The aim of this study is to identify and analyze ways to increase usage of destination website and motivate website visitors’intention to actually visit the destination.The sample population is South Koreans who visi...The aim of this study is to identify and analyze ways to increase usage of destination website and motivate website visitors’intention to actually visit the destination.The sample population is South Koreans who visit the VisitBritain website,the homepage of Britain’s national tourism agency.The data for this study were collected by a self-participated online survey on the blog of VisitBritain Korea,which is directly linked to the VisitBritain Korea website.Using structural equation modeling,six hypotheses were tested.The results show that the destination image on the destination marketing organization(DMO)website,quality of the destination website design including three dimensions(information quality,system quality,and service quality),and customers’satisfaction formed by high quality of the website design have a significant impact on website visitors’use intention and increase their visiting intention to the destination.Based upon the results of the analysis,managerial implications and areas for future research are proposed.展开更多
In recent years,embodied cognition has ushered in a new research upsurge in the academic field,and has become a hot topic in the field of cognitive psychology.In this paper,from the perspective of embodied cognition,t...In recent years,embodied cognition has ushered in a new research upsurge in the academic field,and has become a hot topic in the field of cognitive psychology.In this paper,from the perspective of embodied cognition,the interaction ways of a landscape device for children were discussed to achieve a more real and harmonious interaction between children and scenes.The research data of embodied cognition used by children was analyzed,and the drawbacks and breakthrough points of current landscape devices for children were discussed.The core characteristics of children’s growth period were extracted to establish children’s interaction model and summarize the interactive design methods of landscape devices for children.Embodied cognition has become the most intuitive way for children to know and understand the environment,and plays a pivotal role in children’s growth.Based on embodied cognition principle and interactive behavior mode,the interactive design of a landscape device for children was studied,and three interactive design modes,including simple and convenient interaction mode,multi-sensory interaction mode and game natural interaction mode were summarized.On the basis of this research,relevant design practice and research were carried out to bring a new vision to the design of children’s landscape.展开更多
Nowadays,the elderly have become an increasingly large group of people in China,but still many problems exist in their living space.This paper explores the physiological and psychological behavioral changes of the eld...Nowadays,the elderly have become an increasingly large group of people in China,but still many problems exist in their living space.This paper explores the physiological and psychological behavioral changes of the elderly,studies their living space requirements,and tries to put forward targeted design strategies in response.Therefore,making a better and more reasonable living space for the elderly as well as improving their living quality,finally helping the development of elderly-friendly design in China.展开更多
Edutainment,in the kindergarten education stage,emphasizes the game as the basic activity and combines the content of education with the form of the game,thus it also forms the educational method of gamification teach...Edutainment,in the kindergarten education stage,emphasizes the game as the basic activity and combines the content of education with the form of the game,thus it also forms the educational method of gamification teaching.Through investigation and analysis,it is found that the current kindergarten game activity design has the problem of improper combination of educational content and game form.The current kindergarten game activity design has problems such as stereotypes,children’s lack of active learning opportunities in activities,teachers’insufficient theoretical understanding,inappropriate teacher guidance methods,and so on.Embodied cognition theory attaches importance to the important role of the body in the development of cognition,provides new guidance for classroom teaching,and opens up a new path for classroom teaching reform.Based on the perspective of embodied cognition theory,the concept of body and mind integration should be adhered to in kindergarten teaching with games as the basic activity,experiential teaching situation should be created,children’s subjective experience should be respected,and games and interactions should be designed to promote children’s physical and mental participation,thus laying a foundation for the realization of children’s individual freedom,autonomy,and all-round development.Therefore,this paper aims at the existing problems in the current kindergarten gamification teaching and discusses the design strategy of children’s game activities based on embodied cognition theory.展开更多
γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the ...γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface receptors.Mutations inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as well.However,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-secretase.In this review,we focus on recent studies of structural dynamic mechanisms ofγ-secretase.Different mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics simulations.While an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental findings.The approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-secretase.In addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is discussed.Finally,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations of theγ-secretase-substrate complexes.Comprehensive understanding of the functional mechanisms ofγ-secretase will greatly facilitate the rational design of effective drug molecules for treating familial Alzheimer’s disease and perhaps Alzheimer’s disease in general.展开更多
'Asahi Kasei China Fashion Designer Creative awards'2017 S/S collection Show was held in Beijing Hotel to announce the theme of the nineteenth award-winning designer Richard Li’s works show on the evening of ...'Asahi Kasei China Fashion Designer Creative awards'2017 S/S collection Show was held in Beijing Hotel to announce the theme of the nineteenth award-winning designer Richard Li’s works show on the evening of October 29,2016.This event is directly hosted by the China Fashion Week Organizing Committee,Asahi Kasei Corporation and Asahi Kasei Textile Corporation and Hong Kong Fashion Designers Association展开更多
This paper aims to discuss the real intention behind Caesar’s two British expeditions and the evidence against the conquest theory.In Commentarii de Bello Gallico,Caesar claimed that he invaded Britain because he wou...This paper aims to discuss the real intention behind Caesar’s two British expeditions and the evidence against the conquest theory.In Commentarii de Bello Gallico,Caesar claimed that he invaded Britain because he would like to teach the Britons a lesson for aiding the Gauls.Most modern scholars disagree that Caesar’s true intention is what Caesar has said,so they come up with their own theories.Ranzani says Caesar’s expedition is for glory,while Deutsch argues that Caesar’s expeditions are for pearls.Mitchell suggests that Caesar went to Britain for tin,while Ranzani,Schadee,Raaflaub,and Riggsby all come up with the theory of Caesar’s military and political gains.Brady is one of the few scholars who believe in what Caesar has said-to punish the Gauls.Moreover,Brady also considers Caesar’s expeditions a success since he does not think Caesar’s true goal is to conquer Britain.展开更多
With the development of the internet,online pop-up advertisements(hereinafter,referred to as pop-up ads)have emerged.However,online users may disdain and reject online advertisements,which affects online purchase inte...With the development of the internet,online pop-up advertisements(hereinafter,referred to as pop-up ads)have emerged.However,online users may disdain and reject online advertisements,which affects online purchase intention.This study is on reducing the negative impact of pop-up ads on users and improving the commercial effect.Self-administered questionnaires were used to survey online users and website designers.The data collected were analyzed using SPSS and the open answers were sorted out by thematic analysis.The results revealed that attractive storylines,background music,and exquisite visual presentations are effective in reducing users5 rejection to pop-up ads as well as advertisement customization.It is better for pop-up ads to appear in the middle or end of videos.The VIP system is also a choice for users to eliminate them.Designers are supposed to keep a balance between users and advertisers.In addition,internet regulation needs to be strengthened to reduce eroticism and violence in pop-up ads as well as avoid the negative impact of these kind of pop-up ads on minors.展开更多
After analysis of location feature of the south of lower reaches of Yangtze River and its construction of urban and rural integration,the paper pointed out harmonious combination between natural and artificial factors...After analysis of location feature of the south of lower reaches of Yangtze River and its construction of urban and rural integration,the paper pointed out harmonious combination between natural and artificial factors had been neglected in planning and design of farmers' residential area at the south of lower reaches of Yangtze River,"regional characteristic" losing,residential area in the form of "city community" and buildings in European style.In view of these problems,relevant planning and design thoughts and methods had been proposed as to how to create "regional characteristic" from the perspective of planning,architecture and landscape design.It discussed with emphasis the importance of construction base type and combination of environment with residential area construction;inspirations and design methods obtained from traditional architectures;and the content of landscape overall planning and specific design.It was hoped to enlighten designers to shoulder social and historical responsibility,make exploration unremittingly,and construct beautiful homelands for people.展开更多
