as follows： integrated design should be advocated during plan/design stage,＂ ecohydraulic engineering and its utilization in SHP design and construction; effective technical approaches to relieve and eliminate the impact of river interception and fix the reasonable minimum biological flow; environment-friendly mitigation and compensation measures for high/low-head hydropower schemes applied in diversion works, intake, nature-like fish-passes, penstock and powerhouse design; study and application of the new technology, material and equipments; launching renovation of environmental protection in existing stations; emphasiz- ing public participation and their acceptability for the SHP environment; coordinated inter-disciplinary study at national level, etc. Two case studies in Sweden and Australia are given here.

SMALL HELIOSTATS CSP SYSTEMS ON LONG-SPAN HANGING ROOFS

Building Integrated Concentrating Solar Power (BI-CSP) schematic studies with small scale exterior two-axis tracking heliostats anchored on and semi-shading long span hanging roofs with elevated receiver(s) are presented for populated urban and rural locations. Hanging roofs (inverted shallow dome shape) with two-way structural cables and mostly square infill prefabricated slabs/panels supported from a perimeter horizontal circular donut shape rim-girder-platform without a center tension ring studies are for comparing to radial cable structural configurations with a center tension ring. Cable gap grouting between slabs/panels form a pre-tensioned inverted shell structure after temporary weights are removed. Securing vertical heliostat posts studies include: three vertical bolts cast in grout gap two-way cables intersections for three point adjustment of horizontal post base plates;and one-axis adjustable manufactured post brackets bolted to sloped roof surfaces at holes cast in the gaps/slabs. A main case study schematic is around a 30m/100ft diameter hanging roof with a 0.07 sag/diameter ratio with around 271 1m2 heliostats for 230kWt solar thermal steam or air to around 300degC/572degF building integrated thermal energy storage (molten salt, firebricks, etc.) and applications (water purification, cooling, industrial process heat, etc.). A BI-CSP hanging roofs R&D project proposal is outlined: with a circular roof study diameter range of around 25m/82ft-200m/656ft diameter for comparing two-way and radial cable structural configurations for distributed steam stations and a wide range of application temperatures.

Reliability-Based Optimization:Small Sample Optimization Strategy

The aim of the paper is to present a newly developed approach for reliability-based design optimization. It is based on double loop framework where the outer loop of algorithm covers the optimization part of process of reliability-based optimization and reliability constrains are calculated in inner loop. Innovation of suggested approach is in application of newly developed optimization strategy based on multilevel simulation using an advanced Latin Hypercube Sampling technique. This method is called Aimed multilevel sampling and it is designated for optimization of problems where only limited number of simulations is possible to perform due to enormous com- putational demands.

自拟健脾除积方联合信迪利单抗及化疗对晚期非小细胞肺癌患者的影响

目的:探讨自拟健脾除积方联合信迪利单抗及化疗对晚期非小细胞肺癌患者疾病控制率、中医症候积分及不良反应的影响。方法:选取2020年10月—2022年10月在我院就诊的102例晚期非小细胞肺癌患者,随机分为观察组和对照组,每组各51例,对照组在吉西他滨+顺铂化疗的基础上给予信迪利单抗,观察组在对照组基础上联合自拟健脾除积方治疗。比较两组患者临床疗效、治疗前后中医症候积分、肿瘤标志物水平及不良反应。结果:观察组有效率和疾病控制率明显高于对照组(P<0.05);观察组和对照组治疗后中医症候积分均显著低于治疗前;治疗后,观察组中医症候积分显著低于对照组(P<0.05)。两组治疗后血清铁蛋白(SF)、鳞状细胞癌抗原(SCCA)及癌胚抗原(CEA)水平均显著低于同组治疗前,观察组SF、SCCA、CEA水平均显著低于对照组。观察组白细胞计数减少、恶心、呕吐症状总发生率显著低于对照组(P<0.05)。结论:自拟健脾除积方联合信迪利单抗对晚期非小细胞肺癌患者治疗效果较好,可改善患者中医症候,具有较高的安全性。