Aiming at the problem existing in the computer aided design process that how to express the design intents with high-level engineering terminologies, a mechanical product self-organized semantic feature evolution tech...Aiming at the problem existing in the computer aided design process that how to express the design intents with high-level engineering terminologies, a mechanical product self-organized semantic feature evolution technology for axiomatic design is proposed, so that the constraint relations between mechanical parts could be expressed in a semantic form which is more suitable for designers. By describing the evolution rules for semantic constraint information, the abstract expression of design semantics in mechanical product evolution process is realized and the constraint relations between parts are mapped to the geometric level from the semantic level; With semantic feature relation graph, the abstract semantic description, the semantic relative structure and the semantic constraint information are linked together; And the methods of semantic feature self-organized evolution are classified. Finally, combining a design example of domestic high-speed elevator, how to apply the theory to practical product development is illustrated and this method and its validity is described and verified. According to the study results, the designers are able to represent the design intents at an advanced semantic level in a more intuitional and natural way and the automation, recursion and visualization for mechanical product axiomatic design are also realized.展开更多
文摘The aim of this study is to identify and analyze ways to increase usage of destination website and motivate website visitors’intention to actually visit the destination.The sample population is South Koreans who visit the VisitBritain website,the homepage of Britain’s national tourism agency.The data for this study were collected by a self-participated online survey on the blog of VisitBritain Korea,which is directly linked to the VisitBritain Korea website.Using structural equation modeling,six hypotheses were tested.The results show that the destination image on the destination marketing organization(DMO)website,quality of the destination website design including three dimensions(information quality,system quality,and service quality),and customers’satisfaction formed by high quality of the website design have a significant impact on website visitors’use intention and increase their visiting intention to the destination.Based upon the results of the analysis,managerial implications and areas for future research are proposed.
文摘In recent years,embodied cognition has ushered in a new research upsurge in the academic field,and has become a hot topic in the field of cognitive psychology.In this paper,from the perspective of embodied cognition,the interaction ways of a landscape device for children were discussed to achieve a more real and harmonious interaction between children and scenes.The research data of embodied cognition used by children was analyzed,and the drawbacks and breakthrough points of current landscape devices for children were discussed.The core characteristics of children’s growth period were extracted to establish children’s interaction model and summarize the interactive design methods of landscape devices for children.Embodied cognition has become the most intuitive way for children to know and understand the environment,and plays a pivotal role in children’s growth.Based on embodied cognition principle and interactive behavior mode,the interactive design of a landscape device for children was studied,and three interactive design modes,including simple and convenient interaction mode,multi-sensory interaction mode and game natural interaction mode were summarized.On the basis of this research,relevant design practice and research were carried out to bring a new vision to the design of children’s landscape.
基金“Research on the Design Strategies of the Senior Community from the Perspective of Community Operation and Service Management,”University-level Research Projects in 2023(Project No.XdKY234732).
文摘Nowadays,the elderly have become an increasingly large group of people in China,but still many problems exist in their living space.This paper explores the physiological and psychological behavioral changes of the elderly,studies their living space requirements,and tries to put forward targeted design strategies in response.Therefore,making a better and more reasonable living space for the elderly as well as improving their living quality,finally helping the development of elderly-friendly design in China.
文摘Edutainment,in the kindergarten education stage,emphasizes the game as the basic activity and combines the content of education with the form of the game,thus it also forms the educational method of gamification teaching.Through investigation and analysis,it is found that the current kindergarten game activity design has the problem of improper combination of educational content and game form.The current kindergarten game activity design has problems such as stereotypes,children’s lack of active learning opportunities in activities,teachers’insufficient theoretical understanding,inappropriate teacher guidance methods,and so on.Embodied cognition theory attaches importance to the important role of the body in the development of cognition,provides new guidance for classroom teaching,and opens up a new path for classroom teaching reform.Based on the perspective of embodied cognition theory,the concept of body and mind integration should be adhered to in kindergarten teaching with games as the basic activity,experiential teaching situation should be created,children’s subjective experience should be respected,and games and interactions should be designed to promote children’s physical and mental participation,thus laying a foundation for the realization of children’s individual freedom,autonomy,and all-round development.Therefore,this paper aims at the existing problems in the current kindergarten gamification teaching and discusses the design strategy of children’s game activities based on embodied cognition theory.
基金supported in part by Award 2121063 from National Science Foundation(to YM)AG66986 from the National Institutes of Health(to MSW).
文摘γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface receptors.Mutations inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as well.However,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-secretase.In this review,we focus on recent studies of structural dynamic mechanisms ofγ-secretase.Different mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics simulations.While an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental findings.The approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-secretase.In addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is discussed.Finally,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations of theγ-secretase-substrate complexes.Comprehensive understanding of the functional mechanisms ofγ-secretase will greatly facilitate the rational design of effective drug molecules for treating familial Alzheimer’s disease and perhaps Alzheimer’s disease in general.
文摘'Asahi Kasei China Fashion Designer Creative awards'2017 S/S collection Show was held in Beijing Hotel to announce the theme of the nineteenth award-winning designer Richard Li’s works show on the evening of October 29,2016.This event is directly hosted by the China Fashion Week Organizing Committee,Asahi Kasei Corporation and Asahi Kasei Textile Corporation and Hong Kong Fashion Designers Association
文摘This paper aims to discuss the real intention behind Caesar’s two British expeditions and the evidence against the conquest theory.In Commentarii de Bello Gallico,Caesar claimed that he invaded Britain because he would like to teach the Britons a lesson for aiding the Gauls.Most modern scholars disagree that Caesar’s true intention is what Caesar has said,so they come up with their own theories.Ranzani says Caesar’s expedition is for glory,while Deutsch argues that Caesar’s expeditions are for pearls.Mitchell suggests that Caesar went to Britain for tin,while Ranzani,Schadee,Raaflaub,and Riggsby all come up with the theory of Caesar’s military and political gains.Brady is one of the few scholars who believe in what Caesar has said-to punish the Gauls.Moreover,Brady also considers Caesar’s expeditions a success since he does not think Caesar’s true goal is to conquer Britain.
文摘With the development of the internet,online pop-up advertisements(hereinafter,referred to as pop-up ads)have emerged.However,online users may disdain and reject online advertisements,which affects online purchase intention.This study is on reducing the negative impact of pop-up ads on users and improving the commercial effect.Self-administered questionnaires were used to survey online users and website designers.The data collected were analyzed using SPSS and the open answers were sorted out by thematic analysis.The results revealed that attractive storylines,background music,and exquisite visual presentations are effective in reducing users5 rejection to pop-up ads as well as advertisement customization.It is better for pop-up ads to appear in the middle or end of videos.The VIP system is also a choice for users to eliminate them.Designers are supposed to keep a balance between users and advertisers.In addition,internet regulation needs to be strengthened to reduce eroticism and violence in pop-up ads as well as avoid the negative impact of these kind of pop-up ads on minors.
文摘After analysis of location feature of the south of lower reaches of Yangtze River and its construction of urban and rural integration,the paper pointed out harmonious combination between natural and artificial factors had been neglected in planning and design of farmers' residential area at the south of lower reaches of Yangtze River,"regional characteristic" losing,residential area in the form of "city community" and buildings in European style.In view of these problems,relevant planning and design thoughts and methods had been proposed as to how to create "regional characteristic" from the perspective of planning,architecture and landscape design.It discussed with emphasis the importance of construction base type and combination of environment with residential area construction;inspirations and design methods obtained from traditional architectures;and the content of landscape overall planning and specific design.It was hoped to enlighten designers to shoulder social and historical responsibility,make exploration unremittingly,and construct beautiful homelands for people.
基金National Natural Science Foundation of China (No.50505044)National Hi-tech Research and Development Program of China (863 Program,No.2007AA04Z 190)
文摘Aiming at the problem existing in the computer aided design process that how to express the design intents with high-level engineering terminologies, a mechanical product self-organized semantic feature evolution technology for axiomatic design is proposed, so that the constraint relations between mechanical parts could be expressed in a semantic form which is more suitable for designers. By describing the evolution rules for semantic constraint information, the abstract expression of design semantics in mechanical product evolution process is realized and the constraint relations between parts are mapped to the geometric level from the semantic level; With semantic feature relation graph, the abstract semantic description, the semantic relative structure and the semantic constraint information are linked together; And the methods of semantic feature self-organized evolution are classified. Finally, combining a design example of domestic high-speed elevator, how to apply the theory to practical product development is illustrated and this method and its validity is described and verified. According to the study results, the designers are able to represent the design intents at an advanced semantic level in a more intuitional and natural way and the automation, recursion and visualization for mechanical product axiomatic design are also realized.